The Hawkeyes will play the Trojans on Saturday, November 15th, 2025. The matchup takes place at Los Angeles Memorial Coliseum. Watch this exciting Week 12 matchup at 3:30 pm EST.
Learn more about College Football betting with our handy tutorial and guide. We explain spread, total and money line bets.
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Table of Contents
- Matchup Stats
- Paddy O'Parlay
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Team Schedules & Results
- Other Games Today
Key Matchup Stats
It's now the back half of the 2025 college football season, as we begin looking towards the annual bowl games and college football playoffs. Week 12 action features a matchup between Iowa and USC, kicking off at Los Angeles Memorial Coliseum on Saturday, November 15th, 2025. Have a look at the following season performance stats to better handicap this game.
- SportsBetting3.com Power Rankings - Iowa has a 95.33 conference power ranking for the 2025 season. The conference power ranking for USC is 97.00.
- Away Iowa - As Week 12 looms, Iowa currently has a 2-1 record as an away team for the 2025 regular season. This ranks them 2nd in the Big Ten Conference for away team wins. Remember that a team's overall record and schedule strength will affect whether or not they make a bowl game or the playoffs.
- Home USC - USC has a 5-0 record as a home team as they approach Week 12. They currently rank 2nd in the Big Ten Conference for home team wins. Continue monitoring their performance to see if they have a shot at a postseason bowl game or playoff berth.
- Points Scored - For the 2025 season, Iowa ranks 10th (266) in the Big Ten Conference, with USC currently ranking 2nd (356) for points scored in the Big Ten Conference.
- Points Against - Iowa stands 15th (123) in the Big Ten Conference for points scored by opponents in the 2025 college football season. USC sits at 9th (196) in the Big Ten Conference for points against them heading into Week 12 of the 2025 season.
- Team Records - Iowa has a 6-3 overall record for the 2025 regular season, with USC currently 7-2 for the 2025 college football regular season.
Paddy O'Parlay
The "Sports Network" talking heads have nothing on my Irish arse!
Get ready for an epic clash as Iowa faces USC in a crucial Week 12 matchup.
The game will be held at the iconic Los Angeles Memorial Coliseum in California.
According to SportsBetting3.com Power Rankings, USC has a slight edge over Iowa.
Iowa stands at 6-3 while USC boasts a 7-2 record this season. Don't miss out! Place a bet on this college football game at BetMGM or BetRivers and see this matchup's prop bets below. Compare each sportsbook's point spread, total, and moneyline. Let the games begin!
Best Hawkeyes at Trojans Odds
| Underdog Iowa | Favorite USC |
|---|---|
| Over | Under |
|---|---|
| Underdog Iowa | Favorite USC |
|---|---|
Matchup Odds FAQs
USC is a -6.5 -105 point spread favorite at BetMGM, while Iowa is a +6.5 -115 point spread underdog at BetMGM.
The best over line is 48.5 -115 points at BetMGM, which means you risk $115 to win $100 betting the over. The best under line is 48.5 -105 points at BetMGM, and that means you risk $105 to win $100 betting the under.
USC is a -250 moneyline favorite at BetMGM and Iowa is a +200 moneyline underdog at BetMGM.
College Football Odds Example
|
Game |
 BetMGMBet |
|---|---|
Iowa
USC
11/15/25 3:30pm EST | +6.5 -115-6.5 -105 |
Underdog Iowa - Iowa bettors risk $100 to win $86.96 at -115 odds.
A +6.5 Iowa underdog bet wins if they lose by 6 or fewer, tie, or win outright. Your bet loses if they lose by 7 or more.
Favorite USC - USC bettors risk $100 to win $95.24 at -105 odds.
A -6.5 USC favorite bet wins if they win by 7 or more. Your bet loses if they win by 6 or fewer, tie, or lose outright.
