Syracuse vs Clemson Football Odds

The Orange will play the Tigers on Saturday, September 20th, 2025. The matchup takes place at Memorial Stadium (Clemson, SC). Watch this exciting Week 4 matchup at 12:00 pm EDT. Check local listings for coverage on ESPN.

Learn more about College Football betting with our handy tutorial and guide. We explain spread, total and money line bets.

STATE	Bonus
#1 BetMGM REVIEW	New Customers - Up to $1500 Paid Back in Bonus Bets Bonus Bets Expire in 7 Days One new customer offer/Add'l Terms Bet Now 21+ Playable in Ohio only Gambling Problem? Call 1-800-589-9966

Matchup Stats
Paddy O'Parlay
Best Odds
Interactive Odds Example
Prop Bets
Recent Meetings
Team Standings
Futures Odds
Team Pages
Team Schedules & Results
Other Games Today

Key Matchup Stats

We're now well into the 2025 college football season. Week 4 action features a matchup between Syracuse and Clemson taking place at Memorial Stadium (Clemson, SC). The following are some key season stats to help you size up this game.

SportsBetting3.com Power Rankings - Syracuse has a 96.33 conference power ranking for the 2025 season. The conference power ranking for Clemson is 94.00.
Away Syracuse - Heading into Week 4, Syracuse currently has a 0-0 record as an away team for the 2025 regular season. This ranks them 2nd in the ACC Conference for away team wins. Watch this stat carefully as the season progresses.
Home Clemson - Clemson has a 1-1 record as a home team. Looking ahead to this 2025 Week 4 matchup, they rank 3rd in the ACC Conference for home team wins. Like the Syracuse away record and ranking, you should continually keep tabs on this stat.
Points Scored - For the 2025 season, Syracuse ranks 5th (119) in the ACC Conference, with Clemson currently ranking 15th (58) for points scored in the ACC Conference.
Points Against - Also in 2025, Syracuse stands 3rd (89) in the ACC Conference for points scored by opponents in 2025. Clemson sits at 9th (57) in the ACC Conference for points against in the 2025 season so far.
Team Records - Syracuse has a 2-1 overall record for the 2025 regular season, with Clemson currently 1-2 for the 2025 NCAAF regular season.

Paddy O'Parlay

The "Sports Network" talking heads have nothing on my Irish arse!

Get ready for a wild showdown as Syracuse battles Clemson in a crucial Week 4 matchup!

The game will be held at Memorial Stadium in Clemson, SC, adding to the intense atmosphere.

Syracuse holds a slight edge in the Power Rankings with a rating of 96.33.

Clemson is looking to bounce back with a 1-2 record, while Syracuse sits at 2-1. Bet this game at BetRivers, or BetMGM and review this game's prop bets. Compare the odds below for an exciting betting experience!

Best Orange at Tigers Odds

**Best Point Spread Betting Odds**
Underdog Syracuse	Favorite Clemson
+17 -110 BetMGM Bet	-17 -110 BetMGM Bet

Clemson has a -17 -110 point spread at BetMGM OH. They are the point spread favorite in this matchup. Syracuse has a +17 -110 point spread at BetMGM OH. Syracuse is the point spread underdog. Review how to bet on a point spread with our text and video tutorials.

**Best Total Betting Odds**
Over	Under
54.5 o -110 BetMGM Bet	54.5 u -110 BetMGM Bet

BetMGM has the best over line of 54.5 points. Risk $110 to win $100. BetMGM has the best under line of 54.5 points. Risk $110 to win $100. Our tutorial explains more about total bets.

**Best Moneyline Betting Odds**
Underdog Syracuse	Favorite Clemson
+600 BetMGM Bet	-900 BetMGM Bet

Clemson is the -900 moneyline favorite. Risk $900 to win $100 on Clemson at BetMGM. Syracuse is the +600 underdog at BetMGM. Risk $100 to win $600 on Syracuse. Learn more about how to bet on money lines.

Matchup Odds FAQs

What is the point spread for the Syracuse vs Clemson College Football game on Saturday, September 20th, 2025?

Clemson is a -17 -110 point spread favorite at BetMGM, while Syracuse is a +17 -110 point spread underdog at BetMGM.

What is the over-under total line for the Syracuse vs Clemson College Football game on Saturday, September 20th, 2025?

The best over line is 54.5 -110 points at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 54.5 -110 points at BetMGM, and that means you risk $110 to win $100 betting the under.

What is the moneyline for the Syracuse vs Clemson College Football game on Saturday, September 20th, 2025?

Clemson is a -900 moneyline favorite at BetMGM and Syracuse is a +600 moneyline underdog at BetMGM.

College Football Odds Example

College Football Odds and Outcomes Explained
Game	BetMGM Bet
Syracuse Clemson 9/20/25 12:00pm EDT	+17 -110 -17 -110

Bet $100 at BetMGM Ohio
21+ Playable in Ohio only
Gambling Problem? Call 1-800-589-9966

Underdog Syracuse - Syracuse bettors risk $100 to win $90.91 at -110 odds.

A +17 Syracuse underdog bet wins if they lose by 16 or fewer, tie, or win outright. The bet pushes if they lose by 17. Your bet loses if they lose by 18 or more.

Favorite Clemson - Clemson bettors risk $100 to win $90.91 at -110 odds.

A -17 Clemson favorite bet wins if they win by 18 or more. The bet pushes if they win by 17. Your bet loses if they win by 16 or fewer, tie, or lose outright.

