Iowa vs USC Football Odds - SportsBetting3.com

The Hawkeyes will play the Trojans on Saturday, November 15th, 2025. The matchup takes place at Los Angeles Memorial Coliseum. Watch this exciting Week 12 matchup at 3:30 pm EST. Check local listings for coverage on BTN.

Learn more about College Football betting with our handy tutorial and guide. We explain spread, total and money line bets.

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Matchup Stats
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Key Matchup Stats

It's now the back half of the 2025 college football season, as we begin looking towards the annual bowl games and college football playoffs. Week 12 action features a matchup between Iowa and USC, kicking off at Los Angeles Memorial Coliseum on Saturday, November 15th, 2025. Have a look at the following season performance stats to better handicap this game.

SportsBetting3.com Power Rankings - Iowa has a 95.33 conference power ranking for the 2025 season. The conference power ranking for USC is 97.00.
Away Iowa - As Week 12 looms, Iowa currently has a 2-1 record as an away team for the 2025 regular season. This ranks them 2nd in the Big Ten Conference for away team wins. Remember that a team's overall record and schedule strength will affect whether or not they make a bowl game or the playoffs.
Home USC - USC has a 5-0 record as a home team as they approach Week 12. They currently rank 2nd in the Big Ten Conference for home team wins. Continue monitoring their performance to see if they have a shot at a postseason bowl game or playoff berth.
Points Scored - For the 2025 season, Iowa ranks 10th (266) in the Big Ten Conference, with USC currently ranking 2nd (356) for points scored in the Big Ten Conference.
Points Against - Iowa stands 15th (123) in the Big Ten Conference for points scored by opponents in the 2025 college football season. USC sits at 9th (196) in the Big Ten Conference for points against them heading into Week 12 of the 2025 season.
Team Records - Iowa has a 6-3 overall record for the 2025 regular season, with USC currently 7-2 for the 2025 college football regular season.

Paddy O'Parlay

The "Sports Network" talking heads have nothing on my Irish arse!

Get ready for an epic clash as Iowa faces USC in a crucial Week 12 matchup.

The game will be held at the iconic Los Angeles Memorial Coliseum in California.

According to SportsBetting3.com Power Rankings, USC has a slight edge over Iowa.

Iowa stands at 6-3 while USC boasts a 7-2 record this season. Don't miss out! Place a bet on this college football game at BetMGM or BetRivers and see this matchup's prop bets below. Compare each sportsbook's point spread, total, and moneyline. Let the games begin!

Best Hawkeyes at Trojans Odds

**Best Point Spread Betting Odds**
Underdog Iowa	Favorite USC
+6.5 -105 BetMGM Bet	-6.5 -115 BetMGM Bet

USC has a -6.5 -115 point spread at BetMGM OH. They are the point spread favorite in this matchup. Iowa has a +6.5 -105 point spread at BetMGM OH. Iowa is the point spread underdog. Review how to bet on a point spread with our text and video tutorials.

**Best Total Betting Odds**
Over	Under
48.5 o -105 BetMGM Bet	48.5 u -115 BetMGM Bet

BetMGM has the best over line of 48.5 points. Risk $105 to win $100. BetMGM has the best under line of 48.5 points. Risk $115 to win $100. Our tutorial explains more about total bets.

**Best Moneyline Betting Odds**
Underdog Iowa	Favorite USC
+200 BetMGM Bet	-250 BetMGM Bet

USC is the -250 moneyline favorite. Risk $250 to win $100 on USC at BetMGM. Iowa is the +200 underdog at BetMGM. Risk $100 to win $200 on Iowa. Learn more about how to bet on money lines.

Matchup Odds FAQs

What is the point spread for the Iowa vs USC College Football game on Saturday, November 15th, 2025?

USC is a -6.5 -115 point spread favorite at BetMGM, while Iowa is a +6.5 -105 point spread underdog at BetMGM.

What is the over-under total line for the Iowa vs USC College Football game on Saturday, November 15th, 2025?

The best over line is 48.5 -105 points at BetMGM, which means you risk $105 to win $100 betting the over. The best under line is 48.5 -115 points at BetMGM, and that means you risk $115 to win $100 betting the under.

What is the moneyline for the Iowa vs USC College Football game on Saturday, November 15th, 2025?

USC is a -250 moneyline favorite at BetMGM and Iowa is a +200 moneyline underdog at BetMGM.

College Football Odds Example

College Football Odds and Outcomes Explained
Game	BetMGM Bet
Iowa USC 11/15/25 3:30pm EST	+6.5 -105 -6.5 -115

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Underdog Iowa - Iowa bettors risk $100 to win $95.24 at -105 odds.

A +6.5 Iowa underdog bet wins if they lose by 6 or fewer, tie, or win outright. Your bet loses if they lose by 7 or more.

Favorite USC - USC bettors risk $100 to win $86.96 at -115 odds.

A -6.5 USC favorite bet wins if they win by 7 or more. Your bet loses if they win by 6 or fewer, tie, or lose outright.

