St. Louis Cardinals vs Los Angeles Angels Odds

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The Cardinals will play the Angels on Wednesday, July 22nd, 2026. Your timezone's first pitch time is 4:07 pm EDT. Check local listings or your nearest streaming app for coverage.

Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.


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Table of Contents

Key Matchup Stats

  • SportsBetting3.com Power Rankings - As the 2026 season continues, the St. Louis Cardinals possess a 90.67 SportsBetting3.com power ranking. The Los Angeles Angels now have a 84.33 power ranking. Teams with a higher SportsBetting3.com power ranking will typically be moneyline favorites.
  • Visiting St. Louis Cardinals - The St. Louis Cardinals head into this matchup with a 25-22 record as a visiting team. This standing ranks them 8th Overall for visiting team wins.
  • Home Los Angeles Angels - The Los Angeles Angels will throw the first pitch possessing a 23-27 home team record. That puts them 11th for home team wins in the Overall MLB standings.
  • Runs Scored - St. Louis Cardinals batters have produced 446 runs, ranking them 15th Overall, with the Los Angeles Angels ranking 17th (437) for runs scored.
  • Runs Allowed - St. Louis Cardinals pitchers and fielders have allowed 443 runs, ranking them 17th Overall for runs allowed. Meanwhile, the Los Angeles Angels now rank 7th Overall, allowing 498 runs.
  • Team Streaks - The St. Louis Cardinals have lost their last 3 games. Their opponent, the Los Angeles Angels have won their last 2 games.
  • Team Records - Let's review each team's records. The St. Louis Cardinals have a 51-48 Overall record (11.5 GB National Central Division), with the Los Angeles Angels notching a 40-61 Overall standing (11.0 GB American West Division).

Best Cardinals at Angels Odds


Best Moneyline Betting Odds
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Best Total Betting Odds
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Best Run Line Betting Odds
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MLB Odds Example

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St. Louis Cardinals at Los Angeles Angels Prop Bets

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7/22/26 4:07pm EDT
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St. Louis Cardinals & Los Angeles Angels Futures Odds

Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.

St. Louis Cardinals World Series Odds

No World Series TM St. Louis Cardinals YR: futures available

Los Angeles Angels World Series Odds

No World Series TM Los Angeles Angels YR: futures available

St. Louis Cardinals & Los Angeles Angels Team Pages

Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Standings

2026 MLB Regular Season Standings - St. Louis Cardinals, Los Angeles Angels
Team W L Pct GB Home Away RS RA Diff Strk L10
St. Louis Cardinals72750.490+18.534-3838-37668680-12L34-6
e - Los Angeles Angels56900.384+34.030-4426-46591664-73W24-6

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the St. Louis Cardinals vs Los Angeles Angels MLB Game

  1. Open a new sports betting account before game time.

    Review our list of sports betting sites. Open a new account before the game starts on Wednesday, July 22nd, 2026 at 4:07 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.

  2. Visit the sportsbook’s cashier, banking, or deposit page.

    Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.

  3. Tap to the sportsbook's MLB page, look for the St. Louis Cardinals vs Los Angeles Angels Game.

    Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the St. Louis Cardinals vs Los Angeles Angels Game.

  4. Choose your bet and place a wager.

    Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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