The Jaguars will play the 49ers on Sunday, September 28th, 2025. The matchup takes place at Levi's Stadium. Watch this exciting Week 4 matchup at 4:05 pm EDT. Check local listings for coverage on FOX.
Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.
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Table of Contents
- Matchup Stats
- Captain Shady Lines
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Other Games Today
Key Matchup Stats
The Jacksonville Jaguars and San Francisco 49ers will take the field at Levi's Stadium for a key Week 4 matchup on Sunday, September 28th, 2025. Have a look at each team's key performance stats below as they continue to make their way through the 2025-26 NFL regular season.
- SportsBetting3.com Power Rankings - Heading into Week 4 of the 2025-26 season, the Jacksonville Jaguars have a power ranking of 97.00. Our calculations have the San Francisco 49ers at a 96.33 power ranking.
- Away Jacksonville Jaguars - Now in the middle of the season, the Jacksonville Jaguars have a 0-1-0 record as an away team, ranking them 3rd in the league for away team wins.
- Home San Francisco 49ers - The San Francisco 49ers come to this Week 4 matchup with a 1-0-0 record as a home team. They rank 2nd in the league for home team wins so far this season.
- Points Scored - The Jacksonville Jaguars currently rank 11th (70) on the edge of Week 4, with the San Francisco 49ers ranked 18th (59) for points scored to date.
- Points Against - The Jacksonville Jaguars stand 21st (51) in the middle weeks of the regular season for points against. As for the San Francisco 49ers, they currently rank 23rd (49) for points against.
- Team Records - Standings become more important now more than ever. Approaching Week 4, the Jacksonville Jaguars have a 2-1-0 record, with the San Francisco 49ers at 3-0-0 for the 2025-26 regular season.
Captain Shady Lines
A broken compass is right at least twice a day.
Avast ye scallywags! The Jacksonville Jaguars be headin' to face the San Francisco 49ers.
The Jaguars be standin' at 2-1-0, while the 49ers be at 3-0-0. These mid-season games be crucial for their standings.
This Week 4 showdown be happenin' at Levi's Stadium in the city of San Francisco. The stadium's culture be as fierce as a pirate's crew.
According to SportsBetting3.com NFL Power Rankings, the Jaguars be at 97.00, and the 49ers be at 96.33. Bet this game at BetMGM or our preferred sports betting partner BetRivers, look at this game's prop bets, and compare odds from partner sports betting sites to make yer wager. Arrrr!
Best Jaguars at 49ers Odds
| Underdog Jacksonville Jaguars | Favorite San Francisco 49ers |
|---|---|
| Over | Under |
|---|---|
| Underdog Jacksonville Jaguars | Favorite San Francisco 49ers |
|---|---|
Matchup Odds FAQs
The San Francisco 49ers are -3.5 -105 point spread favorites at BetRivers, while the Jacksonville Jaguars are +3.5 -117 point spread underdogs at BetRivers.
The best over line is 45 -113 points at BetRivers, which means you risk $113 to win $100 betting the over. The best under line is 45 -108 points at BetRivers, and that means you risk $108 to win $100 betting the under.
The San Francisco 49ers are the -182 moneyline favorite at BetRivers and the Jacksonville Jaguars are the +150 moneyline underdog at BetRivers.
NFL Odds Example
|
Game |
 BetRiversBet |
|---|---|
Jaguars
49ers
9/28/25 4:05pm EDT | +3.5 -117-3.5 -105 |
Underdog Jacksonville Jaguars - Jacksonville Jaguars bettors risk $100 to win $85.47 at -117 odds.
A +3.5 Jacksonville Jaguars underdog bet wins if they lose by 3 or fewer, tie, or win outright. Your bet loses if they lose by 4 or more.
Favorite San Francisco 49ers - San Francisco 49ers bettors risk $100 to win $95.24 at -105 odds.
A -3.5 San Francisco 49ers favorite bet wins if they win by 4 or more. Your bet loses if they win by 3 or fewer, tie, or lose outright.
Jacksonville Jaguars at San Francisco 49ers Prop Bets
| BetRivers Bet |
|
|---|---|
Jaguars
49ers
First Field Goal
9/28/25 4:05pm EDT | -107-121Bet |
Jaguars
49ers
First Team To Score
9/28/25 4:05pm EDT | +104-134Bet |
Jaguars
49ers
Tie
First to 15 Points
9/28/25 4:05pm EDT | +128-152+1500Bet |
Jaguars
49ers
Tie
First to 20 Points
9/28/25 4:05pm EDT | +150-127+475Bet |
| BetRivers | |
Jaguars
49ers
Safety to be Scored
9/28/25 4:05pm EDT | Yes +1300No -3335Bet |
49ers
Team Total Points
JAX at SF 9/28/25 4:05pm EDT | 24.5 o -10824.5 u -113Bet |
Recent Meetings Since 2021
| Week | Game | Result | Margin |
|---|---|---|---|
| 2025 Week 4 | Jaguars vs 49ers Sunday, September 28th, 2025 | JAX 26, SF 21 Levi's Stadium | Jaguars by 5 |
| 2023 Week 10 | 49ers vs Jaguars Sunday, November 12th, 2023 | SF 34, JAX 3 EverBank Stadium | 49ers by 31 |
| 2021 Week 11 | 49ers vs Jaguars Sunday, November 21st, 2021 | SF 30, JAX 10 TIAA Bank Field | 49ers by 20 |
Team Standings
| Team | W | L | T | Pct | PF | PA | Home | Away | Div | Div% | Conf | Conf% | Strk | L5 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| xz - Jacksonville Jaguars | 13 | 4 | 0 | 0.765 | 474 | 336 | 7-2-0 | 6-2-0 | 5-1-0 | 0.833 | 10-2-0 | 0.833 | 8W | 5-0-0 |
| xy - San Francisco 49ers | 12 | 5 | 0 | 0.706 | 437 | 371 | 5-3-0 | 7-2-0 | 4-2-0 | 0.667 | 9-3-0 | 0.750 | 1L | 4-1-0 |
Jacksonville Jaguars & San Francisco 49ers Futures Odds
Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.
Jacksonville Jaguars Futures Odds|
Team | BetRivers |
|---|---|
| Jaguars | +2800 Bet |
|
Team | BetRivers |
|---|---|
| 49ers | +1800 Bet |
Jacksonville Jaguars & San Francisco 49ers Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Jacksonville Jaguars vs San Francisco 49ers NFL Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, September 28th, 2025 at 4:05 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's NFL page, look for the Jacksonville Jaguars vs San Francisco 49ers Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the Jacksonville Jaguars vs San Francisco 49ers Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other September 28, 2025 NFL Games
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- Washington Commanders vs Atlanta Falcons
- Tennessee Titans vs Houston Texans
- Indianapolis Colts vs Los Angeles Rams
- Baltimore Ravens vs Kansas City Chiefs
- Chicago Bears vs Las Vegas Raiders
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