Duke vs Clemson Football Odds - SportsBetting3.com

The Blue Devils will play the Tigers on Saturday, November 1st, 2025. The matchup takes place at Memorial Stadium (Clemson, SC). Watch this exciting Week 10 matchup at 12:00 pm EDT. Check local listings for coverage on ACC Network.

Learn more about College Football betting with our handy tutorial and guide. We explain spread, total and money line bets.

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Key Matchup Stats

It's now the back half of the 2025 college football season, as we begin looking towards the annual bowl games and college football playoffs. Week 10 action features a matchup between Duke and Clemson, kicking off at Memorial Stadium (Clemson, SC) on Saturday, November 1st, 2025. Have a look at the following season performance stats to better handicap this game.

SportsBetting3.com Power Rankings - Duke has a 93.67 conference power ranking for the 2025 season. The conference power ranking for Clemson is 92.33.
Away Duke - As Week 10 looms, Duke currently has a 2-1 record as an away team for the 2025 regular season. This ranks them 2nd in the ACC Conference for away team wins. Remember that a team's overall record and schedule strength will affect whether or not they make a bowl game or the playoffs.
Home Clemson - Clemson has a 1-3 record as a home team as they approach Week 10. They currently rank 5th in the ACC Conference for home team wins. Continue monitoring their performance to see if they have a shot at a postseason bowl game or playoff berth.
Points Scored - For the 2025 season, Duke ranks 9th (237) in the ACC Conference, with Clemson currently ranking 14th (182) for points scored in the ACC Conference.
Points Against - Duke stands 6th (180) in the ACC Conference for points scored by opponents in the 2025 college football season. Clemson sits at 14th (146) in the ACC Conference for points against them heading into Week 10 of the 2025 season.
Team Records - Duke has a 4-3 overall record for the 2025 regular season, with Clemson currently 3-4 for the 2025 college football regular season.

Paddy O'Parlay

The "Sports Network" talking heads have nothing on my Irish arse!

Get ready for a fiery matchup between Duke and Clemson on November 1st!

The Week 10 showdown will take place at Memorial Stadium in Clemson, SC.

Duke holds a Power Ranking of 93.67, while Clemson trails closely behind at 92.33.

With a 4-3 record, Duke is looking to extend their lead over 3-4 Clemson.

Place a bet on this college football game at BetMGM or BetRivers. See this matchup's prop bets below and compare each sportsbook's point spread, total, and moneyline.

Best Blue Devils at Tigers Odds

**Best Point Spread Betting Odds**
Underdog Duke	Favorite Clemson
+3.5 -115 BetMGM Bet	-3.5 -105 BetMGM Bet

Clemson has a -3.5 -105 point spread at BetMGM OH. They are the point spread favorite in this matchup. Duke has a +3.5 -115 point spread at BetMGM OH. Duke is the point spread underdog. Review how to bet on a point spread with our text and video tutorials.

**Best Total Betting Odds**
Over	Under
54.5 o -110 BetMGM Bet	54.5 u -110 BetMGM Bet

BetMGM has the best over line of 54.5 points. Risk $110 to win $100. BetMGM has the best under line of 54.5 points. Risk $110 to win $100. Our tutorial explains more about total bets.

**Best Moneyline Betting Odds**
Underdog Duke	Favorite Clemson
+140 BetMGM Bet	-165 BetMGM Bet

Clemson is the -165 moneyline favorite. Risk $165 to win $100 on Clemson at BetMGM. Duke is the +140 underdog at BetMGM. Risk $100 to win $140 on Duke. Learn more about how to bet on money lines.

Matchup Odds FAQs

What is the point spread for the Duke vs Clemson College Football game on Saturday, November 1st, 2025?

Clemson is a -3.5 -105 point spread favorite at BetMGM, while Duke is a +3.5 -115 point spread underdog at BetMGM.

What is the over-under total line for the Duke vs Clemson College Football game on Saturday, November 1st, 2025?

The best over line is 54.5 -110 points at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 54.5 -110 points at BetMGM, and that means you risk $110 to win $100 betting the under.

What is the moneyline for the Duke vs Clemson College Football game on Saturday, November 1st, 2025?

Clemson is a -165 moneyline favorite at BetMGM and Duke is a +140 moneyline underdog at BetMGM.

College Football Odds Example

College Football Odds and Outcomes Explained
Game	BetMGM Bet
Duke Clemson 11/01/25 12:00pm EDT	+3.5 -115 -3.5 -105

Bet $100 at BetMGM Ohio
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Underdog Duke - Duke bettors risk $100 to win $86.96 at -115 odds.

A +3.5 Duke underdog bet wins if they lose by 3 or fewer, tie, or win outright. Your bet loses if they lose by 4 or more.

Favorite Clemson - Clemson bettors risk $100 to win $95.24 at -105 odds.

A -3.5 Clemson favorite bet wins if they win by 4 or more. Your bet loses if they win by 3 or fewer, tie, or lose outright.

Duke at Clemson Prop Bets

Important Note: Some states expressly forbid individual college athlete prop bets. The following wagers may not be available depending on your particular state laws.

