Southern Illinois vs Purdue Football Odds

The Salukis will play the Boilermakers on Saturday, September 6th, 2025. The matchup takes place at Ross-Ade Stadium. Watch this exciting Week 2 matchup at 7:30 pm EDT. Check local listings for coverage on BTN.

Learn more about College Football betting with our handy tutorial and guide. We explain spread, total and money line bets.

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Best Salukis at Boilermakers Odds

**Best Point Spread Betting Odds**
Underdog Southern Illinois	Favorite Purdue
+20.5 -110 BetMGM Bet	-20.5 -110 BetMGM Bet

Purdue has a -20.5 -110 point spread at BetMGM OH. They are the point spread favorite in this matchup. Southern Illinois has a +20.5 -110 point spread at BetMGM OH. Southern Illinois is the point spread underdog. Review how to bet on a point spread with our text and video tutorials.

**Best Total Betting Odds**
Over	Under
52.5 o -110 BetMGM Bet	52.5 u -110 BetMGM Bet

BetMGM has the best over line of 52.5 points. Risk $110 to win $100. BetMGM has the best under line of 52.5 points. Risk $110 to win $100. Our tutorial explains more about total bets.

**Best Moneyline Betting Odds**
Underdog Southern Illinois	Favorite Purdue
+700 BetMGM Bet	-1100 BetMGM Bet

Purdue is the -1100 moneyline favorite. Risk $1,100 to win $100 on Purdue at BetMGM. Southern Illinois is the +700 underdog at BetMGM. Risk $100 to win $700 on Southern Illinois. Learn more about how to bet on money lines.

Matchup Odds FAQs

What is the point spread for the Southern Illinois vs Purdue College Football game on Saturday, September 6th, 2025?

Purdue is a -20.5 -110 point spread favorite at BetMGM, while Southern Illinois is a +20.5 -110 point spread underdog at BetMGM.

What is the over-under total line for the Southern Illinois vs Purdue College Football game on Saturday, September 6th, 2025?

The best over line is 52.5 -110 points at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 52.5 -110 points at BetMGM, and that means you risk $110 to win $100 betting the under.

What is the moneyline for the Southern Illinois vs Purdue College Football game on Saturday, September 6th, 2025?

Purdue is a -1100 moneyline favorite at BetMGM and Southern Illinois is a +700 moneyline underdog at BetMGM.

College Football Odds Example

College Football Odds and Outcomes Explained
Game	BetMGM Bet
Southern Illinois Purdue 9/06/25 7:30pm EDT	+20.5 -110 -20.5 -110

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Underdog Southern Illinois - Southern Illinois bettors risk $100 to win $90.91 at -110 odds.

A +20.5 Southern Illinois underdog bet wins if they lose by 20 or fewer, tie, or win outright. Your bet loses if they lose by 21 or more.

Favorite Purdue - Purdue bettors risk $100 to win $90.91 at -110 odds.

A -20.5 Purdue favorite bet wins if they win by 21 or more. Your bet loses if they win by 20 or fewer, tie, or lose outright.

Southern Illinois at Purdue Prop Bets

Important Note: Some states expressly forbid individual college athlete prop bets. The following wagers may not be available depending on your particular state laws.

College Football Prop Bets
+ Displays more odds
	BetMGM Bet
Southern Illinois Purdue 9/06/25 7:30pm EDT	Pending BetMGM

Recent Meetings Since 2021

Recent Meetings Since 2021
Week	Game	Result	Margin
2025 Week 2	Southern Illinois vs Purdue Saturday, September 6th, 2025	PUR 34, SIU 17 Ross-Ade Stadium	Purdue by 17

Team Standings

2025-2026 College Football Regular Season Standings - Southern Illinois, Purdue
Team	Conf	Conf%	W	L	PF	PA	Home	Away	Strk
Missouri Valley
Southern Illinois	1-2	0.333	4	3	253	188	2-1	2-2	L2
Big Ten
Purdue	0-5	0.000	2	6	183	222	2-3	0-3	L6

Southern Illinois & Purdue Futures Odds

Latest NCAA Championship odds, if available, for each team. Review odds for other teams and learn the best College Football bets.

Southern Illinois Championship Odds

No NCAA College Football Championship TM Southern Illinois YR: futures available

Purdue Championship Odds

No NCAA College Football Championship TM Purdue YR: futures available

Southern Illinois & Purdue Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Schedules & Results

2025-26 Southern Illinois Games & Results
Week	Matchup	Date & Result
Week 2	Southern Illinois vs Purdue	PUR 34, SIU 17 Saturday, September 6th, 2025

2025-26 Purdue Games & Results
Week	Matchup	Date & Result
Week 1	Ball State vs Purdue	PUR 31, BALL 0 Saturday, August 30th, 2025
Week 2	Southern Illinois vs Purdue	PUR 34, SIU 17 Saturday, September 6th, 2025
Week 3	USC vs Purdue	USC 33, PUR 17 Saturday, September 13th, 2025
Week 4	Purdue vs Notre Dame	ND 56, PUR 30 Saturday, September 20th, 2025
Week 6	Illinois vs Purdue	ILL 43, PUR 27 Saturday, October 4th, 2025
Week 7	Purdue vs Minnesota	MINN 27, PUR 20 Saturday, October 11th, 2025
Week 8	Purdue vs Northwestern	NU 19, PUR 0 Saturday, October 18th, 2025
Week 9	Rutgers vs Purdue	Saturday, October 25th, 2025 12:00 pm EDT
Week 10	Purdue vs Michigan	Saturday, November 1st, 2025 7:00 pm EDT
Week 11	Ohio State vs Purdue	Saturday, November 8th, 2025 12:00 am EST
Week 12	Purdue vs Washington	Saturday, November 15th, 2025 12:00 am EST
Week 14	Indiana vs Purdue	Friday, November 28th, 2025 7:30 pm EST

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Southern Illinois vs Purdue College Football Game

Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Saturday, September 6th, 2025 at 7:30 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
Tap to the sportsbook's College Football page, look for the Southern Illinois vs Purdue Game.
Navigate to the sportsbook's College Football page. Next, look for live or upcoming matchups. Select the Southern Illinois vs Purdue Game.
Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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