The Broncos will play the Colts on Sunday, September 14th, 2025. The matchup takes place at Lucas Oil Stadium. Watch this exciting Week 2 matchup at 4:05 pm EDT. Check local listings for coverage on CBS.
Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.
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Table of Contents
- Matchup Stats
- Captain Shady Lines
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Other Games Today
Key Matchup Stats
The 2025-26 NFL regular season keeps rolling for the Denver Broncos and Indianapolis Colts, as they gear up to play an exciting Week 2 matchup at Lucas Oil Stadium. Have a look at the following statistical insights to help you handicap the game.
- SportsBetting3.com Power Rankings - The Denver Broncos have started the 2025-26 season with an initial 98.67 power ranking. The Indianapolis Colts currently have a 100.00 power ranking so far.
- Away Denver Broncos - Though it's still early in the season, the Denver Broncos have a 0-0-0 record as an away team, ranking them 2nd in the league for away team wins.
- Home Indianapolis Colts - Looking at the Indianapolis Colts heading into Week 2, they currently have a 1-0-0 record as a home team. They rank 1st in the league for home team wins.
- Points Scored - The Denver Broncos currently rank 11th (20) up to Week 2, with the Indianapolis Colts ranked 4th (33) for points scored in the 2025-26 regular season.
- Points Against - The Denver Broncos stand 16th (12) in the early weeks of the regular season for points against. The Indianapolis Colts rank 19th (8) for points against.
- Team Records - As Week 2 approaches, the Denver Broncos have a 1-0-0 record, with the Indianapolis Colts at 1-0-0 for the 2025-26 NFL regular season.
Captain Shady Lines
A broken compass is right at least twice a day.
Avast ye scallywags! The Denver Broncos be takin' on the Indianapolis Colts in Week 2!
This crucial match be happenin' at Lucas Oil Stadium, where the Broncos must prove their mettle.
According to SportsBetting3.com NFL Power Rankings, the Colts be holdin' a slight advantage over the Broncos.
Denver be standin' at 1-0-0 while the Colts be matchin' that record at 1-0-0.
Bet this game at BetRivers, or BetMGM, review this game's prop bets, and compare the odds below!
Best Broncos at Colts Odds
| Underdog Indianapolis Colts | Favorite Denver Broncos |
|---|---|
| Over | Under |
|---|---|
| Underdog Indianapolis Colts | Favorite Denver Broncos |
|---|---|
Matchup Odds FAQs
The Denver Broncos are -1.5 -115 point spread favorites at BetMGM, while the Indianapolis Colts are +1.5 -105 point spread underdogs at BetMGM.
The best over line is 43.5 -105 points at BetMGM, which means you risk $105 to win $100 betting the over. The best under line is 43.5 -115 points at BetMGM, and that means you risk $115 to win $100 betting the under.
The Denver Broncos are the -125 moneyline favorite at BetMGM and the Indianapolis Colts are the +105 moneyline underdog at BetMGM.
NFL Odds Example
|
Game |
 BetMGMBet |
|---|---|
Broncos
Colts
9/14/25 4:05pm EDT | -1.5 -115+1.5 -105 |
Underdog Indianapolis Colts - Indianapolis Colts bettors risk $100 to win $95.24 at -105 odds.
A +1.5 Indianapolis Colts underdog bet wins if they lose by 1, tie, or win outright. Your bet loses if they lose by 2 or more.
Favorite Denver Broncos - Denver Broncos bettors risk $100 to win $86.96 at -115 odds.
A -1.5 Denver Broncos favorite bet wins if they win by 2 or more. Your bet loses if they win by 1, tie, or lose outright.
