The Cardinals will play the 49ers on Sunday, October 1st, 2023. The matchup takes place at Levi's Stadium. Watch this exciting Week 4 matchup at 4:25 pm EDT. Check local listings for coverage on FOX.
Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.
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Table of Contents
- Matchup Stats
- Captain Shady Lines
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Other Games Today
Key Matchup Stats
The 2023-24 NFL regular season keeps rolling for the Arizona Cardinals and San Francisco 49ers, as they gear up to play an exciting Week 4 matchup at Levi's Stadium. Have a look at the following statistical insights to help you handicap the game.
- SportsBetting3.com Power Rankings - The Arizona Cardinals have started the 2023-24 season with an initial 93.33 power ranking. The San Francisco 49ers currently have a 99.33 power ranking so far.
- Away Arizona Cardinals - Though it's still early in the season, the Arizona Cardinals have a 0-1-0 record as an away team, ranking them 3rd in the league for away team wins.
- Home San Francisco 49ers - Looking at the San Francisco 49ers heading into Week 4, they currently have a 1-0-0 record as a home team. They rank 2nd in the league for home team wins.
- Points Scored - The Arizona Cardinals currently rank 10th (72) up to Week 4, with the San Francisco 49ers ranked 3rd (90) for points scored in the 2023-24 regular season.
- Points Against - The Arizona Cardinals stand 12th (67) in the early weeks of the regular season for points against. The San Francisco 49ers rank 24th (42) for points against.
- Team Records - As Week 4 approaches, the Arizona Cardinals have a 0-2-0 record, with the San Francisco 49ers at 3-0-0 for the 2023-24 NFL regular season.
Captain Shady Lines
An AI-Powered broken compass is right at least twice a day.

Arrrgh, ye scurvy dogs! Avast, mateys, 'tis the Arizona Cardinals against the San Francisco 49ers... on Sunday, October 1st, 2023, in an important Week 4 matchup at Levi's Stadium. Yarrr, this be a battle worth watchin'!
According to the SportsBetting3.com NFL Power Rankings, the Arizona Cardinals be sittin' at a paltry 93.33... while the San Francisco 49ers be dominatin' with a mighty 99.33! Blimey, that's a sizable difference!
But listen up, ye landlubbers! The Arizona Cardinals be standin' at a lowly 0-2-0, while them 49ers be boastin' a perfect 3-0-0 record. 'Tis a clear advantage for the home team!
If ye be feelin' lucky, ye scallywags, ye can bet this game at BetWay, BetRivers, or BetMGM. And don't forget to review this game's prop bets to add some spice to yer wagerin'! Arrrgh!
But before ye place yer bets, compare the odds below and weigh yer options carefully, me hearties. 'Tis a fierce battle awaitin' at Levi's Stadium, and the outcome be unsure. Will the Arizona Cardinals rise from Davy Jones' locker, or will the San Francisco 49ers keep sailin' on their victorious course? Only time will tell, me mateys, only time will tell...
Best Cardinals at 49ers Odds
Underdog Arizona Cardinals | Favorite San Francisco 49ers |
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Over | Under |
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Underdog Arizona Cardinals | Favorite San Francisco 49ers |
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Matchup Odds FAQs
The San Francisco 49ers are -14 -109 point spread favorites at BetRivers, while the Arizona Cardinals are +14 -110 point spread underdogs at BetMGM.
The best over line is 43.5 -110 points at BetRivers, which means you risk $110 to win $100 betting the over. The best under line is 43.5 -110 points at BetRivers, and that means you risk $110 to win $100 betting the under.
The San Francisco 49ers are the -910 moneyline favorite at BetRivers and the Arizona Cardinals are the +625 moneyline underdog at BetMGM.
NFL Odds Example
Game |
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Cardinals
49ers
10/01/23 4:25pm EDT |
Underdog Arizona Cardinals - Arizona Cardinals bettors risk $100 to win $89.29 at -112 odds.
