New England Patriots vs Buffalo Bills NFL Betting Lines

Odds Preview 529

The Patriots will play the Bills on Monday, December 6th, 2021. The matchup takes place at Highmark Stadium. Watch this exciting week 13 matchup at 8:15 pm on ESPN.

Best Underdog and Favorite Spread Bets
Underdog

New England Patriots
Favorite

Buffalo Bills
+3 -115 Sb3gen2 -3 +100 Sb3gen1
+3 -120 Sb3gen1 -3 -105 Sb3gen2
SportsBetting3.com has analyzed the latest lines. Review our "Best Spread Bets" table above to smash the books this Monday. Sb3gen1 has the best favorite Buffalo Bills spread at -3 points. Sb3gen2 has the best underdog New England Patriots spread at +3 points.

Review our point spread betting tutorial and video for more information.
Best Over and Under Total Lines
OverUnder
40o -110 Sb3gen1 41u -115 Sb3gen2
41o -105 Sb3gen2 40u -110 Sb3gen1
The over under line estimates the combined total of each team's final score. Sb3gen1 has the best over line of 40 points laying $110 to win $100. Sb3gen2 has the best under line of 41 u -115.
Best Money Line Bets
Underdog

New England Patriots
Favorite

Buffalo Bills
+131 Sb3gen1 -145 Sb3gen2
+125 Sb3gen2 -151 Sb3gen1
Here are money lines for the outright winner. Favorite Buffalo Bills has a minus value. Lay $145 at Sb3gen2 to win $100. Underdog New England Patriots has a positive value. Risk $100 at Sb3gen1 to win $131.

New England Patriots vs Buffalo Bills Prop Bets

The following prop bets are available for this matchup.

Super Bowl Odds

Latest Super Bowl odds, if available, for each team. Review odds for other teams and learn the best NFL bets here.

New England Patriots Super Bowl Odds
Super Bowl 2022 Futures Odds
OutcomeSB3Gen SB3Gen
New England Patriots

Cached 2022-01-21 00:11:47
Buffalo Bills Super Bowl Odds
Super Bowl 2022 Futures Odds
OutcomeSB3Gen SB3Gen
Buffalo Bills

Cached 2022-01-21 00:11:47

Team Stats

2021 New England Patriots Team Stats
Stat New England Patriots Opponents
Total 1st Downs 362 308
Total Offensive Yards 6008 5284
Total Rushing Yards 2151 2103
Total Passing Yards 3857 3181
Sacks 36 28
Field Goals 36 / 39 22 / 33
Touchdowns 51 35
Avg Time Of Possession 30:38 29:43
Turnover Ratio +7

2021 Buffalo Bills Team Stats
Stat Buffalo Bills Opponents
Total 1st Downs 398 285
Total Offensive Yards 6493 4637
Total Rushing Yards 2209 1866
Total Passing Yards 4284 2771
Sacks 42 27
Field Goals 28 / 32 21 / 23
Touchdowns 57 32
Avg Time Of Possession 31:42 28:33
Turnover Ratio +8


Team Standings

2021 Regular Season Standings
Team Conf Div W L T Pct Home Road Last 5
xy
New England Patriots
8-4-0 3-3-0 10 7 0 0.588 4-5-0 6-2-0 2-3-0
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Buffalo Bills
7-5-0 5-1-0 11 6 0 0.647 6-3-0 5-3-0 4-1-0

2021 New England Patriots Games & Results

Bye Week: 14
WeekMatchupDate & Time
1 Dolphins vs
Patriots
MIA 17, NE 16
09/12/2021
2 Patriots vs
Jets
NE 25, NYJ 6
09/19/2021
3 Saints vs
Patriots
NO 28, NE 13
09/26/2021
4 Buccaneers vs
Patriots
TB 19, NE 17
10/03/2021
5 Patriots vs
Texans
NE 25, HOU 22
10/10/2021
6 Cowboys vs
Patriots
DAL 35, NE 29 (OT)
10/17/2021
7 Jets vs
Patriots
NE 54, NYJ 13
10/24/2021
8 Patriots vs
Chargers
NE 27, LAC 24
10/31/2021
9 Patriots vs
Panthers
NE 24, CAR 6
11/07/2021
10 Browns vs
Patriots
NE 45, CLE 7
11/14/2021
11 Patriots vs
Falcons
NE 25, ATL 0
11/18/2021
12 Titans vs
Patriots
NE 36, TEN 13
11/28/2021
13 Patriots vs
Bills
NE 14, BUF 10
12/06/2021
14New England Patriots ByeN/A
15 Patriots vs
Colts
IND 27, NE 17
12/18/2021
16 Bills vs
Patriots
BUF 33, NE 21
12/26/2021
17 Jaguars vs
Patriots
NE 50, JAX 10
01/02/2022

2021 Buffalo Bills Games & Results

Bye Week: 7
WeekMatchupDate & Time
1 Steelers vs
Bills
PIT 23, BUF 16
09/12/2021
2 Bills vs
Dolphins
BUF 35, MIA 0
09/19/2021
3 TBD vs
Bills
BUF 43, WSH 21
09/26/2021
4 Texans vs
Bills
BUF 40, HOU 0
10/03/2021
5 Bills vs
Chiefs
BUF 38, KC 20
10/10/2021
6 Bills vs
Titans
TEN 34, BUF 31
10/18/2021
7Buffalo Bills ByeN/A
8 Dolphins vs
Bills
BUF 26, MIA 11
10/31/2021
9 Bills vs
Jaguars
JAX 9, BUF 6
11/07/2021
10 Bills vs
Jets
BUF 45, NYJ 17
11/14/2021
11 Colts vs
Bills
IND 41, BUF 15
11/21/2021
12 Bills vs
Saints
BUF 31, NO 6
11/25/2021
13 Patriots vs
Bills
NE 14, BUF 10
12/06/2021
14 Bills vs
Buccaneers
TB 33, BUF 27 (OT)
12/12/2021
15 Panthers vs
Bills
BUF 31, CAR 14
12/19/2021
16 Bills vs
Patriots
BUF 33, NE 21
12/26/2021
17 Falcons vs
Bills
BUF 29, ATL 15
01/02/2022

Other 2021 Week 13 Matchups

MatchupDate & Time
Cowboys vs
Saints
DAL 27, NO 17
12/02/2021
Buccaneers vs
Falcons
TB 30, ATL 17
12/05/2021
Cardinals vs
Bears
ARI 33, CHI 22
12/05/2021
Chargers vs
Bengals
LAC 41, CIN 22
12/05/2021
Vikings vs
Lions
DET 29, MIN 27
12/05/2021
Giants vs
Dolphins
MIA 20, NYG 9
12/05/2021
Eagles vs
Jets
PHI 33, NYJ 18
12/05/2021
Colts vs
Texans
IND 31, HOU 0
12/05/2021
TBD vs
Raiders
WSH 17, LV 15
12/05/2021
Jaguars vs
Rams
LAR 37, JAX 7
12/05/2021
Ravens vs
Steelers
PIT 20, BAL 19
12/05/2021
49ers vs
Seahawks
SEA 30, SF 23
12/05/2021
Broncos vs
Chiefs
KC 22, DEN 9
12/05/2021
Patriots vs
Bills
NE 14, BUF 10
12/06/2021