The Athletics will play the Pirates on Sunday, September 21st, 2025. Your timezone's first pitch time is 1:35 pm EDT. Check local listings or your nearest streaming app for coverage.
Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.
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 #1 BetRiversREVIEW | New Customers - 2nd Chance Bet up to $500 - Code: SPORTS Bet Now 21+ Playable in PA only Gambling Problem? Call 1-800-GAMBLER |
Table of Contents
- Best Odds
- Interactive Odds Example
- Prop Bets
- Team Futures Odds
- Team Pages
- Team Standings
- Other Games Today
Best Athletics at Pirates Odds
| Underdog Oakland Athletics | Favorite Pittsburgh Pirates |
|---|---|
| Over | Under |
|---|---|
| Underdog Pittsburgh Pirates | Favorite Oakland Athletics |
|---|---|
Matchup Odds FAQs
The Pittsburgh Pirates are the -120 moneyline favorite at BetRivers and the Oakland Athletics are the +102 moneyline underdog at BetRivers.
The best over line is 8.5 -121 runs at BetRivers, which means you risk $121 to win $100 betting the over. The best under line is 8.5 -104 runs at BetRivers, and that means you risk $104 to win $100 betting the under.
The Oakland Athletics are -1.5 +163 run line favorites at BetRivers, while the Pittsburgh Pirates are +1.5 -210 run line underdogs at BetRivers.
MLB Odds Example
|
Game |
 BetRiversBet |
|---|---|
Athletics
Pirates
9/21/25 1:35pm EDT | +102-120 |
- Oakland Athletics bettors risk $100 to win $102 at +102 odds. The implied probability for Oakland Athletics is 49.5%.
- Pittsburgh Pirates bettors risk $100 to win $83.33 at -120 odds. The implied probability for Pittsburgh Pirates is 54.55%.
Oakland Athletics at Pittsburgh Pirates Prop Bets
| BetRivers Bet |
|
|---|---|
Athletics
Pirates
Tie
First 3 Innings Winner
9/21/25 1:35pm EDT | +145+135+275Bet |
Mike Burrows
Strikeouts Thrown
OAK at PIT 9/21/25 1:35pm EDT | 5.5 o +2055.5 u -286Bet |
Mitch Spence
Strikeouts Thrown
OAK at PIT 9/21/25 1:35pm EDT | 3.5 o -1413.5 u +107Bet |
Oakland Athletics & Pittsburgh Pirates Futures Odds
Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.
Oakland Athletics World Series OddsNo World Series TM Oakland Athletics YR: futures available
Pittsburgh Pirates World Series Odds|
Team | BetRivers |
|---|---|
| Pirates | +50000 Bet |
Oakland Athletics & Pittsburgh Pirates Team Pages
Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
Team Standings
| Team | W | L | Pct | GB | Home | Away | RS | RA | Diff | Strk | L10 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| e - Oakland Athletics | 76 | 86 | 0.469 | +21.0 | 36-45 | 40-41 | 733 | 817 | -84 | L2 | 5-5 |
| e - Pittsburgh Pirates | 71 | 91 | 0.438 | +26.0 | 44-37 | 27-54 | 583 | 645 | -62 | L1 | 6-4 |
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Oakland Athletics vs Pittsburgh Pirates MLB Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Sunday, September 21st, 2025 at 1:35 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's MLB page, look for the Oakland Athletics vs Pittsburgh Pirates Game.
Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the Oakland Athletics vs Pittsburgh Pirates Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other September 21, 2025 MLB Games
- New York Yankees vs Baltimore Orioles
- Atlanta Braves vs Detroit Tigers
- Washington Nationals vs New York Mets
- Chicago Cubs vs Cincinnati Reds
- San Diego Padres vs Chicago White Sox
- Cleveland Guardians vs Minnesota Twins
- Toronto Blue Jays vs Kansas City Royals
- Milwaukee Brewers vs St. Louis Cardinals
- Miami Marlins vs Texas Rangers
- Los Angeles Angels vs Colorado Rockies
- San Francisco Giants vs Los Angeles Dodgers
- Philadelphia Phillies vs Arizona Diamondbacks
- Seattle Mariners vs Houston Astros
- Boston Red Sox vs Tampa Bay Rays