The Cavaliers will play the Cardinals on Saturday, October 4th, 2025. The matchup takes place at L&N Federal Credit Union Stadium. Watch this exciting Week 6 matchup at 3:30 pm EDT. Check local listings for coverage on ESPN2.
Learn more about College Football betting with our handy tutorial and guide. We explain spread, total and money line bets.
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Table of Contents
- Matchup Stats
- Paddy O'Parlay
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Team Schedules & Results
- Other Games Today
Key Matchup Stats
We're now well into the 2025 college football season. Week 6 action features a matchup between Virginia and Louisville taking place at L&N Federal Credit Union Stadium. The following are some key season stats to help you size up this game.
- SportsBetting3.com Power Rankings - Virginia has a 98.33 conference power ranking for the 2025 season. The conference power ranking for Louisville is 98.00.
- Away Virginia - Heading into Week 6, Virginia currently has a 0-1 record as an away team for the 2025 regular season. This ranks them 3rd in the ACC Conference for away team wins. Watch this stat carefully as the season progresses.
- Home Louisville - Louisville has a 3-0 record as a home team. Looking ahead to this 2025 Week 6 matchup, they rank 2nd in the ACC Conference for home team wins. Like the Virginia away record and ranking, you should continually keep tabs on this stat.
- Points Scored - For the 2025 season, Virginia ranks 1st (228) in the ACC Conference, with Louisville currently ranking 7th (153) for points scored in the ACC Conference.
- Points Against - Also in 2025, Virginia stands 5th (116) in the ACC Conference for points scored by opponents in 2025. Louisville sits at 12th (75) in the ACC Conference for points against in the 2025 season so far.
- Team Records - Virginia has a 4-1 overall record for the 2025 regular season, with Louisville currently 4-0 for the 2025 NCAAF regular season.
Paddy O'Parlay
The "Sports Network" talking heads have nothing on my Irish arse!
Get ready for a wild showdown as Virginia clashes with Louisville in a Week 6 matchup.
L&N Federal Credit Union Stadium will be rocking as these two teams battle it out.
According to SportsBetting3.com Power Rankings, Virginia has a slight edge over Louisville.
Virginia comes in with a 4-1 record while Louisville remains undefeated at 4-0. Bet this game at BetRivers, or BetMGM.
Review this game's prop bets and compare the odds below for what is sure to be an exciting game.
Best Cavaliers at Cardinals Odds
| Underdog Virginia | Favorite Louisville |
|---|---|
| Over | Under |
|---|---|
| Underdog Virginia | Favorite Louisville |
|---|---|
Matchup Odds FAQs
Louisville is a -6.5 -115 point spread favorite at BetMGM, while Virginia is a +6.5 -105 point spread underdog at BetMGM.
The best over line is 60.5 -110 points at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 60.5 -110 points at BetMGM, and that means you risk $110 to win $100 betting the under.
Louisville is a -250 moneyline favorite at BetMGM and Virginia is a +200 moneyline underdog at BetMGM.
College Football Odds Example
|
Game |
 BetMGMBet |
|---|---|
Virginia
Louisville
10/04/25 3:30pm EDT | +6.5 -105-6.5 -115 |
Underdog Virginia - Virginia bettors risk $100 to win $95.24 at -105 odds.
A +6.5 Virginia underdog bet wins if they lose by 6 or fewer, tie, or win outright. Your bet loses if they lose by 7 or more.
Favorite Louisville - Louisville bettors risk $100 to win $86.96 at -115 odds.
A -6.5 Louisville favorite bet wins if they win by 7 or more. Your bet loses if they win by 6 or fewer, tie, or lose outright.
Virginia at Louisville Prop Bets
Important Note: Some states expressly forbid individual college athlete prop bets. The following wagers may not be available depending on your particular state laws.
| BetMGM Bet |
|
|---|---|
Virginia
Louisville
No Touchdown
To Score 1st Touchdown
10/04/25 3:30pm EDT | +130-190+10000Bet |
Virginia
Louisville
Game to Overtime
10/04/25 3:30pm EDT | Yes +1050No -10000Bet |
Virginia
Louisville
Both Teams Score 10+
10/04/25 3:30pm EDT | Yes -3000No +1000Bet |
Virginia
Louisville
Both Teams Score 20+
10/04/25 3:30pm EDT | Yes -250No +190Bet |
| BetMGM | |
Virginia
Louisville
Both Teams Score 30+
10/04/25 3:30pm EDT | Yes +220No -295Bet |
Recent Meetings Since 2021
| Week | Game | Result | Margin |
|---|---|---|---|
| 2025 Week 6 | Virginia vs Louisville Saturday, October 4th, 2025 | UVA 30, LOU 27 (OT) L&N Federal Credit Union Stadium | Virginia by 3 |
| 2024 Week 7 | Louisville vs Virginia Saturday, October 12th, 2024 | LOU 24, UVA 20 Scott Stadium | Louisville by 4 |
| 2023 Week 11 | Virginia vs Louisville Thursday, November 9th, 2023 | LOU 31, UVA 24 Cardinal Stadium | Louisville by 7 |
| 2022 Week 6 | Louisville vs Virginia Saturday, October 8th, 2022 | LOU 34, UVA 17 Scott Stadium | Louisville by 17 |
| 2021 Week 6 | Virginia vs Louisville Saturday, October 9th, 2021 | UVA 34, LOU 33 Cardinal Stadium | Virginia by 1 |
Team Standings
| Team | Conf | Conf% | W | L | PF | PA | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|---|
| #16 Virginia | 3-0 | 1.000 | 6 | 1 | 280 | 163 | 5-0 | 1-1 | W5 |
| #19 Louisville | 2-1 | 0.667 | 5 | 1 | 204 | 126 | 3-1 | 2-0 | W1 |
Virginia & Louisville Futures Odds
Latest NCAA Championship odds, if available, for each team. Review odds for other teams and learn the best College Football bets.
