Duke vs Syracuse Football Odds - SportsBetting3.com

The Blue Devils will play the Orange on Saturday, September 27th, 2025. The matchup takes place at JMA Wireless Dome. Watch this exciting Week 5 matchup at 12:00 pm EDT. Check local listings for coverage on ACC Network.

Learn more about College Football betting with our handy tutorial and guide. We explain spread, total and money line bets.

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Matchup Stats
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Key Matchup Stats

We're now well into the 2025 college football season. Week 5 action features a matchup between Duke and Syracuse taking place at JMA Wireless Dome. The following are some key season stats to help you size up this game.

SportsBetting3.com Power Rankings - Duke has a 93.67 conference power ranking for the 2025 season. The conference power ranking for Syracuse is 96.67.
Away Duke - Heading into Week 5, Duke currently has a 0-1 record as an away team for the 2025 regular season. This ranks them 2nd in the ACC Conference for away team wins. Watch this stat carefully as the season progresses.
Home Syracuse - Syracuse has a 2-0 record as a home team. Looking ahead to this 2025 Week 5 matchup, they rank 3rd in the ACC Conference for home team wins. Like the Duke away record and ranking, you should continually keep tabs on this stat.
Points Scored - For the 2025 season, Duke ranks 7th (136) in the ACC Conference, with Syracuse currently ranking 4th (153) for points scored in the ACC Conference.
Points Against - Also in 2025, Duke stands 1st (129) in the ACC Conference for points scored by opponents in 2025. Syracuse sits at 5th (110) in the ACC Conference for points against in the 2025 season so far.
Team Records - Duke has a 2-2 overall record for the 2025 regular season, with Syracuse currently 3-1 for the 2025 NCAAF regular season.

Paddy O'Parlay

The "Sports Network" talking heads have nothing on my Irish arse!

Top o' the mornin' to ya, folks! Duke takes on Syracuse in a fierce gridiron battle.

This Week 5 showdown goes down at the JMA Wireless Dome in Syracuse, NY.

According to SportsBetting3.com Power Rankings, Syracuse has a slight edge over Duke.

Duke comes in with a 2-2 record, while Syracuse boasts a 3-1 standing. Bet this game at BetRivers, or BetMGM, review this game's prop bets, and compare the odds below.

Best Blue Devils at Orange Odds

**Best Point Spread Betting Odds**
Underdog Syracuse	Favorite Duke
+4.5 -115 BetMGM Bet	-4.5 -105 BetMGM Bet

Duke has a -4.5 -105 point spread at BetMGM OH. They are the point spread favorite in this matchup. Syracuse has a +4.5 -115 point spread at BetMGM OH. Syracuse is the point spread underdog. Review how to bet on a point spread with our text and video tutorials.

**Best Total Betting Odds**
Over	Under
59.5 o -105 BetMGM Bet	59.5 u -115 BetMGM Bet

BetMGM has the best over line of 59.5 points. Risk $105 to win $100. BetMGM has the best under line of 59.5 points. Risk $115 to win $100. Our tutorial explains more about total bets.

**Best Moneyline Betting Odds**
Underdog Syracuse	Favorite Duke
+150 BetMGM Bet	-185 BetMGM Bet

Duke is the -185 moneyline favorite. Risk $185 to win $100 on Duke at BetMGM. Syracuse is the +150 underdog at BetMGM. Risk $100 to win $150 on Syracuse. Learn more about how to bet on money lines.

Matchup Odds FAQs

What is the point spread for the Duke vs Syracuse College Football game on Saturday, September 27th, 2025?

Duke is a -4.5 -105 point spread favorite at BetMGM, while Syracuse is a +4.5 -115 point spread underdog at BetMGM.

What is the over-under total line for the Duke vs Syracuse College Football game on Saturday, September 27th, 2025?

The best over line is 59.5 -105 points at BetMGM, which means you risk $105 to win $100 betting the over. The best under line is 59.5 -115 points at BetMGM, and that means you risk $115 to win $100 betting the under.

What is the moneyline for the Duke vs Syracuse College Football game on Saturday, September 27th, 2025?

Duke is a -185 moneyline favorite at BetMGM and Syracuse is a +150 moneyline underdog at BetMGM.

College Football Odds Example

College Football Odds and Outcomes Explained
Game	BetMGM Bet
Duke Syracuse 9/27/25 12:00pm EDT	-4.5 -105 +4.5 -115

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Underdog Syracuse - Syracuse bettors risk $100 to win $86.96 at -115 odds.

A +4.5 Syracuse underdog bet wins if they lose by 4 or fewer, tie, or win outright. Your bet loses if they lose by 5 or more.

Favorite Duke - Duke bettors risk $100 to win $95.24 at -105 odds.

A -4.5 Duke favorite bet wins if they win by 5 or more. Your bet loses if they win by 4 or fewer, tie, or lose outright.

