Carolina Panthers vs New England Patriots Odds

The Panthers will play the Patriots on Sunday, September 28th, 2025. The matchup takes place at Gillette Stadium. Watch this exciting Week 4 matchup at 1:00 pm EDT. Check local listings for coverage on FOX.

Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.


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Table of Contents

Key Matchup Stats

The Carolina Panthers and New England Patriots will take the field at Gillette Stadium for a key Week 4 matchup on Sunday, September 28th, 2025. Have a look at each team's key performance stats below as they continue to make their way through the 2025-26 NFL regular season.

  • SportsBetting3.com Power Rankings - Heading into Week 4 of the 2025-26 season, the Carolina Panthers have a power ranking of 94.33. Our calculations have the New England Patriots at a 92.67 power ranking.
  • Away Carolina Panthers - Now in the middle of the season, the Carolina Panthers have a 0-2-0 record as an away team, ranking them 3rd in the league for away team wins.
  • Home New England Patriots - The New England Patriots come to this Week 4 matchup with a 0-2-0 record as a home team. They rank 3rd in the league for home team wins so far this season.
  • Points Scored - The Carolina Panthers currently rank 16th (62) on the edge of Week 4, with the New England Patriots ranked 17th (60) for points scored to date.
  • Points Against - The Carolina Panthers stand 20th (53) in the middle weeks of the regular season for points against. As for the New England Patriots, they currently rank 11th (68) for points against.
  • Team Records - Standings become more important now more than ever. Approaching Week 4, the Carolina Panthers have a 1-2-0 record, with the New England Patriots at 1-2-0 for the 2025-26 regular season.

Captain Shady Lines

A broken compass is right at least twice a day.

Captain Shady Lines
Captain Shady Lines

Avast ye scallywags! The Carolina Panthers be takin' on the New England Patriots in Week 4.

The Panthers be standin' at 1-2-0, while the Patriots be matchin' that record.

Mid-season games be crucial fer settin' the course of the season.

This Week 4 clash be happenin' at Gillette Stadium in a city steeped in sports lore.

The SportsBetting3.com NFL Power Rankings give the Panthers a 94.33 rating, with the Patriots at 92.67.

Ye can bet this game at BetMGM or our preferred sports betting partner BetRivers.

Don't forget to look at this game's prop bets and compare odds from partner sports betting sites.

It be a battle of titans on the gridiron, so grab yer grog and watch the showdown unfold. Argh!

Best Panthers at Patriots Odds


Best Point Spread Betting Odds
Underdog

Carolina Panthers
Favorite

New England Patriots
The New England Patriots have a -5.5 -110 point spread at BetMGM OH. They are the point spread favorite in this matchup. The Carolina Panthers have a +5.5 -110 point spread at BetMGM OH. The Carolina Panthers are the point spread underdogs. Review how to bet on a point spread with our text and video tutorials.

Best Total Betting Odds
OverUnder
BetMGM has the best over line of 43 points. Risk $105 to win $100. BetMGM has the best under line of 43 points. Risk $115 to win $100. Our tutorial explains more about total bets.

Best Moneyline Betting Odds
Underdog

Carolina Panthers
Favorite

New England Patriots
The New England Patriots are the -250 moneyline favorite. Risk $250 to win $100 on the New England Patriots at BetMGM. The Carolina Panthers are the +200 underdog at BetMGM. Risk $100 to win $200 on the Carolina Panthers. Learn more about how to bet on money lines.

Matchup Odds FAQs

What is the point spread for the Carolina Panthers vs New England Patriots NFL game on Sunday, September 28th, 2025?

The New England Patriots are -5.5 -110 point spread favorites at BetMGM, while the Carolina Panthers are +5.5 -110 point spread underdogs at BetMGM.

What is the over-under total line for the Carolina Panthers vs New England Patriots NFL game on Sunday, September 28th, 2025?

The best over line is 43 -105 points at BetMGM, which means you risk $105 to win $100 betting the over. The best under line is 43 -115 points at BetMGM, and that means you risk $115 to win $100 betting the under.

What is the moneyline for the Carolina Panthers vs New England Patriots NFL game on Sunday, September 28th, 2025?

The New England Patriots are the -250 moneyline favorite at BetMGM and the Carolina Panthers are the +200 moneyline underdog at BetMGM.

NFL Odds Example

NFL Odds and Outcomes Explained

Game
BetMGM Sports Betting BetMGM
Bet
Panthers
Patriots
9/28/25 1:00pm EDT
+5.5 -110-5.5 -110
Bet $100 at BetMGM Ohio
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Underdog Carolina Panthers - Carolina Panthers bettors risk $100 to win $90.91 at -110 odds.

A +5.5 Carolina Panthers underdog bet wins if they lose by 5 or fewer, tie, or win outright. Your bet loses if they lose by 6 or more.

