The 49ers will play the Saints on Sunday, September 14th, 2025. The matchup takes place at Caesars Superdome. Watch this exciting Week 2 matchup at 1:00 pm EDT. Check local listings for coverage on FOX.

Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.

STATE	Bonus

Matchup Stats
Captain Shady Lines
Best Odds
Interactive Odds Example
Prop Bets
Recent Meetings
Team Standings
Futures Odds
Team Pages
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Key Matchup Stats

The 2025-26 NFL regular season keeps rolling for the San Francisco 49ers and New Orleans Saints, as they gear up to play an exciting Week 2 matchup at Caesars Superdome. Have a look at the following statistical insights to help you handicap the game.

SportsBetting3.com Power Rankings - The San Francisco 49ers have started the 2025-26 season with an initial 97.33 power ranking. The New Orleans Saints currently have a 92.33 power ranking so far.
Away San Francisco 49ers - Though it's still early in the season, the San Francisco 49ers have a 1-0-0 record as an away team, ranking them 1st in the league for away team wins.
Home New Orleans Saints - Looking at the New Orleans Saints heading into Week 2, they currently have a 0-1-0 record as a home team. They rank 2nd in the league for home team wins.
Points Scored - The San Francisco 49ers currently rank 12th (17) up to Week 2, with the New Orleans Saints ranked 15th (13) for points scored in the 2025-26 regular season.
Points Against - The San Francisco 49ers stand 15th (13) in the early weeks of the regular season for points against. The New Orleans Saints rank 11th (20) for points against.
Team Records - As Week 2 approaches, the San Francisco 49ers have a 1-0-0 record, with the New Orleans Saints at 0-1-0 for the 2025-26 NFL regular season.

Captain Shady Lines

A broken compass is right at least twice a day.

Avast ye mateys! The San Francisco 49ers be sailin' into New Orleans to plunder the Saints!

This Week 2 clash be happenin' at the treacherous Caesars Superdome, a place of many battles.

According to SportsBetting3.com NFL Power Rankings, the 49ers be favored over the Saints.

The 49ers be standin' at 1-0-0, while the Saints be strugglin' at 0-1-0. Bet this game at BetRivers, or BetMGM. Review this game's prop bets and compare the odds below. Arrr!

Best 49ers at Saints Odds

**Best Point Spread Betting Odds**
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Point Spread odds are updating, please check back soon.

**Best Total Betting Odds**
Over	Under

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**Best Moneyline Betting Odds**
TBD	TBD

Moneyline odds are updating, please check back soon.

NFL Odds Example

NFL Odds and Outcomes Explained
Game	Book

San Francisco 49ers at New Orleans Saints Prop Bets

NFL Prop Bets
+ Displays more odds
	Bet
49ers Saints 9/14/25 1:00pm EDT	Pending

Recent Meetings Since 2021

Recent Meetings Since 2021
Week	Game	Result	Margin
2025 Week 2	49ers vs Saints Sunday, September 14th, 2025	SF 26, NO 21 Caesars Superdome	49ers by 5
2024 Preseason Week 2	Saints vs 49ers Sunday, August 18th, 2024	SF 16, NO 10 Levi's Stadium	49ers by 6
2022 Week 12	Saints vs 49ers Sunday, November 27th, 2022	SF 13, NO 0 Levi's Stadium	49ers by 13

Team Standings

2025-2026 NFL Regular Season Standings - San Francisco 49ers, New Orleans Saints
Team	W	L	T	Pct	PF	PA	Home	Away	Div	Div%	Conf	Conf%	Strk	L5
xy - San Francisco 49ers	12	5	0	0.706	437	371	5-3-0	7-2-0	4-2-0	0.667	9-3-0	0.750	1L	4-1-0
New Orleans Saints	6	11	0	0.353	306	383	3-5-0	3-6-0	3-3-0	0.500	4-8-0	0.333	1L	4-1-0

San Francisco 49ers & New Orleans Saints Futures Odds

Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.

San Francisco 49ers Futures Odds

No Super Bowl TM San Francisco 49ers YR: futures available

New Orleans Saints Futures Odds

No Super Bowl TM New Orleans Saints YR: futures available

San Francisco 49ers & New Orleans Saints Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the San Francisco 49ers vs New Orleans Saints NFL Game

Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, September 14th, 2025 at 1:00 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
Tap to the sportsbook's NFL page, look for the San Francisco 49ers vs New Orleans Saints Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the San Francisco 49ers vs New Orleans Saints Game.
Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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San Francisco 49ers vs New Orleans Saints Odds

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