The Cardinals will play the Astros on Sunday, February 22nd, 2026. Your timezone's first pitch time is 1:05 pm EST. Check local listings or your nearest streaming app for coverage.
Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.
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Table of Contents
- Best Odds
- Interactive Odds Example
- Prop Bets
- Team Futures Odds
- Team Pages
- Team Standings
- Other Games Today
Best Cardinals at Astros Odds
| Underdog St. Louis Cardinals | Favorite Houston Astros |
|---|---|
| Over | Under |
|---|---|
| Underdog Houston Astros | Favorite St. Louis Cardinals |
|---|---|
Matchup Odds FAQs
The Houston Astros are the -125 moneyline favorite at BetMGM and the St. Louis Cardinals are the +105 moneyline underdog at BetMGM.
The best over line is 10.5 -110 runs at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 10.5 -110 runs at BetMGM, and that means you risk $110 to win $100 betting the under.
The St. Louis Cardinals are -1.5 +150 run line favorites at BetMGM, while the Houston Astros are +1.5 -185 run line underdogs at BetMGM.
MLB Odds Example
|
Game |
 BetMGMBet |
|---|---|
Cardinals
Astros
2/22/26 1:05pm EST | +105-125 |
- St. Louis Cardinals bettors risk $100 to win $105 at +105 odds. The implied probability for St. Louis Cardinals is 48.78%.
- Houston Astros bettors risk $100 to win $80 at -125 odds. The implied probability for Houston Astros is 55.56%.
St. Louis Cardinals at Houston Astros Prop Bets
| BetMGM Bet |
|
|---|---|
Cardinals
Astros
2/22/26 1:05pm EST | Pending BetMGM |
St. Louis Cardinals & Houston Astros Futures Odds
Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.
St. Louis Cardinals World Series Odds|
Team | BetMGM |
|---|---|
| Cardinals | +25000 Bet |
|
Team | BetMGM |
|---|---|
| Astros | +2200 Bet |
St. Louis Cardinals & Houston Astros Team Pages
Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
Team Standings
| Team | W | L | Pct | GB | Home | Away | RS | RA | Diff | Strk | L10 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| e - Houston Astros | 87 | 75 | 0.537 | +10.0 | 46-35 | 41-40 | 686 | 665 | +21 | W2 | 4-6 |
| e - St. Louis Cardinals | 78 | 84 | 0.481 | +19.0 | 44-37 | 34-47 | 689 | 754 | -65 | L4 | 4-6 |
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the St. Louis Cardinals vs Houston Astros MLB Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, February 22nd, 2026 at 1:05 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's MLB page, look for the St. Louis Cardinals vs Houston Astros Game.
Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the St. Louis Cardinals vs Houston Astros Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other February 22, 2026 MLB Games
- Baltimore Orioles vs Detroit Tigers
- Minnesota Twins vs Atlanta Braves
- New York Mets vs New York Yankees
- Toronto Blue Jays vs Boston Red Sox
- Washington Nationals vs Miami Marlins
- Seattle Mariners vs Cincinnati Reds
- Colorado Rockies vs Texas Rangers
- Cleveland Guardians vs Oakland Athletics
- Chicago Cubs vs San Francisco Giants
- Los Angeles Angels vs Arizona Diamondbacks
- Los Angeles Dodgers vs San Diego Padres