The Blue Devils will play the Tigers on Saturday, November 1st, 2025. The matchup takes place at Memorial Stadium (Clemson, SC). Watch this exciting Week 10 matchup at 12:00 pm EDT. Check local listings for coverage on ACC Network.
Learn more about College Football betting with our handy tutorial and guide. We explain spread, total and money line bets.
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Table of Contents
- Matchup Stats
- Paddy O'Parlay
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Team Schedules & Results
- Other Games Today
Key Matchup Stats
It's now the back half of the 2025 college football season, as we begin looking towards the annual bowl games and college football playoffs. Week 10 action features a matchup between Duke and Clemson, kicking off at Memorial Stadium (Clemson, SC) on Saturday, November 1st, 2025. Have a look at the following season performance stats to better handicap this game.
- SportsBetting3.com Power Rankings - Duke has a 93.67 conference power ranking for the 2025 season. The conference power ranking for Clemson is 92.33.
- Away Duke - As Week 10 looms, Duke currently has a 2-1 record as an away team for the 2025 regular season. This ranks them 2nd in the ACC Conference for away team wins. Remember that a team's overall record and schedule strength will affect whether or not they make a bowl game or the playoffs.
- Home Clemson - Clemson has a 1-3 record as a home team as they approach Week 10. They currently rank 5th in the ACC Conference for home team wins. Continue monitoring their performance to see if they have a shot at a postseason bowl game or playoff berth.
- Points Scored - For the 2025 season, Duke ranks 9th (237) in the ACC Conference, with Clemson currently ranking 14th (182) for points scored in the ACC Conference.
- Points Against - Duke stands 6th (180) in the ACC Conference for points scored by opponents in the 2025 college football season. Clemson sits at 14th (146) in the ACC Conference for points against them heading into Week 10 of the 2025 season.
- Team Records - Duke has a 4-3 overall record for the 2025 regular season, with Clemson currently 3-4 for the 2025 college football regular season.
Paddy O'Parlay
The "Sports Network" talking heads have nothing on my Irish arse!
Get ready for a fiery matchup between Duke and Clemson on November 1st!
The Week 10 showdown will take place at Memorial Stadium in Clemson, SC.
Duke holds a Power Ranking of 93.67, while Clemson trails closely behind at 92.33.
With a 4-3 record, Duke is looking to extend their lead over 3-4 Clemson.
Place a bet on this college football game at BetMGM or BetRivers. See this matchup's prop bets below and compare each sportsbook's point spread, total, and moneyline.
Best Blue Devils at Tigers Odds
| Underdog Duke | Favorite Clemson |
|---|---|
| Over | Under |
|---|---|
| Underdog Duke | Favorite Clemson |
|---|---|
Matchup Odds FAQs
Clemson is a -3.5 -110 point spread favorite at BetMGM, while Duke is a +3.5 -110 point spread underdog at BetMGM.
The best over line is 55.5 -110 points at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 55.5 -110 points at BetMGM, and that means you risk $110 to win $100 betting the under.
Clemson is a -165 moneyline favorite at BetMGM and Duke is a +140 moneyline underdog at BetMGM.
College Football Odds Example
|
Game |
 BetMGMBet |
|---|---|
Duke
Clemson
11/01/25 12:00pm EDT | +3.5 -110-3.5 -110 |
Underdog Duke - Duke bettors risk $100 to win $90.91 at -110 odds.
A +3.5 Duke underdog bet wins if they lose by 3 or fewer, tie, or win outright. Your bet loses if they lose by 4 or more.
Favorite Clemson - Clemson bettors risk $100 to win $90.91 at -110 odds.
A -3.5 Clemson favorite bet wins if they win by 4 or more. Your bet loses if they win by 3 or fewer, tie, or lose outright.
