The Cardinals will play the Panthers on Saturday, September 27th, 2025. The matchup takes place at Acrisure Stadium. Watch this exciting Week 5 matchup at 12:00 pm EDT. Check local listings for coverage on ESPN2.
Learn more about College Football betting with our handy tutorial and guide. We explain spread, total and money line bets.
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Table of Contents
- Matchup Stats
- Paddy O'Parlay
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Team Schedules & Results
- Other Games Today
Key Matchup Stats
We're now well into the 2025 college football season. Week 5 action features a matchup between Louisville and Pittsburgh taking place at Acrisure Stadium. The following are some key season stats to help you size up this game.
- SportsBetting3.com Power Rankings - Louisville has a 97.67 conference power ranking for the 2025 season. The conference power ranking for Pittsburgh is 96.33.
- Away Louisville - Heading into Week 5, Louisville currently has a 0-0 record as an away team for the 2025 regular season. This ranks them 2nd in the ACC Conference for away team wins. Watch this stat carefully as the season progresses.
- Home Pittsburgh - Pittsburgh has a 2-0 record as a home team. Looking ahead to this 2025 Week 5 matchup, they rank 3rd in the ACC Conference for home team wins. Like the Louisville away record and ranking, you should continually keep tabs on this stat.
- Points Scored - For the 2025 season, Louisville ranks 10th (119) in the ACC Conference, with Pittsburgh currently ranking 8th (130) for points scored in the ACC Conference.
- Points Against - Also in 2025, Louisville stands 14th (48) in the ACC Conference for points scored by opponents in 2025. Pittsburgh sits at 12th (57) in the ACC Conference for points against in the 2025 season so far.
- Team Records - Louisville has a 3-0 overall record for the 2025 regular season, with Pittsburgh currently 2-1 for the 2025 NCAAF regular season.
Paddy O'Parlay
The "Sports Network" talking heads have nothing on my Irish arse!
Get ready for a wild showdown between Louisville and Pittsburgh this Saturday, September 27th!
The Week 5 game will be played at Acrisure Stadium, where the energy will be electric.
According to SportsBetting3.com Power Rankings, Louisville is ahead with a 97.67 rating compared to Pittsburgh's 96.33.
Louisville is undefeated with a 3-0 standing, while Pittsburgh currently sits at 2-1.
Don't miss out on the action - bet this game at BetRivers, or BetMGM and review this game's prop bets. Compare the odds below!
Best Cardinals at Panthers Odds
| Underdog Pittsburgh | Favorite Louisville |
|---|---|
| Over | Under |
|---|---|
| Underdog Pittsburgh | Favorite Louisville |
|---|---|
Matchup Odds FAQs
Louisville is a -3.5 -110 point spread favorite at BetMGM, while Pittsburgh is a +3.5 -110 point spread underdog at BetMGM.
The best over line is 55.5 -110 points at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 55.5 -110 points at BetMGM, and that means you risk $110 to win $100 betting the under.
Louisville is a -185 moneyline favorite at BetMGM and Pittsburgh is a +150 moneyline underdog at BetMGM.
College Football Odds Example
|
Game |
 BetMGMBet |
|---|---|
Louisville
Pittsburgh
9/27/25 12:00pm EDT | -3.5 -110+3.5 -110 |
Underdog Pittsburgh - Pittsburgh bettors risk $100 to win $90.91 at -110 odds.
A +3.5 Pittsburgh underdog bet wins if they lose by 3 or fewer, tie, or win outright. Your bet loses if they lose by 4 or more.
Favorite Louisville - Louisville bettors risk $100 to win $90.91 at -110 odds.
A -3.5 Louisville favorite bet wins if they win by 4 or more. Your bet loses if they win by 3 or fewer, tie, or lose outright.
