The Colts will play the Rams on Sunday, September 28th, 2025. The matchup takes place at SoFi Stadium. Watch this exciting Week 4 matchup at 4:05 pm EDT. Check local listings for coverage on FOX.
Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.
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Table of Contents
- Matchup Stats
- Captain Shady Lines
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Other Games Today
Key Matchup Stats
The Indianapolis Colts and Los Angeles Rams will take the field at SoFi Stadium for a key Week 4 matchup on Sunday, September 28th, 2025. Have a look at each team's key performance stats below as they continue to make their way through the 2025-26 NFL regular season.
- SportsBetting3.com Power Rankings - Heading into Week 4 of the 2025-26 season, the Indianapolis Colts have a power ranking of 100.00. Our calculations have the Los Angeles Rams at a 95.67 power ranking.
- Away Indianapolis Colts - Now in the middle of the season, the Indianapolis Colts have a 1-0-0 record as an away team, ranking them 2nd in the league for away team wins.
- Home Los Angeles Rams - The Los Angeles Rams come to this Week 4 matchup with a 1-0-0 record as a home team. They rank 2nd in the league for home team wins so far this season.
- Points Scored - The Indianapolis Colts currently rank 1st (103) on the edge of Week 4, with the Los Angeles Rams ranked 9th (73) for points scored to date.
- Points Against - The Indianapolis Colts stand 19th (56) in the middle weeks of the regular season for points against. As for the Los Angeles Rams, they currently rank 15th (61) for points against.
- Team Records - Standings become more important now more than ever. Approaching Week 4, the Indianapolis Colts have a 3-0-0 record, with the Los Angeles Rams at 2-1-0 for the 2025-26 regular season.
Captain Shady Lines
A broken compass is right at least twice a day.
Avast ye scallywags! The Indianapolis Colts be takin' on the Los Angeles Rams in Week 4 o' the NFL season. The Colts be undefeated with a 3-0-0 record, while the Rams be sittin' at 2-1-0.
This be a crucial game for both teams as they be lookin' to improve their standin's. The battle will be fierce as they clash at the grand SoFi Stadium.
SoFi Stadium be a sight to behold, nestled in the vibrant city o' Los Angeles. The culture be as diverse as the teams themselves.
According to the SportsBetting3.com NFL Power Rankings, the Colts be holdin' a perfect score o' 100.00, while the Rams be close behind with a score o' 95.67. Bet this game at BetMGM or our preferred sports bettin' partner BetRivers. Look at this game's prop bets and compare odds from partner sports bettin' sites. Arrr!
Best Colts at Rams Odds
| Underdog Indianapolis Colts | Favorite Los Angeles Rams |
|---|---|
| Over | Under |
|---|---|
| Underdog Indianapolis Colts | Favorite Los Angeles Rams |
|---|---|
Matchup Odds FAQs
The Los Angeles Rams are -3.5 -105 point spread favorites at BetMGM, while the Indianapolis Colts are +3.5 -115 point spread underdogs at BetMGM.
The best over line is 49.5 -110 points at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 49.5 -110 points at BetMGM, and that means you risk $110 to win $100 betting the under.
The Los Angeles Rams are the -190 moneyline favorite at BetMGM and the Indianapolis Colts are the +155 moneyline underdog at BetMGM.
NFL Odds Example
|
Game |
 BetMGMBet |
|---|---|
Colts
Rams
9/28/25 4:05pm EDT | +3.5 -115-3.5 -105 |
Underdog Indianapolis Colts - Indianapolis Colts bettors risk $100 to win $86.96 at -115 odds.
A +3.5 Indianapolis Colts underdog bet wins if they lose by 3 or fewer, tie, or win outright. Your bet loses if they lose by 4 or more.
Favorite Los Angeles Rams - Los Angeles Rams bettors risk $100 to win $95.24 at -105 odds.
A -3.5 Los Angeles Rams favorite bet wins if they win by 4 or more. Your bet loses if they win by 3 or fewer, tie, or lose outright.
