USC vs Illinois Football Odds - SportsBetting3.com

The Trojans will play the Fighting Illini on Saturday, September 27th, 2025. The matchup takes place at Memorial Stadium (Champaign, IL). Watch this exciting Week 5 matchup at 12:00 pm EDT. Check local listings for coverage on FOX.

Learn more about College Football betting with our handy tutorial and guide. We explain spread, total and money line bets.

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Key Matchup Stats

We're now well into the 2025 college football season. Week 5 action features a matchup between USC and Illinois taking place at Memorial Stadium (Champaign, IL). The following are some key season stats to help you size up this game.

SportsBetting3.com Power Rankings - USC has a 99.33 conference power ranking for the 2025 season. The conference power ranking for Illinois is 94.33.
Away USC - Heading into Week 5, USC currently has a 1-0 record as an away team for the 2025 regular season. This ranks them 1st in the Big Ten Conference for away team wins. Watch this stat carefully as the season progresses.
Home Illinois - Illinois has a 2-0 record as a home team. Looking ahead to this 2025 Week 5 matchup, they rank 3rd in the Big Ten Conference for home team wins. Like the USC away record and ranking, you should continually keep tabs on this stat.
Points Scored - For the 2025 season, USC ranks 2nd (210) in the Big Ten Conference, with Illinois currently ranking 6th (145) for points scored in the Big Ten Conference.
Points Against - Also in 2025, USC stands 6th (81) in the Big Ten Conference for points scored by opponents in 2025. Illinois sits at 5th (85) in the Big Ten Conference for points against in the 2025 season so far.
Team Records - USC has a 4-0 overall record for the 2025 regular season, with Illinois currently 3-1 for the 2025 NCAAF regular season.

Paddy O'Parlay

The "Sports Network" talking heads have nothing on my Irish arse!

Get ready for a wild showdown as USC faces off against Illinois in a key Week 5 matchup!

This intense game will be held at Memorial Stadium in Champaign, IL, adding to the excitement.

According to SportsBetting3.com Power Rankings, USC leads with a rating of 99.33 over Illinois at 94.33.

USC is currently undefeated with a 4-0 standing, while Illinois holds a 3-1 record. Bet this game at BetRivers, or BetMGM, review this game's prop bets, and compare the odds below for an unforgettable experience!

Best Trojans at Fighting Illini Odds

**Best Point Spread Betting Odds**
Underdog Illinois	Favorite USC
+6.5 -105 BetMGM Bet	-6.5 -115 BetMGM Bet

USC has a -6.5 -115 point spread at BetMGM OH. They are the point spread favorite in this matchup. Illinois has a +6.5 -105 point spread at BetMGM OH. Illinois is the point spread underdog. Review how to bet on a point spread with our text and video tutorials.

**Best Total Betting Odds**
Over	Under
61.5 o -115 BetMGM Bet	61.5 u -105 BetMGM Bet

BetMGM has the best over line of 61.5 points. Risk $115 to win $100. BetMGM has the best under line of 61.5 points. Risk $105 to win $100. Our tutorial explains more about total bets.

**Best Moneyline Betting Odds**
Underdog Illinois	Favorite USC
+200 BetMGM Bet	-250 BetMGM Bet

USC is the -250 moneyline favorite. Risk $250 to win $100 on USC at BetMGM. Illinois is the +200 underdog at BetMGM. Risk $100 to win $200 on Illinois. Learn more about how to bet on money lines.

Matchup Odds FAQs

What is the point spread for the USC vs Illinois College Football game on Saturday, September 27th, 2025?

USC is a -6.5 -115 point spread favorite at BetMGM, while Illinois is a +6.5 -105 point spread underdog at BetMGM.

What is the over-under total line for the USC vs Illinois College Football game on Saturday, September 27th, 2025?

The best over line is 61.5 -115 points at BetMGM, which means you risk $115 to win $100 betting the over. The best under line is 61.5 -105 points at BetMGM, and that means you risk $105 to win $100 betting the under.

What is the moneyline for the USC vs Illinois College Football game on Saturday, September 27th, 2025?

USC is a -250 moneyline favorite at BetMGM and Illinois is a +200 moneyline underdog at BetMGM.

College Football Odds Example

College Football Odds and Outcomes Explained
Game	BetMGM Bet
USC Illinois 9/27/25 12:00pm EDT	-6.5 -115 +6.5 -105

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Underdog Illinois - Illinois bettors risk $100 to win $95.24 at -105 odds.

A +6.5 Illinois underdog bet wins if they lose by 6 or fewer, tie, or win outright. Your bet loses if they lose by 7 or more.

Favorite USC - USC bettors risk $100 to win $86.96 at -115 odds.

A -6.5 USC favorite bet wins if they win by 7 or more. Your bet loses if they win by 6 or fewer, tie, or lose outright.

