The Guardians will play the Twins on Wednesday, May 21st, 2025. This is Game 2 of a doubleheader. Your timezone's first pitch time is 7:10 pm EDT. Check local listings or your nearest streaming app for coverage.

Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.

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Matchup Stats
Captain Shady Lines
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Key Matchup Stats

SportsBetting3.com Power Rankings - The Cleveland Guardians have a 90.33 power ranking. The power ranking for the Minnesota Twins is 95.00.
Visiting Cleveland Guardians - The Cleveland Guardians have a 11-13 record as a visiting team, ranking them 4th Overall for visiting team wins.
Home Minnesota Twins - The Minnesota Twins have a 15-6 record as a home team. They rank 3rd for home team wins in the Overall standings.
Runs Scored - The Cleveland Guardians currently stand 22nd (182) Overall, with the Minnesota Twins ranking 19th (194) for runs scored.
Runs Allowed - The Cleveland Guardians are 13th (202) Overall for runs allowed. The Minnesota Twins stand 26th (159) for runs allowed.
Team Streaks - The Cleveland Guardians have lost their last 4 games. Meanwhile, the Minnesota Twins lost their last game.
Team Records - The Cleveland Guardians have a 25-21 Overall record (5.5 GB American Central Division), with the Minnesota Twins possessing a 26-21 Overall standing (5.0 GB American Central Division).

Captain Shady Lines

A broken compass is right at least twice a day.

Avast ye scallywags! The Cleveland Guardians face the Minnesota Twins on Wednesday...

These landlubbers be limping into battle with a pitiful 4-6 record lately...

SportsBetting3.com be the place to wager your doubloons, bet on this game... (review the odds below)

The Twins be on a rampage, plundering their way to a 9-1 record...

The Guardians best be prepared for a fierce showdown on foreign soil...

Ye best be ready to witness a battle of epic proportions on Wednesday!

Best Guardians at Twins Odds

**Best Moneyline Betting Odds**
TBD	TBD

Moneyline odds are updating, please check back soon.

**Best Total Betting Odds**
Over	Under

Total odds are updating, please check back soon.

**Best Run Line Betting Odds**
TBD	TBD

Run Line odds are updating, please check back soon.

MLB Odds Example

MLB Odds and Outcomes Explained
Game	Book

Cleveland Guardians at Minnesota Twins Prop Bets

MLB Prop Bets
+ Displays more odds
	BetMGM Bet
Guardians Twins 5/21/25 7:10pm EDT Doubleheader - Game 2	Pending BetMGM

Cleveland Guardians & Minnesota Twins Futures Odds

Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.

Cleveland Guardians World Series Odds

2025 Cleveland Guardians World Series Odds
Team	BetMGM
Guardians	+5500 Bet

Minnesota Twins World Series Odds

2025 Minnesota Twins World Series Odds
Team	BetMGM
Twins	+3000 Bet

Cleveland Guardians & Minnesota Twins Team Pages

Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Standings

2025 MLB Regular Season Standings - Cleveland Guardians, Minnesota Twins
Team	W	L	Pct	GB	Home	Away	RS	RA	Diff	Strk	L10
Minnesota Twins	30	24	0.556	+5.0	18-8	12-16	216	185	+31	W1	6-4
Cleveland Guardians	29	25	0.537	+6.0	14-10	15-15	216	236	-20	L3	4-6

How to Bet on the Game

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How to Bet on the Cleveland Guardians vs Minnesota Twins MLB Game

Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Wednesday, May 21st, 2025 at 7:10 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
Tap to the sportsbook's MLB page, look for the Cleveland Guardians vs Minnesota Twins Game.
Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the Cleveland Guardians vs Minnesota Twins Game.
Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

Other May 21, 2025 MLB Games

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Cleveland Guardians vs Minnesota Twins Odds

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