Duke at Clemson Prop Bets
Important Note: Some states expressly forbid individual college athlete prop bets. The following wagers may not be available depending on your particular state laws.
| BetMGM Bet |
|
|---|---|
Duke
Clemson
No Touchdown
To Score 1st Touchdown
11/01/25 12:00pm EDT | +120-175+10000Bet |
Duke
Clemson
Game to Overtime
11/01/25 12:00pm EDT | Yes +1150No -5000Bet |
Duke
Clemson
Both Teams Score 10+
11/01/25 12:00pm EDT | Yes -2000No +850Bet |
Duke
Clemson
Both Teams Score 20+
11/01/25 12:00pm EDT | Yes -190No +145Bet |
| BetMGM | |
Duke
Clemson
Both Teams Score 30+
11/01/25 12:00pm EDT | Yes +300No -425Bet |
Recent Meetings Since 2021
| Week | Game | Result | Margin |
|---|---|---|---|
| 2023 Week 1 | Clemson vs Duke Monday, September 4th, 2023 | DUKE 28, CLEM 7 Wallace Wade Stadium | Duke by 21 |
Team Standings
| Team | Conf | Conf% | W | L | PF | PA | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|---|
| Duke | 3-1 | 0.750 | 4 | 3 | 237 | 180 | 2-2 | 2-1 | L1 |
| Clemson | 2-3 | 0.400 | 3 | 4 | 182 | 146 | 1-3 | 2-1 | L1 |
Duke & Clemson Futures Odds
Latest NCAA Championship odds, if available, for each team. Review odds for other teams and learn the best College Football bets.
Duke Championship Odds|
Team | BetMGM |
|---|---|
| Duke | +30000 Bet |
No NCAA College Football Championship TM Clemson YR: futures available
Duke & Clemson Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
Team Schedules & Results
| Week | Matchup | Date & Result |
|---|---|---|
| Week 1 | Elon vs Duke | DUKE 45, ELON 17 Thursday, August 28th, 2025 |
| Week 2 | Illinois vs Duke | ILL 45, DUKE 19 Saturday, September 6th, 2025 |
| Week 3 | Duke vs Tulane | TULN 34, DUKE 27 Saturday, September 13th, 2025 |
| Week 4 | NC State vs Duke | DUKE 45, NCSU 33 Saturday, September 20th, 2025 |
| Week 5 | Duke vs Syracuse | DUKE 38, SYR 3 Saturday, September 27th, 2025 |
| Week 6 | Duke vs California | DUKE 45, CAL 21 Saturday, October 4th, 2025 |
| Week 8 | Georgia Tech vs Duke | GT 27, DUKE 18 Saturday, October 18th, 2025 |
| Week 10 | Duke vs Clemson | Saturday, November 1st, 2025 12:00 pm EDT |
| Week 11 | Duke vs UConn | Saturday, November 8th, 2025 3:30 pm EST |
| Week 12 | Virginia vs Duke | Saturday, November 15th, 2025 12:00 am EST |
| Week 13 | Duke vs North Carolina | Saturday, November 22nd, 2025 12:00 am EST |
| Week 14 | Wake Forest vs Duke | Saturday, November 29th, 2025 12:00 am EST |
| Week | Matchup | Date & Result |
|---|---|---|
| Week 1 | LSU vs Clemson | LSU 17, CLEM 10 Saturday, August 30th, 2025 |
| Week 2 | Troy vs Clemson | CLEM 27, TROY 16 Saturday, September 6th, 2025 |
| Week 3 | Clemson vs Georgia Tech | GT 24, CLEM 21 Saturday, September 13th, 2025 |
| Week 4 | Syracuse vs Clemson | SYR 34, CLEM 21 Saturday, September 20th, 2025 |
| Week 6 | Clemson vs North Carolina | CLEM 38, UNC 10 Saturday, October 4th, 2025 |
| Week 7 | Clemson vs Boston College | CLEM 41, BC 10 Saturday, October 11th, 2025 |
| Week 8 | SMU vs Clemson | SMU 35, CLEM 24 Saturday, October 18th, 2025 |
| Week 10 | Duke vs Clemson | Saturday, November 1st, 2025 12:00 pm EDT |
| Week 11 | Florida State vs Clemson | Saturday, November 8th, 2025 12:00 am EST |
| Week 12 | Clemson vs Louisville | Friday, November 14th, 2025 7:30 pm EST |
| Week 13 | Furman vs Clemson | Saturday, November 22nd, 2025 12:00 am EST |
| Week 14 | Clemson vs South Carolina | Saturday, November 29th, 2025 12:00 pm EST |
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Duke vs Clemson College Football Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Saturday, November 1st, 2025 at 12:00 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's College Football page, look for the Duke vs Clemson Game.
