The Cardinals will play the 49ers on Sunday, September 21st, 2025. The matchup takes place at Levi's Stadium. Watch this exciting Week 3 matchup at 4:25 pm EDT. Check local listings for coverage on FOX.
Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.
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Table of Contents
- Matchup Stats
- Captain Shady Lines
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Other Games Today
Key Matchup Stats
The 2025-26 NFL regular season keeps rolling for the Arizona Cardinals and San Francisco 49ers, as they gear up to play an exciting Week 3 matchup at Levi's Stadium. Have a look at the following statistical insights to help you handicap the game.
- SportsBetting3.com Power Rankings - The Arizona Cardinals have started the 2025-26 season with an initial 98.00 power ranking. The San Francisco 49ers currently have a 97.33 power ranking so far.
- Away Arizona Cardinals - Though it's still early in the season, the Arizona Cardinals have a 1-0-0 record as an away team, ranking them 2nd in the league for away team wins.
- Home San Francisco 49ers - Looking at the San Francisco 49ers heading into Week 3, they currently have a 0-0-0 record as a home team. They rank 3rd in the league for home team wins.
- Points Scored - The Arizona Cardinals currently rank 10th (47) up to Week 3, with the San Francisco 49ers ranked 14th (43) for points scored in the 2025-26 regular season.
- Points Against - The Arizona Cardinals stand 16th (35) in the early weeks of the regular season for points against. The San Francisco 49ers rank 17th (34) for points against.
- Team Records - As Week 3 approaches, the Arizona Cardinals have a 2-0-0 record, with the San Francisco 49ers at 2-0-0 for the 2025-26 NFL regular season.
Captain Shady Lines
A broken compass is right at least twice a day.
Avast ye scurvy dogs! The Arizona Cardinals be on a warpath against the San Francisco 49ers!
This Week 3 showdown be happenin' at Levi's Stadium, where the 49ers be defendin' their turf.
According to SportsBetting3.com NFL Power Rankings, the Cardinals be holdin' a slight edge over the 49ers.
Both teams be undefeated with a 2-0-0 standin', so this be a crucial matchup.
Ye can bet this game at BetRivers, or BetMGM, and be sure to review this game's prop bets. Compare the odds below, and may the best team prevail on Sunday! Arrr!
Best Cardinals at 49ers Odds
| Underdog San Francisco 49ers | Favorite Arizona Cardinals |
|---|---|
| Over | Under |
|---|---|
| Underdog San Francisco 49ers | Favorite Arizona Cardinals |
|---|---|
Matchup Odds FAQs
The Arizona Cardinals are -1 -110 point spread favorites at BetMGM, while the San Francisco 49ers are +1 -110 point spread underdogs at BetMGM.
The best over line is 43.5 -110 points at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 43.5 -110 points at BetMGM, and that means you risk $110 to win $100 betting the under.
The Arizona Cardinals are the -115 moneyline favorite at BetMGM and the San Francisco 49ers are the -105 moneyline underdog at BetMGM.
NFL Odds Example
|
Game |
 BetMGMBet |
|---|---|
Cardinals
49ers
9/21/25 4:25pm EDT | -1 -110+1 -110 |
Underdog San Francisco 49ers - San Francisco 49ers bettors risk $100 to win $90.91 at -110 odds.
A +1 San Francisco 49ers underdog bet wins if the result is a tie, or they win outright. The bet pushes if they lose by 1. Your bet loses if they lose by 2 or more.
Favorite Arizona Cardinals - Arizona Cardinals bettors risk $100 to win $90.91 at -110 odds.
A -1 Arizona Cardinals favorite bet wins if they win by 2 or more. The bet pushes if they win by 1. Your bet loses if the result is a tie, or they lose outright.
