The Tigers will play the Cardinals on Wednesday, May 21st, 2025. Your timezone's first pitch time is 1:15 pm EDT. Check local listings or your nearest streaming app for coverage.

Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.

STATE	Bonus

Matchup Stats
Captain Shady Lines
Best Odds
Interactive Odds Example
Prop Bets
Team Futures Odds
Team Pages
Team Standings
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Key Matchup Stats

SportsBetting3.com Power Rankings - The Detroit Tigers have a 98.00 power ranking. The power ranking for the St. Louis Cardinals is 95.33.
Visiting Detroit Tigers - The Detroit Tigers have a 14-12 record as a visiting team, ranking them 1st Overall for visiting team wins.
Home St. Louis Cardinals - The St. Louis Cardinals have a 16-6 record as a home team. They rank 2nd for home team wins in the Overall standings.
Runs Scored - The Detroit Tigers currently stand 3rd (257) Overall, with the St. Louis Cardinals ranking 6th (235) for runs scored.
Runs Allowed - The Detroit Tigers are 23rd (177) Overall for runs allowed. The St. Louis Cardinals stand 20th (190) for runs allowed.
Team Streaks - The Detroit Tigers lost their last game. Meanwhile, the St. Louis Cardinals won their last game.
Team Records - The Detroit Tigers have a 31-17 Overall record (0.0 GB American Central Division), with the St. Louis Cardinals possessing a 27-21 Overall standing (1.0 GB National Central Division).

Captain Shady Lines

A broken compass is right at least twice a day.

Arrr, the Detroit Tigers be setting sail for enemy territory on Wednesday...

With a record of 31-17, they be lookin' to plunder the Cardinals' treasure...

But the Cardinals be no pushovers with a 27-21 record at home...

The Tigers be needin' to step up their game if they want to win...

Those landlubbers at SportsBetting3.com be sayin' to bet on this game...

So weigh anchor, me hearties, and review the odds below before settin' sail!

Best Tigers at Cardinals Odds

**Best Moneyline Betting Odds**
TBD	TBD

Moneyline odds are updating, please check back soon.

**Best Total Betting Odds**
Over	Under

Total odds are updating, please check back soon.

**Best Run Line Betting Odds**
TBD	TBD

Run Line odds are updating, please check back soon.

MLB Odds Example

MLB Odds and Outcomes Explained
Game	Book

Detroit Tigers at St. Louis Cardinals Prop Bets

MLB Prop Bets
+ Displays more odds
	Bet
Tigers Cardinals 5/21/25 1:15pm EDT	Pending

Detroit Tigers & St. Louis Cardinals Futures Odds

Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.

Detroit Tigers World Series Odds

No World Series TM Detroit Tigers YR: futures available

St. Louis Cardinals World Series Odds

No World Series TM St. Louis Cardinals YR: futures available

Detroit Tigers & St. Louis Cardinals Team Pages

Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Standings

2025 MLB Regular Season Standings - Detroit Tigers, St. Louis Cardinals
Team	W	L	Pct	GB	Home	Away	RS	RA	Diff	Strk	L10
y - Detroit Tigers	87	75	0.537	+10.0	46-35	41-40	758	691	+67	L1	2-8
e - St. Louis Cardinals	78	84	0.481	+19.0	44-37	34-47	689	754	-65	L4	4-6

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Detroit Tigers vs St. Louis Cardinals MLB Game

Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Wednesday, May 21st, 2025 at 1:15 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
Tap to the sportsbook's MLB page, look for the Detroit Tigers vs St. Louis Cardinals Game.
Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the Detroit Tigers vs St. Louis Cardinals Game.
Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

Other May 21, 2025 MLB Games

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Detroit Tigers vs St. Louis Cardinals Odds

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