Virginia vs Louisville Football Odds

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The Cavaliers will play the Cardinals on Saturday, October 4th, 2025. The matchup takes place at L&N Federal Credit Union Stadium. Watch this exciting Week 6 matchup at 3:30 pm EDT. Check local listings for coverage on ESPN2.

Learn more about College Football betting with our handy tutorial and guide. We explain spread, total and money line bets.


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Table of Contents

Key Matchup Stats

We're now well into the 2025 college football season. Week 6 action features a matchup between Virginia and Louisville taking place at L&N Federal Credit Union Stadium. The following are some key season stats to help you size up this game.

  • SportsBetting3.com Power Rankings - Virginia has a 98.33 conference power ranking for the 2025 season. The conference power ranking for Louisville is 98.00.
  • Away Virginia - Heading into Week 6, Virginia currently has a 0-1 record as an away team for the 2025 regular season. This ranks them 3rd in the ACC Conference for away team wins. Watch this stat carefully as the season progresses.
  • Home Louisville - Louisville has a 3-0 record as a home team. Looking ahead to this 2025 Week 6 matchup, they rank 2nd in the ACC Conference for home team wins. Like the Virginia away record and ranking, you should continually keep tabs on this stat.
  • Points Scored - For the 2025 season, Virginia ranks 1st (228) in the ACC Conference, with Louisville currently ranking 7th (153) for points scored in the ACC Conference.
  • Points Against - Also in 2025, Virginia stands 5th (116) in the ACC Conference for points scored by opponents in 2025. Louisville sits at 12th (75) in the ACC Conference for points against in the 2025 season so far.
  • Team Records - Virginia has a 4-1 overall record for the 2025 regular season, with Louisville currently 4-0 for the 2025 NCAAF regular season.

Paddy O'Parlay

The "Sports Network" talking heads have nothing on my Irish arse!

Paddy O'Parlay
Paddy O'Parlay

Get ready for a wild showdown as Virginia clashes with Louisville in a Week 6 matchup.

L&N Federal Credit Union Stadium will be rocking as these two teams battle it out.

According to SportsBetting3.com Power Rankings, Virginia has a slight edge over Louisville.

Virginia comes in with a 4-1 record while Louisville remains undefeated at 4-0. Bet this game at BetRivers, or BetMGM.

Review this game's prop bets and compare the odds below for what is sure to be an exciting game.

Best Cavaliers at Cardinals Odds


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Best Total Betting Odds
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Best Moneyline Betting Odds
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Virginia at Louisville Prop Bets

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Virginia
Louisville
10/04/25 3:30pm EDT
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Recent Meetings Since 2021

Recent Meetings Since 2021
WeekGameResultMargin
2025
Week 6		Virginia vs Louisville
Saturday, October 4th, 2025		UVA 30, LOU 27 (OT)
L&N Federal Credit Union Stadium		Virginia by 3
2024
Week 7		Louisville vs Virginia
Saturday, October 12th, 2024		LOU 24, UVA 20
Scott Stadium		Louisville by 4
2023
Week 11		Virginia vs Louisville
Thursday, November 9th, 2023		LOU 31, UVA 24
Cardinal Stadium		Louisville by 7
2022
Week 6		Louisville vs Virginia
Saturday, October 8th, 2022		LOU 34, UVA 17
Scott Stadium		Louisville by 17
2021
Week 6		Virginia vs Louisville
Saturday, October 9th, 2021		UVA 34, LOU 33
Cardinal Stadium		Virginia by 1

Team Standings

2025-2026 College Football Regular Season Standings - Virginia, Louisville
Team Conf Conf% W L PF PA Home Away Strk
#16 Virginia7-10.8751134312746-14-1W1
Louisville4-40.500943892755-33-1W2

Virginia & Louisville Futures Odds

Latest NCAA Championship odds, if available, for each team. Review odds for other teams and learn the best College Football bets.