Duke at Syracuse Prop Bets

Important Note: Some states expressly forbid individual college athlete prop bets. The following wagers may not be available depending on your particular state laws.

College Football Prop Bets
+ Displays more odds
	BetMGM Bet
Duke Syracuse No Touchdown To Score 1st Touchdown 9/27/25 12:00pm EDT	-150 +105 +10000 Bet
Duke Syracuse Game to Overtime 9/27/25 12:00pm EDT	Yes +950 No -5000 Bet
Duke Syracuse Both Teams Score 10+ 9/27/25 12:00pm EDT	Yes -3000 No +1050 Bet
Duke Syracuse Both Teams Score 20+ 9/27/25 12:00pm EDT	Yes -250 No +190 Bet
	BetMGM
Duke Syracuse Both Teams Score 30+ 9/27/25 12:00pm EDT	Yes +220 No -295 Bet

Recent Meetings Since 2021

Recent Meetings Since 2021
Week	Game	Result	Margin
2025 Week 5	Duke vs Syracuse Saturday, September 27th, 2025	DUKE 38, SYR 3 JMA Wireless Dome	Duke by 35

Team Standings

2025-2026 College Football Regular Season Standings - Duke, Syracuse
Team	Conf	Conf%	W	L	PF	PA	Home	Away	Strk
Duke	3-1	0.750	4	3	237	180	2-2	2-1	L1
Syracuse	1-4	0.200	3	5	203	250	2-2	1-2	L4

Duke & Syracuse Futures Odds

Latest NCAA Championship odds, if available, for each team. Review odds for other teams and learn the best College Football bets.

Duke Championship Odds

2025-26 Duke NCAA College Football Championship Odds
Team	BetMGM
Duke	+50000 Bet

Syracuse Championship Odds

No NCAA College Football Championship TM Syracuse YR: futures available

Duke & Syracuse Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Schedules & Results

2025-26 Duke Games & Results
Week	Matchup	Date & Result
Week 1	Elon vs Duke	DUKE 45, ELON 17 Thursday, August 28th, 2025
Week 2	Illinois vs Duke	ILL 45, DUKE 19 Saturday, September 6th, 2025
Week 3	Duke vs Tulane	TULN 34, DUKE 27 Saturday, September 13th, 2025
Week 4	NC State vs Duke	DUKE 45, NCSU 33 Saturday, September 20th, 2025
Week 5	Duke vs Syracuse	DUKE 38, SYR 3 Saturday, September 27th, 2025
Week 6	Duke vs California	DUKE 45, CAL 21 Saturday, October 4th, 2025
Week 8	Georgia Tech vs Duke	GT 27, DUKE 18 Saturday, October 18th, 2025
Week 10	Duke vs Clemson	Saturday, November 1st, 2025 12:00 pm EDT
Week 11	Duke vs UConn	Saturday, November 8th, 2025 3:30 pm EST
Week 12	Virginia vs Duke	Saturday, November 15th, 2025 12:00 am EST
Week 13	Duke vs North Carolina	Saturday, November 22nd, 2025 12:00 am EST
Week 14	Wake Forest vs Duke	Saturday, November 29th, 2025 12:00 am EST

2025-26 Syracuse Games & Results
Week	Matchup	Date & Result
Week 1	Syracuse vs Tennessee	TENN 45, SYR 26 Saturday, August 30th, 2025
Week 2	UConn vs Syracuse	SYR 27, CONN 20 (OT) Saturday, September 6th, 2025
Week 3	Colgate vs Syracuse	SYR 66, COLG 24 Friday, September 12th, 2025
Week 4	Syracuse vs Clemson	SYR 34, CLEM 21 Saturday, September 20th, 2025
Week 5	Duke vs Syracuse	DUKE 38, SYR 3 Saturday, September 27th, 2025
Week 6	Syracuse vs SMU	SMU 31, SYR 18 Saturday, October 4th, 2025
Week 8	Pittsburgh vs Syracuse	PITT 30, SYR 13 Saturday, October 18th, 2025
Week 9	Syracuse vs Georgia Tech	Saturday, October 25th, 2025 12:00 pm EDT
Week 10	North Carolina vs Syracuse	Friday, October 31st, 2025 7:30 pm EDT
Week 11	Syracuse vs Miami (FL)	Saturday, November 8th, 2025 12:00 am EST
Week 13	Syracuse vs Notre Dame	Saturday, November 22nd, 2025 3:30 pm EST
Week 14	Boston College vs Syracuse	Saturday, November 29th, 2025 12:00 am EST

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Duke vs Syracuse College Football Game

Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Saturday, September 27th, 2025 at 12:00 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
Tap to the sportsbook's College Football page, look for the Duke vs Syracuse Game.
Navigate to the sportsbook's College Football page. Next, look for live or upcoming matchups. Select the Duke vs Syracuse Game.
Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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