The Cardinals will play the Lions on Sunday, December 19th, 2021. The matchup takes place at Ford Field. Watch this exciting Week 15 matchup at 1:00 pm EST. Check local listings for coverage on FOX.

Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.

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Best Cardinals at Lions Odds

**Best Point Spread Betting Odds**
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**Best Total Betting Odds**
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**Best Moneyline Betting Odds**
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Game	Book

Arizona Cardinals at Detroit Lions Prop Bets

NFL Prop Bets
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	BetMGM Bet
Cardinals Lions 12/19/21 1:00pm EST	Pending BetMGM

Recent Meetings Since 2017

Recent Meetings Since 2017
Week	Game	Result	Margin
2024 Week 3	Lions vs Cardinals Sunday, September 22nd, 2024	DET 20, ARI 13 State Farm Stadium	Lions by 7
2021 Week 15	Cardinals vs Lions Sunday, December 19th, 2021	DET 30, ARI 12 Ford Field	Lions by 18
2020 Week 3	Lions vs Cardinals Sunday, September 27th, 2020	DET 26, ARI 23 State Farm Stadium	Lions by 3
2019 Week 1	Lions vs Cardinals Sunday, September 8th, 2019	DET 27, ARI 27 (OT) State Farm Stadium	Tie
2018 Week 14	Lions vs Cardinals Sunday, December 9th, 2018	DET 17, ARI 3 State Farm Stadium	Lions by 14
2017 Week 1	Cardinals vs Lions Sunday, September 10th, 2017	DET 35, ARI 23 Ford Field	Lions by 12

Team Standings

2021-2022 NFL Regular Season Standings - Arizona Cardinals, Detroit Lions
Team	W	L	T	Pct	PF	PA	Home	Away	Div	Div%	Conf	Conf%	Strk	L5
xy - Arizona Cardinals	11	6	0	0.647	449	366	3-5-0	8-1-0	4-2-0	0.667	7-5-0	0.583	1L	1-4-0
Detroit Lions	3	13	1	0.206	325	467	3-5-0	0-8-1	2-4-0	0.333	3-9-0	0.250	1W	2-3-0

Arizona Cardinals & Detroit Lions Futures Odds

Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.

Arizona Cardinals Futures Odds

2025-26 Arizona Cardinals Super Bowl Odds
Team	BetMGM
Cardinals	+5000 Bet

Detroit Lions Futures Odds

2025-26 Detroit Lions Super Bowl Odds
Team	BetMGM
Lions	+1000 Bet

Arizona Cardinals & Detroit Lions Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Arizona Cardinals vs Detroit Lions NFL Game

Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, December 19th, 2021 at 1:00 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
Tap to the sportsbook's NFL page, look for the Arizona Cardinals vs Detroit Lions Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the Arizona Cardinals vs Detroit Lions Game.
Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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Arizona Cardinals vs Detroit Lions Odds

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