The Orange will play the Tigers on Saturday, September 20th, 2025. The matchup takes place at Memorial Stadium (Clemson, SC). Watch this exciting Week 4 matchup at 12:00 pm EDT. Check local listings for coverage on ESPN.
Learn more about College Football betting with our handy tutorial and guide. We explain spread, total and money line bets.
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Table of Contents
- Matchup Stats
- Paddy O'Parlay
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Team Schedules & Results
- Other Games Today
Key Matchup Stats
We're now well into the 2025 college football season. Week 4 action features a matchup between Syracuse and Clemson taking place at Memorial Stadium (Clemson, SC). The following are some key season stats to help you size up this game.
- SportsBetting3.com Power Rankings - Syracuse has a 96.33 conference power ranking for the 2025 season. The conference power ranking for Clemson is 94.00.
- Away Syracuse - Heading into Week 4, Syracuse currently has a 0-0 record as an away team for the 2025 regular season. This ranks them 2nd in the ACC Conference for away team wins. Watch this stat carefully as the season progresses.
- Home Clemson - Clemson has a 1-1 record as a home team. Looking ahead to this 2025 Week 4 matchup, they rank 3rd in the ACC Conference for home team wins. Like the Syracuse away record and ranking, you should continually keep tabs on this stat.
- Points Scored - For the 2025 season, Syracuse ranks 5th (119) in the ACC Conference, with Clemson currently ranking 15th (58) for points scored in the ACC Conference.
- Points Against - Also in 2025, Syracuse stands 3rd (89) in the ACC Conference for points scored by opponents in 2025. Clemson sits at 9th (57) in the ACC Conference for points against in the 2025 season so far.
- Team Records - Syracuse has a 2-1 overall record for the 2025 regular season, with Clemson currently 1-2 for the 2025 NCAAF regular season.
Paddy O'Parlay
The "Sports Network" talking heads have nothing on my Irish arse!
Get ready for a wild showdown as Syracuse battles Clemson in a crucial Week 4 matchup!
The game will be held at Memorial Stadium in Clemson, SC, adding to the intense atmosphere.
Syracuse holds a slight edge in the Power Rankings with a rating of 96.33.
Clemson is looking to bounce back with a 1-2 record, while Syracuse sits at 2-1. Bet this game at BetRivers, or BetMGM and review this game's prop bets. Compare the odds below for an exciting betting experience!
Best Orange at Tigers Odds
| Underdog Syracuse | Favorite Clemson |
|---|---|
| Over | Under |
|---|---|
| Underdog Syracuse | Favorite Clemson |
|---|---|
Matchup Odds FAQs
Clemson is a -17.5 -105 point spread favorite at BetMGM, while Syracuse is a +17.5 -115 point spread underdog at BetMGM.
The best over line is 55.5 -110 points at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 55.5 -110 points at BetMGM, and that means you risk $110 to win $100 betting the under.
Clemson is a -800 moneyline favorite at BetMGM and Syracuse is a +550 moneyline underdog at BetMGM.
College Football Odds Example
|
Game |
 BetMGMBet |
|---|---|
Syracuse
Clemson
9/20/25 12:00pm EDT | +17.5 -115-17.5 -105 |
Underdog Syracuse - Syracuse bettors risk $100 to win $86.96 at -115 odds.
A +17.5 Syracuse underdog bet wins if they lose by 17 or fewer, tie, or win outright. Your bet loses if they lose by 18 or more.
Favorite Clemson - Clemson bettors risk $100 to win $95.24 at -105 odds.
A -17.5 Clemson favorite bet wins if they win by 18 or more. Your bet loses if they win by 17 or fewer, tie, or lose outright.
