St. Louis Cardinals vs Houston Astros Odds

The Cardinals will play the Astros on Wednesday, March 5th, 2025. Your timezone's first pitch time is 1:05 pm EST. Check local listings or your nearest streaming app for coverage.

Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.

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Best Cardinals at Astros Odds

**Best Moneyline Betting Odds**
Underdog St. Louis Cardinals	Favorite Houston Astros
+133 BetRivers Bet	-162 BetRivers Bet

The Houston Astros are the -162 moneyline favorite. Risk $162 to win $100 on the Houston Astros at BetRivers. The St. Louis Cardinals are the +133 underdog at BetRivers. Risk $100 to win $133 on the St. Louis Cardinals. Learn more about how to bet on money lines.

**Best Total Betting Odds**
Over	Under

Total odds are updating, please check back soon.

**Best Run Line Betting Odds**
TBD	TBD

Run Line odds are updating, please check back soon.

Matchup Odds FAQs

What is the moneyline for the St. Louis Cardinals vs Houston Astros MLB game on Wednesday, March 5th, 2025?

The Houston Astros are the -162 moneyline favorite at BetRivers and the St. Louis Cardinals are the +133 moneyline underdog at BetRivers.

MLB Odds Example

MLB Odds and Outcomes Explained
Game	BetRivers Bet
Cardinals Astros 3/05/25 1:05pm EST	+133 -162

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Possible Moneyline Outcomes

St. Louis Cardinals bettors risk $100 to win $133 at +133 odds. The implied probability for St. Louis Cardinals is 42.92%.
Houston Astros bettors risk $100 to win $61.73 at -162 odds. The implied probability for Houston Astros is 61.83%.

St. Louis Cardinals at Houston Astros Prop Bets

MLB Prop Bets
+ Displays more odds
	BetMGM Bet
Cardinals Astros 3/05/25 1:05pm EST	Pending BetMGM

St. Louis Cardinals & Houston Astros Futures Odds

Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.

St. Louis Cardinals World Series Odds

2026 St. Louis Cardinals World Series Odds
Team	BetMGM	BetRivers
Cardinals	+15000 Bet	+7500 Bet

Houston Astros World Series Odds

2026 Houston Astros World Series Odds
Team	BetMGM	BetRivers
Astros	+1600 Bet	+1100 Bet

St. Louis Cardinals & Houston Astros Team Pages

Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Standings

2025 MLB Regular Season Standings - St. Louis Cardinals, Houston Astros
Team	W	L	Pct	GB	Home	Away	RS	RA	Diff	Strk	L10
e - Houston Astros	87	75	0.537	+10.0	46-35	41-40	686	665	+21	W2	4-6
e - St. Louis Cardinals	78	84	0.481	+19.0	44-37	34-47	689	754	-65	L4	4-6

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the St. Louis Cardinals vs Houston Astros MLB Game

Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Wednesday, March 5th, 2025 at 1:05 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
Tap to the sportsbook's MLB page, look for the St. Louis Cardinals vs Houston Astros Game.
Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the St. Louis Cardinals vs Houston Astros Game.
Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

Other March 5, 2025 MLB Games

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