Iowa at USC Prop Bets

Important Note: Some states expressly forbid individual college athlete prop bets. The following wagers may not be available depending on your particular state laws.

College Football Prop Bets
+ Displays more odds
	BetMGM Bet
Iowa USC No Touchdown To Score 1st Touchdown 11/15/25 3:30pm EST	+154 -225 +10000 Bet
Iowa USC Game to Overtime 11/15/25 3:30pm EST	Yes +1150 No -10000 Bet
Iowa USC Both Teams Score 10+ 11/15/25 3:30pm EST	Yes -750 No +475 Bet
Iowa USC Both Teams Score 20+ 11/15/25 3:30pm EST	Yes +110 No -140 Bet
	BetMGM
Iowa USC Both Teams Score 30+ 11/15/25 3:30pm EST	Yes +725 No -1600 Bet

Recent Meetings Since 2021

Recent Meetings Since 2021
Week	Game	Result	Margin
2025 Week 12	Iowa vs USC Saturday, November 15th, 2025	USC 26, IOWA 21 Los Angeles Memorial Coliseum	USC by 5

Team Standings

2025-2026 College Football Regular Season Standings - Iowa, USC
Team	Conf	Conf%	W	L	PF	PA	Home	Away	Strk
#16 USC	7-2	0.778	9	3	438	269	7-0	2-3	W1
#23 Iowa	6-3	0.667	8	4	347	182	5-2	3-2	W2

Iowa & USC Futures Odds

Latest NCAA Championship odds, if available, for each team. Review odds for other teams and learn the best College Football bets.

Iowa Championship Odds

No NCAA College Football Championship TM Iowa YR: futures available

USC Championship Odds

No NCAA College Football Championship TM USC YR: futures available

Iowa & USC Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Schedules & Results

2025-26 Iowa Games & Results
Week	Matchup	Date & Result
Week 1	Albany vs Iowa	IOWA 34, ALB 7 Saturday, August 30th, 2025
Week 2	Iowa vs Iowa State	ISU 16, IOWA 13 Saturday, September 6th, 2025
Week 3	UMass vs Iowa	IOWA 47, MASS 7 Saturday, September 13th, 2025
Week 4	Iowa vs Rutgers	IOWA 38, RUTG 28 Friday, September 19th, 2025
Week 5	Indiana vs Iowa	IU 20, IOWA 15 Saturday, September 27th, 2025
Week 7	Iowa vs Wisconsin	IOWA 37, WIS 0 Saturday, October 11th, 2025
Week 8	Penn State vs Iowa	IOWA 25, PSU 24 Saturday, October 18th, 2025
Week 9	Minnesota vs Iowa	IOWA 41, MINN 3 Saturday, October 25th, 2025
Week 11	Oregon vs Iowa	ORE 18, IOWA 16 Saturday, November 8th, 2025
Week 12	Iowa vs USC	USC 26, IOWA 21 Saturday, November 15th, 2025
Week 13	Michigan State vs Iowa	IOWA 20, MSU 17 Saturday, November 22nd, 2025
Week 14	Iowa vs Nebraska	IOWA 40, NEB 16 Friday, November 28th, 2025
Bowls	Iowa vs Vanderbilt Reliaquest Bowl	Wednesday, December 31st, 2025 12:00 pm EST

2025-26 USC Games & Results
Week	Matchup	Date & Result
Week 1	Missouri State vs USC	USC 73, MOST 13 Saturday, August 30th, 2025
Week 2	Georgia Southern vs USC	USC 59, GASO 20 Saturday, September 6th, 2025
Week 3	USC vs Purdue	USC 33, PUR 17 Saturday, September 13th, 2025
Week 4	Michigan State vs USC	USC 45, MSU 31 Saturday, September 20th, 2025
Week 5	USC vs Illinois	ILL 34, USC 32 Saturday, September 27th, 2025
Week 7	Michigan vs USC	USC 31, MICH 13 Saturday, October 11th, 2025
Week 8	USC vs Notre Dame	ND 34, USC 24 Saturday, October 18th, 2025
Week 10	USC vs Nebraska	USC 21, NEB 17 Saturday, November 1st, 2025
Week 11	Northwestern vs USC	USC 38, NU 17 Friday, November 7th, 2025
Week 12	Iowa vs USC	USC 26, IOWA 21 Saturday, November 15th, 2025
Week 13	USC vs Oregon	ORE 42, USC 27 Saturday, November 22nd, 2025
Week 14	UCLA vs USC	USC 29, UCLA 10 Saturday, November 29th, 2025
Bowls	USC vs TCU Valero Alamo Bowl	Tuesday, December 30th, 2025 9:00 pm EST

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Iowa vs USC College Football Game

Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Saturday, November 15th, 2025 at 3:30 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
Tap to the sportsbook's College Football page, look for the Iowa vs USC Game.
Navigate to the sportsbook's College Football page. Next, look for live or upcoming matchups. Select the Iowa vs USC Game.
Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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