A +14 Arizona Cardinals underdog bet wins if they lose by 13 or fewer, tie, or win outright. The bet pushes if they lose by 14. Your bet loses if they lose by 15 or more.
Favorite San Francisco 49ers - San Francisco 49ers bettors risk $100 to win $91.74 at -109 odds.
A -14 San Francisco 49ers favorite bet wins if they win by 15 or more. The bet pushes if they win by 14. Your bet loses if they win by 13 or fewer, tie, or lose outright.
Arizona Cardinals at San Francisco 49ers Prop Bets
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Cardinals
49ers
First Team To Score
10/01/23 4:25pm EDT | Bet |
Cardinals
49ers
To Score 1st Touchdown
10/01/23 4:25pm EDT | Bet |
Cardinals
49ers
Tie
First to 15 Points
10/01/23 4:25pm EDT | Bet |
Cardinals
49ers
Tie
First to 20 Points
10/01/23 4:25pm EDT | Bet |
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Cardinals
49ers
Safety to be Scored
10/01/23 4:25pm EDT | Bet |
Cardinals
Team Total Points
ARI at SF 10/01/23 4:25pm EDT | Bet |
49ers
Team Total Points
ARI at SF 10/01/23 4:25pm EDT | Bet |
Brock Purdy
Total Touchdown Passes
ARI at SF 10/01/23 4:25pm EDT | Bet |
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Joshua Dobbs
Total Touchdown Passes
ARI at SF 10/01/23 4:25pm EDT | Bet |
Recent Meetings Since 2019
Week | Game | Result | Margin |
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2023 Week 4 | Cardinals vs 49ers Sunday, October 1st, 2023 | SF 35, ARI 16 Levi's Stadium | 49ers by 19 |
2022 Week 18 | Cardinals vs 49ers Sunday, January 8th, 2023 | SF 38, ARI 13 Levi's Stadium | 49ers by 25 |
2022 Week 11 | 49ers vs Cardinals Monday, November 21st, 2022 | SF 38, ARI 10 Estadio Azteca | 49ers by 28 |
2021 Week 9 | Cardinals vs 49ers Sunday, November 7th, 2021 | ARI 31, SF 17 Levi's Stadium | Cardinals by 14 |
2021 Week 5 | 49ers vs Cardinals Sunday, October 10th, 2021 | ARI 17, SF 10 State Farm Stadium | Cardinals by 7 |
2020 Week 16 | 49ers vs Cardinals Saturday, December 26th, 2020 | SF 20, ARI 12 State Farm Stadium | 49ers by 8 |
2020 Week 1 | Cardinals vs 49ers Sunday, September 13th, 2020 | ARI 24, SF 20 Levi's Stadium | Cardinals by 4 |
2019 Week 11 | Cardinals vs 49ers Sunday, November 17th, 2019 | SF 36, ARI 26 Levi's Stadium | 49ers by 10 |
2019 Week 9 | 49ers vs Cardinals Thursday, October 31st, 2019 | SF 28, ARI 25 State Farm Stadium | 49ers by 3 |
Team Standings
Team | W | L | T | Pct | PF | PA | Home | Away | Div | Div% | Conf | Conf% | Strk | L5 |
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San Francisco 49ers | 9 | 3 | 0 | 0.750 | 352 | 189 | 4-1-0 | 5-2-0 | 3-0-0 | 1.000 | 7-1-0 | 0.875 | 4W | 4-1-0 |
Arizona Cardinals | 3 | 10 | 0 | 0.231 | 230 | 331 | 2-4-0 | 1-6-0 | 0-4-0 | 0.000 | 2-6-0 | 0.250 | 1W | 2-3-0 |
Arizona Cardinals & San Francisco 49ers Futures Odds
Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.
Arizona Cardinals Futures Odds
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Arizona Cardinals & San Francisco 49ers Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Arizona Cardinals vs San Francisco 49ers NFL Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, October 1st, 2023 at 4:25 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's NFL page, look for the Arizona Cardinals vs San Francisco 49ers Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the Arizona Cardinals vs San Francisco 49ers Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.