The Spartans will play the Trojans on Saturday, September 20th, 2025. The matchup takes place at Los Angeles Memorial Coliseum. Watch this exciting Week 4 matchup at 11:00 pm EDT. Check local listings for coverage on FOX.
Learn more about College Football betting with our handy tutorial and guide. We explain spread, total and money line bets.
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Table of Contents
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Team Schedules & Results
- Other Games Today
Best Spartans at Trojans Odds
| Underdog Michigan State | Favorite USC |
|---|---|
| Over | Under |
|---|---|
| TBD | TBD |
|---|
Matchup Odds FAQs
USC is a -15.5 -110 point spread favorite at BetMGM, while Michigan State is a +15.5 -110 point spread underdog at BetMGM.
The best over line is 55.5 -110 points at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 55.5 -110 points at BetMGM, and that means you risk $110 to win $100 betting the under.
College Football Odds Example
|
Game |
 BetMGMBet |
|---|---|
Michigan State
USC
9/20/25 11:00pm EDT | +15.5 -110-15.5 -110 |
Underdog Michigan State - Michigan State bettors risk $100 to win $90.91 at -110 odds.
A +15.5 Michigan State underdog bet wins if they lose by 15 or fewer, tie, or win outright. Your bet loses if they lose by 16 or more.
Favorite USC - USC bettors risk $100 to win $90.91 at -110 odds.
A -15.5 USC favorite bet wins if they win by 16 or more. Your bet loses if they win by 15 or fewer, tie, or lose outright.
Michigan State at USC Prop Bets
Important Note: Some states expressly forbid individual college athlete prop bets. The following wagers may not be available depending on your particular state laws.
| BetMGM Bet |
|
|---|---|
Michigan State
USC
9/20/25 11:00pm EDT | Pending BetMGM |
Recent Meetings Since 2021
| Week | Game | Result | Margin |
|---|
Team Standings
| Team | Conf | Conf% | W | L | PF | PA | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|---|
| USC | 1-0 | 1.000 | 3 | 0 | 165 | 50 | 2-0 | 1-0 | W3 |
| Michigan State | 0-0 | 0.000 | 3 | 0 | 106 | 70 | 3-0 | 0-0 | W3 |
Michigan State & USC Futures Odds
Latest NCAA Championship odds, if available, for each team. Review odds for other teams and learn the best College Football bets.
Michigan State Championship Odds|
Team | BetMGM |
|---|---|
| Michigan State | +15000 Bet |
|
Team | BetMGM |
|---|---|
| USC | +5000 Bet |
Michigan State & USC Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
Team Schedules & Results
| Week | Matchup | Date & Result |
|---|---|---|
| Week 1 | Western Michigan vs Michigan State | MSU 23, WMU 6 Friday, August 29th, 2025 |
| Week 2 | Boston College vs Michigan State | MSU 42, BC 40 (2OT) Saturday, September 6th, 2025 |
| Week 3 | Youngstown State vs Michigan State | MSU 41, YSU 24 Saturday, September 13th, 2025 |
| Week 4 | Michigan State vs USC | Saturday, September 20th, 2025 11:00 pm EDT |
| Week 6 | Michigan State vs Nebraska | Saturday, October 4th, 2025 12:00 am EDT |
| Week 7 | UCLA vs Michigan State | Saturday, October 11th, 2025 12:00 pm EDT |
| Week 8 | Michigan State vs Indiana | Saturday, October 18th, 2025 12:00 am EDT |
| Week 9 | Michigan vs Michigan State | Saturday, October 25th, 2025 12:00 am EDT |
| Week 10 | Michigan State vs Minnesota | Saturday, November 1st, 2025 12:00 am EDT |
| Week 12 | Penn State vs Michigan State | Saturday, November 15th, 2025 12:00 am EST |
| Week 13 | Michigan State vs Iowa | Saturday, November 22nd, 2025 12:00 am EST |
| Week 14 | Maryland vs Michigan State | Saturday, November 29th, 2025 12:00 am EST |
| Week | Matchup | Date & Result |
|---|---|---|
| Week 1 | Missouri State vs USC | USC 73, MOST 13 Saturday, August 30th, 2025 |
| Week 2 | Georgia Southern vs USC | USC 59, GASO 20 Saturday, September 6th, 2025 |
| Week 3 | USC vs Purdue | USC 33, PUR 17 Saturday, September 13th, 2025 |
| Week 4 | Michigan State vs USC | Saturday, September 20th, 2025 11:00 pm EDT |
| Week 5 | USC vs Illinois | Saturday, September 27th, 2025 12:00 am EDT |
| Week 7 | Michigan vs USC | Saturday, October 11th, 2025 12:00 am EDT |
| Week 8 | USC vs Notre Dame | Saturday, October 18th, 2025 7:30 pm EDT |
| Week 10 | USC vs Nebraska | Saturday, November 1st, 2025 12:00 am EDT |
| Week 11 | Northwestern vs USC | Friday, November 7th, 2025 9:00 pm EST |
| Week 12 | Iowa vs USC | Saturday, November 15th, 2025 12:00 am EST |
| Week 13 | USC vs Oregon | Saturday, November 22nd, 2025 12:00 am EST |
| Week 14 | UCLA vs USC | Saturday, November 29th, 2025 12:00 am EST |
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Michigan State vs USC College Football Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Saturday, September 20th, 2025 at 11:00 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's College Football page, look for the Michigan State vs USC Game.
