Michigan State vs USC Football Odds

The Spartans will play the Trojans on Saturday, September 20th, 2025. The matchup takes place at Los Angeles Memorial Coliseum. Watch this exciting Week 4 matchup at 11:00 pm EDT. Check local listings for coverage on FOX.

Learn more about College Football betting with our handy tutorial and guide. We explain spread, total and money line bets.

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Matchup Stats
Paddy O'Parlay
Best Odds
Interactive Odds Example
Prop Bets
Recent Meetings
Team Standings
Futures Odds
Team Pages
Team Schedules & Results
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Key Matchup Stats

We're now well into the 2025 college football season. Week 4 action features a matchup between Michigan State and USC taking place at Los Angeles Memorial Coliseum. The following are some key season stats to help you size up this game.

SportsBetting3.com Power Rankings - Michigan State has a 96.33 conference power ranking for the 2025 season. The conference power ranking for USC is 99.00.
Away Michigan State - Heading into Week 4, Michigan State currently has a 0-0 record as an away team for the 2025 regular season. This ranks them 2nd in the Big Ten Conference for away team wins. Watch this stat carefully as the season progresses.
Home USC - USC has a 2-0 record as a home team. Looking ahead to this 2025 Week 4 matchup, they rank 2nd in the Big Ten Conference for home team wins. Like the Michigan State away record and ranking, you should continually keep tabs on this stat.
Points Scored - For the 2025 season, Michigan State ranks 11th (106) in the Big Ten Conference, with USC currently ranking 1st (165) for points scored in the Big Ten Conference.
Points Against - Also in 2025, Michigan State stands 2nd (70) in the Big Ten Conference for points scored by opponents in 2025. USC sits at 5th (50) in the Big Ten Conference for points against in the 2025 season so far.
Team Records - Michigan State has a 3-0 overall record for the 2025 regular season, with USC currently 3-0 for the 2025 NCAAF regular season.

Paddy O'Parlay

The "Sports Network" talking heads have nothing on my Irish arse!

Top o' the mornin' to ya! Michigan State faces USC in a fierce battle on Saturday!

This pivotal Week 4 matchup will be held at the historic Los Angeles Memorial Coliseum.

According to SportsBetting3.com Power Rankings, USC has a slight advantage over Michigan State.

Both teams are undefeated with Michigan State at 3-0 and USC at 3-0.

Bet this game at BetRivers, or BetMGM and be sure to review this game's prop bets. Compare the odds below!

Best Spartans at Trojans Odds

**Best Point Spread Betting Odds**
Underdog Michigan State	Favorite USC
+19.5 -110 BetMGM Bet	-19.5 -110 BetMGM Bet

USC has a -19.5 -110 point spread at BetMGM OH. They are the point spread favorite in this matchup. Michigan State has a +19.5 -110 point spread at BetMGM OH. Michigan State is the point spread underdog. Review how to bet on a point spread with our text and video tutorials.

**Best Total Betting Odds**
Over	Under
55.5 o -105 BetMGM Bet	55.5 u -115 BetMGM Bet

BetMGM has the best over line of 55.5 points. Risk $105 to win $100. BetMGM has the best under line of 55.5 points. Risk $115 to win $100. Our tutorial explains more about total bets.

**Best Moneyline Betting Odds**
Underdog Michigan State	Favorite USC
+625 BetMGM Bet	-1000 BetMGM Bet

USC is the -1000 moneyline favorite. Risk $1,000 to win $100 on USC at BetMGM. Michigan State is the +625 underdog at BetMGM. Risk $100 to win $625 on Michigan State. Learn more about how to bet on money lines.

Matchup Odds FAQs

What is the point spread for the Michigan State vs USC College Football game on Saturday, September 20th, 2025?

USC is a -19.5 -110 point spread favorite at BetMGM, while Michigan State is a +19.5 -110 point spread underdog at BetMGM.

What is the over-under total line for the Michigan State vs USC College Football game on Saturday, September 20th, 2025?

The best over line is 55.5 -105 points at BetMGM, which means you risk $105 to win $100 betting the over. The best under line is 55.5 -115 points at BetMGM, and that means you risk $115 to win $100 betting the under.

What is the moneyline for the Michigan State vs USC College Football game on Saturday, September 20th, 2025?

USC is a -1000 moneyline favorite at BetMGM and Michigan State is a +625 moneyline underdog at BetMGM.

College Football Odds Example

College Football Odds and Outcomes Explained
Game	BetMGM Bet
Michigan State USC 9/20/25 11:00pm EDT	+19.5 -110 -19.5 -110

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Underdog Michigan State - Michigan State bettors risk $100 to win $90.91 at -110 odds.

A +19.5 Michigan State underdog bet wins if they lose by 19 or fewer, tie, or win outright. Your bet loses if they lose by 20 or more.

Favorite USC - USC bettors risk $100 to win $90.91 at -110 odds.

