The Gamecocks will play the Tigers on Saturday, September 20th, 2025. The matchup takes place at Memorial Stadium. Watch this exciting Week 4 matchup at 7:00 pm EDT. Check local listings for coverage on ESPN.
Learn more about College Football betting with our handy tutorial and guide. We explain spread, total and money line bets.
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Table of Contents
- Matchup Stats
- Paddy O'Parlay
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Team Schedules & Results
- Other Games Today
Key Matchup Stats
We're now well into the 2025 college football season. Week 4 action features a matchup between South Carolina and Missouri taking place at Memorial Stadium. The following are some key season stats to help you size up this game.
- SportsBetting3.com Power Rankings - South Carolina has a 94.33 conference power ranking for the 2025 season. The conference power ranking for Missouri is 100.00.
- Away South Carolina - Heading into Week 4, South Carolina currently has a 0-0 record as an away team for the 2025 regular season. This ranks them 3rd in the SEC Conference for away team wins. Watch this stat carefully as the season progresses.
- Home Missouri - Missouri has a 3-0 record as a home team. Looking ahead to this 2025 Week 4 matchup, they rank 1st in the SEC Conference for home team wins. Like the South Carolina away record and ranking, you should continually keep tabs on this stat.
- Points Scored - For the 2025 season, South Carolina ranks 15th (69) in the SEC Conference, with Missouri currently ranking 2nd (155) for points scored in the SEC Conference.
- Points Against - Also in 2025, South Carolina stands 7th (52) in the SEC Conference for points scored by opponents in 2025. Missouri sits at 8th (47) in the SEC Conference for points against in the 2025 season so far.
- Team Records - South Carolina has a 2-1 overall record for the 2025 regular season, with Missouri currently 3-0 for the 2025 NCAAF regular season.
Paddy O'Parlay
The "Sports Network" talking heads have nothing on my Irish arse!
Top o' the mornin' to ya, college football fans! It's gonna be a wild one when South Carolina faces off against Missouri in this Week 4 showdown. Grab yer lucky charms and get ready for some gridiron shenanigans!
This epic battle will take place at Memorial Stadium, where the Missouri faithful will be out in full force. The atmosphere is sure to be electric as these two teams clash on the field.
According to SportsBetting3.com Power Rankings, Missouri has the edge with a rating of 100.00 compared to South Carolina's 94.33. It's sure to be a close contest between these two powerhouse programs.
South Carolina comes into this game with a 2-1 record, while Missouri boasts a perfect 3-0 standing. Both teams will be looking to secure a key victory in this crucial matchup.
Don't miss out on the action - bet this game at BetRivers, or BetMGM and be sure to review this game's prop bets. Compare the odds below and get ready for a thrilling game of college football!
Best Gamecocks at Tigers Odds
| Underdog South Carolina | Favorite Missouri |
|---|---|
| Over | Under |
|---|---|
| Underdog South Carolina | Favorite Missouri |
|---|---|
Matchup Odds FAQs
Missouri is a -10 -110 point spread favorite at BetMGM, while South Carolina is a +10 -110 point spread underdog at BetMGM.
The best over line is 48.5 -110 points at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 48.5 -110 points at BetMGM, and that means you risk $110 to win $100 betting the under.
Missouri is a -350 moneyline favorite at BetMGM and South Carolina is a +270 moneyline underdog at BetMGM.
College Football Odds Example
|
Game |
 BetMGMBet |
|---|---|
South Carolina
Missouri
9/20/25 7:00pm EDT | +10 -110-10 -110 |
Underdog South Carolina - South Carolina bettors risk $100 to win $90.91 at -110 odds.
A +10 South Carolina underdog bet wins if they lose by 9 or fewer, tie, or win outright. The bet pushes if they lose by 10. Your bet loses if they lose by 11 or more.
Favorite Missouri - Missouri bettors risk $100 to win $90.91 at -110 odds.
A -10 Missouri favorite bet wins if they win by 11 or more. The bet pushes if they win by 10. Your bet loses if they win by 9 or fewer, tie, or lose outright.