Syracuse at Clemson Prop Bets

Important Note: Some states expressly forbid individual college athlete prop bets. The following wagers may not be available depending on your particular state laws.

College Football Prop Bets
+ Displays more odds
	BetMGM Bet
Syracuse Clemson No Touchdown To Score 1st Touchdown 9/20/25 12:00pm EDT	+240 -375 +10000 Bet
Syracuse Clemson Game to Overtime 9/20/25 12:00pm EDT	Yes +1650 No -10000 Bet
Syracuse Clemson Both Teams Score 10+ 9/20/25 12:00pm EDT	Yes -625 No +400 Bet
Syracuse Clemson Both Teams Score 20+ 9/20/25 12:00pm EDT	Yes +110 No -140 Bet
	BetMGM
Syracuse Clemson Both Teams Score 30+ 9/20/25 12:00pm EDT	Yes +600 No -1100 Bet

Recent Meetings Since 2021

Recent Meetings Since 2021
Week	Game	Result	Margin
2025 Week 4	Syracuse vs Clemson Saturday, September 20th, 2025	SYR 34, CLEM 21 Memorial Stadium (Clemson, SC)	Syracuse by 13
2023 Week 5	Clemson vs Syracuse Saturday, September 30th, 2023	CLEM 31, SYR 14 JMA Wireless Dome	Clemson by 17
2022 Week 8	Syracuse vs Clemson Saturday, October 22nd, 2022	CLEM 27, SYR 21 Memorial Stadium (Clemson, SC)	Clemson by 6
2021 Week 7	Clemson vs Syracuse Friday, October 15th, 2021	CLEM 17, SYR 14 JMA Wireless Dome	Clemson by 3

Team Standings

2025-2026 College Football Regular Season Standings - Syracuse, Clemson
Team	Conf	Conf%	W	L	PF	PA	Home	Away	Strk
Clemson	2-3	0.400	3	4	182	146	1-3	2-1	L1
Syracuse	1-3	0.250	3	4	187	209	2-2	1-1	L3

Syracuse & Clemson Futures Odds

Latest NCAA Championship odds, if available, for each team. Review odds for other teams and learn the best College Football bets.

Syracuse Championship Odds

No NCAA College Football Championship TM Syracuse YR: futures available

Clemson Championship Odds

2025-26 Clemson NCAA College Football Championship Odds
Team	BetMGM
Clemson	+50000 Bet

Syracuse & Clemson Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Schedules & Results

2025-26 Syracuse Games & Results
Week	Matchup	Date & Result
Week 1	Syracuse vs Tennessee	TENN 45, SYR 26 Saturday, August 30th, 2025
Week 2	UConn vs Syracuse	SYR 27, CONN 20 (OT) Saturday, September 6th, 2025
Week 3	Colgate vs Syracuse	SYR 66, COLG 24 Friday, September 12th, 2025
Week 4	Syracuse vs Clemson	SYR 34, CLEM 21 Saturday, September 20th, 2025
Week 5	Duke vs Syracuse	DUKE 38, SYR 3 Saturday, September 27th, 2025
Week 6	Syracuse vs SMU	SMU 31, SYR 18 Saturday, October 4th, 2025
Week 8	Pittsburgh vs Syracuse	PITT 30, SYR 13 Saturday, October 18th, 2025
Week 9	Syracuse vs Georgia Tech	Saturday, October 25th, 2025 12:00 pm EDT
Week 10	North Carolina vs Syracuse	Friday, October 31st, 2025 7:30 pm EDT
Week 11	Syracuse vs Miami (FL)	Saturday, November 8th, 2025 12:00 am EST
Week 13	Syracuse vs Notre Dame	Saturday, November 22nd, 2025 3:30 pm EST
Week 14	Boston College vs Syracuse	Saturday, November 29th, 2025 12:00 am EST

2025-26 Clemson Games & Results
Week	Matchup	Date & Result
Week 1	LSU vs Clemson	LSU 17, CLEM 10 Saturday, August 30th, 2025
Week 2	Troy vs Clemson	CLEM 27, TROY 16 Saturday, September 6th, 2025
Week 3	Clemson vs Georgia Tech	GT 24, CLEM 21 Saturday, September 13th, 2025
Week 4	Syracuse vs Clemson	SYR 34, CLEM 21 Saturday, September 20th, 2025
Week 6	Clemson vs North Carolina	CLEM 38, UNC 10 Saturday, October 4th, 2025
Week 7	Clemson vs Boston College	CLEM 41, BC 10 Saturday, October 11th, 2025
Week 8	SMU vs Clemson	SMU 35, CLEM 24 Saturday, October 18th, 2025
Week 10	Duke vs Clemson	Saturday, November 1st, 2025 12:00 pm EDT
Week 11	Florida State vs Clemson	Saturday, November 8th, 2025 12:00 am EST
Week 12	Clemson vs Louisville	Friday, November 14th, 2025 7:30 pm EST
Week 13	Furman vs Clemson	Saturday, November 22nd, 2025 12:00 am EST
Week 14	Clemson vs South Carolina	Saturday, November 29th, 2025 12:00 pm EST

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Syracuse vs Clemson College Football Game

Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Saturday, September 20th, 2025 at 12:00 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
Tap to the sportsbook's College Football page, look for the Syracuse vs Clemson Game.
Navigate to the sportsbook's College Football page. Next, look for live or upcoming matchups. Select the Syracuse vs Clemson Game.
Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

Other September 20, 2025 NCAAFB Games

Odds Preview 6750

Table of Contents