A -19.5 USC favorite bet wins if they win by 20 or more. Your bet loses if they win by 19 or fewer, tie, or lose outright.

Michigan State at USC Prop Bets

Important Note: Some states expressly forbid individual college athlete prop bets. The following wagers may not be available depending on your particular state laws.

College Football Prop Bets
+ Displays more odds
	BetMGM Bet
Michigan State USC No Touchdown To Score 1st Touchdown 9/20/25 11:00pm EDT	+250 -425 +10000 Bet
Michigan State USC Game to Overtime 9/20/25 11:00pm EDT	Yes +1800 No -10000 Bet
Michigan State USC Both Teams Score 10+ 9/20/25 11:00pm EDT	Yes -525 No +360 Bet
Michigan State USC Both Teams Score 20+ 9/20/25 11:00pm EDT	Yes +118 No -150 Bet
	BetMGM
Michigan State USC Both Teams Score 30+ 9/20/25 11:00pm EDT	Yes +625 No -1200 Bet

Recent Meetings Since 2021

Recent Meetings Since 2021
Week	Game	Result	Margin
2025 Week 4	Michigan State vs USC Saturday, September 20th, 2025	USC 45, MSU 31 Los Angeles Memorial Coliseum	USC by 14

Team Standings

2025-2026 College Football Regular Season Standings - Michigan State, USC
Team	Conf	Conf%	W	L	PF	PA	Home	Away	Strk
#23 USC	3-1	0.750	5	2	297	162	4-0	1-2	L1
Michigan State	0-5	0.000	3	5	210	260	3-2	0-3	L5

Michigan State & USC Futures Odds

Latest NCAA Championship odds, if available, for each team. Review odds for other teams and learn the best College Football bets.

Michigan State Championship Odds

No NCAA College Football Championship TM Michigan State YR: futures available

USC Championship Odds

2025-26 USC NCAA College Football Championship Odds
Team	BetMGM
USC	+10000 Bet

Michigan State & USC Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Schedules & Results

2025-26 Michigan State Games & Results
Week	Matchup	Date & Result
Week 1	Western Michigan vs Michigan State	MSU 23, WMU 6 Friday, August 29th, 2025
Week 2	Boston College vs Michigan State	MSU 42, BC 40 (2OT) Saturday, September 6th, 2025
Week 3	Youngstown State vs Michigan State	MSU 41, YSU 24 Saturday, September 13th, 2025
Week 4	Michigan State vs USC	USC 45, MSU 31 Saturday, September 20th, 2025
Week 6	Michigan State vs Nebraska	NEB 38, MSU 27 Saturday, October 4th, 2025
Week 7	UCLA vs Michigan State	UCLA 38, MSU 13 Saturday, October 11th, 2025
Week 8	Michigan State vs Indiana	IU 38, MSU 13 Saturday, October 18th, 2025
Week 9	Michigan vs Michigan State	Saturday, October 25th, 2025 7:30 pm EDT
Week 10	Michigan State vs Minnesota	Saturday, November 1st, 2025 3:30 pm EDT
Week 12	Penn State vs Michigan State	Saturday, November 15th, 2025 12:00 am EST
Week 13	Michigan State vs Iowa	Saturday, November 22nd, 2025 12:00 am EST
Week 14	Maryland vs Michigan State	Saturday, November 29th, 2025 12:00 am EST

2025-26 USC Games & Results
Week	Matchup	Date & Result
Week 1	Missouri State vs USC	USC 73, MOST 13 Saturday, August 30th, 2025
Week 2	Georgia Southern vs USC	USC 59, GASO 20 Saturday, September 6th, 2025
Week 3	USC vs Purdue	USC 33, PUR 17 Saturday, September 13th, 2025
Week 4	Michigan State vs USC	USC 45, MSU 31 Saturday, September 20th, 2025
Week 5	USC vs Illinois	ILL 34, USC 32 Saturday, September 27th, 2025
Week 7	Michigan vs USC	USC 31, MICH 13 Saturday, October 11th, 2025
Week 8	USC vs Notre Dame	ND 34, USC 24 Saturday, October 18th, 2025
Week 10	USC vs Nebraska	Saturday, November 1st, 2025 7:30 pm EDT
Week 11	Northwestern vs USC	Friday, November 7th, 2025 9:00 pm EST
Week 12	Iowa vs USC	Saturday, November 15th, 2025 12:00 am EST
Week 13	USC vs Oregon	Saturday, November 22nd, 2025 12:00 am EST
Week 14	UCLA vs USC	Saturday, November 29th, 2025 12:00 am EST

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Michigan State vs USC College Football Game

Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Saturday, September 20th, 2025 at 11:00 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
Tap to the sportsbook's College Football page, look for the Michigan State vs USC Game.
Navigate to the sportsbook's College Football page. Next, look for live or upcoming matchups. Select the Michigan State vs USC Game.
Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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