The Cardinals will play the 49ers on Sunday, September 27th, 2026. The matchup takes place at Levi's Stadium. Watch this exciting Week 3 matchup at 4:05 pm EDT. Check local listings for coverage on Fox.

Learn more about NFL betting with our handy tutorial and guide. Know when to bet the spread, moneyline, totals or props.

STATE	Bonus

Matchup Stats
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Key Matchup Stats

The 2026-27 NFL regular season keeps rolling for the Arizona Cardinals and San Francisco 49ers, as they gear up to play an exciting Week 3 matchup at Levi's Stadium. Have a look at the following statistical insights to help you handicap the game.

SportsBetting3.com Power Rankings - The Arizona Cardinals have started the 2026-27 season with an initial 93.00 power ranking. The San Francisco 49ers currently have a 100.00 power ranking so far.
Away Arizona Cardinals - Though it's still early in the season, the Arizona Cardinals have a 1-0-0 record as an away team, ranking them 1st in the league for away team wins.
Home San Francisco 49ers - Looking at the San Francisco 49ers heading into Week 3, they currently have a 1-0-0 record as a home team. They rank 2nd in the league for home team wins.
Points Scored - The Arizona Cardinals currently rank 16th (33) up to Week 3, with the San Francisco 49ers ranked 4th (62) for points scored in the 2026-27 regular season.
Points Against - The Arizona Cardinals stand 12th (45) in the early weeks of the regular season for points against. The San Francisco 49ers rank 20th (20) for points against.
Team Records - As Week 3 approaches, the Arizona Cardinals have a 1-1-0 record, with the San Francisco 49ers at 2-0-0 for the 2026-27 NFL regular season.

Best Cardinals at 49ers Odds

**Best Point Spread Betting Odds**
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Point Spread odds are updating, please check back soon.

**Best Total Betting Odds**
Over	Under

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**Best Moneyline Betting Odds**
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Moneyline odds are updating, please check back soon.

NFL Odds Example

NFL Odds and Outcomes Explained
Game	Book

Arizona Cardinals at San Francisco 49ers Prop Bets

NFL Prop Bets
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	Bet
Cardinals 49ers 9/27/26 4:05pm EDT	Pending

Recent Meetings Since 2022

Recent Meetings Since 2022
Week	Game	Result	Margin
2026 Week 3	Cardinals vs 49ers Sunday, September 27th, 2026	SF 36, ARI 30 Levi's Stadium	49ers by 6
2025 Week 11	49ers vs Cardinals Sunday, November 16th, 2025	SF 41, ARI 22 State Farm Stadium	49ers by 19
2025 Week 3	Cardinals vs 49ers Sunday, September 21st, 2025	SF 16, ARI 15 Levi's Stadium	49ers by 1
2024 Week 18	49ers vs Cardinals Sunday, January 5th, 2025	ARI 47, SF 24 State Farm Stadium	Cardinals by 23
2024 Week 5	Cardinals vs 49ers Sunday, October 6th, 2024	ARI 24, SF 23 Levi's Stadium	Cardinals by 1
2023 Week 15	49ers vs Cardinals Sunday, December 17th, 2023	SF 45, ARI 29 State Farm Stadium	49ers by 16
2023 Week 4	Cardinals vs 49ers Sunday, October 1st, 2023	SF 35, ARI 16 Levi's Stadium	49ers by 19
2022 Week 18	Cardinals vs 49ers Sunday, January 8th, 2023	SF 38, ARI 13 Levi's Stadium	49ers by 25
2022 Week 11	49ers vs Cardinals Monday, November 21st, 2022	SF 38, ARI 10 Estadio Azteca	49ers by 28

Team Standings

2026-2027 NFL Regular Season Standings - Arizona Cardinals, San Francisco 49ers
Team	W	L	T	Pct	PF	PA	Home	Away	Div	Div%	Conf	Conf%	Strk	L5
San Francisco 49ers	6	0	0	1.000	177	110	4-0-0	2-0-0	3-0-0	1.000	4-0-0	1.000	6W	5-0-0
Arizona Cardinals	2	4	0	0.333	126	178	0-2-0	2-2-0	1-2-0	0.333	1-4-0	0.200	1W	1-4-0

Arizona Cardinals & San Francisco 49ers Futures Odds

Here are each team's Super Bowl, conference, and division futures odds. Review odds for other matchups and learn the best NFL bets.

Arizona Cardinals Futures Odds

No Super Bowl TM Arizona Cardinals YR: futures available

San Francisco 49ers Futures Odds

No Super Bowl TM San Francisco 49ers YR: futures available

Arizona Cardinals & San Francisco 49ers Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Arizona Cardinals vs San Francisco 49ers NFL Game

Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, September 27th, 2026 at 4:05 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
Tap to the sportsbook's NFL page, look for the Arizona Cardinals vs San Francisco 49ers Game.
Navigate to the sportsbook's NFL page. Next, look for live or upcoming matchups. Select the Arizona Cardinals vs San Francisco 49ers Game.
Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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Arizona Cardinals vs San Francisco 49ers Odds

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