The Tigers will play the Cardinals on Wednesday, May 21st, 2025. Your timezone's first pitch time is 1:15 pm EDT. Check local listings or your nearest streaming app for coverage.
Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.
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Table of Contents
- Matchup Stats
- Captain Shady Lines
- Best Odds
- Interactive Odds Example
- Prop Bets
- Team Futures Odds
- Team Pages
- Team Standings
- Other Games Today
Key Matchup Stats
- SportsBetting3.com Power Rankings - The Detroit Tigers have a 98.00 power ranking. The power ranking for the St. Louis Cardinals is 95.33.
- Visiting Detroit Tigers - The Detroit Tigers have a 14-12 record as a visiting team, ranking them 1st Overall for visiting team wins.
- Home St. Louis Cardinals - The St. Louis Cardinals have a 16-6 record as a home team. They rank 2nd for home team wins in the Overall standings.
- Runs Scored - The Detroit Tigers currently stand 3rd (257) Overall, with the St. Louis Cardinals ranking 6th (235) for runs scored.
- Runs Allowed - The Detroit Tigers are 23rd (177) Overall for runs allowed. The St. Louis Cardinals stand 20th (190) for runs allowed.
- Team Streaks - The Detroit Tigers lost their last game. Meanwhile, the St. Louis Cardinals won their last game.
- Team Records - The Detroit Tigers have a 31-17 Overall record (0.0 GB American Central Division), with the St. Louis Cardinals possessing a 27-21 Overall standing (1.0 GB National Central Division).
Captain Shady Lines
A broken compass is right at least twice a day.
Arrr, the Detroit Tigers be setting sail for enemy territory on Wednesday...
With a record of 31-17, they be lookin' to plunder the Cardinals' treasure...
But the Cardinals be no pushovers with a 27-21 record at home...
The Tigers be needin' to step up their game if they want to win...
Those landlubbers at SportsBetting3.com be sayin' to bet on this game...
So weigh anchor, me hearties, and review the odds below before settin' sail!
Best Tigers at Cardinals Odds
| Underdog Detroit Tigers | Favorite St. Louis Cardinals |
|---|---|
| Over | Under |
|---|---|
| Underdog St. Louis Cardinals | Favorite Detroit Tigers |
|---|---|
Matchup Odds FAQs
The St. Louis Cardinals are the -115 moneyline favorite at BetMGM and the Detroit Tigers are the -105 moneyline underdog at BetMGM.
The best over line is 8.5 -120 runs at BetMGM, which means you risk $120 to win $100 betting the over. The best under line is 8.5 +100 runs at BetMGM, and that means you risk $100 to win $100 betting the under.
The Detroit Tigers are -1.5 +155 run line favorites at BetMGM, while the St. Louis Cardinals are +1.5 -190 run line underdogs at BetMGM.
MLB Odds Example
|
Game |
 BetMGMBet |
|---|---|
Tigers
Cardinals
5/21/25 1:15pm EDT | -105-115 |
- Detroit Tigers bettors risk $100 to win $95.24 at -105 odds. The implied probability for Detroit Tigers is 51.22%.
- St. Louis Cardinals bettors risk $100 to win $86.96 at -115 odds. The implied probability for St. Louis Cardinals is 53.49%.
Detroit Tigers at St. Louis Cardinals Prop Bets
| BetMGM Bet |
|
|---|---|
Tigers
Cardinals
First Team to Score
5/21/25 1:15pm EDT | -160+125Bet |
Tigers
Cardinals
Tie
1st Inning Winner
5/21/25 1:15pm EDT | +280+290-130Bet |
Tigers
Cardinals
Tie
First 3 Innings Winner
5/21/25 1:15pm EDT | +140+135+300Bet |
Tigers
Cardinals
To Extra Innings
5/21/25 1:15pm EDT | Yes +750No -1200Bet |
| BetMGM | |
Tigers
Cardinals
1st Team to Score Will Win
5/21/25 1:15pm EDT | Yes -250No +190Bet |
Tigers
Total Runs
DET at STL 5/21/25 1:15pm EDT | 4.5 o +1004.5 u -130Bet |
Cardinals
Total Runs
DET at STL 5/21/25 1:15pm EDT | 4.5 o +1104.5 u -145Bet |
Andre Pallante
Strikeouts Thrown
DET at STL 5/21/25 1:15pm EDT | 4.5 o +1304.5 u -175Bet |
| BetMGM | |
Brant Hurter
Strikeouts Thrown
DET at STL 5/21/25 1:15pm EDT | 1.5 o +1001.5 u -135Bet |
Detroit Tigers & St. Louis Cardinals Futures Odds
Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.
Detroit Tigers World Series Odds|
Team | BetMGM |
|---|---|
| Tigers | +900 Bet |
|
Team | BetMGM |
|---|---|
| Cardinals | +6600 Bet |
Detroit Tigers & St. Louis Cardinals Team Pages
Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
Team Standings
| Team | W | L | Pct | GB | Home | Away | RS | RA | Diff | Strk | L10 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Detroit Tigers | 36 | 20 | 0.643 | 0.0 | 20-8 | 16-12 | 284 | 201 | +83 | W3 | 6-4 |
| St. Louis Cardinals | 30 | 24 | 0.556 | +5.0 | 19-8 | 11-16 | 256 | 216 | +40 | L1 | 6-4 |
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Detroit Tigers vs St. Louis Cardinals MLB Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Wednesday, May 21st, 2025 at 1:15 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's MLB page, look for the Detroit Tigers vs St. Louis Cardinals Game.
Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the Detroit Tigers vs St. Louis Cardinals Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other May 21, 2025 MLB Games
- Cincinnati Reds vs Pittsburgh Pirates
- Baltimore Orioles vs Milwaukee Brewers
- Chicago Cubs vs Miami Marlins
- Houston Astros vs Tampa Bay Rays
- Seattle Mariners vs Chicago White Sox
- Cleveland Guardians vs Minnesota Twins
- Kansas City Royals vs San Francisco Giants
- New York Mets vs Boston Red Sox
- Atlanta Braves vs Washington Nationals
- Texas Rangers vs New York Yankees
- San Diego Padres vs Toronto Blue Jays
- Cleveland Guardians vs Minnesota Twins
- Philadelphia Phillies vs Colorado Rockies
- Los Angeles Angels vs Oakland Athletics
- Arizona Diamondbacks vs Los Angeles Dodgers