Arizona Cardinals at San Francisco 49ers Prop Bets
| BetMGM Bet |
|
|---|---|
Cardinals
49ers
9/21/25 4:25pm EDT | Pending BetMGM |
Recent Meetings Since 2021
| Week | Game | Result | Margin |
|---|---|---|---|
| 2024 Week 18 | 49ers vs Cardinals Sunday, January 5th, 2025 | ARI 47, SF 24 State Farm Stadium | Cardinals by 23 |
| 2024 Week 5 | Cardinals vs 49ers Sunday, October 6th, 2024 | ARI 24, SF 23 Levi's Stadium | Cardinals by 1 |
| 2023 Week 15 | 49ers vs Cardinals Sunday, December 17th, 2023 | SF 45, ARI 29 State Farm Stadium | 49ers by 16 |
| 2023 Week 4 | Cardinals vs 49ers Sunday, October 1st, 2023 | SF 35, ARI 16 Levi's Stadium | 49ers by 19 |
| 2022 Week 18 | Cardinals vs 49ers Sunday, January 8th, 2023 | SF 38, ARI 13 Levi's Stadium | 49ers by 25 |
| 2022 Week 11 | 49ers vs Cardinals Monday, November 21st, 2022 | SF 38, ARI 10 Estadio Azteca | 49ers by 28 |
| 2021 Week 9 | Cardinals vs 49ers Sunday, November 7th, 2021 | ARI 31, SF 17 Levi's Stadium | Cardinals by 14 |
| 2021 Week 5 | 49ers vs Cardinals Sunday, October 10th, 2021 | ARI 17, SF 10 State Farm Stadium | Cardinals by 7 |
Team Standings
| Team | W | L | T | Pct | PF | PA | Home | Away | Div | Div% | Conf | Conf% | Strk | L5 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Arizona Cardinals | 2 | 0 | 0 | 1.000 | 47 | 35 | 1-0-0 | 1-0-0 | 0-0-0 | 0.000 | 2-0-0 | 1.000 | 2W | 2-0-0 |
| San Francisco 49ers | 2 | 0 | 0 | 1.000 | 43 | 34 | 0-0-0 | 2-0-0 | 1-0-0 | 1.000 | 2-0-0 | 1.000 | 2W | 2-0-0 |
Arizona Cardinals & San Francisco 49ers Futures Odds
Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.
Arizona Cardinals Futures Odds|
Team | BetMGM |
|---|---|
| Cardinals | +5000 Bet |
|
Team | BetMGM |
|---|---|
| 49ers | +2000 Bet |
Arizona Cardinals & San Francisco 49ers Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Arizona Cardinals vs San Francisco 49ers NFL Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, September 21st, 2025 at 4:25 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's NFL page, look for the Arizona Cardinals vs San Francisco 49ers Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the Arizona Cardinals vs San Francisco 49ers Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other September 21, 2025 NFL Games
- Indianapolis Colts vs Tennessee Titans - 9/21/25 1:00pm EDT
- Las Vegas Raiders vs Washington Commanders - 9/21/25 1:00pm EDT
- New York Jets vs Tampa Bay Buccaneers - 9/21/25 1:00pm EDT
- Los Angeles Rams vs Philadelphia Eagles - 9/21/25 1:00pm EDT
- Pittsburgh Steelers vs New England Patriots - 9/21/25 1:00pm EDT
- Houston Texans vs Jacksonville Jaguars - 9/21/25 1:00pm EDT
- Green Bay Packers vs Cleveland Browns - 9/21/25 1:00pm EDT
- Atlanta Falcons vs Carolina Panthers - 9/21/25 1:00pm EDT
- Cincinnati Bengals vs Minnesota Vikings - 9/21/25 1:00pm EDT
- Denver Broncos vs Los Angeles Chargers - 9/21/25 4:05pm EDT
- New Orleans Saints vs Seattle Seahawks - 9/21/25 4:05pm EDT
- Dallas Cowboys vs Chicago Bears - 9/21/25 4:25pm EDT
- Kansas City Chiefs vs New York Giants - 9/21/25 8:20pm EDT