Indianapolis Colts at Los Angeles Rams Prop Bets
| BetMGM Bet |
|
|---|---|
Colts
Rams
First Team To Score
9/28/25 4:05pm EDT | -102-125Bet |
Colts
Rams
No Touchdown
To Score 1st Touchdown
9/28/25 4:05pm EDT | +105-145+15000Bet |
Colts
Rams
Game to Overtime
9/28/25 4:05pm EDT | Yes +700No -2000Bet |
Colts
Rams
Safety to be Scored
9/28/25 4:05pm EDT | Yes +1000No -3000Bet |
| BetMGM | |
Daniel Jones
Interceptions Thrown
IND at LAR 9/28/25 4:05pm EDT | 0.5 o +1200.5 u -160Bet |
Matthew Stafford
Interceptions Thrown
IND at LAR 9/28/25 4:05pm EDT | 0.5 o +1050.5 u -140Bet |
Daniel Jones
Longest Passing Completion
IND at LAR 9/28/25 4:05pm EDT | 34.5 o -11034.5 u -120Bet |
Matthew Stafford
Longest Passing Completion
IND at LAR 9/28/25 4:05pm EDT | 36.5 o -11836.5 u -110Bet |
| BetMGM | |
Joshua Karty
Total Kicking Points
IND at LAR 9/28/25 4:05pm EDT | 7.5 o -1057.5 u -125Bet |
Spencer Shrader
Total Kicking Points
IND at LAR 9/28/25 4:05pm EDT | 6.5 o -1256.5 u -105Bet |
Daniel Jones
Total Pass Completions
IND at LAR 9/28/25 4:05pm EDT | 19.5 o -15019.5 u +115Bet |
Matthew Stafford
Total Pass Completions
IND at LAR 9/28/25 4:05pm EDT | 22.5 o -10522.5 u -130Bet |
| BetMGM | |
Daniel Jones
Total Passing Yards
IND at LAR 9/28/25 4:05pm EDT | 215.5 o -115215.5 u -115Bet |
Matthew Stafford
Total Passing Yards
IND at LAR 9/28/25 4:05pm EDT | 254.5 o -115254.5 u -115Bet |
Daniel Jones
Total Touchdown Passes
IND at LAR 9/28/25 4:05pm EDT | 1.5 o +1601.5 u -220Bet |
Matthew Stafford
Total Touchdown Passes
IND at LAR 9/28/25 4:05pm EDT | 1.5 o -1451.5 u +110Bet |
Recent Meetings Since 2021
| Week | Game | Result | Margin |
|---|---|---|---|
| 2025 Week 4 | Colts vs Rams Sunday, September 28th, 2025 | LAR 27, IND 20 SoFi Stadium | Rams by 7 |
| 2023 Week 4 | Rams vs Colts Sunday, October 1st, 2023 | LAR 29, IND 23 (OT) Lucas Oil Stadium | Rams by 6 |
| 2021 Week 2 | Rams vs Colts Sunday, September 19th, 2021 | LAR 27, IND 24 Lucas Oil Stadium | Rams by 3 |
Team Standings
| Team | W | L | T | Pct | PF | PA | Home | Away | Div | Div% | Conf | Conf% | Strk | L5 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Indianapolis Colts | 7 | 1 | 0 | 0.875 | 270 | 154 | 5-0-0 | 2-1-0 | 2-0-0 | 1.000 | 6-0-0 | 1.000 | 4W | 4-1-0 |
| Los Angeles Rams | 5 | 2 | 0 | 0.714 | 175 | 117 | 2-1-0 | 3-1-0 | 0-1-0 | 0.000 | 0-2-0 | 0.000 | 2W | 3-2-0 |
Indianapolis Colts & Los Angeles Rams Futures Odds
Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.
Indianapolis Colts Futures Odds|
Team | BetMGM |
|---|---|
| Colts | +1100 Bet |
|
Team | BetMGM |
|---|---|
| Rams | +1000 Bet |
Indianapolis Colts & Los Angeles Rams Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Indianapolis Colts vs Los Angeles Rams NFL Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, September 28th, 2025 at 4:05 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's NFL page, look for the Indianapolis Colts vs Los Angeles Rams Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the Indianapolis Colts vs Los Angeles Rams Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other September 28, 2025 NFL Games
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- New Orleans Saints vs Buffalo Bills
- Washington Commanders vs Atlanta Falcons
- Tennessee Titans vs Houston Texans
- Jacksonville Jaguars vs San Francisco 49ers
- Baltimore Ravens vs Kansas City Chiefs
- Chicago Bears vs Las Vegas Raiders
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