Louisville at Pittsburgh Prop Bets
Important Note: Some states expressly forbid individual college athlete prop bets. The following wagers may not be available depending on your particular state laws.
| BetMGM Bet |
|
|---|---|
Louisville
Pittsburgh
No Touchdown
To Score 1st Touchdown
9/27/25 12:00pm EDT | -155+105+10000Bet |
Louisville
Pittsburgh
Game to Overtime
9/27/25 12:00pm EDT | Yes +1000No -10000Bet |
Louisville
Pittsburgh
Both Teams Score 10+
9/27/25 12:00pm EDT | Yes -2000No +825Bet |
Louisville
Pittsburgh
Both Teams Score 20+
9/27/25 12:00pm EDT | Yes -190No +145Bet |
| BetMGM | |
Louisville
Pittsburgh
Both Teams Score 30+
9/27/25 12:00pm EDT | Yes +300No -425Bet |
Recent Meetings Since 2021
| Week | Game | Result | Margin |
|---|---|---|---|
| 2025 Week 5 | Louisville vs Pittsburgh Saturday, September 27th, 2025 | LOU 34, PITT 27 Acrisure Stadium | Louisville by 7 |
| 2024 Week 13 | Pittsburgh vs Louisville Saturday, November 23rd, 2024 | LOU 37, PITT 9 L&N Federal Credit Union Stadium | Louisville by 28 |
| 2023 Week 7 | Louisville vs Pittsburgh Saturday, October 14th, 2023 | PITT 38, LOU 21 Acrisure Stadium | Pittsburgh by 17 |
| 2022 Week 8 | Pittsburgh vs Louisville Saturday, October 22nd, 2022 | LOU 24, PITT 10 Cardinal Stadium | Louisville by 14 |
Team Standings
| Team | Conf | Conf% | W | L | PF | PA | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|---|
| #22 Pittsburgh | 6-2 | 0.750 | 8 | 4 | 421 | 299 | 4-3 | 4-1 | L1 |
| Louisville | 4-4 | 0.500 | 8 | 4 | 362 | 253 | 5-3 | 3-1 | W1 |
Louisville & Pittsburgh Futures Odds
Latest NCAA Championship odds, if available, for each team. Review odds for other teams and learn the best College Football bets.
Louisville Championship Odds|
Team | BetMGM |
|---|---|
| Louisville | +50000 Bet |
No NCAA College Football Championship TM Pittsburgh YR: futures available
Louisville & Pittsburgh Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
Team Schedules & Results
| Week | Matchup | Date & Result |
|---|---|---|
| Week 1 | Eastern Kentucky vs Louisville | LOU 51, EKU 17 Saturday, August 30th, 2025 |
| Week 2 | James Madison vs Louisville | LOU 28, JMU 14 Friday, September 5th, 2025 |
| Week 4 | Bowling Green vs Louisville | LOU 40, BGSU 17 Saturday, September 20th, 2025 |
| Week 5 | Louisville vs Pittsburgh | LOU 34, PITT 27 Saturday, September 27th, 2025 |
| Week 6 | Virginia vs Louisville | UVA 30, LOU 27 (OT) Saturday, October 4th, 2025 |
| Week 8 | Louisville vs Miami (FL) | LOU 24, MIA 21 Friday, October 17th, 2025 |
| Week 9 | Boston College vs Louisville | Saturday, October 25th, 2025 7:30 pm EDT |
| Week 10 | Louisville vs Virginia Tech | Saturday, November 1st, 2025 3:00 pm EDT |
| Week 11 | California vs Louisville | Saturday, November 8th, 2025 12:00 am EST |
| Week 12 | Clemson vs Louisville | Friday, November 14th, 2025 7:30 pm EST |
| Week 13 | Louisville vs SMU | Saturday, November 22nd, 2025 12:00 am EST |
| Week 14 | Kentucky vs Louisville | Saturday, November 29th, 2025 12:00 am EST |
| Week | Matchup | Date & Result |
|---|---|---|
| Week 1 | Duquesne vs Pittsburgh | PITT 61, DUQ 9 Saturday, August 30th, 2025 |
| Week 2 | Central Michigan vs Pittsburgh | PITT 45, CMU 17 Saturday, September 6th, 2025 |
| Week 3 | Pittsburgh vs West Virginia | WVU 31, PITT 24 (OT) Saturday, September 13th, 2025 |
| Week 5 | Louisville vs Pittsburgh | LOU 34, PITT 27 Saturday, September 27th, 2025 |
| Week 6 | Boston College vs Pittsburgh | PITT 48, BC 7 Saturday, October 4th, 2025 |
| Week 7 | Pittsburgh vs Florida State | PITT 34, FSU 31 Saturday, October 11th, 2025 |
| Week 8 | Pittsburgh vs Syracuse | PITT 30, SYR 13 Saturday, October 18th, 2025 |
| Week 9 | NC State vs Pittsburgh | Saturday, October 25th, 2025 3:30 pm EDT |
| Week 10 | Pittsburgh vs Stanford | Saturday, November 1st, 2025 3:30 pm EDT |
| Week 12 | Notre Dame vs Pittsburgh | Saturday, November 15th, 2025 12:00 am EST |
| Week 13 | Pittsburgh vs Georgia Tech | Saturday, November 22nd, 2025 12:00 am EST |
| Week 14 | Miami (FL) vs Pittsburgh | Saturday, November 29th, 2025 12:00 am EST |
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Louisville vs Pittsburgh College Football Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Saturday, September 27th, 2025 at 12:00 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's College Football page, look for the Louisville vs Pittsburgh Game.
