The Spartans will play the Trojans on Saturday, September 20th, 2025. The matchup takes place at Los Angeles Memorial Coliseum. Watch this exciting Week 4 matchup at 11:00 pm EDT. Check local listings for coverage on FOX.
Learn more about College Football betting with our handy tutorial and guide. We explain spread, total and money line bets.
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Table of Contents
- Matchup Stats
- Paddy O'Parlay
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Team Schedules & Results
- Other Games Today
Key Matchup Stats
We're now well into the 2025 college football season. Week 4 action features a matchup between Michigan State and USC taking place at Los Angeles Memorial Coliseum. The following are some key season stats to help you size up this game.
- SportsBetting3.com Power Rankings - Michigan State has a 96.33 conference power ranking for the 2025 season. The conference power ranking for USC is 99.00.
- Away Michigan State - Heading into Week 4, Michigan State currently has a 0-0 record as an away team for the 2025 regular season. This ranks them 2nd in the Big Ten Conference for away team wins. Watch this stat carefully as the season progresses.
- Home USC - USC has a 2-0 record as a home team. Looking ahead to this 2025 Week 4 matchup, they rank 2nd in the Big Ten Conference for home team wins. Like the Michigan State away record and ranking, you should continually keep tabs on this stat.
- Points Scored - For the 2025 season, Michigan State ranks 11th (106) in the Big Ten Conference, with USC currently ranking 1st (165) for points scored in the Big Ten Conference.
- Points Against - Also in 2025, Michigan State stands 2nd (70) in the Big Ten Conference for points scored by opponents in 2025. USC sits at 5th (50) in the Big Ten Conference for points against in the 2025 season so far.
- Team Records - Michigan State has a 3-0 overall record for the 2025 regular season, with USC currently 3-0 for the 2025 NCAAF regular season.
Paddy O'Parlay
The "Sports Network" talking heads have nothing on my Irish arse!
Top o' the mornin' to ya! Michigan State faces USC in a fierce battle on Saturday!
This pivotal Week 4 matchup will be held at the historic Los Angeles Memorial Coliseum.
According to SportsBetting3.com Power Rankings, USC has a slight advantage over Michigan State.
Both teams are undefeated with Michigan State at 3-0 and USC at 3-0.
Bet this game at BetRivers, or BetMGM and be sure to review this game's prop bets. Compare the odds below!
Best Spartans at Trojans Odds
| Underdog Michigan State | Favorite USC |
|---|---|
| Over | Under |
|---|---|
| Underdog Michigan State | Favorite USC |
|---|---|
Matchup Odds FAQs
USC is a -19 -113 point spread favorite at BetRivers, while Michigan State is a +19 -110 point spread underdog at BetRivers.
The best over line is 55.5 -114 points at BetRivers, which means you risk $114 to win $100 betting the over. The best under line is 55.5 -109 points at BetRivers, and that means you risk $109 to win $100 betting the under.
USC is a -1000 moneyline favorite at BetRivers and Michigan State is a +600 moneyline underdog at BetRivers.
College Football Odds Example
|
Game |
 BetRiversBet |
|---|---|
Michigan State
USC
9/20/25 11:00pm EDT | +19 -110-19 -113 |
Underdog Michigan State - Michigan State bettors risk $100 to win $90.91 at -110 odds.
A +19 Michigan State underdog bet wins if they lose by 18 or fewer, tie, or win outright. The bet pushes if they lose by 19. Your bet loses if they lose by 20 or more.
Favorite USC - USC bettors risk $100 to win $88.5 at -113 odds.
A -19 USC favorite bet wins if they win by 20 or more. The bet pushes if they win by 19. Your bet loses if they win by 18 or fewer, tie, or lose outright.