Virginia Championship Odds|
Team | BetMGM |
|---|---|
| Virginia |
|
Team | BetMGM |
|---|---|
| Louisville | +15000 Bet |
Virginia & Louisville Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
Team Schedules & Results
| Week | Matchup | Date & Result |
|---|---|---|
| Week 1 | Coastal Carolina vs Virginia | UVA 48, CCU 7 Saturday, August 30th, 2025 |
| Week 2 | Virginia vs NC State | NCSU 35, UVA 31 Saturday, September 6th, 2025 |
| Week 3 | William & Mary vs Virginia | UVA 55, W&M 16 Saturday, September 13th, 2025 |
| Week 4 | Stanford vs Virginia | UVA 48, STAN 20 Saturday, September 20th, 2025 |
| Week 5 | Florida State vs Virginia | UVA 46, FSU 38 (2OT) Friday, September 26th, 2025 |
| Week 6 | Virginia vs Louisville | UVA 30, LOU 27 (OT) Saturday, October 4th, 2025 |
| Week 8 | Washington State vs Virginia | UVA 22, WSU 20 Saturday, October 18th, 2025 |
| Week 9 | Virginia vs North Carolina | Saturday, October 25th, 2025 12:00 pm EDT |
| Week 10 | Virginia vs California | Saturday, November 1st, 2025 12:00 am EDT |
| Week 11 | Wake Forest vs Virginia | Saturday, November 8th, 2025 12:00 am EST |
| Week 12 | Virginia vs Duke | Saturday, November 15th, 2025 12:00 am EST |
| Week 14 | Virginia Tech vs Virginia | Saturday, November 29th, 2025 12:00 am EST |
| Week | Matchup | Date & Result |
|---|---|---|
| Week 1 | Eastern Kentucky vs Louisville | LOU 51, EKU 17 Saturday, August 30th, 2025 |
| Week 2 | James Madison vs Louisville | LOU 28, JMU 14 Friday, September 5th, 2025 |
| Week 4 | Bowling Green vs Louisville | LOU 40, BGSU 17 Saturday, September 20th, 2025 |
| Week 5 | Louisville vs Pittsburgh | LOU 34, PITT 27 Saturday, September 27th, 2025 |
| Week 6 | Virginia vs Louisville | UVA 30, LOU 27 (OT) Saturday, October 4th, 2025 |
| Week 8 | Louisville vs Miami (FL) | LOU 24, MIA 21 Friday, October 17th, 2025 |
| Week 9 | Boston College vs Louisville | Saturday, October 25th, 2025 7:30 pm EDT |
| Week 10 | Louisville vs Virginia Tech | Saturday, November 1st, 2025 3:00 pm EDT |
| Week 11 | California vs Louisville | Saturday, November 8th, 2025 12:00 am EST |
| Week 12 | Clemson vs Louisville | Friday, November 14th, 2025 7:30 pm EST |
| Week 13 | Louisville vs SMU | Saturday, November 22nd, 2025 12:00 am EST |
| Week 14 | Kentucky vs Louisville | Saturday, November 29th, 2025 12:00 am EST |
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Virginia vs Louisville College Football Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Saturday, October 4th, 2025 at 3:30 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's College Football page, look for the Virginia vs Louisville Game.
Navigate to the sportsbook's College Football page. Next, look for live or upcoming matchups. Select the Virginia vs Louisville Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other October 4, 2025 NCAAFB Games
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- Washington vs Maryland - 10/04/25 3:30pm EDT
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- Texas vs Florida - 10/04/25 3:30pm EDT
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- Jackson State vs Alabama A&M - 10/04/25 5:00pm EDT
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- Mississippi State vs Texas A&M - 10/04/25 7:30pm EDT
- Minnesota vs Ohio State - 10/04/25 7:30pm EDT
- Colorado vs TCU - 10/04/25 7:30pm EDT
- Kansas vs UCF - 10/04/25 7:30pm EDT
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- Tulsa vs Memphis - 10/04/25 8:05pm EDT
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