Louisville vs Virginia Tech Football Odds

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The Cardinals will play the Hokies on Saturday, November 1st, 2025. The matchup takes place at Lane Stadium. Watch this exciting Week 10 matchup at 3:00 pm EDT. Check local listings for coverage on The CW Network.

Learn more about College Football betting with our handy tutorial and guide. We explain spread, total and money line bets.


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Key Matchup Stats

It's now the back half of the 2025 college football season, as we begin looking towards the annual bowl games and college football playoffs. Week 10 action features a matchup between Louisville and Virginia Tech, kicking off at Lane Stadium on Saturday, November 1st, 2025. Have a look at the following season performance stats to better handicap this game.

  • SportsBetting3.com Power Rankings - Louisville has a 96.33 conference power ranking for the 2025 season. The conference power ranking for Virginia Tech is 91.67.
  • Away Louisville - As Week 10 looms, Louisville currently has a 2-0 record as an away team for the 2025 regular season. This ranks them 2nd in the ACC Conference for away team wins. Remember that a team's overall record and schedule strength will affect whether or not they make a bowl game or the playoffs.
  • Home Virginia Tech - Virginia Tech has a 2-3 record as a home team as they approach Week 10. They currently rank 4th in the ACC Conference for home team wins. Continue monitoring their performance to see if they have a shot at a postseason bowl game or playoff berth.
  • Points Scored - For the 2025 season, Louisville ranks 7th (242) in the ACC Conference, with Virginia Tech currently ranking 11th (203) for points scored in the ACC Conference.
  • Points Against - Louisville stands 13th (150) in the ACC Conference for points scored by opponents in the 2025 college football season. Virginia Tech sits at 3rd (239) in the ACC Conference for points against them heading into Week 10 of the 2025 season.
  • Team Records - Louisville has a 6-1 overall record for the 2025 regular season, with Virginia Tech currently 3-5 for the 2025 college football regular season.

Paddy O'Parlay

The "Sports Network" talking heads have nothing on my Irish arse!

Paddy O'Parlay
Paddy O'Parlay

Get ready for a wild showdown as Louisville faces off against Virginia Tech!

On Saturday, November 1st, the Cardinals will take on the Hokies at Lane Stadium.

Louisville comes in hot with a Power Ranking of 96.33, while Virginia Tech trails at 91.67.

The Cardinals boast a 6-1 record, while the Hokies are struggling at 3-5. Place a bet on this college football game at BetMGM or BetRivers and see this matchup's prop bets below. Compare each sportsbook's point spread, total, and moneyline.

Best Cardinals at Hokies Odds


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Louisville at Virginia Tech Prop Bets

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Louisville
Virginia Tech
11/01/25 3:00pm EDT
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Recent Meetings Since 2021

Recent Meetings Since 2021
WeekGameResultMargin
2025
Week 10		Louisville vs Virginia Tech
Saturday, November 1st, 2025		LOU 28, VT 16
Lane Stadium		Louisville by 12
2023
Week 10		Virginia Tech vs Louisville
Saturday, November 4th, 2023		LOU 34, VT 3
Cardinal Stadium		Louisville by 31

Team Standings

2025-2026 College Football Regular Season Standings - Louisville, Virginia Tech
Team Conf Conf% W L PF PA Home Away Strk
Louisville4-40.500943892755-33-1W2
Virginia Tech2-60.250392573622-51-3L4

Louisville & Virginia Tech Futures Odds

Latest NCAA Championship odds, if available, for each team. Review odds for other teams and learn the best College Football bets.

Louisville Championship Odds

No NCAA College Football Championship TM Louisville YR: futures available

Virginia Tech Championship Odds

No NCAA College Football Championship TM Virginia Tech YR: futures available

Louisville & Virginia Tech Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Schedules & Results


2025-26 Louisville Games & Results
WeekMatchupDate & Result
Week 1Eastern Kentucky vs
Louisville		LOU 51, EKU 17
Saturday, August 30th, 2025
Week 2James Madison vs
Louisville		LOU 28, JMU 14
Friday, September 5th, 2025
Week 4Bowling Green vs
Louisville		LOU 40, BGSU 17
Saturday, September 20th, 2025
Week 5Louisville vs
Pittsburgh		LOU 34, PITT 27
Saturday, September 27th, 2025
Week 6Virginia vs
Louisville		UVA 30, LOU 27 (OT)
Saturday, October 4th, 2025
Week 8Louisville vs
Miami (FL)		LOU 24, MIA 21
Friday, October 17th, 2025
Week 9Boston College vs
Louisville		LOU 38, BC 24
Saturday, October 25th, 2025
Week 10Louisville vs
Virginia Tech		LOU 28, VT 16
Saturday, November 1st, 2025
Week 11California vs
Louisville		CAL 29, LOU 26 (OT)
Saturday, November 8th, 2025
Week 12Clemson vs
Louisville		CLEM 20, LOU 19
Friday, November 14th, 2025
Week 13Louisville vs
SMU		SMU 38, LOU 6
Saturday, November 22nd, 2025
Week 14Kentucky vs
Louisville		LOU 41, UK 0
Saturday, November 29th, 2025
BowlsToledo vs
Louisville
Bush's Boca Raton Bowl		LOU 27, TOL 22
Tuesday, December 23rd, 2025


2025-26 Virginia Tech Games & Results
WeekMatchupDate & Result
Week 1Virginia Tech vs
South Carolina		SC 24, VT 11
Sunday, August 31st, 2025
Week 2Vanderbilt vs
Virginia Tech		VAN 44, VT 20
Saturday, September 6th, 2025
Week 3Old Dominion vs
Virginia Tech		ODU 45, VT 26
Saturday, September 13th, 2025
Week 4Wofford vs
Virginia Tech		VT 38, WOF 6
Saturday, September 20th, 2025
Week 5Virginia Tech vs
NC State		VT 23, NCSU 21
Saturday, September 27th, 2025
Week 6Wake Forest vs
Virginia Tech		WAKE 30, VT 23
Saturday, October 4th, 2025
Week 7Virginia Tech vs
Georgia Tech		GT 35, VT 20
Saturday, October 11th, 2025
Week 9California vs
Virginia Tech		VT 42, CAL 34 (2OT)
Friday, October 24th, 2025
Week 10Louisville vs
Virginia Tech		LOU 28, VT 16
Saturday, November 1st, 2025
Week 12Virginia Tech vs
Florida State		FSU 34, VT 14
Saturday, November 15th, 2025
Week 13Miami (FL) vs
Virginia Tech		MIA 34, VT 17
Saturday, November 22nd, 2025
Week 14Virginia Tech vs
Virginia		UVA 27, VT 7
Saturday, November 29th, 2025

How to Bet on the Game

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How to Bet on the Louisville vs Virginia Tech College Football Game

  1. Open a new sports betting account before game time.

    Review our list of sports betting sites. Open a new account before the game starts on Saturday, November 1st, 2025 at 3:00 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.

  2. Visit the sportsbook’s cashier, banking, or deposit page.

    Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.

  3. Tap to the sportsbook's College Football page, look for the Louisville vs Virginia Tech Game.

    Navigate to the sportsbook's College Football page. Next, look for live or upcoming matchups. Select the Louisville vs Virginia Tech Game.

  4. Choose your bet and place a wager.

    Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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