The Saints will play the Bills on Sunday, September 28th, 2025. The matchup takes place at Highmark Stadium. Watch this exciting Week 4 matchup at 1:00 pm EDT. Check local listings for coverage on CBS.
Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.
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Table of Contents
- Matchup Stats
- Captain Shady Lines
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Other Games Today
Key Matchup Stats
The New Orleans Saints and Buffalo Bills will take the field at Highmark Stadium for a key Week 4 matchup on Sunday, September 28th, 2025. Have a look at each team's key performance stats below as they continue to make their way through the 2025-26 NFL regular season.
- SportsBetting3.com Power Rankings - Heading into Week 4 of the 2025-26 season, the New Orleans Saints have a power ranking of 88.33. Our calculations have the Buffalo Bills at a 99.33 power ranking.
- Away New Orleans Saints - Now in the middle of the season, the New Orleans Saints have a 0-1-0 record as an away team, ranking them 3rd in the league for away team wins.
- Home Buffalo Bills - The Buffalo Bills come to this Week 4 matchup with a 2-0-0 record as a home team. They rank 1st in the league for home team wins so far this season.
- Points Scored - The New Orleans Saints currently rank 24th (47) on the edge of Week 4, with the Buffalo Bills ranked 2nd (102) for points scored to date.
- Points Against - The New Orleans Saints stand 6th (90) in the middle weeks of the regular season for points against. As for the Buffalo Bills, they currently rank 10th (71) for points against.
- Team Records - Standings become more important now more than ever. Approaching Week 4, the New Orleans Saints have a 0-3-0 record, with the Buffalo Bills at 3-0-0 for the 2025-26 regular season.
Captain Shady Lines
A broken compass is right at least twice a day.
Arrr, the Saints be ready to plunder the Bills in this Week 4 matchup!
New Orleans be winless, while Buffalo be undefeated. A crucial clash for both crews.
This battle be takin' place at Highmark Stadium in Buffalo, a city of true grit. Bet this game at BetMGM or our preferred sports betting partner BetRivers, me hearties. Look at this game's prop bets and compare odds from partner sports betting sites to get yer gold.
Best Saints at Bills Odds
| Underdog New Orleans Saints | Favorite Buffalo Bills |
|---|---|
| Over | Under |
|---|---|
| Underdog New Orleans Saints | Favorite Buffalo Bills |
|---|---|
Matchup Odds FAQs
The Buffalo Bills are -14.5 -113 point spread favorites at BetRivers, while the New Orleans Saints are +14.5 -108 point spread underdogs at BetRivers.
The best over line is 48 -108 points at BetRivers, which means you risk $108 to win $100 betting the over. The best under line is 48 -113 points at BetRivers, and that means you risk $113 to win $100 betting the under.
The Buffalo Bills are the -1430 moneyline favorite at BetRivers and the New Orleans Saints are the +800 moneyline underdog at BetRivers.
NFL Odds Example
|
Game |
 BetRiversBet |
|---|---|
Saints
Bills
9/28/25 1:00pm EDT | +14.5 -108-14.5 -113 |
Underdog New Orleans Saints - New Orleans Saints bettors risk $100 to win $92.59 at -108 odds.
A +14.5 New Orleans Saints underdog bet wins if they lose by 14 or fewer, tie, or win outright. Your bet loses if they lose by 15 or more.
Favorite Buffalo Bills - Buffalo Bills bettors risk $100 to win $88.5 at -113 odds.
A -14.5 Buffalo Bills favorite bet wins if they win by 15 or more. Your bet loses if they win by 14 or fewer, tie, or lose outright.
New Orleans Saints at Buffalo Bills Prop Bets
| BetRivers Bet |
|
|---|---|
Saints
Bills
First Field Goal
9/28/25 1:00pm EDT | +107-137Bet |
Saints
Bills
First Team To Score
9/28/25 1:00pm EDT | +185-245Bet |
Saints
Bills
Tie
First to 15 Points
9/28/25 1:00pm EDT | +410-715+3000Bet |
Saints
Bills
Tie
First to 20 Points
9/28/25 1:00pm EDT | +540-625+1050Bet |
| BetRivers | |
Saints
Bills
Safety to be Scored
9/28/25 1:00pm EDT | Yes +1600No -5000Bet |
Bills
Team Total Points
NO at BUF 9/28/25 1:00pm EDT | 31.5 o -10831.5 u -114Bet |
Saints
Team Total Points
NO at BUF 9/28/25 1:00pm EDT | 15.5 o -11215.5 u -109Bet |
Recent Meetings Since 2021
| Week | Game | Result | Margin |
|---|---|---|---|
| 2025 Week 4 | Saints vs Bills Sunday, September 28th, 2025 | BUF 31, NO 19 Highmark Stadium | Bills by 12 |
| 2021 Week 12 | Bills vs Saints Thursday, November 25th, 2021 | BUF 31, NO 6 Caesars Superdome | Bills by 25 |
Team Standings
| Team | W | L | T | Pct | PF | PA | Home | Away | Div | Div% | Conf | Conf% | Strk | L5 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| xy - Buffalo Bills | 12 | 5 | 0 | 0.706 | 481 | 365 | 7-2-0 | 5-3-0 | 4-2-0 | 0.667 | 9-3-0 | 0.750 | 1W | 4-1-0 |
| New Orleans Saints | 6 | 11 | 0 | 0.353 | 306 | 383 | 3-5-0 | 3-6-0 | 3-3-0 | 0.500 | 4-8-0 | 0.333 | 1L | 4-1-0 |
New Orleans Saints & Buffalo Bills Futures Odds
Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.
New Orleans Saints Futures Odds|
Team | BetRivers |
|---|---|
| Saints | +15000 Bet |
|
Team | BetRivers |
|---|---|
| Bills | +750 Bet |
New Orleans Saints & Buffalo Bills Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the New Orleans Saints vs Buffalo Bills NFL Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, September 28th, 2025 at 1:00 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's NFL page, look for the New Orleans Saints vs Buffalo Bills Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the New Orleans Saints vs Buffalo Bills Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other September 28, 2025 NFL Games
- Minnesota Vikings vs Pittsburgh Steelers
- Philadelphia Eagles vs Tampa Bay Buccaneers
- Los Angeles Chargers vs New York Giants
- Carolina Panthers vs New England Patriots
- Cleveland Browns vs Detroit Lions
- Washington Commanders vs Atlanta Falcons
- Tennessee Titans vs Houston Texans
- Indianapolis Colts vs Los Angeles Rams
- Jacksonville Jaguars vs San Francisco 49ers
- Baltimore Ravens vs Kansas City Chiefs
- Chicago Bears vs Las Vegas Raiders
- Green Bay Packers vs Dallas Cowboys