Michigan State at USC Prop Bets
Important Note: Some states expressly forbid individual college athlete prop bets. The following wagers may not be available depending on your particular state laws.
| BetRivers Bet |
|
|---|---|
Michigan State
USC
First Team To Score
9/20/25 11:00pm EDT | +180-250Bet |
Michigan State
USC
Tie
First to 20 Points
9/20/25 11:00pm EDT | +450-1000+3300Bet |
Michigan State
USC
Tie
First to 25 Points
9/20/25 11:00pm EDT | +650-715+850Bet |
Michigan State
USC
Tie
First to 30 Points
9/20/25 11:00pm EDT | +850-400+360Bet |
| BetRivers | |
Michigan State
USC
Tie
First to 35 Points
9/20/25 11:00pm EDT | +1500-177+138Bet |
Michigan State
Team Total Points
MSU at USC 9/20/25 11:00pm EDT | 17.5 o -11017.5 u -118Bet |
USC
Team Total Points
MSU at USC 9/20/25 11:00pm EDT | 37.5 o -12437.5 u -107Bet |
Michigan State
To Score First & Win
MSU at USC 9/20/25 11:00pm EDT | Yes +1050No -5000Bet |
| BetRivers | |
USC
To Score First & Win
MSU at USC 9/20/25 11:00pm EDT | Yes -195No +143Bet |
Recent Meetings Since 2021
| Week | Game | Result | Margin |
|---|---|---|---|
| 2025 Week 4 | Michigan State vs USC Saturday, September 20th, 2025 | USC 45, MSU 31 Los Angeles Memorial Coliseum | USC by 14 |
Team Standings
| Team | Conf | Conf% | W | L | PF | PA | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|---|
| #20 USC | 7-2 | 0.778 | 9 | 4 | 465 | 299 | 7-0 | 2-3 | L1 |
| Michigan State | 1-8 | 0.111 | 4 | 8 | 295 | 359 | 3-3 | 0-5 | W1 |
Michigan State & USC Futures Odds
Latest NCAA Championship odds, if available, for each team. Review odds for other teams and learn the best College Football bets.
Michigan State Championship Odds|
Team | BetRivers |
|---|---|
| Michigan State | +100000 Bet |
|
Team | BetRivers |
|---|---|
| USC | +5000 Bet |
Michigan State & USC Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
Team Schedules & Results
| Week | Matchup | Date & Result |
|---|---|---|
| Week 1 | Western Michigan vs Michigan State | MSU 23, WMU 6 Friday, August 29th, 2025 |
| Week 2 | Boston College vs Michigan State | MSU 42, BC 40 (2OT) Saturday, September 6th, 2025 |
| Week 3 | Youngstown State vs Michigan State | MSU 41, YSU 24 Saturday, September 13th, 2025 |
| Week 4 | Michigan State vs USC | USC 45, MSU 31 Saturday, September 20th, 2025 |
| Week 6 | Michigan State vs Nebraska | NEB 38, MSU 27 Saturday, October 4th, 2025 |
| Week 7 | UCLA vs Michigan State | UCLA 38, MSU 13 Saturday, October 11th, 2025 |
| Week 8 | Michigan State vs Indiana | IU 38, MSU 13 Saturday, October 18th, 2025 |
| Week 9 | Michigan vs Michigan State | MICH 31, MSU 20 Saturday, October 25th, 2025 |
| Week 10 | Michigan State vs Minnesota | MINN 23, MSU 20 (OT) Saturday, November 1st, 2025 |
| Week 12 | Penn State vs Michigan State | PSU 28, MSU 10 Saturday, November 15th, 2025 |
| Week 13 | Michigan State vs Iowa | IOWA 20, MSU 17 Saturday, November 22nd, 2025 |
| Week 14 | Maryland vs Michigan State | MSU 38, MD 28 Saturday, November 29th, 2025 |
| Week | Matchup | Date & Result |
|---|---|---|
| Week 1 | Missouri State vs USC | USC 73, MOST 13 Saturday, August 30th, 2025 |
| Week 2 | Georgia Southern vs USC | USC 59, GASO 20 Saturday, September 6th, 2025 |
| Week 3 | USC vs Purdue | USC 33, PUR 17 Saturday, September 13th, 2025 |
| Week 4 | Michigan State vs USC | USC 45, MSU 31 Saturday, September 20th, 2025 |
| Week 5 | USC vs Illinois | ILL 34, USC 32 Saturday, September 27th, 2025 |
| Week 7 | Michigan vs USC | USC 31, MICH 13 Saturday, October 11th, 2025 |
| Week 8 | USC vs Notre Dame | ND 34, USC 24 Saturday, October 18th, 2025 |
| Week 10 | USC vs Nebraska | USC 21, NEB 17 Saturday, November 1st, 2025 |
| Week 11 | Northwestern vs USC | USC 38, NU 17 Friday, November 7th, 2025 |
| Week 12 | Iowa vs USC | USC 26, IOWA 21 Saturday, November 15th, 2025 |
| Week 13 | USC vs Oregon | ORE 42, USC 27 Saturday, November 22nd, 2025 |
| Week 14 | UCLA vs USC | USC 29, UCLA 10 Saturday, November 29th, 2025 |
| Bowls | USC vs TCU Valero Alamo Bowl | TCU 30, USC 27 (OT) Tuesday, December 30th, 2025 |
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Michigan State vs USC College Football Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Saturday, September 20th, 2025 at 11:00 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's College Football page, look for the Michigan State vs USC Game.