Favorite New England Patriots - New England Patriots bettors risk $100 to win $90.91 at -110 odds.

A -5.5 New England Patriots favorite bet wins if they win by 6 or more. Your bet loses if they win by 5 or fewer, tie, or lose outright.

Carolina Panthers at New England Patriots Prop Bets

NFL Prop Bets
+ Displays more odds
BetMGM Sports Betting BetMGM
Bet
Panthers
Patriots
First Team To Score
9/28/25 1:00pm EDT
+110-140Bet
Panthers
Patriots
No Touchdown
To Score 1st Touchdown
9/28/25 1:00pm EDT
+125-165+8000Bet
Panthers
Patriots
Game to Overtime
9/28/25 1:00pm EDT
Yes +750No -2500Bet
Panthers
Patriots
Safety to be Scored
9/28/25 1:00pm EDT
Yes +1000No -3000Bet
BetMGM Sports Betting BetMGM
Bryce Young
Interceptions Thrown
CAR at NE
9/28/25 1:00pm EDT
0.5 o -1100.5 u -120Bet
Drake Maye
Interceptions Thrown
CAR at NE
9/28/25 1:00pm EDT
0.5 o +1150.5 u -150Bet
Bryce Young
Longest Passing Completion
CAR at NE
9/28/25 1:00pm EDT
32.5 o -11532.5 u -115Bet
Drake Maye
Longest Passing Completion
CAR at NE
9/28/25 1:00pm EDT
32.5 o -11032.5 u -120Bet
BetMGM Sports Betting BetMGM
Andres Borregales
Total Kicking Points
CAR at NE
9/28/25 1:00pm EDT
6.5 o -1206.5 u -110Bet
Ryan Fitzgerald
Total Kicking Points
CAR at NE
9/28/25 1:00pm EDT
5.5 o -1185.5 u -115Bet
Bryce Young
Total Pass Completions
CAR at NE
9/28/25 1:00pm EDT
20.5 o -11020.5 u -120Bet
Drake Maye
Total Pass Completions
CAR at NE
9/28/25 1:00pm EDT
21.5 o -10521.5 u -125Bet
BetMGM Sports Betting BetMGM
Bryce Young
Total Passing Yards
CAR at NE
9/28/25 1:00pm EDT
209.5 o +105209.5 u -135Bet
Drake Maye
Total Passing Yards
CAR at NE
9/28/25 1:00pm EDT
217.5 o -115217.5 u -115Bet
Bryce Young
Total Touchdown Passes
CAR at NE
9/28/25 1:00pm EDT
1.5 o +1701.5 u -225Bet
Drake Maye
Total Touchdown Passes
CAR at NE
9/28/25 1:00pm EDT
1.5 o -1101.5 u -120Bet

Recent Meetings Since 2021

Recent Meetings Since 2021
WeekGameResultMargin
2025
Week 4
Panthers vs Patriots
Sunday, September 28th, 2025
NE 42, CAR 13
Gillette Stadium
Patriots by 29
2024
Preseason Week 1
Panthers vs Patriots
Thursday, August 8th, 2024
NE 17, CAR 3
Gillette Stadium
Patriots by 14
2022
Preseason Week 2
Panthers vs Patriots
Friday, August 19th, 2022
NE 20, CAR 10
Gillette Stadium
Patriots by 10
2021
Week 9
Patriots vs Panthers
Sunday, November 7th, 2021
NE 24, CAR 6
Bank of America Stadium
Patriots by 18

Team Standings

2025-2026 NFL Regular Season Standings - Carolina Panthers, New England Patriots
Team W L T Pct PF PA Home Away Div Div% Conf Conf% Strk L5
New England Patriots4200.6671501201-2-03-0-02-0-01.0002-2-00.5003W4-1-0
Carolina Panthers3300.5001321463-0-00-3-01-0-01.0002-1-00.6672W3-2-0

Carolina Panthers & New England Patriots Futures Odds

Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.

Carolina Panthers Futures Odds
2025-26 Carolina Panthers Super Bowl Odds

Team
BetMGM Sports Betting BetMGM
Panthers
+50000
Bet
New England Patriots Futures Odds
2025-26 New England Patriots Super Bowl Odds

Team
BetMGM Sports Betting BetMGM
Patriots
+5500
Bet

Carolina Panthers & New England Patriots Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Carolina Panthers vs New England Patriots NFL Game

  1. Open a new sports betting account before game time.

    Review our list of sports betting sites. Open a new account before the game starts on Sunday, September 28th, 2025 at 1:00 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.

  2. Visit the sportsbook’s cashier, banking, or deposit page.

    Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.

  3. Tap to the sportsbook's NFL page, look for the Carolina Panthers vs New England Patriots Game.

    Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the Carolina Panthers vs New England Patriots Game.

  4. Choose your bet and place a wager.

    Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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