Iowa at USC Prop Bets
Important Note: Some states expressly forbid individual college athlete prop bets. The following wagers may not be available depending on your particular state laws.
| BetMGM Bet |
|
|---|---|
Iowa
USC
No Touchdown
To Score 1st Touchdown
11/15/25 3:30pm EST | +150-220+10000Bet |
Iowa
USC
Game to Overtime
11/15/25 3:30pm EST | Yes +1150No -10000Bet |
Iowa
USC
Both Teams Score 10+
11/15/25 3:30pm EST | Yes -800No +500Bet |
Iowa
USC
Both Teams Score 20+
11/15/25 3:30pm EST | Yes -102No -125Bet |
| BetMGM | |
Iowa
USC
Both Teams Score 30+
11/15/25 3:30pm EST | Yes +650No -1200Bet |
Recent Meetings Since 2021
| Week | Game | Result | Margin |
|---|
Team Standings
| Team | Conf | Conf% | W | L | PF | PA | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|---|
| #17 USC | 5-1 | 0.833 | 7 | 2 | 356 | 196 | 5-0 | 2-2 | W2 |
| #21 Iowa | 4-2 | 0.667 | 6 | 3 | 266 | 123 | 4-2 | 2-1 | L1 |
Iowa & USC Futures Odds
Latest NCAA Championship odds, if available, for each team. Review odds for other teams and learn the best College Football bets.
Iowa Championship OddsNo NCAA College Football Championship TM Iowa YR: futures available
USC Championship Odds|
Team | BetMGM |
|---|---|
| USC | +8000 Bet |
Iowa & USC Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
Team Schedules & Results
| Week | Matchup | Date & Result |
|---|---|---|
| Week 1 | Albany vs Iowa | IOWA 34, ALB 7 Saturday, August 30th, 2025 |
| Week 2 | Iowa vs Iowa State | ISU 16, IOWA 13 Saturday, September 6th, 2025 |
| Week 3 | UMass vs Iowa | IOWA 47, MASS 7 Saturday, September 13th, 2025 |
| Week 4 | Iowa vs Rutgers | IOWA 38, RUTG 28 Friday, September 19th, 2025 |
| Week 5 | Indiana vs Iowa | IU 20, IOWA 15 Saturday, September 27th, 2025 |
| Week 7 | Iowa vs Wisconsin | IOWA 37, WIS 0 Saturday, October 11th, 2025 |
| Week 8 | Penn State vs Iowa | IOWA 25, PSU 24 Saturday, October 18th, 2025 |
| Week 9 | Minnesota vs Iowa | Saturday, October 25th, 2025 3:30 pm EDT |
| Week 11 | Oregon vs Iowa | Saturday, November 8th, 2025 12:00 am EST |
| Week 12 | Iowa vs USC | Saturday, November 15th, 2025 12:00 am EST |
| Week 13 | Michigan State vs Iowa | Saturday, November 22nd, 2025 12:00 am EST |
| Week 14 | Iowa vs Nebraska | Friday, November 28th, 2025 12:00 pm EST |
| Week | Matchup | Date & Result |
|---|---|---|
| Week 1 | Missouri State vs USC | USC 73, MOST 13 Saturday, August 30th, 2025 |
| Week 2 | Georgia Southern vs USC | USC 59, GASO 20 Saturday, September 6th, 2025 |
| Week 3 | USC vs Purdue | USC 33, PUR 17 Saturday, September 13th, 2025 |
| Week 4 | Michigan State vs USC | USC 45, MSU 31 Saturday, September 20th, 2025 |
| Week 5 | USC vs Illinois | ILL 34, USC 32 Saturday, September 27th, 2025 |
| Week 7 | Michigan vs USC | USC 31, MICH 13 Saturday, October 11th, 2025 |
| Week 8 | USC vs Notre Dame | ND 34, USC 24 Saturday, October 18th, 2025 |
| Week 10 | USC vs Nebraska | Saturday, November 1st, 2025 7:30 pm EDT |
| Week 11 | Northwestern vs USC | Friday, November 7th, 2025 9:00 pm EST |
| Week 12 | Iowa vs USC | Saturday, November 15th, 2025 12:00 am EST |
| Week 13 | USC vs Oregon | Saturday, November 22nd, 2025 12:00 am EST |
| Week 14 | UCLA vs USC | Saturday, November 29th, 2025 12:00 am EST |
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Iowa vs USC College Football Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Saturday, November 15th, 2025 at 3:30 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's College Football page, look for the Iowa vs USC Game.