Navigate to the sportsbook's College Football page. Next, look for live or upcoming matchups. Select the Michigan State vs USC Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other September 20, 2025 NCAAFB Games
- SMU vs TCU
- UNLV vs Miami (OH)
- Syracuse vs Clemson
- Maryland vs Wisconsin
- Arkansas vs Memphis
- Bowling Green vs Louisville
- North Texas vs Army
- Texas Tech vs Utah
- UAB vs Tennessee
- VMI vs Richmond
- Dayton vs Robert Morris
- Mercer vs The Citadel
- Drake vs South Dakota
- Samford vs Western Carolina
- Oregon State vs Oregon
- Mercyhurst vs Montana State
- Indiana State vs Montana
- Toledo vs Western Michigan
- Louisiana vs Eastern Michigan
- Gardner-Webb vs Ohio
- Kent State vs Florida State
- North Carolina vs UCF
- Troy vs Buffalo
- James Madison vs Liberty
- Ball State vs UConn
- Purdue vs Notre Dame
- Tulane vs Ole Miss
- Auburn vs Oklahoma
- Michigan vs Nebraska
- NC State vs Duke
- Northern Illinois vs Mississippi State
- Incarnate Word vs Northern Arizona
- Temple vs Georgia Tech
- Elon vs East Tennessee State
- Bryant vs Campbell
- LIU vs Rhode Island
- Central Connecticut vs Merrimack College
- Duquesne vs Akron
- Eastern Kentucky vs West Georgia
- Youngstown State vs Towson
- Lehigh vs Bucknell
- West Virginia vs Kansas
- Delaware vs FIU
- Arkansas State vs Kennesaw State
- Nevada vs Western Kentucky
- Cornell vs Albany
- Marshall vs Middle Tennessee
- Coastal Carolina vs South Alabama
- Boise State vs Air Force
- Chattanooga vs Tarleton
- East Texas A&M vs Grambling State
- Murray State vs Jacksonville State
- Western Illinois vs Eastern Washington
- UT-Martin vs Missouri State
- Stony Brook vs Lindenwood
- Maine vs Georgia Southern
- Southern Illinois vs Southeast Missouri State
- Northwestern State vs Prairie View A&M
- Northern Colorado vs Houston Christian
- South Carolina vs Missouri
- Stanford vs Virginia
- Illinois vs Indiana
- Washington vs Washington State
- Southern Miss vs Louisiana Tech
- BYU vs East Carolina
- Florida vs Miami (FL)
- Arizona State vs Baylor
- Southeastern Louisiana vs LSU
- Sam Houston State vs Texas
- Cal Poly vs Stephen F. Austin
- Butler vs Weber State
- Austin Peay vs Abilene Christian
- Nicholls vs Texas State
- Northern Iowa vs Utah Tech
- Georgia State vs Vanderbilt
- McNeese State vs Utah State
- Louisiana-Monroe vs UTEP
- Central Arkansas vs Sacramento State
- UTSA vs Colorado State
- Southern Utah vs UC Davis
- Wyoming vs Colorado
- California vs San Diego State