Michigan State vs USC Football Odds

The Spartans will play the Trojans on Saturday, September 20th, 2025. The matchup takes place at Los Angeles Memorial Coliseum. Watch this exciting Week 4 matchup at 11:00 pm EDT. Check local listings for coverage on FOX.

Learn more about College Football betting with our handy tutorial and guide. We explain spread, total and money line bets.


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Table of Contents

Key Matchup Stats

We're now well into the 2025 college football season. Week 4 action features a matchup between Michigan State and USC taking place at Los Angeles Memorial Coliseum. The following are some key season stats to help you size up this game.

  • SportsBetting3.com Power Rankings - Michigan State has a 96.33 conference power ranking for the 2025 season. The conference power ranking for USC is 99.00.
  • Away Michigan State - Heading into Week 4, Michigan State currently has a 0-0 record as an away team for the 2025 regular season. This ranks them 2nd in the Big Ten Conference for away team wins. Watch this stat carefully as the season progresses.
  • Home USC - USC has a 2-0 record as a home team. Looking ahead to this 2025 Week 4 matchup, they rank 2nd in the Big Ten Conference for home team wins. Like the Michigan State away record and ranking, you should continually keep tabs on this stat.
  • Points Scored - For the 2025 season, Michigan State ranks 11th (106) in the Big Ten Conference, with USC currently ranking 1st (165) for points scored in the Big Ten Conference.
  • Points Against - Also in 2025, Michigan State stands 2nd (70) in the Big Ten Conference for points scored by opponents in 2025. USC sits at 5th (50) in the Big Ten Conference for points against in the 2025 season so far.
  • Team Records - Michigan State has a 3-0 overall record for the 2025 regular season, with USC currently 3-0 for the 2025 NCAAF regular season.

Paddy O'Parlay

The "Sports Network" talking heads have nothing on my Irish arse!

Paddy O'Parlay
Paddy O'Parlay

Top o' the mornin' to ya! Michigan State faces USC in a fierce battle on Saturday!

This pivotal Week 4 matchup will be held at the historic Los Angeles Memorial Coliseum.

According to SportsBetting3.com Power Rankings, USC has a slight advantage over Michigan State.

Both teams are undefeated with Michigan State at 3-0 and USC at 3-0.

Bet this game at BetRivers, or BetMGM and be sure to review this game's prop bets. Compare the odds below!

Best Spartans at Trojans Odds


Best Point Spread Betting Odds
Underdog

Michigan State
Favorite

USC
USC has a -19.5 -110 point spread at BetMGM OH. They are the point spread favorite in this matchup. Michigan State has a +19.5 -110 point spread at BetMGM OH. Michigan State is the point spread underdog. Review how to bet on a point spread with our text and video tutorials.

Best Total Betting Odds
OverUnder
BetMGM has the best over line of 55.5 points. Risk $105 to win $100. BetMGM has the best under line of 55.5 points. Risk $115 to win $100. Our tutorial explains more about total bets.

Best Moneyline Betting Odds
Underdog

Michigan State
Favorite

USC
USC is the -1000 moneyline favorite. Risk $1,000 to win $100 on USC at BetMGM. Michigan State is the +625 underdog at BetMGM. Risk $100 to win $625 on Michigan State. Learn more about how to bet on money lines.

Matchup Odds FAQs

What is the point spread for the Michigan State vs USC College Football game on Saturday, September 20th, 2025?

USC is a -19.5 -110 point spread favorite at BetMGM, while Michigan State is a +19.5 -110 point spread underdog at BetMGM.

What is the over-under total line for the Michigan State vs USC College Football game on Saturday, September 20th, 2025?

The best over line is 55.5 -105 points at BetMGM, which means you risk $105 to win $100 betting the over. The best under line is 55.5 -115 points at BetMGM, and that means you risk $115 to win $100 betting the under.

What is the moneyline for the Michigan State vs USC College Football game on Saturday, September 20th, 2025?

USC is a -1000 moneyline favorite at BetMGM and Michigan State is a +625 moneyline underdog at BetMGM.

College Football Odds Example

College Football Odds and Outcomes Explained

Game
BetMGM Sports Betting BetMGM
Bet
Michigan State
USC
9/20/25 11:00pm EDT
+19.5 -110-19.5 -110
Bet $100 at BetMGM Ohio
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Underdog Michigan State - Michigan State bettors risk $100 to win $90.91 at -110 odds.

A +19.5 Michigan State underdog bet wins if they lose by 19 or fewer, tie, or win outright. Your bet loses if they lose by 20 or more.

Favorite USC - USC bettors risk $100 to win $90.91 at -110 odds.

A -19.5 USC favorite bet wins if they win by 20 or more. Your bet loses if they win by 19 or fewer, tie, or lose outright.

Michigan State at USC Prop Bets

Important Note: Some states expressly forbid individual college athlete prop bets. The following wagers may not be available depending on your particular state laws.

