Indiana State vs Southern Illinois Football Odds

The Sycamores will play the Salukis on Saturday, October 4th, 2025.

Learn more about College Football betting with our handy tutorial and guide. We explain spread, total and money line bets.

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Recent Meetings
Team Standings
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Best Sycamores at Salukis Odds

**Best Point Spread Betting Odds**
Underdog Indiana State	Favorite Southern Illinois
+23.5 -110 BetMGM Bet	-23.5 -110 BetMGM Bet

Southern Illinois has a -23.5 -110 point spread at BetMGM OH. They are the point spread favorite in this matchup. Indiana State has a +23.5 -110 point spread at BetMGM OH. Indiana State is the point spread underdog. Review how to bet on a point spread with our text and video tutorials.

**Best Total Betting Odds**
Over	Under
58.5 o -110 BetMGM Bet	58.5 u -110 BetMGM Bet

BetMGM has the best over line of 58.5 points. Risk $110 to win $100. BetMGM has the best under line of 58.5 points. Risk $110 to win $100. Our tutorial explains more about total bets.

**Best Moneyline Betting Odds**
Underdog Indiana State	Favorite Southern Illinois
+1500 BetMGM Bet	-5000 BetMGM Bet

Southern Illinois is the -5000 moneyline favorite. Risk $5,000 to win $100 on Southern Illinois at BetMGM. Indiana State is the +1500 underdog at BetMGM. Risk $100 to win $1,500 on Indiana State. Learn more about how to bet on money lines.

Matchup Odds FAQs

What is the point spread for the Indiana State vs Southern Illinois College Football game on Saturday, October 4th, 2025?

Southern Illinois is a -23.5 -110 point spread favorite at BetMGM, while Indiana State is a +23.5 -110 point spread underdog at BetMGM.

What is the over-under total line for the Indiana State vs Southern Illinois College Football game on Saturday, October 4th, 2025?

The best over line is 58.5 -110 points at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 58.5 -110 points at BetMGM, and that means you risk $110 to win $100 betting the under.

What is the moneyline for the Indiana State vs Southern Illinois College Football game on Saturday, October 4th, 2025?

Southern Illinois is a -5000 moneyline favorite at BetMGM and Indiana State is a +1500 moneyline underdog at BetMGM.

College Football Odds Example

College Football Odds and Outcomes Explained
Game	BetMGM Bet
Indiana State Southern Illinois 10/04/25 7:00pm EDT	+23.5 -110 -23.5 -110

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Underdog Indiana State - Indiana State bettors risk $100 to win $90.91 at -110 odds.

A +23.5 Indiana State underdog bet wins if they lose by 23 or fewer, tie, or win outright. Your bet loses if they lose by 24 or more.

Favorite Southern Illinois - Southern Illinois bettors risk $100 to win $90.91 at -110 odds.

A -23.5 Southern Illinois favorite bet wins if they win by 24 or more. Your bet loses if they win by 23 or fewer, tie, or lose outright.

Indiana State at Southern Illinois Prop Bets

Important Note: Some states expressly forbid individual college athlete prop bets. The following wagers may not be available depending on your particular state laws.

College Football Prop Bets
+ Displays more odds
	BetMGM Bet
Indiana State Southern Illinois 10/04/25 7:00pm EDT	Pending BetMGM

Recent Meetings Since 2021

Recent Meetings Since 2021
Week	Game	Result	Margin

Team Standings

2025-2026 College Football Regular Season Standings - Indiana State, Southern Illinois
Team	Conf	Conf%	W	L	PF	PA	Home	Away	Strk
Southern Illinois	1-2	0.333	4	3	253	188	2-1	2-2	L2
Indiana State	0-3	0.000	2	5	147	286	2-2	0-3	L5

Indiana State & Southern Illinois Futures Odds

Latest NCAA Championship odds, if available, for each team. Review odds for other teams and learn the best College Football bets.

Indiana State Championship Odds

No NCAA College Football Championship TM Indiana State YR: futures available

Southern Illinois Championship Odds

No NCAA College Football Championship TM Southern Illinois YR: futures available

Indiana State & Southern Illinois Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Schedules & Results

2025-26 Indiana State Games & Results
Week	Matchup	Date & Result
Week 3	Indiana State vs Indiana	IU 73, INST 0 Friday, September 12th, 2025

2025-26 Southern Illinois Games & Results
Week	Matchup	Date & Result
Week 2	Southern Illinois vs Purdue	PUR 34, SIU 17 Saturday, September 6th, 2025

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Indiana State vs Southern Illinois College Football Game

Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Saturday, October 4th, 2025 at 7:00 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
Tap to the sportsbook's College Football page, look for the Indiana State vs Southern Illinois Game.
Navigate to the sportsbook's College Football page. Next, look for live or upcoming matchups. Select the Indiana State vs Southern Illinois Game.
Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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