The Jaguars will play the 49ers on Sunday, September 28th, 2025. The matchup takes place at Levi's Stadium. Watch this exciting Week 4 matchup at 4:05 pm EDT. Check local listings for coverage on FOX.

Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.

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Matchup Stats
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Key Matchup Stats

The Jacksonville Jaguars and San Francisco 49ers will take the field at Levi's Stadium for a key Week 4 matchup on Sunday, September 28th, 2025. Have a look at each team's key performance stats below as they continue to make their way through the 2025-26 NFL regular season.

SportsBetting3.com Power Rankings - Heading into Week 4 of the 2025-26 season, the Jacksonville Jaguars have a power ranking of 97.00. Our calculations have the San Francisco 49ers at a 96.33 power ranking.
Away Jacksonville Jaguars - Now in the middle of the season, the Jacksonville Jaguars have a 0-1-0 record as an away team, ranking them 3rd in the league for away team wins.
Home San Francisco 49ers - The San Francisco 49ers come to this Week 4 matchup with a 1-0-0 record as a home team. They rank 2nd in the league for home team wins so far this season.
Points Scored - The Jacksonville Jaguars currently rank 11th (70) on the edge of Week 4, with the San Francisco 49ers ranked 18th (59) for points scored to date.
Points Against - The Jacksonville Jaguars stand 21st (51) in the middle weeks of the regular season for points against. As for the San Francisco 49ers, they currently rank 23rd (49) for points against.
Team Records - Standings become more important now more than ever. Approaching Week 4, the Jacksonville Jaguars have a 2-1-0 record, with the San Francisco 49ers at 3-0-0 for the 2025-26 regular season.

Captain Shady Lines

A broken compass is right at least twice a day.

Avast ye scallywags! The Jacksonville Jaguars be headin' to face the San Francisco 49ers.

The Jaguars be standin' at 2-1-0, while the 49ers be at 3-0-0. These mid-season games be crucial for their standings.

This Week 4 showdown be happenin' at Levi's Stadium in the city of San Francisco. The stadium's culture be as fierce as a pirate's crew.

According to SportsBetting3.com NFL Power Rankings, the Jaguars be at 97.00, and the 49ers be at 96.33. Bet this game at BetMGM or our preferred sports betting partner BetRivers, look at this game's prop bets, and compare odds from partner sports betting sites to make yer wager. Arrrr!

Best Jaguars at 49ers Odds

**Best Point Spread Betting Odds**
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**Best Total Betting Odds**
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**Best Moneyline Betting Odds**
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NFL Odds Example

NFL Odds and Outcomes Explained
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Jacksonville Jaguars at San Francisco 49ers Prop Bets

NFL Prop Bets
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	Bet
Jaguars 49ers 9/28/25 4:05pm EDT	Pending

Recent Meetings Since 2021

Recent Meetings Since 2021
Week	Game	Result	Margin
2025 Week 4	Jaguars vs 49ers Sunday, September 28th, 2025	JAX 26, SF 21 Levi's Stadium	Jaguars by 5
2023 Week 10	49ers vs Jaguars Sunday, November 12th, 2023	SF 34, JAX 3 EverBank Stadium	49ers by 31
2021 Week 11	49ers vs Jaguars Sunday, November 21st, 2021	SF 30, JAX 10 TIAA Bank Field	49ers by 20

Team Standings

2025-2026 NFL Regular Season Standings - Jacksonville Jaguars, San Francisco 49ers
Team	W	L	T	Pct	PF	PA	Home	Away	Div	Div%	Conf	Conf%	Strk	L5
xz - Jacksonville Jaguars	13	4	0	0.765	474	336	7-2-0	6-2-0	5-1-0	0.833	10-2-0	0.833	8W	5-0-0
xy - San Francisco 49ers	12	5	0	0.706	437	371	5-3-0	7-2-0	4-2-0	0.667	9-3-0	0.750	1L	4-1-0

Jacksonville Jaguars & San Francisco 49ers Futures Odds

Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.

Jacksonville Jaguars Futures Odds

No Super Bowl TM Jacksonville Jaguars YR: futures available

San Francisco 49ers Futures Odds

No Super Bowl TM San Francisco 49ers YR: futures available

Jacksonville Jaguars & San Francisco 49ers Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Jacksonville Jaguars vs San Francisco 49ers NFL Game

Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, September 28th, 2025 at 4:05 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
Tap to the sportsbook's NFL page, look for the Jacksonville Jaguars vs San Francisco 49ers Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the Jacksonville Jaguars vs San Francisco 49ers Game.
Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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Jacksonville Jaguars vs San Francisco 49ers Odds

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