The Colts will play the Titans on Sunday, September 21st, 2025. The matchup takes place at Nissan Stadium. Watch this exciting Week 3 matchup at 1:03 pm EDT. Check local listings for coverage on CBS.
Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.
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Table of Contents
- Matchup Stats
- Captain Shady Lines
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Other Games Today
Key Matchup Stats
The 2025-26 NFL regular season keeps rolling for the Indianapolis Colts and Tennessee Titans, as they gear up to play an exciting Week 3 matchup at Nissan Stadium. Have a look at the following statistical insights to help you handicap the game.
- SportsBetting3.com Power Rankings - The Indianapolis Colts have started the 2025-26 season with an initial 100.00 power ranking. The Tennessee Titans currently have a 91.00 power ranking so far.
- Away Indianapolis Colts - Though it's still early in the season, the Indianapolis Colts have a 0-0-0 record as an away team, ranking them 3rd in the league for away team wins.
- Home Tennessee Titans - Looking at the Tennessee Titans heading into Week 3, they currently have a 0-1-0 record as a home team. They rank 3rd in the league for home team wins.
- Points Scored - The Indianapolis Colts currently rank 4th (62) up to Week 3, with the Tennessee Titans ranked 22nd (31) for points scored in the 2025-26 regular season.
- Points Against - The Indianapolis Colts stand 15th (36) in the early weeks of the regular season for points against. The Tennessee Titans rank 7th (53) for points against.
- Team Records - As Week 3 approaches, the Indianapolis Colts have a 2-0-0 record, with the Tennessee Titans at 0-2-0 for the 2025-26 NFL regular season.
Captain Shady Lines
A broken compass is right at least twice a day.
Avast ye mateys! The Indianapolis Colts be comin' to Tennessee to plunder the Titans' treasure!
This Week 3 showdown be happenin' at the mighty Nissan Stadium, where the Titans be lookin' to defend their home turf against the Colts.
The SportsBetting3.com NFL Power Rankings give the Colts a perfect score of 100.00, while the Titans be holdin' a rating of 91.00.
The Colts be sittin' pretty with a 2-0-0 record, while the Titans be strugglin' at 0-2-0. Bet this game at BetRivers, or BetMGM, review this game's prop bets, and compare the odds below to see who be walkin' away with the booty on Sunday! Arrr!
Best Colts at Titans Odds
| Underdog Tennessee Titans | Favorite Indianapolis Colts |
|---|---|
| Over | Under |
|---|---|
| Underdog Tennessee Titans | Favorite Indianapolis Colts |
|---|---|
Matchup Odds FAQs
The Indianapolis Colts are -13 -115 point spread favorites at BetRivers, while the Tennessee Titans are +13 -121 point spread underdogs at BetRivers.
The best over line is 49.5 -121 points at BetRivers, which means you risk $121 to win $100 betting the over. The best under line is 49.5 -117 points at BetRivers, and that means you risk $117 to win $100 betting the under.
The Indianapolis Colts are the -770 moneyline favorite at BetRivers and the Tennessee Titans are the +420 moneyline underdog at BetRivers.
NFL Odds Example
|
Game |
 BetRiversBet |
|---|---|
Colts
Titans
9/21/25 1:03pm EDT | -13 -115+13 -121 |
Underdog Tennessee Titans - Tennessee Titans bettors risk $100 to win $82.64 at -121 odds.
A +13 Tennessee Titans underdog bet wins if they lose by 12 or fewer, tie, or win outright. The bet pushes if they lose by 13. Your bet loses if they lose by 14 or more.
Favorite Indianapolis Colts - Indianapolis Colts bettors risk $100 to win $86.96 at -115 odds.
A -13 Indianapolis Colts favorite bet wins if they win by 14 or more. The bet pushes if they win by 13. Your bet loses if they win by 12 or fewer, tie, or lose outright.
Indianapolis Colts at Tennessee Titans Prop Bets
| BetRivers Bet |
|
|---|---|
Colts
Titans
First Field Goal
9/21/25 1:03pm EDT | +175-278Bet |
Colts
Titans
Tie
First to 15 Points
9/21/25 1:03pm EDT | -770+420+4000Bet |
Colts
Titans
Tie
First to 20 Points
9/21/25 1:03pm EDT | -715+475+1400Bet |
Recent Meetings Since 2021
| Week | Game | Result | Margin |
|---|---|---|---|
| 2025 Week 8 | Titans vs Colts Sunday, October 26th, 2025 | IND 38, TEN 14 Lucas Oil Stadium | Colts by 24 |
| 2025 Week 3 | Colts vs Titans Sunday, September 21st, 2025 | IND 41, TEN 20 Nissan Stadium | Colts by 21 |
| 2024 Week 16 | Titans vs Colts Sunday, December 22nd, 2024 | IND 38, TEN 30 Lucas Oil Stadium | Colts by 8 |
| 2024 Week 6 | Colts vs Titans Sunday, October 13th, 2024 | IND 20, TEN 17 Nissan Stadium | Colts by 3 |
| 2023 Week 13 | Colts vs Titans Sunday, December 3rd, 2023 | IND 31, TEN 28 (OT) Nissan Stadium | Colts by 3 |
| 2023 Week 5 | Titans vs Colts Sunday, October 8th, 2023 | IND 23, TEN 16 Lucas Oil Stadium | Colts by 7 |
| 2022 Week 7 | Colts vs Titans Sunday, October 23rd, 2022 | TEN 19, IND 10 Nissan Stadium | Titans by 9 |
| 2022 Week 4 | Titans vs Colts Sunday, October 2nd, 2022 | TEN 24, IND 17 Lucas Oil Stadium | Titans by 7 |
| 2021 Week 8 | Titans vs Colts Sunday, October 31st, 2021 | TEN 34, IND 31 (OT) Lucas Oil Stadium | Titans by 3 |
| 2021 Week 3 | Colts vs Titans Sunday, September 26th, 2021 | TEN 25, IND 16 Nissan Stadium | Titans by 9 |
Team Standings
| Team | W | L | T | Pct | PF | PA | Home | Away | Div | Div% | Conf | Conf% | Strk | L5 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Indianapolis Colts | 8 | 9 | 0 | 0.471 | 466 | 412 | 6-3-0 | 2-6-0 | 2-4-0 | 0.333 | 6-6-0 | 0.500 | 7L | 0-5-0 |
| Tennessee Titans | 3 | 14 | 0 | 0.176 | 284 | 478 | 1-8-0 | 2-6-0 | 0-6-0 | 0.000 | 2-10-0 | 0.167 | 2L | 2-3-0 |
Indianapolis Colts & Tennessee Titans Futures Odds
Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.
Indianapolis Colts Futures Odds|
Team | BetRivers |
|---|---|
| Colts | +5000 Bet |
|
Team | BetRivers |
|---|---|
| Titans | +15000 Bet |
Indianapolis Colts & Tennessee Titans Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Indianapolis Colts vs Tennessee Titans NFL Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, September 21st, 2025 at 1:03 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's NFL page, look for the Indianapolis Colts vs Tennessee Titans Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the Indianapolis Colts vs Tennessee Titans Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other September 21, 2025 NFL Games
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- Green Bay Packers vs Cleveland Browns
- Atlanta Falcons vs Carolina Panthers
- Los Angeles Rams vs Philadelphia Eagles
- Denver Broncos vs Los Angeles Chargers
- New Orleans Saints vs Seattle Seahawks
- Arizona Cardinals vs San Francisco 49ers
- Dallas Cowboys vs Chicago Bears
- Kansas City Chiefs vs New York Giants