The Chargers will play the Bills on Sunday, September 27th, 2026. The matchup takes place at Highmark Stadium. Watch this exciting Week 3 matchup at 1:00 pm EDT. Check local listings for coverage on Fox.
Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.
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Table of Contents
- Matchup Stats
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Other Games Today
Key Matchup Stats
The 2026-27 NFL regular season keeps rolling for the Los Angeles Chargers and Buffalo Bills, as they gear up to play an exciting Week 3 matchup at Highmark Stadium. Have a look at the following statistical insights to help you handicap the game.
- SportsBetting3.com Power Rankings - The Los Angeles Chargers have started the 2026-27 season with an initial 90.00 power ranking. The Buffalo Bills currently have a 97.33 power ranking so far.
- Away Los Angeles Chargers - Though it's still early in the season, the Los Angeles Chargers have a 0-0-0 record as an away team, ranking them 2nd in the league for away team wins.
- Home Buffalo Bills - Looking at the Buffalo Bills heading into Week 3, they currently have a 1-0-0 record as a home team. They rank 2nd in the league for home team wins.
- Points Scored - The Los Angeles Chargers currently rank 18th (28) up to Week 3, with the Buffalo Bills ranked 1st (77) for points scored in the 2026-27 regular season.
- Points Against - The Los Angeles Chargers stand 8th (52) in the early weeks of the regular season for points against. The Buffalo Bills rank 3rd (62) for points against.
- Team Records - As Week 3 approaches, the Los Angeles Chargers have a 0-2-0 record, with the Buffalo Bills at 2-0-0 for the 2026-27 NFL regular season.
Best Chargers at Bills Odds
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NFL Odds Example
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Los Angeles Chargers at Buffalo Bills Prop Bets
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Chargers
Bills
9/27/26 1:00pm EDT | Pending |
Recent Meetings Since 2022
| Week | Game | Result | Margin |
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| 2026 Week 3 | Chargers vs Bills Sunday, September 27th, 2026 | BUF 24, LAC 16 Highmark Stadium | Bills by 8 |
| 2023 Week 16 | Bills vs Chargers Saturday, December 23rd, 2023 | BUF 24, LAC 22 SoFi Stadium | Bills by 2 |
Team Standings
| Team | W | L | T | Pct | PF | PA | Home | Away | Div | Div% | Conf | Conf% | Strk | L5 |
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| Buffalo Bills | 3 | 1 | 0 | 0.750 | 127 | 107 | 2-1-0 | 1-0-0 | 0-1-0 | 0.000 | 2-1-0 | 0.667 | 1L | 3-1-0 |
| Los Angeles Chargers | 0 | 5 | 0 | 0.000 | 84 | 129 | 0-3-0 | 0-2-0 | 0-2-0 | 0.000 | 0-3-0 | 0.000 | 5L | 0-5-0 |
Los Angeles Chargers & Buffalo Bills Futures Odds
Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.
Los Angeles Chargers Futures OddsNo Super Bowl TM Los Angeles Chargers YR: futures available
Buffalo Bills Futures OddsNo Super Bowl TM Buffalo Bills YR: futures available
Los Angeles Chargers & Buffalo Bills Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Los Angeles Chargers vs Buffalo Bills NFL Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, September 27th, 2026 at 1:00 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's NFL page, look for the Los Angeles Chargers vs Buffalo Bills Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the Los Angeles Chargers vs Buffalo Bills Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other September 27, 2026 NFL Games
- Tennessee Titans vs New York Giants - 9/27/26 1:00pm EDT
- Carolina Panthers vs Cleveland Browns - 9/27/26 1:00pm EDT
- New York Jets vs Detroit Lions - 9/27/26 1:00pm EDT
- Houston Texans vs Indianapolis Colts - 9/27/26 1:00pm EDT
- Seattle Seahawks vs Washington Commanders - 9/27/26 1:00pm EDT
- Cincinnati Bengals vs Pittsburgh Steelers - 9/27/26 1:02pm EDT
- Kansas City Chiefs vs Miami Dolphins - 9/27/26 1:02pm EDT
- New England Patriots vs Jacksonville Jaguars - 9/27/26 1:02pm EDT
- Arizona Cardinals vs San Francisco 49ers - 9/27/26 4:05pm EDT
- Minnesota Vikings vs Tampa Bay Buccaneers - 9/27/26 4:05pm EDT
- Las Vegas Raiders vs New Orleans Saints - 9/27/26 4:25pm EDT
- Baltimore Ravens vs Dallas Cowboys - 9/27/26 4:25pm EDT
- Los Angeles Rams vs Denver Broncos - 9/27/26 8:20pm EDT