The 49ers will play the Panthers on Sunday, October 9th, 2022. The matchup takes place at Bank of America Stadium. Watch this exciting Week 5 matchup at 4:05 pm EDT. Check local listings for coverage on CBS.

Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.

STATE	Bonus

Best Odds
Interactive Odds Example
Prop Bets
Recent Meetings
Team Standings
Futures Odds
Team Pages
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Best 49ers at Panthers Odds

**Best Point Spread Betting Odds**
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Point Spread odds are updating, please check back soon.

**Best Total Betting Odds**
Over	Under

Total odds are updating, please check back soon.

**Best Moneyline Betting Odds**
TBD	TBD

Moneyline odds are updating, please check back soon.

NFL Odds Example

NFL Odds and Outcomes Explained
Game	Book

San Francisco 49ers at Carolina Panthers Prop Bets

NFL Prop Bets
+ Displays more odds
	Bet
49ers Panthers 10/09/22 4:05pm EDT	Pending

Recent Meetings Since 2018

Recent Meetings Since 2018
Week	Game	Result	Margin
2025 Week 12	Panthers vs 49ers Monday, November 24th, 2025	SF 20, CAR 9 Levi's Stadium	49ers by 11
2022 Week 5	49ers vs Panthers Sunday, October 9th, 2022	SF 37, CAR 15 Bank of America Stadium	49ers by 22
2019 Week 8	Panthers vs 49ers Sunday, October 27th, 2019	SF 51, CAR 13 Levi's Stadium	49ers by 38

Team Standings

2022-2023 NFL Regular Season Standings - San Francisco 49ers, Carolina Panthers
Team	W	L	T	Pct	PF	PA	Home	Away	Div	Div%	Conf	Conf%	Strk	L5
xz - San Francisco 49ers	13	4	0	0.765	450	277	8-1-0	5-3-0	6-0-0	1.000	10-2-0	0.833	10W	5-0-0
Carolina Panthers	7	10	0	0.412	347	374	5-4-0	2-6-0	4-2-0	0.667	6-6-0	0.500	1W	3-2-0

San Francisco 49ers & Carolina Panthers Futures Odds

Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.

San Francisco 49ers Futures Odds

No Super Bowl TM San Francisco 49ers YR: futures available

Carolina Panthers Futures Odds

No Super Bowl TM Carolina Panthers YR: futures available

San Francisco 49ers & Carolina Panthers Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the San Francisco 49ers vs Carolina Panthers NFL Game

Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, October 9th, 2022 at 4:05 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
Tap to the sportsbook's NFL page, look for the San Francisco 49ers vs Carolina Panthers Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the San Francisco 49ers vs Carolina Panthers Game.
Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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San Francisco 49ers vs Carolina Panthers Odds

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