Oakland Athletics vs Pittsburgh Pirates Odds

The Athletics will play the Pirates on Sunday, September 21st, 2025. Your timezone's first pitch time is 1:35 pm EDT. Check local listings or your nearest streaming app for coverage.

Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.

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Best Athletics at Pirates Odds

**Best Moneyline Betting Odds**
Underdog Oakland Athletics	Favorite Pittsburgh Pirates
+100 BetMGM Bet	-120 BetMGM Bet

The Pittsburgh Pirates are the -120 moneyline favorite. Risk $120 to win $100 on the Pittsburgh Pirates at BetMGM. The Oakland Athletics are the +100 underdog at BetMGM. Risk $100 to win $100 on the Oakland Athletics. Learn more about how to bet on money lines.

**Best Total Betting Odds**
Over	Under
8.5 o -110 BetMGM Bet	8.5 u -110 BetMGM Bet

BetMGM has the best over line of 8.5 runs. Risk $110 to win $100. BetMGM has the best under line of 8.5 runs. Risk $110 to win $100. Our tutorial explains more about total bets.

**Best Run Line Betting Odds**
Underdog Pittsburgh Pirates	Favorite Oakland Athletics
+1.5 -200 BetMGM Bet	-1.5 +165 BetMGM Bet

The Oakland Athletics have a -1.5 +165 run line at BetMGM OH. They are the run line favorite in this matchup. The Pittsburgh Pirates have a +1.5 -200 run line at BetMGM OH. The Pittsburgh Pirates are the run line underdogs. Review how to bet on a point spread with our text and video tutorials.

Matchup Odds FAQs

What is the moneyline for the Oakland Athletics vs Pittsburgh Pirates MLB game on Sunday, September 21st, 2025?

The Pittsburgh Pirates are the -120 moneyline favorite at BetMGM and the Oakland Athletics are the +100 moneyline underdog at BetMGM.

What is the over-under total line for the Oakland Athletics vs Pittsburgh Pirates MLB game on Sunday, September 21st, 2025?

The best over line is 8.5 -110 runs at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 8.5 -110 runs at BetMGM, and that means you risk $110 to win $100 betting the under.

What is the run line for the Oakland Athletics vs Pittsburgh Pirates MLB game on Sunday, September 21st, 2025?

The Oakland Athletics are -1.5 +165 run line favorites at BetMGM, while the Pittsburgh Pirates are +1.5 -200 run line underdogs at BetMGM.

MLB Odds Example

MLB Odds and Outcomes Explained
Game	BetMGM Bet
Athletics Pirates 9/21/25 1:35pm EDT	+100 -120

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Possible Moneyline Outcomes

Oakland Athletics bettors risk $100 to win $100 at +100 odds. The implied probability for Oakland Athletics is 50%.
Pittsburgh Pirates bettors risk $100 to win $83.33 at -120 odds. The implied probability for Pittsburgh Pirates is 54.55%.

Oakland Athletics at Pittsburgh Pirates Prop Bets

MLB Prop Bets
+ Displays more odds
	BetMGM Bet
Athletics Pirates First Team to Score 9/21/25 1:35pm EDT	-160 +125 Bet
Athletics Pirates Tie 1st Inning Winner 9/21/25 1:35pm EDT	+290 +300 -135 Bet
Athletics Pirates Tie First 3 Innings Winner 9/21/25 1:35pm EDT	+140 +140 +290 Bet
Athletics Pirates To Extra Innings 9/21/25 1:35pm EDT	Yes +725 No -1200 Bet
	BetMGM
Athletics Pirates 1st Team to Score Will Win 9/21/25 1:35pm EDT	Yes -250 No +190 Bet
Pirates Total Runs OAK at PIT 9/21/25 1:35pm EDT	4.5 o +115 4.5 u -150 Bet
Mike Burrows Strikeouts Thrown OAK at PIT 9/21/25 1:35pm EDT	4.5 o -120 4.5 u -110 Bet
Mitch Spence Strikeouts Thrown OAK at PIT 9/21/25 1:35pm EDT	3.5 o -125 3.5 u -105 Bet

Oakland Athletics & Pittsburgh Pirates Futures Odds

Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.

Oakland Athletics World Series Odds

No World Series TM Oakland Athletics YR: futures available

Pittsburgh Pirates World Series Odds

No World Series TM Pittsburgh Pirates YR: futures available

Oakland Athletics & Pittsburgh Pirates Team Pages

Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Standings

2025 MLB Regular Season Standings - Oakland Athletics, Pittsburgh Pirates
Team	W	L	Pct	GB	Home	Away	RS	RA	Diff	Strk	L10
e - Oakland Athletics	76	86	0.469	+21.0	36-45	40-41	733	817	-84	L2	5-5
e - Pittsburgh Pirates	71	91	0.438	+26.0	44-37	27-54	583	645	-62	L1	6-4

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Oakland Athletics vs Pittsburgh Pirates MLB Game

Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, September 21st, 2025 at 1:35 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
Tap to the sportsbook's MLB page, look for the Oakland Athletics vs Pittsburgh Pirates Game.
Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the Oakland Athletics vs Pittsburgh Pirates Game.
Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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