St. Louis Cardinals vs Chicago White Sox Odds

The Cardinals will play the White Sox on Thursday, June 19th, 2025. This is Game 2 of a doubleheader. Your timezone's first pitch time is 5:10 pm EDT. Check local listings or your nearest streaming app for coverage.

Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.


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Table of Contents

Key Matchup Stats

  • SportsBetting3.com Power Rankings - As the 2025 season continues, the St. Louis Cardinals possess a 95.33 SportsBetting3.com power ranking. The Chicago White Sox now have a 85.67 power ranking. Teams with a higher SportsBetting3.com power ranking will typically be moneyline favorites.
  • Visiting St. Louis Cardinals - The St. Louis Cardinals head into this matchup with a 11-16 record as a visiting team. This standing ranks them 7th Overall for visiting team wins.
  • Home Chicago White Sox - The Chicago White Sox will throw the first pitch possessing a 12-15 home team record. That puts them 8th for home team wins in the Overall MLB standings.
  • Runs Scored - St. Louis Cardinals batters have produced 256 runs, ranking them 8th Overall, with the Chicago White Sox ranking 24th (183) for runs scored.
  • Runs Allowed - St. Louis Cardinals pitchers and fielders have allowed 216 runs, ranking them 18th Overall for runs allowed. Meanwhile, the Chicago White Sox now rank 12th Overall, allowing 234 runs.
  • Team Streaks - The St. Louis Cardinals lost their last game. Their opponent, the Chicago White Sox have lost their last 2 games.
  • Team Records - Let's review each team's records. The St. Louis Cardinals have a 30-24 Overall record (3.0 GB National Central Division), with the Chicago White Sox notching a 17-37 Overall standing (18.5 GB American Central Division).

Captain Shady Lines

A broken compass is right at least twice a day.

Captain Shady Lines
Captain Shady Lines

Avast ye scallywags! The Cardinals be sailing into enemy territory... (Get ready for a battle of the bats on Thursday afternoon). Chicago be a sinking ship with a record as dreadful as Davy Jones' locker. (The White Sox don't stand a chance against the Cardinals' might). Arrr, the Red Birds be on a 6-4 tear lately... (Their cannons be loaded and ready to fire against the White Sox). Prepare for a showdown on the diamond, me hearties... (This be a game ye won't want to miss. Check out this game's prop bets below). Bet on MLB baseball at legal US sportsbooks... (Ye can win some doubloons while watching the Cardinals crush the White Sox). Review each team's standing at the bottom of the page... (And see why the Cardinals be the team to beat in this matchup). So raise the Jolly Roger and root for the Cardinals to victory!

Best Cardinals at White Sox Odds


Best Moneyline Betting Odds
Underdog

Chicago White Sox
Favorite

St. Louis Cardinals
The St. Louis Cardinals are the -160 moneyline favorite. Risk $160 to win $100 on the St. Louis Cardinals at BetMGM. The Chicago White Sox are the +135 underdog at BetMGM. Risk $100 to win $135 on the Chicago White Sox. Learn more about how to bet on money lines.

Best Total Betting Odds
OverUnder
BetMGM has the best over line of 8 runs. Risk $110 to win $100. BetMGM has the best under line of 8 runs. Risk $110 to win $100. Our tutorial explains more about total bets.

Best Run Line Betting Odds
Underdog

Chicago White Sox
Favorite

St. Louis Cardinals
The St. Louis Cardinals have a -1.5 +110 run line at BetMGM OH. They are the run line favorite in this matchup. The Chicago White Sox have a +1.5 -135 run line at BetMGM OH. The Chicago White Sox are the run line underdogs. Review how to bet on a point spread with our text and video tutorials.

Matchup Odds FAQs

What is the moneyline for the St. Louis Cardinals vs Chicago White Sox MLB game on Thursday, June 19th, 2025?

The St. Louis Cardinals are the -160 moneyline favorite at BetMGM and the Chicago White Sox are the +135 moneyline underdog at BetMGM.

What is the over-under total line for the St. Louis Cardinals vs Chicago White Sox MLB game on Thursday, June 19th, 2025?

The best over line is 8 -110 runs at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 8 -110 runs at BetMGM, and that means you risk $110 to win $100 betting the under.

What is the run line for the St. Louis Cardinals vs Chicago White Sox MLB game on Thursday, June 19th, 2025?

The St. Louis Cardinals are -1.5 +110 run line favorites at BetMGM, while the Chicago White Sox are +1.5 -135 run line underdogs at BetMGM.

MLB Odds Example

MLB Odds and Outcomes Explained

Game
BetMGM Sports Betting BetMGM
Bet
Cardinals
White Sox
Doubleheader - Game 2 - 6/19/25 5:10pm EDT
-160+135
Bet $100 at BetMGM Ohio
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Possible Moneyline Outcomes
  • Chicago White Sox bettors risk $100 to win $135 at +135 odds. The implied probability for Chicago White Sox is 42.55%.
  • St. Louis Cardinals bettors risk $100 to win $62.5 at -160 odds. The implied probability for St. Louis Cardinals is 61.54%.

St. Louis Cardinals at Chicago White Sox Prop Bets

MLB Prop Bets
+ Displays more odds
BetMGM Sports Betting BetMGM
Bet
Cardinals
White Sox
6/19/25 5:10pm EDT
Doubleheader - Game 2
Pending BetMGM

St. Louis Cardinals & Chicago White Sox Futures Odds

Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.

St. Louis Cardinals World Series Odds
2025 St. Louis Cardinals World Series Odds

Team
BetMGM Sports Betting BetMGM
Cardinals
+8000
Bet
Chicago White Sox World Series Odds
2025 Chicago White Sox World Series Odds

Team
BetMGM Sports Betting BetMGM
White Sox
+200000
Bet

St. Louis Cardinals & Chicago White Sox Team Pages

Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Standings

2025 MLB Regular Season Standings - St. Louis Cardinals, Chicago White Sox
Team W L Pct GB Home Away RS RA Diff Strk L10
St. Louis Cardinals51460.526+8.029-2022-26444427+17W14-6
Chicago White Sox32650.330+27.021-2911-36332430-98L24-6

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the St. Louis Cardinals vs Chicago White Sox MLB Game

  1. Open a new sports betting account before game time.

    Review our list of sports betting sites. Open a new account before the game starts on Thursday, June 19th, 2025 at 5:10 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.

  2. Visit the sportsbook’s cashier, banking, or deposit page.

    Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.

  3. Tap to the sportsbook's MLB page, look for the St. Louis Cardinals vs Chicago White Sox Game.

    Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the St. Louis Cardinals vs Chicago White Sox Game.

  4. Choose your bet and place a wager.

    Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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