Navigate to the sportsbook's College Football page. Next, look for live or upcoming matchups. Select the Michigan State vs USC Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other September 20, 2025 NCAAFB Games
- SMU vs TCU - 9/20/25 3:00pm EDT
- West Virginia vs Kansas - 9/20/25 3:00pm EDT
- South Carolina vs Missouri - 9/20/25 3:00pm EDT
- Florida vs Miami (FL) - 9/20/25 3:00pm EDT
- Oregon State vs Oregon - 9/20/25 3:00pm EDT
- Arizona State vs Baylor - 9/20/25 3:00pm EDT
- Maryland vs Wisconsin - 9/20/25 3:00pm EDT
- UTSA vs Colorado State - 9/20/25 3:00pm EDT
- UNLV vs Miami (OH) - 9/20/25 3:00pm EDT
- Syracuse vs Clemson - 9/20/25 3:00pm EDT
- Texas Tech vs Utah - 9/20/25 3:00pm EDT
- North Texas vs Army - 9/20/25 3:00pm EDT
- Bowling Green vs Louisville - 9/20/25 3:00pm EDT
- Arkansas vs Memphis - 9/20/25 3:00pm EDT
- Illinois vs Indiana - 9/20/25 3:00pm EDT
- Louisiana vs Eastern Michigan - 9/20/25 3:30pm EDT
- James Madison vs Liberty - 9/20/25 3:30pm EDT
- Toledo vs Western Michigan - 9/20/25 3:30pm EDT
- Kent State vs Florida State - 9/20/25 3:30pm EDT
- Ball State vs UConn - 9/20/25 3:30pm EDT
- Michigan vs Nebraska - 9/20/25 3:30pm EDT
- Troy vs Buffalo - 9/20/25 3:30pm EDT
- Purdue vs Notre Dame - 9/20/25 3:30pm EDT
- Tulane vs Ole Miss - 9/20/25 3:30pm EDT
- Auburn vs Oklahoma - 9/20/25 3:30pm EDT
- North Carolina vs UCF - 9/20/25 3:30pm EDT
- UAB vs Tennessee - 9/20/25 3:45pm EDT
- NC State vs Duke - 9/20/25 4:00pm EDT
- Northern Illinois vs Mississippi State - 9/20/25 4:15pm EDT
- Temple vs Georgia Tech - 9/20/25 4:30pm EDT
- Delaware vs FIU - 9/20/25 6:00pm EDT
- Arkansas State vs Kennesaw State - 9/20/25 6:00pm EDT
- Nevada vs Western Kentucky - 9/20/25 7:00pm EDT
- Marshall vs Middle Tennessee - 9/20/25 7:00pm EDT
- Coastal Carolina vs South Alabama - 9/20/25 7:00pm EDT
- Boise State vs Air Force - 9/20/25 7:00pm EDT
- Washington vs Washington State - 9/20/25 7:30pm EDT
- Stanford vs Virginia - 9/20/25 7:30pm EDT
- Southern Miss vs Louisiana Tech - 9/20/25 7:30pm EDT
- Georgia State vs Vanderbilt - 9/20/25 7:30pm EDT
- BYU vs East Carolina - 9/20/25 7:30pm EDT
- Sam Houston State vs Texas - 9/20/25 8:00pm EDT
- Louisiana-Monroe vs UTEP - 9/20/25 9:00pm EDT
- Wyoming vs Colorado - 9/20/25 10:15pm EDT
- California vs San Diego State - 9/20/25 10:30pm EDT