The 49ers will play the Seahawks on Sunday, September 7th, 2025. The matchup takes place at Lumen Field. Watch this exciting Week 1 matchup at 4:05 pm EDT. Check local listings for coverage on FOX.
Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.
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Table of Contents
- Matchup Stats
- Captain Shady Lines
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Other Games Today
Key Matchup Stats
It's early in the 2025-26 NFL regular season for the San Francisco 49ers and Seattle Seahawks. Let's review some stats from the 2024 regular season to get an idea of how these teams will fare.
- SportsBetting3.com Power Rankings - The San Francisco 49ers had a 89.00 power ranking in the 2024 regular season. The power ranking for the Seattle Seahawks in the 2024 regular season was 93.00.
- Away San Francisco 49ers - At the end of the 2024 regular season, the San Francisco 49ers had a 2-6-0 record as an away team, ranking them 7th in the regular season for away team wins.
- Home Seattle Seahawks - The Seattle Seahawks finished the 2024 regular season with a 3-6-0 record as a home team. They ranked 6th for home team wins in the regular season standings.
- Points Scored - The San Francisco 49ers wound up 13th (389) in the regular season, with the Seattle Seahawks ranked 17th (375) for points scored in the 2024 regular season.
- Points Against - The San Francisco 49ers finished 4th (436) in the regular season for points against. The Seattle Seahawks wound up 19th (368) in the 2024 regular season for points against.
- Team Records - The San Francisco 49ers had a 6-11-0 regular season record, with the Seattle Seahawks notching a 10-7-0 regular season standing last year.
Captain Shady Lines
A broken compass is right at least twice a day.
Avast ye, mateys! The San Francisco 49ers be sailin' to Lumen Field to face the Seattle Seahawks in a battle on September 7th. Last season, the Niners be endin' with a sorry 6-11-0 record, while them Seahawks had a 10-7-0 standing.
This be a clash of titans, with both crews seekin' to start the season strong. Ye can bet on this game at SportsBetting3.com and review the odds below. The Seahawks be lookin' to defend their home turf against the 49ers' onslaught.
So grab yer grog, me hearties, and get ready for a fierce showdown on the gridiron. Will the 49ers plunder a victory, or will the Seahawks reign supreme? Tune in to find out, and may the best team claim victory on the high seas of the NFL!
Best 49ers at Seahawks Odds
| Underdog Seattle Seahawks | Favorite San Francisco 49ers |
|---|---|
| Over | Under |
|---|---|
| Underdog Seattle Seahawks | Favorite San Francisco 49ers |
|---|---|
Matchup Odds FAQs
The San Francisco 49ers are -1.5 -110 point spread favorites at BetMGM, while the Seattle Seahawks are +1.5 -110 point spread underdogs at BetMGM.
The best over line is 43.5 -110 points at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 43.5 -110 points at BetMGM, and that means you risk $110 to win $100 betting the under.
The San Francisco 49ers are the -125 moneyline favorite at BetMGM and the Seattle Seahawks are the +105 moneyline underdog at BetMGM.
NFL Odds Example
|
Game |
 BetMGMBet |
|---|---|
49ers
Seahawks
9/07/25 4:05pm EDT | -1.5 -110+1.5 -110 |
Underdog Seattle Seahawks - Seattle Seahawks bettors risk $100 to win $90.91 at -110 odds.
A +1.5 Seattle Seahawks underdog bet wins if they lose by 1, tie, or win outright. Your bet loses if they lose by 2 or more.
Favorite San Francisco 49ers - San Francisco 49ers bettors risk $100 to win $90.91 at -110 odds.
A -1.5 San Francisco 49ers favorite bet wins if they win by 2 or more. Your bet loses if they win by 1, tie, or lose outright.
