The 49ers will play the Saints on Sunday, September 14th, 2025. The matchup takes place at Caesars Superdome. Watch this exciting Week 2 matchup at 1:00 pm EDT. Check local listings for coverage on FOX.
Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.
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Table of Contents
- Matchup Stats
- Captain Shady Lines
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Other Games Today
Key Matchup Stats
The 2025-26 NFL regular season keeps rolling for the San Francisco 49ers and New Orleans Saints, as they gear up to play an exciting Week 2 matchup at Caesars Superdome. Have a look at the following statistical insights to help you handicap the game.
- SportsBetting3.com Power Rankings - The San Francisco 49ers have started the 2025-26 season with an initial 97.33 power ranking. The New Orleans Saints currently have a 92.33 power ranking so far.
- Away San Francisco 49ers - Though it's still early in the season, the San Francisco 49ers have a 1-0-0 record as an away team, ranking them 1st in the league for away team wins.
- Home New Orleans Saints - Looking at the New Orleans Saints heading into Week 2, they currently have a 0-1-0 record as a home team. They rank 2nd in the league for home team wins.
- Points Scored - The San Francisco 49ers currently rank 12th (17) up to Week 2, with the New Orleans Saints ranked 15th (13) for points scored in the 2025-26 regular season.
- Points Against - The San Francisco 49ers stand 15th (13) in the early weeks of the regular season for points against. The New Orleans Saints rank 11th (20) for points against.
- Team Records - As Week 2 approaches, the San Francisco 49ers have a 1-0-0 record, with the New Orleans Saints at 0-1-0 for the 2025-26 NFL regular season.
Captain Shady Lines
A broken compass is right at least twice a day.
Avast ye mateys! The San Francisco 49ers be sailin' into New Orleans to plunder the Saints!
This Week 2 clash be happenin' at the treacherous Caesars Superdome, a place of many battles.
According to SportsBetting3.com NFL Power Rankings, the 49ers be favored over the Saints.
The 49ers be standin' at 1-0-0, while the Saints be strugglin' at 0-1-0. Bet this game at BetRivers, or BetMGM. Review this game's prop bets and compare the odds below. Arrr!
Best 49ers at Saints Odds
| Underdog New Orleans Saints | Favorite San Francisco 49ers |
|---|---|
| Over | Under |
|---|---|
| Underdog New Orleans Saints | Favorite San Francisco 49ers |
|---|---|
Matchup Odds FAQs
The San Francisco 49ers are -3 -105 point spread favorites at BetMGM, while the New Orleans Saints are +3 -115 point spread underdogs at BetMGM.
The best over line is 40.5 -110 points at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 40.5 -110 points at BetMGM, and that means you risk $110 to win $100 betting the under.
The San Francisco 49ers are the -160 moneyline favorite at BetMGM and the New Orleans Saints are the +135 moneyline underdog at BetMGM.
NFL Odds Example
|
Game |
 BetMGMBet |
|---|---|
49ers
Saints
9/14/25 1:00pm EDT | -3 -105+3 -115 |
Underdog New Orleans Saints - New Orleans Saints bettors risk $100 to win $86.96 at -115 odds.
A +3 New Orleans Saints underdog bet wins if they lose by 2 or fewer, tie, or win outright. The bet pushes if they lose by 3. Your bet loses if they lose by 4 or more.
Favorite San Francisco 49ers - San Francisco 49ers bettors risk $100 to win $95.24 at -105 odds.
A -3 San Francisco 49ers favorite bet wins if they win by 4 or more. The bet pushes if they win by 3. Your bet loses if they win by 2 or fewer, tie, or lose outright.
