St. Louis Cardinals vs Houston Astros Odds

The Cardinals will play the Astros on Sunday, February 22nd, 2026. Your timezone's first pitch time is 1:05 pm EST. Check local listings or your nearest streaming app for coverage.

Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.


Bonus
BetMGM Sportsbook#1 BetMGM
REVIEW
New Customers - Up to $1500 Paid Back in Bonus Bets
Bonus Bets Expire in 7 Days
One new customer offer/Add'l Terms

Bet Now
21+ Playable in Ohio only
Gambling Problem? Call 1-800-589-9966

Table of Contents

Best Cardinals at Astros Odds


Best Moneyline Betting Odds
Underdog

St. Louis Cardinals
Favorite

Houston Astros
The Houston Astros are the -125 moneyline favorite. Risk $125 to win $100 on the Houston Astros at BetMGM. The St. Louis Cardinals are the +105 underdog at BetMGM. Risk $100 to win $105 on the St. Louis Cardinals. Learn more about how to bet on money lines.

Best Total Betting Odds
OverUnder
BetMGM has the best over line of 10.5 runs. Risk $110 to win $100. BetMGM has the best under line of 10.5 runs. Risk $110 to win $100. Our tutorial explains more about total bets.

Best Run Line Betting Odds
Underdog

Houston Astros
Favorite

St. Louis Cardinals
The St. Louis Cardinals have a -1.5 +150 run line at BetMGM OH. They are the run line favorite in this matchup. The Houston Astros have a +1.5 -185 run line at BetMGM OH. The Houston Astros are the run line underdogs. Review how to bet on a point spread with our text and video tutorials.

Matchup Odds FAQs

What is the moneyline for the St. Louis Cardinals vs Houston Astros MLB game on Sunday, February 22nd, 2026?

The Houston Astros are the -125 moneyline favorite at BetMGM and the St. Louis Cardinals are the +105 moneyline underdog at BetMGM.

What is the over-under total line for the St. Louis Cardinals vs Houston Astros MLB game on Sunday, February 22nd, 2026?

The best over line is 10.5 -110 runs at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 10.5 -110 runs at BetMGM, and that means you risk $110 to win $100 betting the under.

What is the run line for the St. Louis Cardinals vs Houston Astros MLB game on Sunday, February 22nd, 2026?

The St. Louis Cardinals are -1.5 +150 run line favorites at BetMGM, while the Houston Astros are +1.5 -185 run line underdogs at BetMGM.

MLB Odds Example

MLB Odds and Outcomes Explained

Game
BetMGM Sports Betting BetMGM
Bet
Cardinals
Astros
2/22/26 1:05pm EST
+105-125
Bet $100 at BetMGM Ohio
21+ Playable in Ohio only
Gambling Problem? Call 1-800-589-9966
Possible Moneyline Outcomes
  • St. Louis Cardinals bettors risk $100 to win $105 at +105 odds. The implied probability for St. Louis Cardinals is 48.78%.
  • Houston Astros bettors risk $100 to win $80 at -125 odds. The implied probability for Houston Astros is 55.56%.

St. Louis Cardinals at Houston Astros Prop Bets

MLB Prop Bets
+ Displays more odds
BetMGM Sports Betting BetMGM
Bet
Cardinals
Astros
2/22/26 1:05pm EST
Pending BetMGM

St. Louis Cardinals & Houston Astros Futures Odds

Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.

St. Louis Cardinals World Series Odds
2026 St. Louis Cardinals World Series Odds

Team
BetMGM Sports Betting BetMGM
Cardinals
+25000
Bet
Houston Astros World Series Odds
2026 Houston Astros World Series Odds

Team
BetMGM Sports Betting BetMGM
Astros
+2200
Bet

St. Louis Cardinals & Houston Astros Team Pages

Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Standings

2025 MLB Regular Season Standings - St. Louis Cardinals, Houston Astros
Team W L Pct GB Home Away RS RA Diff Strk L10
e - Houston Astros87750.537+10.046-3541-40686665+21W24-6
e - St. Louis Cardinals78840.481+19.044-3734-47689754-65L44-6

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the St. Louis Cardinals vs Houston Astros MLB Game

  1. Open a new sports betting account before game time.

    Review our list of sports betting sites. Open a new account before the game starts on Sunday, February 22nd, 2026 at 1:05 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.

  2. Visit the sportsbook’s cashier, banking, or deposit page.

    Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.

  3. Tap to the sportsbook's MLB page, look for the St. Louis Cardinals vs Houston Astros Game.

    Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the St. Louis Cardinals vs Houston Astros Game.

  4. Choose your bet and place a wager.

    Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

Other February 22, 2026 MLB Games

Odds Preview 14570