Iowa vs USC Football Odds

by
Share on Reddit

The Hawkeyes will play the Trojans on Saturday, November 15th, 2025. The matchup takes place at Los Angeles Memorial Coliseum. Watch this exciting Week 12 matchup at 3:30 pm EST. Check local listings for coverage on BTN.

Learn more about College Football betting with our handy tutorial and guide. We explain spread, total and money line bets.


 Bonus

Table of Contents

Key Matchup Stats

It's now the back half of the 2025 college football season, as we begin looking towards the annual bowl games and college football playoffs. Week 12 action features a matchup between Iowa and USC, kicking off at Los Angeles Memorial Coliseum on Saturday, November 15th, 2025. Have a look at the following season performance stats to better handicap this game.

  • SportsBetting3.com Power Rankings - Iowa has a 95.33 conference power ranking for the 2025 season. The conference power ranking for USC is 97.00.
  • Away Iowa - As Week 12 looms, Iowa currently has a 2-1 record as an away team for the 2025 regular season. This ranks them 2nd in the Big Ten Conference for away team wins. Remember that a team's overall record and schedule strength will affect whether or not they make a bowl game or the playoffs.
  • Home USC - USC has a 5-0 record as a home team as they approach Week 12. They currently rank 2nd in the Big Ten Conference for home team wins. Continue monitoring their performance to see if they have a shot at a postseason bowl game or playoff berth.
  • Points Scored - For the 2025 season, Iowa ranks 10th (266) in the Big Ten Conference, with USC currently ranking 2nd (356) for points scored in the Big Ten Conference.
  • Points Against - Iowa stands 15th (123) in the Big Ten Conference for points scored by opponents in the 2025 college football season. USC sits at 9th (196) in the Big Ten Conference for points against them heading into Week 12 of the 2025 season.
  • Team Records - Iowa has a 6-3 overall record for the 2025 regular season, with USC currently 7-2 for the 2025 college football regular season.

Paddy O'Parlay

The "Sports Network" talking heads have nothing on my Irish arse!

Paddy O'Parlay
Paddy O'Parlay

Get ready for an epic clash as Iowa faces USC in a crucial Week 12 matchup.

The game will be held at the iconic Los Angeles Memorial Coliseum in California.

According to SportsBetting3.com Power Rankings, USC has a slight edge over Iowa.

Iowa stands at 6-3 while USC boasts a 7-2 record this season. Don't miss out! Place a bet on this college football game at BetMGM or BetRivers and see this matchup's prop bets below. Compare each sportsbook's point spread, total, and moneyline. Let the games begin!

Best Hawkeyes at Trojans Odds


Best Point Spread Betting Odds
TBDTBD
Point Spread odds are updating, please check back soon.

Best Total Betting Odds
OverUnder
Total odds are updating, please check back soon.

Best Moneyline Betting Odds
TBDTBD
Moneyline odds are updating, please check back soon.

College Football Odds Example

College Football Odds and Outcomes Explained
Game Book

Iowa at USC Prop Bets

Important Note: Some states expressly forbid individual college athlete prop bets. The following wagers may not be available depending on your particular state laws.

College Football Prop Bets
+ Displays more odds

Bet
Iowa
USC
11/15/25 3:30pm EST
Pending

Recent Meetings Since 2021

Recent Meetings Since 2021
WeekGameResultMargin
2025
Week 12		Iowa vs USC
Saturday, November 15th, 2025		USC 26, IOWA 21
Los Angeles Memorial Coliseum		USC by 5

Team Standings

2025-2026 College Football Regular Season Standings - Iowa, USC
Team Conf Conf% W L PF PA Home Away Strk
#20 USC7-20.778944652997-02-3L1
#17 Iowa6-30.667943812095-23-2W3

Iowa & USC Futures Odds

Latest NCAA Championship odds, if available, for each team. Review odds for other teams and learn the best College Football bets.

Iowa Championship Odds

No NCAA College Football Championship TM Iowa YR: futures available

USC Championship Odds

No NCAA College Football Championship TM USC YR: futures available

Iowa & USC Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Schedules & Results


2025-26 Iowa Games & Results
WeekMatchupDate & Result
Week 1Albany vs
Iowa		IOWA 34, ALB 7
Saturday, August 30th, 2025
Week 2Iowa vs
Iowa State		ISU 16, IOWA 13
Saturday, September 6th, 2025
Week 3UMass vs
Iowa		IOWA 47, MASS 7
Saturday, September 13th, 2025
Week 4Iowa vs
Rutgers		IOWA 38, RUTG 28
Friday, September 19th, 2025
Week 5Indiana vs
Iowa		IU 20, IOWA 15
Saturday, September 27th, 2025
Week 7Iowa vs
Wisconsin		IOWA 37, WIS 0
Saturday, October 11th, 2025
Week 8Penn State vs
Iowa		IOWA 25, PSU 24
Saturday, October 18th, 2025
Week 9Minnesota vs
Iowa		IOWA 41, MINN 3
Saturday, October 25th, 2025
Week 11Oregon vs
Iowa		ORE 18, IOWA 16
Saturday, November 8th, 2025
Week 12Iowa vs
USC		USC 26, IOWA 21
Saturday, November 15th, 2025
Week 13Michigan State vs
Iowa		IOWA 20, MSU 17
Saturday, November 22nd, 2025
Week 14Iowa vs
Nebraska		IOWA 40, NEB 16
Friday, November 28th, 2025
BowlsIowa vs
Vanderbilt
Reliaquest Bowl		IOWA 34, VAN 27
Wednesday, December 31st, 2025


2025-26 USC Games & Results
WeekMatchupDate & Result
Week 1Missouri State vs
USC		USC 73, MOST 13
Saturday, August 30th, 2025
Week 2Georgia Southern vs
USC		USC 59, GASO 20
Saturday, September 6th, 2025
Week 3USC vs
Purdue		USC 33, PUR 17
Saturday, September 13th, 2025
Week 4Michigan State vs
USC		USC 45, MSU 31
Saturday, September 20th, 2025
Week 5USC vs
Illinois		ILL 34, USC 32
Saturday, September 27th, 2025
Week 7Michigan vs
USC		USC 31, MICH 13
Saturday, October 11th, 2025
Week 8USC vs
Notre Dame		ND 34, USC 24
Saturday, October 18th, 2025
Week 10USC vs
Nebraska		USC 21, NEB 17
Saturday, November 1st, 2025
Week 11Northwestern vs
USC		USC 38, NU 17
Friday, November 7th, 2025
Week 12Iowa vs
USC		USC 26, IOWA 21
Saturday, November 15th, 2025
Week 13USC vs
Oregon		ORE 42, USC 27
Saturday, November 22nd, 2025
Week 14UCLA vs
USC		USC 29, UCLA 10
Saturday, November 29th, 2025
BowlsUSC vs
TCU
Valero Alamo Bowl		TCU 30, USC 27 (OT)
Tuesday, December 30th, 2025

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Iowa vs USC College Football Game

  1. Open a new sports betting account before game time.

    Review our list of sports betting sites. Open a new account before the game starts on Saturday, November 15th, 2025 at 3:30 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.

  2. Visit the sportsbook’s cashier, banking, or deposit page.

    Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.

  3. Tap to the sportsbook's College Football page, look for the Iowa vs USC Game.

    Navigate to the sportsbook's College Football page. Next, look for live or upcoming matchups. Select the Iowa vs USC Game.

  4. Choose your bet and place a wager.

    Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

Other November 15, 2025 NCAAFB Games

Odds Preview 7525