San Francisco 49ers at New Orleans Saints Prop Bets
| BetMGM Bet |
|
|---|---|
49ers
Saints
First Team To Score
9/14/25 1:00pm EDT | -135+105Bet |
49ers
Saints
No Touchdown
To Score 1st Touchdown
9/14/25 1:00pm EDT | -145+110+6600Bet |
49ers
Saints
Game to Overtime
9/14/25 1:00pm EDT | Yes +750No -2500Bet |
49ers
Saints
Safety to be Scored
9/14/25 1:00pm EDT | Yes +1000No -3000Bet |
| BetMGM | |
Mac Jones
Interceptions Thrown
SF at NO 9/14/25 1:00pm EDT | 0.5 o -1180.5 u -110Bet |
Spencer Rattler
Interceptions Thrown
SF at NO 9/14/25 1:00pm EDT | 0.5 o -1600.5 u +125Bet |
Mac Jones
Longest Passing Completion
SF at NO 9/14/25 1:00pm EDT | 33.5 o -11033.5 u -118Bet |
Spencer Rattler
Longest Passing Completion
SF at NO 9/14/25 1:00pm EDT | 32.5 o -12032.5 u -110Bet |
| BetMGM | |
Blake Grupe
Total Kicking Points
SF at NO 9/14/25 1:00pm EDT | 6.5 o -1106.5 u -120Bet |
Eddy Pineiro
Total Kicking Points
SF at NO 9/14/25 1:00pm EDT | 6.5 o -1456.5 u +110Bet |
Mac Jones
Total Pass Completions
SF at NO 9/14/25 1:00pm EDT | 19.5 o -12519.5 u -105Bet |
Spencer Rattler
Total Pass Completions
SF at NO 9/14/25 1:00pm EDT | 20.5 o +10020.5 u -130Bet |
| BetMGM | |
Mac Jones
Total Passing Yards
SF at NO 9/14/25 1:00pm EDT | 205.5 o -115205.5 u -115Bet |
Spencer Rattler
Total Passing Yards
SF at NO 9/14/25 1:00pm EDT | 207.5 o +100207.5 u -135Bet |
Mac Jones
Total Touchdown Passes
SF at NO 9/14/25 1:00pm EDT | 1.5 o +1901.5 u -250Bet |
Spencer Rattler
Total Touchdown Passes
SF at NO 9/14/25 1:00pm EDT | 0.5 o -2350.5 u +170Bet |
Recent Meetings Since 2021
| Week | Game | Result | Margin |
|---|---|---|---|
| 2025 Week 2 | 49ers vs Saints Sunday, September 14th, 2025 | SF 26, NO 21 Caesars Superdome | 49ers by 5 |
| 2024 Preseason Week 2 | Saints vs 49ers Sunday, August 18th, 2024 | SF 16, NO 10 Levi's Stadium | 49ers by 6 |
| 2022 Week 12 | Saints vs 49ers Sunday, November 27th, 2022 | SF 13, NO 0 Levi's Stadium | 49ers by 13 |
Team Standings
| Team | W | L | T | Pct | PF | PA | Home | Away | Div | Div% | Conf | Conf% | Strk | L5 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| San Francisco 49ers | 2 | 0 | 0 | 1.000 | 43 | 34 | 0-0-0 | 2-0-0 | 1-0-0 | 1.000 | 2-0-0 | 1.000 | 2W | 2-0-0 |
| New Orleans Saints | 0 | 2 | 0 | 0.000 | 34 | 46 | 0-2-0 | 0-0-0 | 0-0-0 | 0.000 | 0-2-0 | 0.000 | 2L | 0-2-0 |
San Francisco 49ers & New Orleans Saints Futures Odds
Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.
San Francisco 49ers Futures Odds|
Team | BetMGM |
|---|---|
| 49ers | +2000 Bet |
|
Team | BetMGM |
|---|---|
| Saints | +50000 Bet |
San Francisco 49ers & New Orleans Saints Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the San Francisco 49ers vs New Orleans Saints NFL Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, September 14th, 2025 at 1:00 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's NFL page, look for the San Francisco 49ers vs New Orleans Saints Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the San Francisco 49ers vs New Orleans Saints Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other September 14, 2025 NFL Games
- Buffalo Bills vs New York Jets - 9/14/25 1:00pm EDT
- Seattle Seahawks vs Pittsburgh Steelers - 9/14/25 1:00pm EDT
- New York Giants vs Dallas Cowboys - 9/14/25 1:00pm EDT
- New England Patriots vs Miami Dolphins - 9/14/25 1:00pm EDT
- Los Angeles Rams vs Tennessee Titans - 9/14/25 1:00pm EDT
- Jacksonville Jaguars vs Cincinnati Bengals - 9/14/25 1:00pm EDT
- Cleveland Browns vs Baltimore Ravens - 9/14/25 1:00pm EDT
- Chicago Bears vs Detroit Lions - 9/14/25 1:00pm EDT
- Carolina Panthers vs Arizona Cardinals - 9/14/25 4:05pm EDT
- Denver Broncos vs Indianapolis Colts - 9/14/25 4:05pm EDT
- Philadelphia Eagles vs Kansas City Chiefs - 9/14/25 4:25pm EDT
- Atlanta Falcons vs Minnesota Vikings - 9/14/25 8:20pm EDT