Syracuse at Clemson Prop Bets
Important Note: Some states expressly forbid individual college athlete prop bets. The following wagers may not be available depending on your particular state laws.
| BetMGM Bet |
|
|---|---|
Syracuse
Clemson
No Touchdown
To Score 1st Touchdown
9/20/25 12:00pm EDT | +240-400+10000Bet |
Syracuse
Clemson
Game to Overtime
9/20/25 12:00pm EDT | Yes +1650No -10000Bet |
Syracuse
Clemson
Both Teams Score 10+
9/20/25 12:00pm EDT | Yes -650No +425Bet |
Syracuse
Clemson
Both Teams Score 20+
9/20/25 12:00pm EDT | Yes +100No -125Bet |
| BetMGM | |
Syracuse
Clemson
Both Teams Score 30+
9/20/25 12:00pm EDT | Yes +525No -900Bet |
Recent Meetings Since 2021
| Week | Game | Result | Margin |
|---|---|---|---|
| 2023 Week 5 | Clemson vs Syracuse Saturday, September 30th, 2023 | CLEM 31, SYR 14 JMA Wireless Dome | Clemson by 17 |
| 2022 Week 8 | Syracuse vs Clemson Saturday, October 22nd, 2022 | CLEM 27, SYR 21 Memorial Stadium (Clemson, SC) | Clemson by 6 |
| 2021 Week 7 | Clemson vs Syracuse Friday, October 15th, 2021 | CLEM 17, SYR 14 JMA Wireless Dome | Clemson by 3 |
Team Standings
| Team | Conf | Conf% | W | L | PF | PA | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|---|
| Clemson | 0-1 | 0.000 | 1 | 2 | 58 | 57 | 1-1 | 0-1 | L1 |
| Syracuse | 0-0 | 0.000 | 2 | 1 | 119 | 89 | 2-0 | 0-0 | W2 |
Syracuse & Clemson Futures Odds
Latest NCAA Championship odds, if available, for each team. Review odds for other teams and learn the best College Football bets.
Syracuse Championship Odds|
Team | BetMGM |
|---|---|
| Syracuse |
|
Team | BetMGM |
|---|---|
| Clemson | +5000 Bet |
Syracuse & Clemson Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
Team Schedules & Results
| Week | Matchup | Date & Result |
|---|---|---|
| Week 1 | Syracuse vs Tennessee | TENN 45, SYR 26 Saturday, August 30th, 2025 |
| Week 2 | UConn vs Syracuse | SYR 27, CONN 20 (OT) Saturday, September 6th, 2025 |
| Week 3 | Colgate vs Syracuse | SYR 66, COLG 24 Friday, September 12th, 2025 |
| Week 4 | Syracuse vs Clemson | Saturday, September 20th, 2025 12:00 pm EDT |
| Week 5 | Duke vs Syracuse | Saturday, September 27th, 2025 12:00 pm EDT |
| Week 6 | Syracuse vs SMU | Saturday, October 4th, 2025 12:00 am EDT |
| Week 8 | Pittsburgh vs Syracuse | Saturday, October 18th, 2025 12:00 am EDT |
| Week 9 | Syracuse vs Georgia Tech | Saturday, October 25th, 2025 12:00 am EDT |
| Week 10 | North Carolina vs Syracuse | Friday, October 31st, 2025 7:30 pm EDT |
| Week 11 | Syracuse vs Miami (FL) | Saturday, November 8th, 2025 12:00 am EST |
| Week 13 | Syracuse vs Notre Dame | Saturday, November 22nd, 2025 3:30 pm EST |
| Week 14 | Boston College vs Syracuse | Saturday, November 29th, 2025 12:00 am EST |
| Week | Matchup | Date & Result |
|---|---|---|
| Week 1 | LSU vs Clemson | LSU 17, CLEM 10 Saturday, August 30th, 2025 |
| Week 2 | Troy vs Clemson | CLEM 27, TROY 16 Saturday, September 6th, 2025 |
| Week 3 | Clemson vs Georgia Tech | GT 24, CLEM 21 Saturday, September 13th, 2025 |
| Week 4 | Syracuse vs Clemson | Saturday, September 20th, 2025 12:00 pm EDT |
| Week 6 | Clemson vs North Carolina | Saturday, October 4th, 2025 12:00 am EDT |
| Week 7 | Clemson vs Boston College | Saturday, October 11th, 2025 12:00 am EDT |
| Week 8 | SMU vs Clemson | Saturday, October 18th, 2025 12:00 am EDT |
| Week 10 | Duke vs Clemson | Saturday, November 1st, 2025 12:00 am EDT |
| Week 11 | Florida State vs Clemson | Saturday, November 8th, 2025 12:00 am EST |
| Week 12 | Clemson vs Louisville | Friday, November 14th, 2025 7:30 pm EST |
| Week 13 | Furman vs Clemson | Saturday, November 22nd, 2025 12:00 am EST |
| Week 14 | Clemson vs South Carolina | Saturday, November 29th, 2025 12:00 pm EST |
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Syracuse vs Clemson College Football Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Saturday, September 20th, 2025 at 12:00 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's College Football page, look for the Syracuse vs Clemson Game.
