The Royals will play the Giants on Wednesday, May 21st, 2025. Your timezone's first pitch time is 3:45 pm EDT. Check local listings or your nearest streaming app for coverage.
Learn more about MLB Betting with our handy tutorial and guide. We explain money line, total and run line bets. Plus, a great discussion about exotic bets like MLB Baseball parlays and props.
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Table of Contents
- Matchup Stats
- Captain Shady Lines
- Best Odds
- Interactive Odds Example
- Prop Bets
- Team Futures Odds
- Team Pages
- Team Standings
- Other Games Today
Key Matchup Stats
- SportsBetting3.com Power Rankings - The Kansas City Royals have a 92.00 power ranking. The power ranking for the San Francisco Giants is 95.33.
- Visiting Kansas City Royals - The Kansas City Royals have a 10-13 record as a visiting team, ranking them 5th Overall for visiting team wins.
- Home San Francisco Giants - The San Francisco Giants have a 16-8 record as a home team. They rank 2nd for home team wins in the Overall standings.
- Runs Scored - The Kansas City Royals currently stand 24th (162) Overall, with the San Francisco Giants ranking 9th (223) for runs scored.
- Runs Allowed - The Kansas City Royals are 27th (161) Overall for runs allowed. The San Francisco Giants stand 22nd (178) for runs allowed.
- Team Streaks - The Kansas City Royals have won their last 2 games. Meanwhile, the San Francisco Giants lost their last game.
- Team Records - The Kansas City Royals have a 27-22 Overall record (4.5 GB American Central Division), with the San Francisco Giants possessing a 28-20 Overall standing (1.0 GB National West Division).
Captain Shady Lines
A broken compass is right at least twice a day.
Argh, ye scurvy dogs! The Royals face the Giants on Wednesday night...
Kansas City better shape up with their losing streak against San Francisco...
SportsBetting3.com has the odds for this matchup, so bet on this game...
The Royals need to turn their luck around with a victory on the road...
San Francisco is a tough opponent with a higher win percentage...
Review the odds below and place yer bets before the first pitch is thrown!
Best Royals at Giants Odds
| Underdog Kansas City Royals | Favorite San Francisco Giants |
|---|---|
| Over | Under |
|---|---|
| Underdog Kansas City Royals | Favorite San Francisco Giants |
|---|---|
Matchup Odds FAQs
The San Francisco Giants are the -220 moneyline favorite at BetMGM and the Kansas City Royals are the +180 moneyline underdog at BetMGM.
The best over line is 7.5 +105 runs at BetMGM, which means you risk $100 to win $105 betting the over. The best under line is 7.5 -125 runs at BetMGM, and that means you risk $125 to win $100 betting the under.
The San Francisco Giants are -1.5 +105 run line favorites at BetMGM, while the Kansas City Royals are +1.5 -125 run line underdogs at BetMGM.
MLB Odds Example
|
Game |
 BetMGMBet |
|---|---|
Royals
Giants
5/21/25 3:45pm EDT | +180-220 |
- Kansas City Royals bettors risk $100 to win $180 at +180 odds. The implied probability for Kansas City Royals is 35.71%.
- San Francisco Giants bettors risk $100 to win $45.45 at -220 odds. The implied probability for San Francisco Giants is 68.75%.
Kansas City Royals at San Francisco Giants Prop Bets
| BetMGM Bet |
|
|---|---|
Royals
Giants
First Team to Score
5/21/25 3:45pm EDT | +100-130Bet |
Royals
Giants
Tie
1st Inning Winner
5/21/25 3:45pm EDT | +425+270-160Bet |
Royals
Giants
Tie
First 3 Innings Winner
5/21/25 3:45pm EDT | +230+105+230Bet |
Royals
Giants
To Extra Innings
5/21/25 3:45pm EDT | Yes +725No -1200Bet |
| BetMGM |
Kansas City Royals & San Francisco Giants Futures Odds
Latest World Series odds, if available, for each team. Review odds for other teams and learn how to bet on the tournament. See past Championship results and learn how to bet World Series teasers, props and parlays.
Kansas City Royals World Series Odds|
Team | BetMGM |
|---|---|
| Royals | +5000 Bet |
|
Team | BetMGM |
|---|---|
| Giants | +3500 Bet |
Kansas City Royals & San Francisco Giants Team Pages
Review each team's season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
Team Standings
| Team | W | L | Pct | GB | Home | Away | RS | RA | Diff | Strk | L10 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| San Francisco Giants | 31 | 24 | 0.564 | +4.5 | 17-9 | 14-15 | 239 | 199 | +40 | L2 | 5-5 |
| Kansas City Royals | 29 | 26 | 0.527 | +6.5 | 17-10 | 12-16 | 183 | 184 | -1 | L1 | 4-6 |
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Kansas City Royals vs San Francisco Giants MLB Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Wednesday, May 21st, 2025 at 3:45 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's MLB page, look for the Kansas City Royals vs San Francisco Giants Game.
Navigate to the sportsbook's MLB page. Next, look for live or upcoming matchups. Select the Kansas City Royals vs San Francisco Giants Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other May 21, 2025 MLB Games
- Cincinnati Reds vs Pittsburgh Pirates - 5/21/25 12:35pm EDT
- Baltimore Orioles vs Milwaukee Brewers - 5/21/25 1:10pm EDT
- Chicago Cubs vs Miami Marlins - 5/21/25 1:10pm EDT
- Houston Astros vs Tampa Bay Rays - 5/21/25 1:10pm EDT
- Detroit Tigers vs St. Louis Cardinals - 5/21/25 1:15pm EDT
- Seattle Mariners vs Chicago White Sox - 5/21/25 2:10pm EDT
- Cleveland Guardians vs Minnesota Twins - 5/21/25 3:30pm EDT
- New York Mets vs Boston Red Sox - 5/21/25 6:45pm EDT
- Atlanta Braves vs Washington Nationals - 5/21/25 6:45pm EDT
- Texas Rangers vs New York Yankees - 5/21/25 7:05pm EDT
- San Diego Padres vs Toronto Blue Jays - 5/21/25 7:07pm EDT
- Cleveland Guardians vs Minnesota Twins - 5/21/25 7:10pm EDT
- Philadelphia Phillies vs Colorado Rockies - 5/21/25 8:40pm EDT
- Los Angeles Angels vs Oakland Athletics - 5/21/25 10:05pm EDT
- Arizona Diamondbacks vs Los Angeles Dodgers - 5/21/25 10:10pm EDT