The Patriots will play the Bills on Sunday, December 22nd, 2024. The matchup takes place at Highmark Stadium. Watch this exciting Week 16 matchup at 4:25 pm EST. Check local listings for coverage on CBS.
Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.
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Table of Contents
- Matchup Stats
- Captain Shady Lines
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Other Games Today
Key Matchup Stats
It's now Week 16, as the 2024-25 NFL regular season is coming to a close. This week's action includes a matchup between the New England Patriots and Buffalo Bills. They'll play on Sunday, December 22nd, 2024 at Highmark Stadium, in a game that may affect this season's playoff picture. We've highlighted each team's key performance stats below. Take note of the following as you handicap this matchup.
- SportsBetting3.com Power Rankings - Now Week 16 of the 2024-25 NFL regular season, the New England Patriots have a 87.33 power ranking based on our formula. Their opponent, the Buffalo Bills, currently possess a 98.67 power ranking.
- Away New England Patriots - With the season coming to a close, the New England Patriots have a 2-6-0 record as an away team, ranking them 5th in the league for away team wins.
- Home Buffalo Bills - The Buffalo Bills come to this Week 16 game with a 6-0-0 record as a home team. They rank 2nd in the league for home team wins as the 2024-25 regular season wraps up.
- Points Scored - The New England Patriots currently rank 27th (238) headed into Week 16, with the Buffalo Bills ranked 2nd (445) for points scored to date.
- Points Against - As the regular season winds down, the New England Patriots rank 9th (337) for points score against them. Note that the Buffalo Bills now rank 20th (310) for points scored against.
- Team Records - The final games of the season will determine who heads to the playoffs. Heading into Week 16, the New England Patriots have a 3-11-0 record, with the Buffalo Bills at 11-3-0 for the 2024-25 NFL regular season.
Captain Shady Lines
A broken compass is right at least twice a day.
Avast ye landlubbers! The Patriots sail to Buffalo for a crucial Week 16 battle.
The regular season be windin' down and this game be shapin' the playoff picture.
The Bills be lookin' to plunder another win against the struggling Patriots. Place a bet at BetRivers or BetMGM and be sure to look at this matchup's prop bets below. We've compared odds from our partner sportsbooks, so get ready for a showdown at Highmark Stadium. Argh!
Best Patriots at Bills Odds
| Underdog New England Patriots | Favorite Buffalo Bills |
|---|---|
| Over | Under |
|---|---|
| Underdog New England Patriots | Favorite Buffalo Bills |
|---|---|
Matchup Odds FAQs
The Buffalo Bills are -14 -109 point spread favorites at BetRivers, while the New England Patriots are +14 -110 point spread underdogs at BetMGM.
The best over line is 46.5 -110 points at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 46.5 -110 points at BetMGM, and that means you risk $110 to win $100 betting the under.
The Buffalo Bills are the -1000 moneyline favorite at BetMGM and the New England Patriots are the +700 moneyline underdog at BetRivers.
NFL Odds Example
|
Game |
 BetMGMBet |
|---|---|
Patriots
Bills
12/22/24 4:25pm EST | +14 -110-14 -110 |
Underdog New England Patriots - New England Patriots bettors risk $100 to win $90.91 at -110 odds.
A +14 New England Patriots underdog bet wins if they lose by 13 or fewer, tie, or win outright. The bet pushes if they lose by 14. Your bet loses if they lose by 15 or more.
Favorite Buffalo Bills - Buffalo Bills bettors risk $100 to win $90.91 at -110 odds.
A -14 Buffalo Bills favorite bet wins if they win by 15 or more. The bet pushes if they win by 14. Your bet loses if they win by 13 or fewer, tie, or lose outright.