Navigate to the sportsbook's College Football page. Next, look for live or upcoming matchups. Select the Duke vs Clemson Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other November 1, 2025 NCAAFB Games
- Arizona vs Colorado - 11/01/25 12:00pm EDT
- UAB vs UConn - 11/01/25 12:00pm EDT
- Buffalo vs Bowling Green - 11/01/25 12:00pm EDT
- Rutgers vs Illinois - 11/01/25 12:00pm EDT
- West Virginia vs Houston - 11/01/25 12:00pm EDT
- Miami (FL) vs SMU - 11/01/25 12:00pm EDT
- UCF vs Baylor - 11/01/25 12:00pm EDT
- Vanderbilt vs Texas - 11/01/25 12:00pm EDT
- Army vs Air Force - 11/01/25 12:00pm EDT
- Navy vs North Texas - 11/01/25 12:00pm EDT
- Arizona State vs Iowa State - 11/01/25 1:00pm EDT
- East Carolina vs Temple - 11/01/25 2:00pm EDT
- Louisville vs Virginia Tech - 11/01/25 3:00pm EDT
- New Mexico vs UNLV - 11/01/25 3:00pm EDT
- Old Dominion vs Louisiana-Monroe - 11/01/25 3:30pm EDT
- Delaware vs Liberty - 11/01/25 3:30pm EDT
- New Mexico State vs Western Kentucky - 11/01/25 3:30pm EDT
- Louisiana vs South Alabama - 11/01/25 3:30pm EDT
- Pittsburgh vs Stanford - 11/01/25 3:30pm EDT
- Fresno State vs Boise State - 11/01/25 3:30pm EDT
- Notre Dame vs Boston College - 11/01/25 3:30pm EDT
- Michigan State vs Minnesota - 11/01/25 3:30pm EDT
- Georgia vs Florida - 11/01/25 3:30pm EDT
- Indiana vs Maryland - 11/01/25 3:30pm EDT
- Texas Tech vs Kansas State - 11/01/25 3:30pm EDT
- Virginia vs California - 11/01/25 3:45pm EDT
- Central Michigan vs Western Michigan - 11/01/25 4:00pm EDT
- Oklahoma State vs Kansas - 11/01/25 4:00pm EDT
- Mississippi State vs Arkansas - 11/01/25 4:00pm EDT
- South Carolina vs Ole Miss - 11/01/25 7:00pm EDT
- Purdue vs Michigan - 11/01/25 7:00pm EDT
- Wyoming vs San Diego State - 11/01/25 7:00pm EDT
- Washington State vs Oregon State - 11/01/25 7:30pm EDT
- Kentucky vs Auburn - 11/01/25 7:30pm EDT
- Georgia Tech vs NC State - 11/01/25 7:30pm EDT
- Wake Forest vs Florida State - 11/01/25 7:30pm EDT
- Oklahoma vs Tennessee - 11/01/25 7:30pm EDT
- USC vs Nebraska - 11/01/25 7:30pm EDT
- Arkansas State vs Troy - 11/01/25 8:00pm EDT
- Penn State vs Ohio State - 11/01/25 8:30pm EDT
- Cincinnati vs Utah - 11/01/25 10:15pm EDT
- Hawaii vs San Jose State - 11/01/25 10:30pm EDT