South Carolina at Missouri Prop Bets
Important Note: Some states expressly forbid individual college athlete prop bets. The following wagers may not be available depending on your particular state laws.
| BetMGM Bet |
|
|---|---|
South Carolina
Missouri
No Touchdown
To Score 1st Touchdown
9/20/25 7:00pm EDT | +160-235+10000Bet |
South Carolina
Missouri
Game to Overtime
9/20/25 7:00pm EDT | Yes +1300No -10000Bet |
South Carolina
Missouri
Both Teams Score 10+
9/20/25 7:00pm EDT | Yes -550No +375Bet |
South Carolina
Missouri
Both Teams Score 20+
9/20/25 7:00pm EDT | Yes +120No -155Bet |
| BetMGM | |
South Carolina
Missouri
Both Teams Score 30+
9/20/25 7:00pm EDT | Yes +700No -1400Bet |
Recent Meetings Since 2021
| Week | Game | Result | Margin |
|---|---|---|---|
| 2025 Week 4 | South Carolina vs Missouri Saturday, September 20th, 2025 | MIZ 29, SC 20 Memorial Stadium | Missouri by 9 |
| 2024 Week 12 | Missouri vs South Carolina Saturday, November 16th, 2024 | SC 34, MIZ 30 Williams-Brice Stadium | South Carolina by 4 |
| 2023 Week 8 | South Carolina vs Missouri Saturday, October 21st, 2023 | MIZ 34, SC 12 Memorial Stadium/Faurot Field | Missouri by 22 |
| 2022 Week 9 | Missouri vs South Carolina Saturday, October 29th, 2022 | MIZ 23, SC 10 Williams-Brice Stadium | Missouri by 13 |
| 2021 Week 11 | South Carolina vs Missouri Saturday, November 13th, 2021 | MIZ 31, SC 28 Memorial Stadium/Faurot Field | Missouri by 3 |
Team Standings
| Team | Conf | Conf% | W | L | PF | PA | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|---|
| #14 Missouri | 1-1 | 0.500 | 5 | 1 | 250 | 100 | 5-1 | 0-0 | L1 |
| South Carolina | 1-3 | 0.250 | 3 | 3 | 134 | 114 | 2-1 | 0-2 | L1 |
South Carolina & Missouri Futures Odds
Latest NCAA Championship odds, if available, for each team. Review odds for other teams and learn the best College Football bets.
South Carolina Championship Odds|
Team | BetMGM |
|---|---|
| South Carolina | +50000 Bet |
|
Team | BetMGM |
|---|---|
| Missouri | +4000 Bet |
South Carolina & Missouri Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
Team Schedules & Results
| Week | Matchup | Date & Result |
|---|---|---|
| Week 1 | Virginia Tech vs South Carolina | SC 24, VT 11 Sunday, August 31st, 2025 |
| Week 2 | South Carolina State vs South Carolina | SC 38, SCST 10 Saturday, September 6th, 2025 |
| Week 3 | Vanderbilt vs South Carolina | VAN 31, SC 7 Saturday, September 13th, 2025 |
| Week 4 | South Carolina vs Missouri | MIZ 29, SC 20 Saturday, September 20th, 2025 |
| Week 5 | Kentucky vs South Carolina | SC 35, UK 13 Saturday, September 27th, 2025 |
| Week 7 | South Carolina vs LSU | LSU 20, SC 10 Saturday, October 11th, 2025 |
| Week 8 | Oklahoma vs South Carolina | Saturday, October 18th, 2025 12:45 pm EDT |
| Week 9 | Alabama vs South Carolina | Saturday, October 25th, 2025 12:00 am EDT |
| Week 10 | South Carolina vs Ole Miss | Saturday, November 1st, 2025 12:00 am EDT |
| Week 12 | South Carolina vs Texas A&M | Saturday, November 15th, 2025 12:00 am EST |
| Week 13 | Coastal Carolina vs South Carolina | Saturday, November 22nd, 2025 12:00 am EST |
| Week 14 | Clemson vs South Carolina | Saturday, November 29th, 2025 12:00 pm EST |
| Week | Matchup | Date & Result |
|---|---|---|
| Week 1 | Central Arkansas vs Missouri | MIZ 61, CARK 6 Thursday, August 28th, 2025 |
| Week 2 | Kansas vs Missouri | MIZ 42, KU 31 Saturday, September 6th, 2025 |
| Week 3 | Louisiana vs Missouri | MIZ 52, UL 10 Saturday, September 13th, 2025 |
| Week 4 | South Carolina vs Missouri | MIZ 29, SC 20 Saturday, September 20th, 2025 |
| Week 5 | UMass vs Missouri | MIZ 42, MASS 6 Saturday, September 27th, 2025 |
| Week 7 | Alabama vs Missouri | ALA 27, MIZ 24 Saturday, October 11th, 2025 |
| Week 8 | Missouri vs Auburn | Saturday, October 18th, 2025 7:45 pm EDT |
| Week 9 | Missouri vs Vanderbilt | Saturday, October 25th, 2025 12:00 am EDT |
| Week 11 | Texas A&M vs Missouri | Saturday, November 8th, 2025 12:00 am EST |
| Week 12 | Mississippi State vs Missouri | Saturday, November 15th, 2025 12:00 am EST |
| Week 13 | Missouri vs Oklahoma | Saturday, November 22nd, 2025 12:00 pm EST |
| Week 14 | Missouri vs Arkansas | Saturday, November 29th, 2025 12:00 am EST |
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the South Carolina vs Missouri College Football Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Saturday, September 20th, 2025 at 7:00 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's College Football page, look for the South Carolina vs Missouri Game.
