The Colts will play the Rams on Sunday, September 28th, 2025. The matchup takes place at SoFi Stadium. Watch this exciting Week 4 matchup at 4:05 pm EDT. Check local listings for coverage on FOX.

Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.

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Matchup Stats
Captain Shady Lines
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Key Matchup Stats

The Indianapolis Colts and Los Angeles Rams will take the field at SoFi Stadium for a key Week 4 matchup on Sunday, September 28th, 2025. Have a look at each team's key performance stats below as they continue to make their way through the 2025-26 NFL regular season.

SportsBetting3.com Power Rankings - Heading into Week 4 of the 2025-26 season, the Indianapolis Colts have a power ranking of 100.00. Our calculations have the Los Angeles Rams at a 95.67 power ranking.
Away Indianapolis Colts - Now in the middle of the season, the Indianapolis Colts have a 1-0-0 record as an away team, ranking them 2nd in the league for away team wins.
Home Los Angeles Rams - The Los Angeles Rams come to this Week 4 matchup with a 1-0-0 record as a home team. They rank 2nd in the league for home team wins so far this season.
Points Scored - The Indianapolis Colts currently rank 1st (103) on the edge of Week 4, with the Los Angeles Rams ranked 9th (73) for points scored to date.
Points Against - The Indianapolis Colts stand 19th (56) in the middle weeks of the regular season for points against. As for the Los Angeles Rams, they currently rank 15th (61) for points against.
Team Records - Standings become more important now more than ever. Approaching Week 4, the Indianapolis Colts have a 3-0-0 record, with the Los Angeles Rams at 2-1-0 for the 2025-26 regular season.

Captain Shady Lines

A broken compass is right at least twice a day.

Avast ye scallywags! The Indianapolis Colts be takin' on the Los Angeles Rams in Week 4 o' the NFL season. The Colts be undefeated with a 3-0-0 record, while the Rams be sittin' at 2-1-0.

This be a crucial game for both teams as they be lookin' to improve their standin's. The battle will be fierce as they clash at the grand SoFi Stadium.

SoFi Stadium be a sight to behold, nestled in the vibrant city o' Los Angeles. The culture be as diverse as the teams themselves.

According to the SportsBetting3.com NFL Power Rankings, the Colts be holdin' a perfect score o' 100.00, while the Rams be close behind with a score o' 95.67. Bet this game at BetMGM or our preferred sports bettin' partner BetRivers. Look at this game's prop bets and compare odds from partner sports bettin' sites. Arrr!

Best Colts at Rams Odds

**Best Point Spread Betting Odds**
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**Best Total Betting Odds**
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**Best Moneyline Betting Odds**
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NFL Odds Example

NFL Odds and Outcomes Explained
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Indianapolis Colts at Los Angeles Rams Prop Bets

NFL Prop Bets
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Colts Rams 9/28/25 4:05pm EDT	Pending

Recent Meetings Since 2021

Recent Meetings Since 2021
Week	Game	Result	Margin
2025 Week 4	Colts vs Rams Sunday, September 28th, 2025	LAR 27, IND 20 SoFi Stadium	Rams by 7
2023 Week 4	Rams vs Colts Sunday, October 1st, 2023	LAR 29, IND 23 (OT) Lucas Oil Stadium	Rams by 6
2021 Week 2	Rams vs Colts Sunday, September 19th, 2021	LAR 27, IND 24 Lucas Oil Stadium	Rams by 3

Team Standings

2025-2026 NFL Regular Season Standings - Indianapolis Colts, Los Angeles Rams
Team	W	L	T	Pct	PF	PA	Home	Away	Div	Div%	Conf	Conf%	Strk	L5
xy - Los Angeles Rams	12	5	0	0.706	518	346	7-1-0	5-4-0	4-2-0	0.667	7-5-0	0.583	1W	3-2-0
Indianapolis Colts	8	9	0	0.471	466	412	6-3-0	2-6-0	2-4-0	0.333	6-6-0	0.500	7L	0-5-0

Indianapolis Colts & Los Angeles Rams Futures Odds

Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.

Indianapolis Colts Futures Odds

No Super Bowl TM Indianapolis Colts YR: futures available

Los Angeles Rams Futures Odds

No Super Bowl TM Los Angeles Rams YR: futures available

Indianapolis Colts & Los Angeles Rams Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Indianapolis Colts vs Los Angeles Rams NFL Game

Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, September 28th, 2025 at 4:05 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
Tap to the sportsbook's NFL page, look for the Indianapolis Colts vs Los Angeles Rams Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the Indianapolis Colts vs Los Angeles Rams Game.
Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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