San Francisco 49ers at Seattle Seahawks Prop Bets
| BetMGM Bet |
|
|---|---|
49ers
Seahawks
First Team To Score
9/07/25 4:05pm EDT | -120-105Bet |
49ers
Seahawks
No Touchdown
To Score 1st Touchdown
9/07/25 4:05pm EDT | -125-105+10000Bet |
49ers
Seahawks
Game to Overtime
9/07/25 4:05pm EDT | Yes +700No -2000Bet |
49ers
Seahawks
Safety to be Scored
9/07/25 4:05pm EDT | Yes +1000No -3000Bet |
| BetMGM | |
Brock Purdy
Interceptions Thrown
SF at SEA 9/07/25 4:05pm EDT | 0.5 o -1050.5 u -125Bet |
Sam Darnold
Interceptions Thrown
SF at SEA 9/07/25 4:05pm EDT | 0.5 o -1250.5 u -105Bet |
Brock Purdy
Longest Passing Completion
SF at SEA 9/07/25 4:05pm EDT | 35.5 o -11535.5 u -115Bet |
Sam Darnold
Longest Passing Completion
SF at SEA 9/07/25 4:05pm EDT | 33.5 o -11833.5 u -110Bet |
| BetMGM | |
Jake Moody
Total Kicking Points
SF at SEA 9/07/25 4:05pm EDT | 6.5 o -1356.5 u +100Bet |
Jason Myers
Total Kicking Points
SF at SEA 9/07/25 4:05pm EDT | 6.5 o -1156.5 u -115Bet |
Brock Purdy
Total Pass Completions
SF at SEA 9/07/25 4:05pm EDT | 21.5 o -11521.5 u -118Bet |
Sam Darnold
Total Pass Completions
SF at SEA 9/07/25 4:05pm EDT | 19.5 o -13519.5 u +100Bet |
| BetMGM | |
Brock Purdy
Total Passing Yards
SF at SEA 9/07/25 4:05pm EDT | 246.5 o -115246.5 u -115Bet |
Sam Darnold
Total Passing Yards
SF at SEA 9/07/25 4:05pm EDT | 205.5 o -115205.5 u -115Bet |
Brock Purdy
Total Touchdown Passes
SF at SEA 9/07/25 4:05pm EDT | 1.5 o -1201.5 u -110Bet |
Sam Darnold
Total Touchdown Passes
SF at SEA 9/07/25 4:05pm EDT | 1.5 o +1451.5 u -200Bet |
Recent Meetings Since 2021
| Week | Game | Result | Margin |
|---|---|---|---|
| 2025 Week 1 | 49ers vs Seahawks Sunday, September 7th, 2025 | SF 17, SEA 13 Lumen Field | 49ers by 4 |
| 2024 Week 11 | Seahawks vs 49ers Sunday, November 17th, 2024 | SEA 20, SF 17 Levi's Stadium | Seahawks by 3 |
| 2024 Week 6 | 49ers vs Seahawks Thursday, October 10th, 2024 | SF 36, SEA 24 Lumen Field | 49ers by 12 |
| 2023 Week 14 | Seahawks vs 49ers Sunday, December 10th, 2023 | SF 28, SEA 16 Levi's Stadium | 49ers by 12 |
| 2023 Week 12 | 49ers vs Seahawks Thursday, November 23rd, 2023 | SF 31, SEA 13 Lumen Field | 49ers by 18 |
| 2022 Wild Card | Seahawks vs 49ers Saturday, January 14th, 2023 NFC Wild Card Playoffs | SF 41, SEA 23 Levi's Stadium | 49ers by 18 |
| 2022 Week 15 | 49ers vs Seahawks Thursday, December 15th, 2022 | SF 21, SEA 13 Lumen Field | 49ers by 8 |
| 2022 Week 2 | Seahawks vs 49ers Sunday, September 18th, 2022 | SF 27, SEA 7 Levi's Stadium | 49ers by 20 |
| 2021 Week 13 | 49ers vs Seahawks Sunday, December 5th, 2021 | SEA 30, SF 23 Lumen Field | Seahawks by 7 |
| 2021 Week 4 | Seahawks vs 49ers Sunday, October 3rd, 2021 | SEA 28, SF 21 Levi's Stadium | Seahawks by 7 |
Team Standings
| Team | W | L | T | Pct | PF | PA | Home | Away | Div | Div% | Conf | Conf% | Strk | L5 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| San Francisco 49ers | 2 | 0 | 0 | 1.000 | 43 | 34 | 0-0-0 | 2-0-0 | 1-0-0 | 1.000 | 2-0-0 | 1.000 | 2W | 2-0-0 |
| Seattle Seahawks | 1 | 1 | 0 | 0.500 | 44 | 34 | 0-1-0 | 1-0-0 | 0-1-0 | 0.000 | 0-1-0 | 0.000 | 1W | 1-1-0 |
San Francisco 49ers & Seattle Seahawks Futures Odds
Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.
San Francisco 49ers Futures Odds|
Team | BetMGM |
|---|---|
| 49ers | +2000 Bet |
|
Team | BetMGM |
|---|---|
| Seahawks | +8000 Bet |
San Francisco 49ers & Seattle Seahawks Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the San Francisco 49ers vs Seattle Seahawks NFL Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, September 7th, 2025 at 4:05 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's NFL page, look for the San Francisco 49ers vs Seattle Seahawks Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the San Francisco 49ers vs Seattle Seahawks Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other September 7, 2025 NFL Games
- Tampa Bay Buccaneers vs Atlanta Falcons - 9/07/25 1:00pm EDT
- Pittsburgh Steelers vs New York Jets - 9/07/25 1:00pm EDT
- Arizona Cardinals vs New Orleans Saints - 9/07/25 1:00pm EDT
- Las Vegas Raiders vs New England Patriots - 9/07/25 1:00pm EDT
- Carolina Panthers vs Jacksonville Jaguars - 9/07/25 1:00pm EDT
- Cincinnati Bengals vs Cleveland Browns - 9/07/25 1:00pm EDT
- Miami Dolphins vs Indianapolis Colts - 9/07/25 1:03pm EDT
- New York Giants vs Washington Commanders - 9/07/25 1:03pm EDT
- Tennessee Titans vs Denver Broncos - 9/07/25 4:05pm EDT
- Detroit Lions vs Green Bay Packers - 9/07/25 4:25pm EDT
- Houston Texans vs Los Angeles Rams - 9/07/25 4:25pm EDT
- Baltimore Ravens vs Buffalo Bills - 9/07/25 8:22pm EDT