Navigate to the sportsbook's College Football page. Next, look for live or upcoming matchups. Select the Louisville vs Pittsburgh Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other September 27, 2025 NCAAFB Games
- South Alabama vs North Texas
- Duke vs Syracuse
- Georgia Tech vs Wake Forest
- New Haven vs Duquesne
- Norfolk State vs Wagner
- Bowling Green vs Ohio
- Stetson vs Dayton
- Penn vs Lehigh
- Rutgers vs Minnesota
- UCF vs Kansas State
- Cincinnati vs Kansas
- Georgetown vs Columbia
- Delaware State vs Sacred Heart
- Dartmouth vs Central Connecticut
- Notre Dame vs Arkansas
- Cornell vs Yale
- USC vs Illinois
- Utah State vs Vanderbilt
- Eastern Michigan vs Central Michigan
- Georgia Southern vs James Madison
- Howard vs Richmond
- South Dakota vs North Dakota State
- Utah Tech vs Austin Peay
- Hampton vs Elon
- Arkansas State vs Louisiana-Monroe
- Alabama State vs Florida A&M
- Idaho State vs Northern Colorado
- Mercyhurst vs South Dakota State
- Alabama A&M vs Bethune-Cookman
- Lindenwood vs Miami (OH)
- Merrimack College vs Stony Brook
- Furman vs Samford
- North Carolina A&T vs Maine
- Princeton vs Lafayette
- Western Carolina vs Campbell
- San Diego State vs Northern Illinois
- UConn vs Buffalo
- UCLA vs Northwestern
- Akron vs Toledo
- Baylor vs Oklahoma State
- California vs Boston College
- LSU vs Ole Miss
- Rice vs Navy
- Utah vs West Virginia
- Ohio State vs Washington
- Indiana vs Iowa
- Auburn vs Texas A&M
- New Mexico State vs New Mexico
- Hawaii vs Air Force
- Tulane vs Tulsa
- Tennessee vs Mississippi State
- Mercer vs East Tennessee State
- The Citadel vs Chattanooga
- Nicholls vs Eastern Kentucky
- South Carolina State vs Charleston Southern
- St. Francis (PA) vs Bucknell
- Brown vs Harvard
- Middle Tennessee vs Kennesaw State
- Liberty vs Old Dominion
- Rhode Island vs Western Michigan
- Virginia Tech vs NC State
- UTRGV vs Southeastern Louisiana
- Alcorn State vs Arkansas-Pine Bluff
- Memphis vs Florida Atlantic
- Southeast Missouri State vs UT-Martin
- Abilene Christian vs Incarnate Word
- Central Arkansas vs Lamar
- Grambling State vs Prairie View A&M
- Jacksonville State vs Southern Miss
- North Carolina Central vs East Texas A&M
- Jackson State vs Southern
- Arizona vs Iowa State
- Western Kentucky vs Missouri State
- San Jose State vs Stanford
- UMass vs Missouri
- Alabama vs Georgia
- Oregon vs Penn State
- Appalachian State vs Boise State
- Washington State vs Colorado State
- Kentucky vs South Carolina
- McNeese State vs Stephen F. Austin
- Marshall vs Louisiana
- West Georgia vs Southern Utah
- Louisiana Tech vs UTEP
- Cal Poly vs Sacramento State
- Weber State vs UC Davis
- Idaho vs Montana
- BYU vs Colorado