Cleveland Guardians vs Washington Nationals Odds

The Guardians will play the Nationals on Wednesday, May 7th, 2025. Your timezone's first pitch time is 12:05 pm EDT. Check local listings or your nearest streaming app for coverage.

Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.


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Table of Contents

Key Matchup Stats

  • SportsBetting3.com Power Rankings - The Cleveland Guardians have a 90.33 power ranking. The power ranking for the Washington Nationals is 89.00.
  • Visiting Cleveland Guardians - The Cleveland Guardians have a 9-10 record as a visiting team, ranking them 4th Overall for visiting team wins.
  • Home Washington Nationals - The Washington Nationals have a 10-7 record as a home team. They rank 6th for home team wins in the Overall standings.
  • Runs Scored - The Cleveland Guardians currently stand 16th (140) Overall, with the Washington Nationals ranking 12th (161) for runs scored.
  • Runs Allowed - The Cleveland Guardians are 10th (164) Overall for runs allowed. The Washington Nationals stand 3rd (188) for runs allowed.
  • Team Streaks - The Cleveland Guardians lost their last game. Meanwhile, the Washington Nationals have won their last 3 games.
  • Team Records - The Cleveland Guardians have a 20-15 Overall record (1.5 GB American Central Division), with the Washington Nationals possessing a 17-19 Overall standing (6.0 GB National East Division).

Captain Shady Lines

A broken compass is right at least twice a day.

Captain Shady Lines
Captain Shady Lines

Avast ye scallywags! The Guardians be takin' on the Nationals in Washington...

Cleveland be sittin' at a solid 20-15 record, ready to plunder more wins...

But don't count out the Nationals, holdin' their ground at home with a 17-19 record...

Ye better head over to SportsBetting3.com, bet on this game, and review the odds below...

The Guardians be lookin' to increase their win percentage on the road...

So grab yer grog, raise the Jolly Roger, and let the battle begin!

Best Guardians at Nationals Odds


Best Moneyline Betting Odds
Underdog

Washington Nationals
Favorite

Cleveland Guardians
The Cleveland Guardians are the -115 moneyline favorite. Risk $115 to win $100 on the Cleveland Guardians at BetMGM. The Washington Nationals are the +112 underdog at BetRivers. Risk $100 to win $112 on the Washington Nationals. Learn more about how to bet on money lines.

Best Total Betting Odds
OverUnder
BetRivers has the best over line of 9 runs. Risk $115 to win $100. BetMGM has the best under line of 9 runs. Risk $102 to win $100. Our tutorial explains more about total bets.

Best Run Line Betting Odds
Underdog

Washington Nationals
Favorite

Cleveland Guardians
The Cleveland Guardians have a -1.5 +140 run line at BetMGM PA. They are the run line favorite in this matchup. The Washington Nationals have a +1.5 -155 run line at BetRivers PA. The Washington Nationals are the run line underdogs. Review how to bet on a point spread with our text and video tutorials.

Matchup Odds FAQs

What is the moneyline for the Cleveland Guardians vs Washington Nationals MLB game on Wednesday, May 7th, 2025?

The Cleveland Guardians are the -115 moneyline favorite at BetMGM and the Washington Nationals are the +112 moneyline underdog at BetRivers.

What is the over-under total line for the Cleveland Guardians vs Washington Nationals MLB game on Wednesday, May 7th, 2025?

The best over line is 9 -115 runs at BetRivers, which means you risk $115 to win $100 betting the over. The best under line is 9 -102 runs at BetMGM, and that means you risk $102 to win $100 betting the under.

What is the run line for the Cleveland Guardians vs Washington Nationals MLB game on Wednesday, May 7th, 2025?

The Cleveland Guardians are -1.5 +140 run line favorites at BetMGM, while the Washington Nationals are +1.5 -155 run line underdogs at BetRivers.

MLB Odds Example

MLB Odds and Outcomes Explained

Game
BetMGM Sports Betting BetMGM
Bet
Guardians
Nationals
5/07/25 12:05pm EDT
-115-105
Bet $100 at BetMGM Pennsylvania
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Possible Moneyline Outcomes
  • Washington Nationals bettors risk $100 to win $95.24 at -105 odds. The implied probability for Washington Nationals is 51.22%.
  • Cleveland Guardians bettors risk $100 to win $86.96 at -115 odds. The implied probability for Cleveland Guardians is 53.49%.

Cleveland Guardians at Washington Nationals Prop Bets

MLB Prop Bets
+ Displays more odds
BetMGM Sports Betting BetMGM
Bet
Guardians
Nationals
First Team to Score
5/07/25 12:05pm EDT
-160+125Bet
Guardians
Nationals
Tie
1st Inning Winner
5/07/25 12:05pm EDT
+270+280-120Bet
Guardians
Nationals
Tie
First 3 Innings Winner
5/07/25 12:05pm EDT
+130+135+333Bet
Guardians
Nationals
To Extra Innings
5/07/25 12:05pm EDT
Yes +800No -1400Bet
BetMGM Sports Betting BetMGM
Guardians
Nationals
1st Team to Score Will Win
5/07/25 12:05pm EDT
Yes -250No +190Bet
Guardians
Total Runs
CLE at WAS
5/07/25 12:05pm EDT
4.5 o -1184.5 u -110Bet
Nationals
Total Runs
CLE at WAS
5/07/25 12:05pm EDT
4.5 o +1004.5 u -130Bet
Logan Allen
Strikeouts Thrown
CLE at WAS
5/07/25 12:05pm EDT
3.5 o -1303.5 u +100Bet

Cleveland Guardians & Washington Nationals Futures Odds

Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.

Cleveland Guardians World Series Odds
2025 Cleveland Guardians World Series Odds

Team
BetMGM Sports Betting BetMGM BetRivers Sports Betting BetRivers
Guardians
+4000
Bet
+4000
Bet
Washington Nationals World Series Odds
2025 Washington Nationals World Series Odds

Team
BetMGM Sports Betting BetMGM BetRivers Sports Betting BetRivers
Nationals
+50000
Bet
+25000
Bet

Cleveland Guardians & Washington Nationals Team Pages

Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Standings

2025 MLB Regular Season Standings - Cleveland Guardians, Washington Nationals
Team W L Pct GB Home Away RS RA Diff Strk L10
Cleveland Guardians25180.581+3.514-811-10176190-14L16-4
Washington Nationals18260.409+11.010-128-14181238-57W13-7

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Cleveland Guardians vs Washington Nationals MLB Game

  1. Open a new sports betting account before game time.

    Review our list of sports betting sites. Open a new account before the game starts on Wednesday, May 7th, 2025 at 12:05 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.

  2. Visit the sportsbook’s cashier, banking, or deposit page.

    Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.

  3. Tap to the sportsbook's MLB page, look for the Cleveland Guardians vs Washington Nationals Game.

    Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the Cleveland Guardians vs Washington Nationals Game.

  4. Choose your bet and place a wager.

    Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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