Virginia Championship Odds

No NCAA College Football Championship TM Virginia YR: futures available

Louisville Championship Odds

No NCAA College Football Championship TM Louisville YR: futures available

Virginia & Louisville Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Schedules & Results


2025-26 Virginia Games & Results
WeekMatchupDate & Result
Week 1Coastal Carolina vs
Virginia		UVA 48, CCU 7
Saturday, August 30th, 2025
Week 2Virginia vs
NC State		NCSU 35, UVA 31
Saturday, September 6th, 2025
Week 3William & Mary vs
Virginia		UVA 55, W&M 16
Saturday, September 13th, 2025
Week 4Stanford vs
Virginia		UVA 48, STAN 20
Saturday, September 20th, 2025
Week 5Florida State vs
Virginia		UVA 46, FSU 38 (2OT)
Friday, September 26th, 2025
Week 6Virginia vs
Louisville		UVA 30, LOU 27 (OT)
Saturday, October 4th, 2025
Week 8Washington State vs
Virginia		UVA 22, WSU 20
Saturday, October 18th, 2025
Week 9Virginia vs
North Carolina		UVA 17, UNC 16 (OT)
Saturday, October 25th, 2025
Week 10Virginia vs
California		UVA 31, CAL 21
Saturday, November 1st, 2025
Week 11Wake Forest vs
Virginia		WAKE 16, UVA 9
Saturday, November 8th, 2025
Week 12Virginia vs
Duke		UVA 34, DUKE 17
Saturday, November 15th, 2025
Week 14Virginia Tech vs
Virginia		UVA 27, VT 7
Saturday, November 29th, 2025
Week 15Duke vs
Virginia		DUKE 27, UVA 20 (OT)
Saturday, December 6th, 2025
BowlsVirginia vs
Missouri
Taxslayer Gator Bowl		UVA 13, MIZ 7
Saturday, December 27th, 2025


2025-26 Louisville Games & Results
WeekMatchupDate & Result
Week 1Eastern Kentucky vs
Louisville		LOU 51, EKU 17
Saturday, August 30th, 2025
Week 2James Madison vs
Louisville		LOU 28, JMU 14
Friday, September 5th, 2025
Week 4Bowling Green vs
Louisville		LOU 40, BGSU 17
Saturday, September 20th, 2025
Week 5Louisville vs
Pittsburgh		LOU 34, PITT 27
Saturday, September 27th, 2025
Week 6Virginia vs
Louisville		UVA 30, LOU 27 (OT)
Saturday, October 4th, 2025
Week 8Louisville vs
Miami (FL)		LOU 24, MIA 21
Friday, October 17th, 2025
Week 9Boston College vs
Louisville		LOU 38, BC 24
Saturday, October 25th, 2025
Week 10Louisville vs
Virginia Tech		LOU 28, VT 16
Saturday, November 1st, 2025
Week 11California vs
Louisville		CAL 29, LOU 26 (OT)
Saturday, November 8th, 2025
Week 12Clemson vs
Louisville		CLEM 20, LOU 19
Friday, November 14th, 2025
Week 13Louisville vs
SMU		SMU 38, LOU 6
Saturday, November 22nd, 2025
Week 14Kentucky vs
Louisville		LOU 41, UK 0
Saturday, November 29th, 2025
BowlsToledo vs
Louisville
Bush's Boca Raton Bowl		LOU 27, TOL 22
Tuesday, December 23rd, 2025

How to Bet on the Game

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How to Bet on the Virginia vs Louisville College Football Game

  1. Open a new sports betting account before game time.

    Review our list of sports betting sites. Open a new account before the game starts on Saturday, October 4th, 2025 at 3:30 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.

  2. Visit the sportsbook’s cashier, banking, or deposit page.

    Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.

  3. Tap to the sportsbook's College Football page, look for the Virginia vs Louisville Game.

    Navigate to the sportsbook's College Football page. Next, look for live or upcoming matchups. Select the Virginia vs Louisville Game.

  4. Choose your bet and place a wager.

    Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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