Cleveland Guardians vs Minnesota Twins Odds

The Guardians will play the Twins on Sunday, September 21st, 2025. Your timezone's first pitch time is 2:10 pm EDT. Check local listings or your nearest streaming app for coverage.

Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.

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Best Guardians at Twins Odds

**Best Moneyline Betting Odds**
Underdog Minnesota Twins	Favorite Cleveland Guardians
+118 BetMGM Bet	-145 BetMGM Bet

The Cleveland Guardians are the -145 moneyline favorite. Risk $145 to win $100 on the Cleveland Guardians at BetMGM. The Minnesota Twins are the +118 underdog at BetMGM. Risk $100 to win $118 on the Minnesota Twins. Learn more about how to bet on money lines.

**Best Total Betting Odds**
Over	Under
8.5 o -102 BetMGM Bet	8.5 u -118 BetMGM Bet

BetMGM has the best over line of 8.5 runs. Risk $102 to win $100. BetMGM has the best under line of 8.5 runs. Risk $118 to win $100. Our tutorial explains more about total bets.

**Best Run Line Betting Odds**
Underdog Minnesota Twins	Favorite Cleveland Guardians
+1.5 -135 BetMGM Bet	-1.5 +115 BetMGM Bet

The Cleveland Guardians have a -1.5 +115 run line at BetMGM OH. They are the run line favorite in this matchup. The Minnesota Twins have a +1.5 -135 run line at BetMGM OH. The Minnesota Twins are the run line underdogs. Review how to bet on a point spread with our text and video tutorials.

Matchup Odds FAQs

What is the moneyline for the Cleveland Guardians vs Minnesota Twins MLB game on Sunday, September 21st, 2025?

The Cleveland Guardians are the -145 moneyline favorite at BetMGM and the Minnesota Twins are the +118 moneyline underdog at BetMGM.

What is the over-under total line for the Cleveland Guardians vs Minnesota Twins MLB game on Sunday, September 21st, 2025?

The best over line is 8.5 -102 runs at BetMGM, which means you risk $102 to win $100 betting the over. The best under line is 8.5 -118 runs at BetMGM, and that means you risk $118 to win $100 betting the under.

What is the run line for the Cleveland Guardians vs Minnesota Twins MLB game on Sunday, September 21st, 2025?

The Cleveland Guardians are -1.5 +115 run line favorites at BetMGM, while the Minnesota Twins are +1.5 -135 run line underdogs at BetMGM.

MLB Odds Example

MLB Odds and Outcomes Explained
Game	BetMGM Bet
Guardians Twins 9/21/25 2:10pm EDT	-145 +118

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Possible Moneyline Outcomes

Minnesota Twins bettors risk $100 to win $118 at +118 odds. The implied probability for Minnesota Twins is 45.87%.
Cleveland Guardians bettors risk $100 to win $68.97 at -145 odds. The implied probability for Cleveland Guardians is 59.18%.

Cleveland Guardians at Minnesota Twins Prop Bets

MLB Prop Bets
+ Displays more odds
	BetMGM Bet
Guardians Twins First Team to Score 9/21/25 2:10pm EDT	-175 +135 Bet
Guardians Twins Tie 1st Inning Winner 9/21/25 2:10pm EDT	+260 +320 -130 Bet
Guardians Twins Tie First 3 Innings Winner 9/21/25 2:10pm EDT	+125 +154 +300 Bet
Guardians Twins To Extra Innings 9/21/25 2:10pm EDT	Yes +750 No -1200 Bet
	BetMGM
Guardians Twins 1st Team to Score Will Win 9/21/25 2:10pm EDT	Yes -250 No +190 Bet
Guardians Total Runs CLE at MIN 9/21/25 2:10pm EDT	4.5 o -105 4.5 u -125 Bet
Twins Total Runs CLE at MIN 9/21/25 2:10pm EDT	3.5 o -125 3.5 u -105 Bet
Joey Cantillo Strikeouts Thrown CLE at MIN 9/21/25 2:10pm EDT	5.5 o -105 5.5 u -125 Bet
	BetMGM
Simeon Woods Richardson Strikeouts Thrown CLE at MIN 9/21/25 2:10pm EDT	4.5 o -140 4.5 u +110 Bet

Cleveland Guardians & Minnesota Twins Futures Odds

Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.

Cleveland Guardians World Series Odds

No World Series TM Cleveland Guardians YR: futures available

Minnesota Twins World Series Odds

No World Series TM Minnesota Twins YR: futures available

Cleveland Guardians & Minnesota Twins Team Pages

Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Standings

2025 MLB Regular Season Standings - Cleveland Guardians, Minnesota Twins
Team	W	L	Pct	GB	Home	Away	RS	RA	Diff	Strk	L10
x - Cleveland Guardians	88	74	0.543	+9.0	45-36	43-38	643	649	-6	W2	7-3
e - Minnesota Twins	70	92	0.432	+27.0	38-43	32-49	678	773	-95	L1	4-6

How to Bet on the Game

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How to Bet on the Cleveland Guardians vs Minnesota Twins MLB Game

Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, September 21st, 2025 at 2:10 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
Tap to the sportsbook's MLB page, look for the Cleveland Guardians vs Minnesota Twins Game.
Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the Cleveland Guardians vs Minnesota Twins Game.
Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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