Houston Astros vs Minnesota Twins Odds

The Astros will play the Twins on Wednesday, May 20th, 2026. Your timezone's first pitch time is 1:40 pm EDT. Check local listings or your nearest streaming app for coverage.

Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.


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Table of Contents

Key Matchup Stats

  • SportsBetting3.com Power Rankings - The Houston Astros have a 88.00 power ranking. The power ranking for the Minnesota Twins is 94.33.
  • Visiting Houston Astros - The Houston Astros have a 2-10 record as a visiting team, ranking them 8th Overall for visiting team wins.
  • Home Minnesota Twins - The Minnesota Twins have a 7-6 record as a home team. They rank 3rd for home team wins in the Overall standings.
  • Runs Scored - The Houston Astros currently stand 2nd (135) Overall, with the Minnesota Twins ranking 7th (117) for runs scored.
  • Runs Allowed - The Houston Astros are 1st (150) Overall for runs allowed. The Minnesota Twins stand 13th (103) for runs allowed.
  • Team Streaks - The Houston Astros lost their last game. Meanwhile, the Minnesota Twins won their last game.
  • Team Records - The Houston Astros have a 9-16 Overall record (4.5 GB American West Division), with the Minnesota Twins possessing a 12-11 Overall standing (1.0 GB American Central Division).

Best Astros at Twins Odds


Best Moneyline Betting Odds
Underdog

Houston Astros
Favorite

Minnesota Twins
The Minnesota Twins are the -155 moneyline favorite. Risk $155 to win $100 on the Minnesota Twins at BetMGM. The Houston Astros are the +125 underdog at BetMGM. Risk $100 to win $125 on the Houston Astros. Learn more about how to bet on money lines.

Best Total Betting Odds
OverUnder
BetMGM has the best over line of 8 runs. Risk $110 to win $100. BetMGM has the best under line of 8 runs. Risk $110 to win $100. Our tutorial explains more about total bets.

Best Run Line Betting Odds
Underdog

Houston Astros
Favorite

Minnesota Twins
The Minnesota Twins have a -1.5 +135 run line at BetMGM OH. They are the run line favorite in this matchup. The Houston Astros have a +1.5 -160 run line at BetMGM OH. The Houston Astros are the run line underdogs. Review how to bet on a point spread with our text and video tutorials.

Matchup Odds FAQs

What is the moneyline for the Houston Astros vs Minnesota Twins MLB game on Wednesday, May 20th, 2026?

The Minnesota Twins are the -155 moneyline favorite at BetMGM and the Houston Astros are the +125 moneyline underdog at BetMGM.

What is the over-under total line for the Houston Astros vs Minnesota Twins MLB game on Wednesday, May 20th, 2026?

The best over line is 8 -110 runs at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 8 -110 runs at BetMGM, and that means you risk $110 to win $100 betting the under.

What is the run line for the Houston Astros vs Minnesota Twins MLB game on Wednesday, May 20th, 2026?

The Minnesota Twins are -1.5 +135 run line favorites at BetMGM, while the Houston Astros are +1.5 -160 run line underdogs at BetMGM.

MLB Odds Example

MLB Odds and Outcomes Explained

Game
BetMGM Sports Betting BetMGM
Bet
Astros
Twins
5/20/26 1:40pm EDT
+125-155
Bet $100 at BetMGM Ohio
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Possible Moneyline Outcomes
  • Houston Astros bettors risk $100 to win $125 at +125 odds. The implied probability for Houston Astros is 44.44%.
  • Minnesota Twins bettors risk $100 to win $64.52 at -155 odds. The implied probability for Minnesota Twins is 60.78%.

Houston Astros at Minnesota Twins Prop Bets

MLB Prop Bets
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BetMGM Sports Betting BetMGM
Bet
Astros
Twins
5/20/26 1:40pm EDT
Pending BetMGM

Houston Astros & Minnesota Twins Futures Odds

Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.

Houston Astros World Series Odds
2026 Houston Astros World Series Odds

Team
BetMGM Sports Betting BetMGM
Astros
+8000
Bet
Minnesota Twins World Series Odds
2026 Minnesota Twins World Series Odds

Team
BetMGM Sports Betting BetMGM
Twins
+12500
Bet

Houston Astros & Minnesota Twins Team Pages

Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Standings

2026 MLB Regular Season Standings - Houston Astros, Minnesota Twins
Team W L Pct GB Home Away RS RA Diff Strk L10
Houston Astros31380.449+15.016-1915-19313350-37L15-5
Minnesota Twins30380.441+15.518-1812-20312344-32L33-7

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Houston Astros vs Minnesota Twins MLB Game

  1. Open a new sports betting account before game time.

    Review our list of sports betting sites. Open a new account before the game starts on Wednesday, May 20th, 2026 at 1:40 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.

  2. Visit the sportsbook’s cashier, banking, or deposit page.

    Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.

  3. Tap to the sportsbook's MLB page, look for the Houston Astros vs Minnesota Twins Game.

    Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the Houston Astros vs Minnesota Twins Game.

  4. Choose your bet and place a wager.

    Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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