Navigate to the sportsbook's College Football page. Next, look for live or upcoming matchups. Select the Iowa vs USC Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other November 15, 2025 NCAAFB Games
- Air Force vs UConn - 11/15/25 12:00pm EST
- Eastern Michigan vs Ball State - 11/15/25 12:00pm EST
- Kansas State vs Oklahoma State - 11/15/25 12:00pm EST
- South Florida vs Navy - 11/15/25 12:00pm EST
- UTSA vs Charlotte - 11/15/25 12:00pm EST
- Michigan vs Northwestern - 11/15/25 12:00pm EST
- Wisconsin vs Indiana - 11/15/25 12:00pm EST
- Notre Dame vs Pittsburgh - 11/15/25 12:00pm EST
- South Carolina vs Texas A&M - 11/15/25 12:00pm EST
- Arizona vs Cincinnati - 11/15/25 12:00pm EST
- Arkansas vs LSU - 11/15/25 12:45pm EST
- Oregon State vs Tulsa - 11/15/25 1:00pm EST
- West Virginia vs Arizona State - 11/15/25 1:00pm EST
- North Texas vs UAB - 11/15/25 2:00pm EST
- Marshall vs Georgia State - 11/15/25 2:00pm EST
- UTEP vs Missouri State - 11/15/25 3:00pm EST
- Colorado State vs New Mexico - 11/15/25 3:00pm EST
- Maryland vs Illinois - 11/15/25 3:30pm EST
- Middle Tennessee vs Western Kentucky - 11/15/25 3:30pm EST
- NC State vs Miami (FL) - 11/15/25 3:30pm EST
- Penn State vs Michigan State - 11/15/25 3:30pm EST
- San Jose State vs Nevada - 11/15/25 3:30pm EST
- South Alabama vs Louisiana-Monroe - 11/15/25 3:30pm EST
- Texas State vs Southern Miss - 11/15/25 3:30pm EST
- Virginia vs Duke - 11/15/25 3:30pm EST
- Georgia Tech vs Boston College - 11/15/25 3:30pm EST
- Appalachian State vs James Madison - 11/15/25 3:30pm EST
- Oklahoma vs Alabama - 11/15/25 3:30pm EST
- UCF vs Texas Tech - 11/15/25 3:30pm EST
- Florida Atlantic vs Tulane - 11/15/25 4:00pm EST
- Memphis vs East Carolina - 11/15/25 4:00pm EST
- New Mexico State vs Tennessee - 11/15/25 4:15pm EST
- North Carolina vs Wake Forest - 11/15/25 4:30pm EST
- Liberty vs FIU - 11/15/25 5:00pm EST
- Coastal Carolina vs Georgia Southern - 11/15/25 6:00pm EST
- Purdue vs Washington - 11/15/25 7:00pm EST
- Utah State vs UNLV - 11/15/25 7:00pm EST
- Delaware vs Sam Houston State - 11/15/25 7:00pm EST
- Florida vs Ole Miss - 11/15/25 7:00pm EST
- Utah vs Baylor - 11/15/25 7:00pm EST
- Virginia Tech vs Florida State - 11/15/25 7:30pm EST
- UCLA vs Ohio State - 11/15/25 7:30pm EST
- Texas vs Georgia - 11/15/25 7:30pm EST
- Mississippi State vs Missouri - 11/15/25 7:45pm EST
- Kennesaw State vs Jacksonville State - 11/15/25 8:00pm EST
- Louisiana Tech vs Washington State - 11/15/25 10:00pm EST
- TCU vs BYU - 11/15/25 10:15pm EST
- Boise State vs San Diego State - 11/15/25 10:30pm EST
- Wyoming vs Fresno State - 11/15/25 10:30pm EST