Southern Illinois vs Southeast Missouri State Football Odds

The Salukis will play the Redhawks on Saturday, September 20th, 2025.

Learn more about College Football betting with our handy tutorial and guide. We explain spread, total and money line bets.

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Best Salukis at Redhawks Odds

**Best Point Spread Betting Odds**
Underdog Southeast Missouri State	Favorite Southern Illinois
+4.5 +100 BetMGM Bet	-4.5 -120 BetMGM Bet

Southern Illinois has a -4.5 -120 point spread at BetMGM OH. They are the point spread favorite in this matchup. Southeast Missouri State has a +4.5 +100 point spread at BetMGM OH. Southeast Missouri State is the point spread underdog. Review how to bet on a point spread with our text and video tutorials.

**Best Total Betting Odds**
Over	Under
54.5 o -110 BetMGM Bet	54.5 u -110 BetMGM Bet

BetMGM has the best over line of 54.5 points. Risk $110 to win $100. BetMGM has the best under line of 54.5 points. Risk $110 to win $100. Our tutorial explains more about total bets.

**Best Moneyline Betting Odds**
Underdog Southeast Missouri State	Favorite Southern Illinois
+165 BetMGM Bet	-200 BetMGM Bet

Southern Illinois is the -200 moneyline favorite. Risk $200 to win $100 on Southern Illinois at BetMGM. Southeast Missouri State is the +165 underdog at BetMGM. Risk $100 to win $165 on Southeast Missouri State. Learn more about how to bet on money lines.

Matchup Odds FAQs

What is the point spread for the Southern Illinois vs Southeast Missouri State College Football game on Saturday, September 20th, 2025?

Southern Illinois is a -4.5 -120 point spread favorite at BetMGM, while Southeast Missouri State is a +4.5 +100 point spread underdog at BetMGM.

What is the over-under total line for the Southern Illinois vs Southeast Missouri State College Football game on Saturday, September 20th, 2025?

The best over line is 54.5 -110 points at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 54.5 -110 points at BetMGM, and that means you risk $110 to win $100 betting the under.

What is the moneyline for the Southern Illinois vs Southeast Missouri State College Football game on Saturday, September 20th, 2025?

Southern Illinois is a -200 moneyline favorite at BetMGM and Southeast Missouri State is a +165 moneyline underdog at BetMGM.

College Football Odds Example

College Football Odds and Outcomes Explained
Game	BetMGM Bet
Southern Illinois Southeast Missouri State 9/20/25 7:00pm EDT	-4.5 -120 +4.5 +100

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Underdog Southeast Missouri State - Southeast Missouri State bettors risk $100 to win $100 at +100 odds.

A +4.5 Southeast Missouri State underdog bet wins if they lose by 4 or fewer, tie, or win outright. Your bet loses if they lose by 5 or more.

Favorite Southern Illinois - Southern Illinois bettors risk $100 to win $83.33 at -120 odds.

A -4.5 Southern Illinois favorite bet wins if they win by 5 or more. Your bet loses if they win by 4 or fewer, tie, or lose outright.

Southern Illinois at Southeast Missouri State Prop Bets

Important Note: Some states expressly forbid individual college athlete prop bets. The following wagers may not be available depending on your particular state laws.

College Football Prop Bets
+ Displays more odds
	BetMGM Bet
Southern Illinois Southeast Missouri State 9/20/25 7:00pm EDT	Pending BetMGM

Recent Meetings Since 2021

Recent Meetings Since 2021
Week	Game	Result	Margin

Team Standings

2025-2026 College Football Regular Season Standings - Southern Illinois, Southeast Missouri State
Team	Conf	Conf%	W	L	PF	PA	Home	Away	Strk
Missouri Valley
Southern Illinois	1-2	0.333	4	3	253	188	2-1	2-2	L2
Big South-OVC
Southeast Missouri State	2-1	0.667	3	4	179	222	3-1	0-3	W2

Southern Illinois & Southeast Missouri State Futures Odds

Latest NCAA Championship odds, if available, for each team. Review odds for other teams and learn the best College Football bets.

Southern Illinois Championship Odds

No NCAA College Football Championship TM Southern Illinois YR: futures available

Southeast Missouri State Championship Odds

No NCAA College Football Championship TM Southeast Missouri State YR: futures available

Southern Illinois & Southeast Missouri State Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Schedules & Results

2025-26 Southern Illinois Games & Results
Week	Matchup	Date & Result
Week 2	Southern Illinois vs Purdue	PUR 34, SIU 17 Saturday, September 6th, 2025

2025-26 Southeast Missouri State Games & Results
Week	Matchup	Date & Result
Week 1	Southeast Missouri State vs Arkansas State	ARST 42, SEMO 24 Saturday, August 30th, 2025

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Southern Illinois vs Southeast Missouri State College Football Game

Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Saturday, September 20th, 2025 at 7:00 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
Tap to the sportsbook's College Football page, look for the Southern Illinois vs Southeast Missouri State Game.
Navigate to the sportsbook's College Football page. Next, look for live or upcoming matchups. Select the Southern Illinois vs Southeast Missouri State Game.
Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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