The White Sox will play the Nationals on Sunday, September 28th, 2025. Your timezone's first pitch time is 3:05 pm EDT. Check local listings or your nearest streaming app for coverage.
Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.
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Table of Contents
- Best Odds
- Interactive Odds Example
- Prop Bets
- Team Futures Odds
- Team Pages
- Team Standings
- Other Games Today
Best White Sox at Nationals Odds
| Underdog Chicago White Sox | Favorite Washington Nationals |
|---|---|
| Over | Under |
|---|---|
| Underdog Washington Nationals | Favorite Chicago White Sox |
|---|---|
Matchup Odds FAQs
The Washington Nationals are the -118 moneyline favorite at BetMGM and the Chicago White Sox are the -102 moneyline underdog at BetMGM.
The best over line is 8.5 -102 runs at BetMGM, which means you risk $102 to win $100 betting the over. The best under line is 8.5 -118 runs at BetMGM, and that means you risk $118 to win $100 betting the under.
The Chicago White Sox are -1.5 +165 run line favorites at BetMGM, while the Washington Nationals are +1.5 -200 run line underdogs at BetMGM.
MLB Odds Example
|
Game |
 BetMGMBet |
|---|---|
White Sox
Nationals
9/28/25 3:05pm EDT | -102-118 |
- Chicago White Sox bettors risk $100 to win $98.04 at -102 odds. The implied probability for Chicago White Sox is 50.5%.
- Washington Nationals bettors risk $100 to win $84.75 at -118 odds. The implied probability for Washington Nationals is 54.13%.
Chicago White Sox at Washington Nationals Prop Bets
| BetMGM Bet |
|
|---|---|
White Sox
Nationals
First Team to Score
9/28/25 3:05pm EDT | -155+120Bet |
White Sox
Nationals
Tie
1st Inning Winner
9/28/25 3:05pm EDT | +300+300-140Bet |
White Sox
Nationals
Tie
First 3 Innings Winner
9/28/25 3:05pm EDT | +145+140+275Bet |
White Sox
Nationals
To Extra Innings
9/28/25 3:05pm EDT | Yes +750No -1200Bet |
| BetMGM | |
White Sox
Nationals
1st Team to Score Will Win
9/28/25 3:05pm EDT | Yes -250No +190Bet |
Nationals
Total Runs
CWS at WAS 9/28/25 3:05pm EDT | 3.5 o -1503.5 u +115Bet |
Brad Lord
Strikeouts Thrown
CWS at WAS 9/28/25 3:05pm EDT | 4.5 o -1054.5 u -125Bet |
Shane Smith
Strikeouts Thrown
CWS at WAS 9/28/25 3:05pm EDT | 4.5 o -1604.5 u +120Bet |
Chicago White Sox & Washington Nationals Futures Odds
Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.
Chicago White Sox World Series OddsNo World Series TM Chicago White Sox YR: futures available
Washington Nationals World Series OddsNo World Series TM Washington Nationals YR: futures available
Chicago White Sox & Washington Nationals Team Pages
Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
Team Standings
| Team | W | L | Pct | GB | Home | Away | RS | RA | Diff | Strk | L10 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| e - Washington Nationals | 66 | 96 | 0.407 | +31.0 | 32-49 | 34-47 | 687 | 899 | -212 | L1 | 4-6 |
| e - Chicago White Sox | 60 | 102 | 0.370 | +37.0 | 33-48 | 27-54 | 647 | 742 | -95 | W1 | 3-7 |
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Chicago White Sox vs Washington Nationals MLB Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, September 28th, 2025 at 3:05 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's MLB page, look for the Chicago White Sox vs Washington Nationals Game.
Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the Chicago White Sox vs Washington Nationals Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other September 28, 2025 MLB Games
- Colorado Rockies vs San Francisco Giants - 9/28/25 3:05pm EDT
- Minnesota Twins vs Philadelphia Phillies - 9/28/25 3:05pm EDT
- Baltimore Orioles vs New York Yankees - 9/28/25 3:05pm EDT
- Detroit Tigers vs Boston Red Sox - 9/28/25 3:05pm EDT
- Kansas City Royals vs Oakland Athletics - 9/28/25 3:05pm EDT
- Tampa Bay Rays vs Toronto Blue Jays - 9/28/25 3:07pm EDT
- Houston Astros vs Los Angeles Angels - 9/28/25 3:07pm EDT
- Texas Rangers vs Cleveland Guardians - 9/28/25 3:10pm EDT
- New York Mets vs Miami Marlins - 9/28/25 3:10pm EDT
- Arizona Diamondbacks vs San Diego Padres - 9/28/25 3:10pm EDT
- Cincinnati Reds vs Milwaukee Brewers - 9/28/25 3:10pm EDT
- Los Angeles Dodgers vs Seattle Mariners - 9/28/25 3:10pm EDT
- Pittsburgh Pirates vs Atlanta Braves - 9/28/25 3:15pm EDT
- St. Louis Cardinals vs Chicago Cubs - 9/28/25 3:20pm EDT