College Football Prop Bets
+ Displays more odds
	BetMGM Bet
Duke Clemson No Touchdown To Score 1st Touchdown 11/01/25 12:00pm EDT	+110 -160 +10000 Bet
Duke Clemson Game to Overtime 11/01/25 12:00pm EDT	Yes +950 No -5000 Bet
Duke Clemson Both Teams Score 10+ 11/01/25 12:00pm EDT	Yes -1600 No +775 Bet
Duke Clemson Both Teams Score 20+ 11/01/25 12:00pm EDT	Yes -165 No +130 Bet
	BetMGM
Duke Clemson Both Teams Score 30+ 11/01/25 12:00pm EDT	Yes +333 No -475 Bet

Recent Meetings Since 2021

Recent Meetings Since 2021
Week	Game	Result	Margin
2025 Week 10	Duke vs Clemson Saturday, November 1st, 2025	DUKE 46, CLEM 45 Memorial Stadium (Clemson, SC)	Duke by 1
2023 Week 1	Clemson vs Duke Monday, September 4th, 2023	DUKE 28, CLEM 7 Wallace Wade Stadium	Duke by 21

Team Standings

2025-2026 College Football Regular Season Standings - Duke, Clemson
Team	Conf	Conf%	W	L	PF	PA	Home	Away	Strk
Duke	6-2	0.750	8	5	442	373	3-3	4-2	W3
Clemson	4-4	0.500	7	5	344	245	3-4	4-1	W4

Duke & Clemson Futures Odds

Latest NCAA Championship odds, if available, for each team. Review odds for other teams and learn the best College Football bets.

Duke Championship Odds

No NCAA College Football Championship TM Duke YR: futures available

Clemson Championship Odds

No NCAA College Football Championship TM Clemson YR: futures available

Duke & Clemson Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Schedules & Results

2025-26 Duke Games & Results
Week	Matchup	Date & Result
Week 1	Elon vs Duke	DUKE 45, ELON 17 Thursday, August 28th, 2025
Week 2	Illinois vs Duke	ILL 45, DUKE 19 Saturday, September 6th, 2025
Week 3	Duke vs Tulane	TULN 34, DUKE 27 Saturday, September 13th, 2025
Week 4	NC State vs Duke	DUKE 45, NCSU 33 Saturday, September 20th, 2025
Week 5	Duke vs Syracuse	DUKE 38, SYR 3 Saturday, September 27th, 2025
Week 6	Duke vs California	DUKE 45, CAL 21 Saturday, October 4th, 2025
Week 8	Georgia Tech vs Duke	GT 27, DUKE 18 Saturday, October 18th, 2025
Week 10	Duke vs Clemson	DUKE 46, CLEM 45 Saturday, November 1st, 2025
Week 11	Duke vs UConn	CONN 37, DUKE 34 Saturday, November 8th, 2025
Week 12	Virginia vs Duke	UVA 34, DUKE 17 Saturday, November 15th, 2025
Week 13	Duke vs North Carolina	DUKE 32, UNC 25 Saturday, November 22nd, 2025
Week 14	Wake Forest vs Duke	DUKE 49, WAKE 32 Saturday, November 29th, 2025
Week 15	Duke vs Virginia	DUKE 27, UVA 20 (OT) Saturday, December 6th, 2025
Bowls	Arizona State vs Duke Tony The Tiger Sun Bowl	Wednesday, December 31st, 2025 2:00 pm EST

2025-26 Clemson Games & Results
Week	Matchup	Date & Result
Week 1	LSU vs Clemson	LSU 17, CLEM 10 Saturday, August 30th, 2025
Week 2	Troy vs Clemson	CLEM 27, TROY 16 Saturday, September 6th, 2025
Week 3	Clemson vs Georgia Tech	GT 24, CLEM 21 Saturday, September 13th, 2025
Week 4	Syracuse vs Clemson	SYR 34, CLEM 21 Saturday, September 20th, 2025
Week 6	Clemson vs North Carolina	CLEM 38, UNC 10 Saturday, October 4th, 2025
Week 7	Clemson vs Boston College	CLEM 41, BC 10 Saturday, October 11th, 2025
Week 8	SMU vs Clemson	SMU 35, CLEM 24 Saturday, October 18th, 2025
Week 10	Duke vs Clemson	DUKE 46, CLEM 45 Saturday, November 1st, 2025
Week 11	Florida State vs Clemson	CLEM 24, FSU 10 Saturday, November 8th, 2025
Week 12	Clemson vs Louisville	CLEM 20, LOU 19 Friday, November 14th, 2025
Week 13	Furman vs Clemson	CLEM 45, FUR 10 Saturday, November 22nd, 2025
Week 14	Clemson vs South Carolina	CLEM 28, SC 14 Saturday, November 29th, 2025
Bowls	Penn State vs Clemson Bad Boy Mowers Pinstripe Bowl	Saturday, December 27th, 2025 12:00 pm EST

How to Bet on the Game

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How to Bet on the Duke vs Clemson College Football Game

Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Saturday, November 1st, 2025 at 12:00 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
Tap to the sportsbook's College Football page, look for the Duke vs Clemson Game.
Navigate to the sportsbook's College Football page. Next, look for live or upcoming matchups. Select the Duke vs Clemson Game.
Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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