Navigate to the sportsbook's College Football page. Next, look for live or upcoming matchups. Select the Syracuse vs Clemson Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other September 20, 2025 NCAAFB Games
- SMU vs TCU - 9/20/25 12:00pm EDT
- Maryland vs Wisconsin - 9/20/25 12:00pm EDT
- UNLV vs Miami (OH) - 9/20/25 12:00pm EDT
- Arkansas vs Memphis - 9/20/25 12:00pm EDT
- Bowling Green vs Louisville - 9/20/25 12:00pm EDT
- North Texas vs Army - 9/20/25 12:00pm EDT
- Texas Tech vs Utah - 9/20/25 12:00pm EDT
- UAB vs Tennessee - 9/20/25 12:45pm EDT
- Oregon State vs Oregon - 9/20/25 3:00pm EDT
- Louisiana vs Eastern Michigan - 9/20/25 3:30pm EDT
- James Madison vs Liberty - 9/20/25 3:30pm EDT
- Ball State vs UConn - 9/20/25 3:30pm EDT
- Toledo vs Western Michigan - 9/20/25 3:30pm EDT
- Kent State vs Florida State - 9/20/25 3:30pm EDT
- Troy vs Buffalo - 9/20/25 3:30pm EDT
- Purdue vs Notre Dame - 9/20/25 3:30pm EDT
- Tulane vs Ole Miss - 9/20/25 3:30pm EDT
- Auburn vs Oklahoma - 9/20/25 3:30pm EDT
- Michigan vs Nebraska - 9/20/25 3:30pm EDT
- North Carolina vs UCF - 9/20/25 3:30pm EDT
- NC State vs Duke - 9/20/25 4:00pm EDT
- Northern Illinois vs Mississippi State - 9/20/25 4:15pm EDT
- Temple vs Georgia Tech - 9/20/25 4:30pm EDT
- Delaware vs FIU - 9/20/25 6:00pm EDT
- West Virginia vs Kansas - 9/20/25 6:00pm EDT
- Marshall vs Middle Tennessee - 9/20/25 7:00pm EDT
- Nevada vs Western Kentucky - 9/20/25 7:00pm EDT
- Boise State vs Air Force - 9/20/25 7:00pm EDT
- Arkansas State vs Kennesaw State - 9/20/25 7:00pm EDT
- Coastal Carolina vs South Alabama - 9/20/25 7:00pm EDT
- South Carolina vs Missouri - 9/20/25 7:00pm EDT
- Illinois vs Indiana - 9/20/25 7:30pm EDT
- Sam Houston State vs Texas - 9/20/25 7:30pm EDT
- Washington vs Washington State - 9/20/25 7:30pm EDT
- Stanford vs Virginia - 9/20/25 7:30pm EDT
- Southern Miss vs Louisiana Tech - 9/20/25 7:30pm EDT
- Georgia State vs Vanderbilt - 9/20/25 7:30pm EDT
- BYU vs East Carolina - 9/20/25 7:30pm EDT
- Florida vs Miami (FL) - 9/20/25 7:30pm EDT
- Arizona State vs Baylor - 9/20/25 7:30pm EDT
- Louisiana-Monroe vs UTEP - 9/20/25 9:00pm EDT
- UTSA vs Colorado State - 9/20/25 9:30pm EDT
- Wyoming vs Colorado - 9/20/25 10:15pm EDT
- California vs San Diego State - 9/20/25 10:30pm EDT
- Michigan State vs USC - 9/20/25 11:00pm EDT