Denver Broncos at Indianapolis Colts Prop Bets
| BetMGM Bet |
|
|---|---|
Broncos
Colts
First Team To Score
9/14/25 4:05pm EDT | -120-105Bet |
Broncos
Colts
No Touchdown
To Score 1st Touchdown
9/14/25 4:05pm EDT | -125-105+8000Bet |
Broncos
Colts
Game to Overtime
9/14/25 4:05pm EDT | Yes +700No -2000Bet |
Broncos
Colts
Safety to be Scored
9/14/25 4:05pm EDT | Yes +1000No -3000Bet |
| BetMGM | |
Bo Nix
Interceptions Thrown
DEN at IND 9/14/25 4:05pm EDT | 0.5 o -1250.5 u -105Bet |
Daniel Jones
Interceptions Thrown
DEN at IND 9/14/25 4:05pm EDT | 0.5 o +1100.5 u -150Bet |
Bo Nix
Longest Passing Completion
DEN at IND 9/14/25 4:05pm EDT | 37.5 o -11037.5 u -120Bet |
Daniel Jones
Longest Passing Completion
DEN at IND 9/14/25 4:05pm EDT | 31.5 o -12031.5 u -110Bet |
| BetMGM | |
Spencer Shrader
Total Kicking Points
DEN at IND 9/14/25 4:05pm EDT | 6.5 o -1206.5 u -110Bet |
Wil Lutz
Total Kicking Points
DEN at IND 9/14/25 4:05pm EDT | 7.5 o +1057.5 u -145Bet |
Bo Nix
Total Pass Completions
DEN at IND 9/14/25 4:05pm EDT | 19.5 o -19019.5 u +140Bet |
Daniel Jones
Total Pass Completions
DEN at IND 9/14/25 4:05pm EDT | 18.5 o -13518.5 u +100Bet |
| BetMGM | |
Bo Nix
Total Passing Yards
DEN at IND 9/14/25 4:05pm EDT | 227.5 o -115227.5 u -115Bet |
Daniel Jones
Total Passing Yards
DEN at IND 9/14/25 4:05pm EDT | 199.5 o -115199.5 u -115Bet |
Bo Nix
Total Touchdown Passes
DEN at IND 9/14/25 4:05pm EDT | 1.5 o +1101.5 u -150Bet |
Daniel Jones
Total Touchdown Passes
DEN at IND 9/14/25 4:05pm EDT | 1.5 o +1851.5 u -250Bet |
Recent Meetings Since 2021
| Week | Game | Result | Margin |
|---|---|---|---|
| 2025 Week 2 | Broncos vs Colts Sunday, September 14th, 2025 | IND 29, DEN 28 Lucas Oil Stadium | Colts by 1 |
| 2024 Week 15 | Colts vs Broncos Sunday, December 15th, 2024 | DEN 31, IND 13 Empower Field at Mile High | Broncos by 18 |
| 2024 Preseason Week 1 | Broncos vs Colts Sunday, August 11th, 2024 | DEN 34, IND 30 Lucas Oil Stadium | Broncos by 4 |
| 2022 Week 5 | Colts vs Broncos Thursday, October 6th, 2022 | IND 12, DEN 9 (OT) Empower Field at Mile High | Colts by 3 |
Team Standings
| Team | W | L | T | Pct | PF | PA | Home | Away | Div | Div% | Conf | Conf% | Strk | L5 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Indianapolis Colts | 2 | 0 | 0 | 1.000 | 62 | 36 | 2-0-0 | 0-0-0 | 0-0-0 | 0.000 | 2-0-0 | 1.000 | 2W | 2-0-0 |
| Denver Broncos | 1 | 1 | 0 | 0.500 | 48 | 41 | 1-0-0 | 0-1-0 | 0-0-0 | 0.000 | 1-1-0 | 0.500 | 1L | 1-1-0 |
Denver Broncos & Indianapolis Colts Futures Odds
Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.
Denver Broncos Futures Odds|
Team | BetMGM |
|---|---|
| Broncos | +2500 Bet |
|
Team | BetMGM |
|---|---|
| Colts | +8000 Bet |
Denver Broncos & Indianapolis Colts Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Denver Broncos vs Indianapolis Colts NFL Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, September 14th, 2025 at 4:05 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's NFL page, look for the Denver Broncos vs Indianapolis Colts Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the Denver Broncos vs Indianapolis Colts Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other September 14, 2025 NFL Games
- Buffalo Bills vs New York Jets - 9/14/25 1:00pm EDT
- Seattle Seahawks vs Pittsburgh Steelers - 9/14/25 1:00pm EDT
- San Francisco 49ers vs New Orleans Saints - 9/14/25 1:00pm EDT
- New York Giants vs Dallas Cowboys - 9/14/25 1:00pm EDT
- New England Patriots vs Miami Dolphins - 9/14/25 1:00pm EDT
- Los Angeles Rams vs Tennessee Titans - 9/14/25 1:00pm EDT
- Jacksonville Jaguars vs Cincinnati Bengals - 9/14/25 1:00pm EDT
- Cleveland Browns vs Baltimore Ravens - 9/14/25 1:00pm EDT
- Chicago Bears vs Detroit Lions - 9/14/25 1:00pm EDT
- Carolina Panthers vs Arizona Cardinals - 9/14/25 4:05pm EDT
- Philadelphia Eagles vs Kansas City Chiefs - 9/14/25 4:25pm EDT
- Atlanta Falcons vs Minnesota Vikings - 9/14/25 8:20pm EDT