USC at Illinois Prop Bets

Important Note: Some states expressly forbid individual college athlete prop bets. The following wagers may not be available depending on your particular state laws.

College Football Prop Bets
+ Displays more odds
	BetMGM Bet
USC Illinois No Touchdown To Score 1st Touchdown 9/27/25 12:00pm EDT	-190 +130 +10000 Bet
USC Illinois Game to Overtime 9/27/25 12:00pm EDT	Yes +1050 No -10000 Bet
USC Illinois Both Teams Score 10+ 9/27/25 12:00pm EDT	Yes -3000 No +1050 Bet
USC Illinois Both Teams Score 20+ 9/27/25 12:00pm EDT	Yes -295 No +220 Bet
	BetMGM
USC Illinois Both Teams Score 30+ 9/27/25 12:00pm EDT	Yes +190 No -250 Bet

Recent Meetings Since 2021

Recent Meetings Since 2021
Week	Game	Result	Margin
2025 Week 5	USC vs Illinois Saturday, September 27th, 2025	ILL 34, USC 32 Memorial Stadium (Champaign, IL)	Illinois by 2

Team Standings

2025-2026 College Football Regular Season Standings - USC, Illinois
Team	Conf	Conf%	W	L	PF	PA	Home	Away	Strk
#17 USC	6-2	0.750	8	3	409	259	6-0	2-3	L1
Illinois	4-4	0.500	7	4	332	266	5-1	2-3	L1

USC & Illinois Futures Odds

Latest NCAA Championship odds, if available, for each team. Review odds for other teams and learn the best College Football bets.

USC Championship Odds

2025-26 USC NCAA College Football Championship Odds
Team	BetMGM
USC

Illinois Championship Odds

No NCAA College Football Championship TM Illinois YR: futures available

USC & Illinois Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Schedules & Results

2025-26 USC Games & Results
Week	Matchup	Date & Result
Week 1	Missouri State vs USC	USC 73, MOST 13 Saturday, August 30th, 2025
Week 2	Georgia Southern vs USC	USC 59, GASO 20 Saturday, September 6th, 2025
Week 3	USC vs Purdue	USC 33, PUR 17 Saturday, September 13th, 2025
Week 4	Michigan State vs USC	USC 45, MSU 31 Saturday, September 20th, 2025
Week 5	USC vs Illinois	ILL 34, USC 32 Saturday, September 27th, 2025
Week 7	Michigan vs USC	USC 31, MICH 13 Saturday, October 11th, 2025
Week 8	USC vs Notre Dame	ND 34, USC 24 Saturday, October 18th, 2025
Week 10	USC vs Nebraska	Saturday, November 1st, 2025 7:30 pm EDT
Week 11	Northwestern vs USC	Friday, November 7th, 2025 9:00 pm EST
Week 12	Iowa vs USC	Saturday, November 15th, 2025 12:00 am EST
Week 13	USC vs Oregon	Saturday, November 22nd, 2025 12:00 am EST
Week 14	UCLA vs USC	Saturday, November 29th, 2025 12:00 am EST

2025-26 Illinois Games & Results
Week	Matchup	Date & Result
Week 1	Western Illinois vs Illinois	ILL 52, WIU 3 Friday, August 29th, 2025
Week 2	Illinois vs Duke	ILL 45, DUKE 19 Saturday, September 6th, 2025
Week 3	Western Michigan vs Illinois	ILL 38, WMU 0 Saturday, September 13th, 2025
Week 4	Illinois vs Indiana	IU 63, ILL 10 Saturday, September 20th, 2025
Week 5	USC vs Illinois	ILL 34, USC 32 Saturday, September 27th, 2025
Week 6	Illinois vs Purdue	ILL 43, PUR 27 Saturday, October 4th, 2025
Week 7	Ohio State vs Illinois	OSU 34, ILL 16 Saturday, October 11th, 2025
Week 9	Illinois vs Washington	Saturday, October 25th, 2025 3:30 pm EDT
Week 10	Rutgers vs Illinois	Saturday, November 1st, 2025 12:00 pm EDT
Week 12	Maryland vs Illinois	Saturday, November 15th, 2025 12:00 am EST
Week 13	Illinois vs Wisconsin	Saturday, November 22nd, 2025 12:00 am EST
Week 14	Northwestern vs Illinois	Saturday, November 29th, 2025 12:00 am EST

How to Bet on the Game

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How to Bet on the USC vs Illinois College Football Game

Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Saturday, September 27th, 2025 at 12:00 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
Tap to the sportsbook's College Football page, look for the USC vs Illinois Game.
Navigate to the sportsbook's College Football page. Next, look for live or upcoming matchups. Select the USC vs Illinois Game.
Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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