St. Louis Cardinals vs Los Angeles Angels Odds

The Cardinals will play the Angels on Tuesday, July 21st, 2026. Your timezone's first pitch time is 9:38 pm EDT. Check local listings or your nearest streaming app for coverage.

Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.


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Table of Contents

Key Matchup Stats

  • SportsBetting3.com Power Rankings - As the 2026 season continues, the St. Louis Cardinals possess a 91.67 SportsBetting3.com power ranking. The Los Angeles Angels now have a 84.33 power ranking. Teams with a higher SportsBetting3.com power ranking will typically be moneyline favorites.
  • Visiting St. Louis Cardinals - The St. Louis Cardinals head into this matchup with a 25-21 record as a visiting team. This standing ranks them 8th Overall for visiting team wins.
  • Home Los Angeles Angels - The Los Angeles Angels will throw the first pitch possessing a 22-27 home team record. That puts them 11th for home team wins in the Overall MLB standings.
  • Runs Scored - St. Louis Cardinals batters have produced 444 runs, ranking them 13th Overall, with the Los Angeles Angels ranking 16th (434) for runs scored.
  • Runs Allowed - St. Louis Cardinals pitchers and fielders have allowed 440 runs, ranking them 17th Overall for runs allowed. Meanwhile, the Los Angeles Angels now rank 7th Overall, allowing 496 runs.
  • Team Streaks - The St. Louis Cardinals have lost their last 2 games. Their opponent, the Los Angeles Angels won their last game.
  • Team Records - Let's review each team's records. The St. Louis Cardinals have a 51-47 Overall record (10.5 GB National Central Division), with the Los Angeles Angels notching a 39-61 Overall standing (11.5 GB American West Division).

Best Cardinals at Angels Odds


Best Moneyline Betting Odds
Underdog

St. Louis Cardinals
Favorite

Los Angeles Angels
The Los Angeles Angels are the -118 moneyline favorite. Risk $118 to win $100 on the Los Angeles Angels at BetMGM. The St. Louis Cardinals are the -102 underdog at BetMGM. Risk $102 to win $100 on the St. Louis Cardinals. Learn more about how to bet on money lines.

Best Total Betting Odds
OverUnder
BetMGM has the best over line of 9 runs. Risk $120 to win $100. BetMGM has the best under line of 9 runs. Risk $100 to win $100. Our tutorial explains more about total bets.

Best Run Line Betting Odds
Underdog

Los Angeles Angels
Favorite

St. Louis Cardinals
The St. Louis Cardinals have a -1.5 +145 run line at BetMGM OH. They are the run line favorite in this matchup. The Los Angeles Angels have a +1.5 -180 run line at BetMGM OH. The Los Angeles Angels are the run line underdogs. Review how to bet on a point spread with our text and video tutorials.

Matchup Odds FAQs

What is the moneyline for the St. Louis Cardinals vs Los Angeles Angels MLB game on Tuesday, July 21st, 2026?

The Los Angeles Angels are the -118 moneyline favorite at BetMGM and the St. Louis Cardinals are the -102 moneyline underdog at BetMGM.

What is the over-under total line for the St. Louis Cardinals vs Los Angeles Angels MLB game on Tuesday, July 21st, 2026?

The best over line is 9 -120 runs at BetMGM, which means you risk $120 to win $100 betting the over. The best under line is 9 +100 runs at BetMGM, and that means you risk $100 to win $100 betting the under.

What is the run line for the St. Louis Cardinals vs Los Angeles Angels MLB game on Tuesday, July 21st, 2026?

The St. Louis Cardinals are -1.5 +145 run line favorites at BetMGM, while the Los Angeles Angels are +1.5 -180 run line underdogs at BetMGM.

MLB Odds Example

MLB Odds and Outcomes Explained

Game
BetMGM Sports Betting BetMGM
Bet
Cardinals
Angels
9:38pm EDT
-102-118
Bet $100 at BetMGM Ohio
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Possible Moneyline Outcomes
  • St. Louis Cardinals bettors risk $100 to win $98.04 at -102 odds. The implied probability for St. Louis Cardinals is 50.5%.
  • Los Angeles Angels bettors risk $100 to win $84.75 at -118 odds. The implied probability for Los Angeles Angels is 54.13%.

St. Louis Cardinals at Los Angeles Angels Prop Bets

MLB Prop Bets
+ Displays more odds
BetMGM Sports Betting BetMGM
Bet
Cardinals
Angels
First Team to Score
9:38pm EDT
-155+120Bet
Cardinals
Angels
Tie
1st Inning Winner
9:38pm EDT
+280+275-120Bet
Cardinals
Angels
Tie
First 3 Innings Winner
9:38pm EDT
+140+135+320Bet
Cardinals
Angels
To Extra Innings
9:38pm EDT
Yes +800No -1400Bet
BetMGM Sports Betting BetMGM
Angels
Total Runs
STL at LAA
9:38pm EDT
4.5 o -1054.5 u -125Bet
Cardinals
Total Runs
STL at LAA
9:38pm EDT
4.5 o -1154.5 u -115Bet

St. Louis Cardinals & Los Angeles Angels Futures Odds

Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.

St. Louis Cardinals World Series Odds
2026 St. Louis Cardinals World Series Odds

Team
BetMGM Sports Betting BetMGM
Cardinals
+15000
Bet
Los Angeles Angels World Series Odds
2026 Los Angeles Angels World Series Odds

Team
BetMGM Sports Betting BetMGM
Angels
+50000
Bet

St. Louis Cardinals & Los Angeles Angels Team Pages

Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Standings

2026 MLB Regular Season Standings - St. Louis Cardinals, Los Angeles Angels
Team W L Pct GB Home Away RS RA Diff Strk L10
St. Louis Cardinals51470.520+11.026-2625-21444440+4L24-6
Los Angeles Angels39610.390+24.022-2717-34434496-62W13-7

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the St. Louis Cardinals vs Los Angeles Angels MLB Game

  1. Open a new sports betting account before game time.

    Review our list of sports betting sites. Open a new account before the game starts on Tuesday, July 21st, 2026 at 9:38 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.

  2. Visit the sportsbook’s cashier, banking, or deposit page.

    Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.

  3. Tap to the sportsbook's MLB page, look for the St. Louis Cardinals vs Los Angeles Angels Game.

    Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the St. Louis Cardinals vs Los Angeles Angels Game.

  4. Choose your bet and place a wager.

    Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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