New England Patriots at Buffalo Bills Prop Bets
| BetMGM Bet |
|
|---|---|
Patriots
Bills
First Team To Score
12/22/24 4:25pm EST | +190-250Bet |
Patriots
Bills
No Touchdown
To Score 1st Touchdown
12/22/24 4:25pm EST | +250-350+10000Bet |
Patriots
Bills
Game to Overtime
12/22/24 4:25pm EST | Yes +1200No -10000Bet |
Patriots
Bills
Safety to be Scored
12/22/24 4:25pm EST | Yes +1000No -3000Bet |
| BetMGM | |
Drake Maye
Interceptions Thrown
NE at BUF 12/22/24 4:25pm EST | 0.5 o -1550.5 u +115Bet |
Josh Allen
Interceptions Thrown
NE at BUF 12/22/24 4:25pm EST | 0.5 o -1100.5 u -120Bet |
Drake Maye
Longest Passing Completion
NE at BUF 12/22/24 4:25pm EST | 32.5 o -11032.5 u -120Bet |
Josh Allen
Longest Passing Completion
NE at BUF 12/22/24 4:25pm EST | 36.5 o -12036.5 u -110Bet |
| BetMGM | |
Joey Slye
Total Kicking Points
NE at BUF 12/22/24 4:25pm EST | 5.5 o +1005.5 u -135Bet |
Tyler Bass
Total Kicking Points
NE at BUF 12/22/24 4:25pm EST | 7.5 o -1307.5 u -105Bet |
Drake Maye
Total Pass Completions
NE at BUF 12/22/24 4:25pm EST | 20.5 o -11520.5 u -115Bet |
Josh Allen
Total Pass Completions
NE at BUF 12/22/24 4:25pm EST | 20.5 o -12020.5 u -110Bet |
| BetMGM | |
Drake Maye
Total Passing Yards
NE at BUF 12/22/24 4:25pm EST | 204.5 o -115204.5 u -115Bet |
Josh Allen
Total Passing Yards
NE at BUF 12/22/24 4:25pm EST | 237.5 o -115237.5 u -115Bet |
Drake Maye
Total Touchdown Passes
NE at BUF 12/22/24 4:25pm EST | 1.5 o +2001.5 u -275Bet |
Josh Allen
Total Touchdown Passes
NE at BUF 12/22/24 4:25pm EST | 1.5 o -1651.5 u +125Bet |
Recent Meetings Since 2020
| Week | Game | Result | Margin |
|---|---|---|---|
| 2024 Week 18 | Bills vs Patriots Sunday, January 5th, 2025 | NE 23, BUF 16 Gillette Stadium | Patriots by 7 |
| 2024 Week 16 | Patriots vs Bills Sunday, December 22nd, 2024 | BUF 24, NE 21 Highmark Stadium | Bills by 3 |
| 2023 Week 17 | Patriots vs Bills Sunday, December 31st, 2023 | BUF 27, NE 21 Highmark Stadium | Bills by 6 |
| 2023 Week 7 | Bills vs Patriots Sunday, October 22nd, 2023 | NE 29, BUF 25 Gillette Stadium | Patriots by 4 |
| 2022 Week 18 | Patriots vs Bills Sunday, January 8th, 2023 | BUF 35, NE 23 Highmark Stadium | Bills by 12 |
| 2022 Week 13 | Bills vs Patriots Thursday, December 1st, 2022 | BUF 24, NE 10 Gillette Stadium | Bills by 14 |
| 2021 Wild Card | Patriots vs Bills Saturday, January 15th, 2022 AFC Wild Card Playoffs | BUF 47, NE 17 Highmark Stadium | Bills by 30 |
| 2021 Week 16 | Bills vs Patriots Sunday, December 26th, 2021 | BUF 33, NE 21 Gillette Stadium | Bills by 12 |
| 2021 Week 13 | Patriots vs Bills Monday, December 6th, 2021 | NE 14, BUF 10 Highmark Stadium | Patriots by 4 |
| 2020 Week 16 | Bills vs Patriots Monday, December 28th, 2020 | BUF 38, NE 9 Gillette Stadium | Bills by 29 |
| 2020 Week 8 | Patriots vs Bills Sunday, November 1st, 2020 | BUF 24, NE 21 Highmark Stadium | Bills by 3 |
Team Standings
| Team | W | L | T | Pct | PF | PA | Home | Away | Div | Div% | Conf | Conf% | Strk | L5 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| xz - Buffalo Bills | 13 | 4 | 0 | 0.765 | 525 | 368 | 8-0-0 | 5-4-0 | 5-1-0 | 0.833 | 9-3-0 | 0.750 | 1L | 3-2-0 |
| New England Patriots | 4 | 13 | 0 | 0.235 | 289 | 417 | 2-6-0 | 2-7-0 | 2-4-0 | 0.333 | 3-9-0 | 0.250 | 1W | 1-4-0 |
New England Patriots & Buffalo Bills Futures Odds
Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.
New England Patriots Futures Odds|
Team | BetMGM |
 BetRivers |
|---|---|---|
| Patriots | +6600 Bet | +5500 Bet |
|
Team | BetMGM |
BetRivers |
|---|---|---|
| Bills | +700 Bet | +700 Bet |
New England Patriots & Buffalo Bills Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the New England Patriots vs Buffalo Bills NFL Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, December 22nd, 2024 at 4:25 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's NFL page, look for the New England Patriots vs Buffalo Bills Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the New England Patriots vs Buffalo Bills Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other December 22, 2024 NFL Games
- Los Angeles Rams vs New York Jets
- Philadelphia Eagles vs Washington Commanders
- Arizona Cardinals vs Carolina Panthers
- Detroit Lions vs Chicago Bears
- Cleveland Browns vs Cincinnati Bengals
- Tennessee Titans vs Indianapolis Colts
- New York Giants vs Atlanta Falcons
- Minnesota Vikings vs Seattle Seahawks
- Jacksonville Jaguars vs Las Vegas Raiders
- San Francisco 49ers vs Miami Dolphins
- Tampa Bay Buccaneers vs Dallas Cowboys