Navigate to the sportsbook's College Football page. Next, look for live or upcoming matchups. Select the South Carolina vs Missouri Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other September 20, 2025 NCAAFB Games
- SMU vs TCU
- UNLV vs Miami (OH)
- Syracuse vs Clemson
- Maryland vs Wisconsin
- Arkansas vs Memphis
- Bowling Green vs Louisville
- North Texas vs Army
- Texas Tech vs Utah
- UAB vs Tennessee
- VMI vs Richmond
- Dayton vs Robert Morris
- Mercer vs The Citadel
- Drake vs South Dakota
- Samford vs Western Carolina
- Oregon State vs Oregon
- Mercyhurst vs Montana State
- Indiana State vs Montana
- Toledo vs Western Michigan
- Louisiana vs Eastern Michigan
- Gardner-Webb vs Ohio
- Kent State vs Florida State
- North Carolina vs UCF
- Troy vs Buffalo
- James Madison vs Liberty
- Ball State vs UConn
- Purdue vs Notre Dame
- Tulane vs Ole Miss
- Auburn vs Oklahoma
- Michigan vs Nebraska
- NC State vs Duke
- Northern Illinois vs Mississippi State
- Temple vs Georgia Tech
- Elon vs East Tennessee State
- Bryant vs Campbell
- LIU vs Rhode Island
- Central Connecticut vs Merrimack College
- Duquesne vs Akron
- Eastern Kentucky vs West Georgia
- Youngstown State vs Towson
- Lehigh vs Bucknell
- West Virginia vs Kansas
- Delaware vs FIU
- Arkansas State vs Kennesaw State
- Nevada vs Western Kentucky
- Cornell vs Albany
- Marshall vs Middle Tennessee
- Coastal Carolina vs South Alabama
- Boise State vs Air Force
- Chattanooga vs Tarleton
- East Texas A&M vs Grambling State
- Murray State vs Jacksonville State
- Western Illinois vs Eastern Washington
- UT-Martin vs Missouri State
- Stony Brook vs Lindenwood
- Maine vs Georgia Southern
- Southern Illinois vs Southeast Missouri State
- Northwestern State vs Prairie View A&M
- Northern Colorado vs Houston Christian
- Stanford vs Virginia
- Illinois vs Indiana
- Washington vs Washington State
- Southern Miss vs Louisiana Tech
- BYU vs East Carolina
- Florida vs Miami (FL)
- Arizona State vs Baylor
- Southeastern Louisiana vs LSU
- Sam Houston State vs Texas
- Cal Poly vs Stephen F. Austin
- Butler vs Weber State
- Austin Peay vs Abilene Christian
- Nicholls vs Texas State
- Northern Iowa vs Utah Tech
- Georgia State vs Vanderbilt
- McNeese State vs Utah State
- Louisiana-Monroe vs UTEP
- Central Arkansas vs Sacramento State
- UTSA vs Colorado State
- Southern Utah vs UC Davis
- Wyoming vs Colorado
- California vs San Diego State
- Michigan State vs USC