College Football Prop Bets
+ Displays more odds
BetMGM Sports Betting BetMGM
Bet
Michigan State
USC
No Touchdown
To Score 1st Touchdown
9/20/25 11:00pm EDT
+250-425+10000Bet
Michigan State
USC
Game to Overtime
9/20/25 11:00pm EDT
Yes +1800No -10000Bet
Michigan State
USC
Both Teams Score 10+
9/20/25 11:00pm EDT
Yes -525No +360Bet
Michigan State
USC
Both Teams Score 20+
9/20/25 11:00pm EDT
Yes +118No -150Bet
BetMGM Sports Betting BetMGM
Michigan State
USC
Both Teams Score 30+
9/20/25 11:00pm EDT
Yes +625No -1200Bet

Recent Meetings Since 2021

Recent Meetings Since 2021
WeekGameResultMargin
2025
Week 4
Michigan State vs USC
Saturday, September 20th, 2025
USC 45, MSU 31
Los Angeles Memorial Coliseum
USC by 14

Team Standings

2025-2026 College Football Regular Season Standings - Michigan State, USC
Team Conf Conf% W L PF PA Home Away Strk
#23 USC3-10.750522971624-01-2L1
Michigan State0-50.000352102603-20-3L5

Michigan State & USC Futures Odds

Latest NCAA Championship odds, if available, for each team. Review odds for other teams and learn the best College Football bets.

Michigan State Championship Odds

No NCAA College Football Championship TM Michigan State YR: futures available

USC Championship Odds
2025-26 USC NCAA College Football Championship Odds

Team
BetMGM Sports Betting BetMGM
USC
+10000
Bet

Michigan State & USC Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Schedules & Results


2025-26 Michigan State Games & Results
WeekMatchupDate & Result
Week 1Western Michigan vs
Michigan State
MSU 23, WMU 6
Friday, August 29th, 2025
Week 2Boston College vs
Michigan State
MSU 42, BC 40 (2OT)
Saturday, September 6th, 2025
Week 3Youngstown State vs
Michigan State
MSU 41, YSU 24
Saturday, September 13th, 2025
Week 4Michigan State vs
USC
USC 45, MSU 31
Saturday, September 20th, 2025
Week 6Michigan State vs
Nebraska
NEB 38, MSU 27
Saturday, October 4th, 2025
Week 7UCLA vs
Michigan State
UCLA 38, MSU 13
Saturday, October 11th, 2025
Week 8Michigan State vs
Indiana
IU 38, MSU 13
Saturday, October 18th, 2025
Week 9Michigan vs
Michigan State
Saturday, October 25th, 2025
7:30 pm EDT
Week 10Michigan State vs
Minnesota
Saturday, November 1st, 2025
3:30 pm EDT
Week 12Penn State vs
Michigan State
Saturday, November 15th, 2025
12:00 am EST
Week 13Michigan State vs
Iowa
Saturday, November 22nd, 2025
12:00 am EST
Week 14Maryland vs
Michigan State
Saturday, November 29th, 2025
12:00 am EST


2025-26 USC Games & Results
WeekMatchupDate & Result
Week 1Missouri State vs
USC
USC 73, MOST 13
Saturday, August 30th, 2025
Week 2Georgia Southern vs
USC
USC 59, GASO 20
Saturday, September 6th, 2025
Week 3USC vs
Purdue
USC 33, PUR 17
Saturday, September 13th, 2025
Week 4Michigan State vs
USC
USC 45, MSU 31
Saturday, September 20th, 2025
Week 5USC vs
Illinois
ILL 34, USC 32
Saturday, September 27th, 2025
Week 7Michigan vs
USC
USC 31, MICH 13
Saturday, October 11th, 2025
Week 8USC vs
Notre Dame
ND 34, USC 24
Saturday, October 18th, 2025
Week 10USC vs
Nebraska
Saturday, November 1st, 2025
7:30 pm EDT
Week 11Northwestern vs
USC
Friday, November 7th, 2025
9:00 pm EST
Week 12Iowa vs
USC
Saturday, November 15th, 2025
12:00 am EST
Week 13USC vs
Oregon
Saturday, November 22nd, 2025
12:00 am EST
Week 14UCLA vs
USC
Saturday, November 29th, 2025
12:00 am EST

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Michigan State vs USC College Football Game

  1. Open a new sports betting account before game time.

    Review our list of sports betting sites. Open a new account before the game starts on Saturday, September 20th, 2025 at 11:00 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.

  2. Visit the sportsbook’s cashier, banking, or deposit page.

    Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.

  3. Tap to the sportsbook's College Football page, look for the Michigan State vs USC Game.

    Navigate to the sportsbook's College Football page. Next, look for live or upcoming matchups. Select the Michigan State vs USC Game.

  4. Choose your bet and place a wager.

    Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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