The Cowboys will play the Buffaloes on Saturday, September 20th, 2025. The matchup takes place at Folsom Field. Watch this exciting Week 4 matchup at 10:15 pm EDT. Check local listings for coverage on ESPN.
Learn more about College Football betting with our handy tutorial and guide. We explain spread, total and money line bets.
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Table of Contents
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Team Schedules & Results
- Other Games Today
Best Cowboys at Buffaloes Odds
| Underdog Wyoming | Favorite Colorado |
|---|---|
| Over | Under |
|---|---|
| TBD | TBD |
|---|
Matchup Odds FAQs
Colorado is a -13.5 -105 point spread favorite at BetMGM, while Wyoming is a +13.5 -115 point spread underdog at BetMGM.
The best over line is 44.5 -105 points at BetMGM, which means you risk $105 to win $100 betting the over. The best under line is 44.5 -115 points at BetMGM, and that means you risk $115 to win $100 betting the under.
College Football Odds Example
|
Game |
 BetMGMBet |
|---|---|
Wyoming
Colorado
9/20/25 10:15pm EDT | +13.5 -115-13.5 -105 |
Underdog Wyoming - Wyoming bettors risk $100 to win $86.96 at -115 odds.
A +13.5 Wyoming underdog bet wins if they lose by 13 or fewer, tie, or win outright. Your bet loses if they lose by 14 or more.
Favorite Colorado - Colorado bettors risk $100 to win $95.24 at -105 odds.
A -13.5 Colorado favorite bet wins if they win by 14 or more. Your bet loses if they win by 13 or fewer, tie, or lose outright.
Wyoming at Colorado Prop Bets
Important Note: Some states expressly forbid individual college athlete prop bets. The following wagers may not be available depending on your particular state laws.
| BetMGM Bet |
|
|---|---|
Wyoming
Colorado
9/20/25 10:15pm EDT | Pending BetMGM |
Recent Meetings Since 2021
| Week | Game | Result | Margin |
|---|
Team Standings
| Team | Conf | Conf% | W | L | PF | PA | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|---|
| Big 12 | |||||||||
| Colorado | 0-1 | 0.000 | 1 | 2 | 71 | 70 | 1-1 | 0-1 | L1 |
| Mountain West | |||||||||
| Wyoming | 0-0 | 0.000 | 2 | 1 | 47 | 38 | 1-1 | 1-0 | L1 |
Wyoming & Colorado Futures Odds
Latest NCAA Championship odds, if available, for each team. Review odds for other teams and learn the best College Football bets.
Wyoming Championship Odds|
Team | BetMGM |
|---|---|
| Wyoming | +100000 Bet |
|
Team | BetMGM |
|---|---|
| Colorado | +30000 Bet |
Wyoming & Colorado Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
Team Schedules & Results
| Week | Matchup | Date & Result |
|---|---|---|
| Week 1 | Wyoming vs Akron | WYO 10, AKR 0 Thursday, August 28th, 2025 |
| Week 1 | Wyoming vs Akron | Saturday, August 30th, 2025 12:00 am EDT |
| Week 2 | Northern Iowa vs Wyoming | WYO 31, UNI 7 Saturday, September 6th, 2025 |
| Week 3 | Utah vs Wyoming | UTAH 31, WYO 6 Saturday, September 13th, 2025 |
| Week 4 | Wyoming vs Colorado | Saturday, September 20th, 2025 10:15 pm EDT |
| Week 6 | UNLV vs Wyoming | Saturday, October 4th, 2025 7:00 pm EDT |
| Week 7 | San Jose State vs Wyoming | Saturday, October 11th, 2025 7:00 pm EDT |
| Week 8 | Wyoming vs Air Force | Saturday, October 18th, 2025 3:30 pm EDT |
| Week 9 | Colorado State vs Wyoming | Saturday, October 25th, 2025 7:30 pm EDT |
| Week 10 | Wyoming vs San Diego State | Saturday, November 1st, 2025 7:00 pm EDT |
| Week 12 | Wyoming vs Fresno State | Saturday, November 15th, 2025 12:00 am EST |
| Week 13 | Nevada vs Wyoming | Saturday, November 22nd, 2025 2:00 pm EST |
| Week 14 | Wyoming vs Hawaii | Saturday, November 29th, 2025 11:00 pm EST |
| Week | Matchup | Date & Result |
|---|---|---|
| Week 1 | Georgia Tech vs Colorado | GT 27, COLO 20 Friday, August 29th, 2025 |
| Week 2 | Delaware vs Colorado | COLO 31, DEL 7 Saturday, September 6th, 2025 |
| Week 3 | Colorado vs Houston | HOU 36, COLO 20 Friday, September 12th, 2025 |
| Week 4 | Wyoming vs Colorado | Saturday, September 20th, 2025 10:15 pm EDT |
| Week 5 | BYU vs Colorado | Saturday, September 27th, 2025 10:15 pm EDT |
| Week 6 | Colorado vs TCU | Saturday, October 4th, 2025 12:00 am EDT |
| Week 7 | Iowa State vs Colorado | Saturday, October 11th, 2025 12:00 am EDT |
| Week 9 | Colorado vs Utah | Saturday, October 25th, 2025 12:00 am EDT |
| Week 10 | Arizona vs Colorado | Saturday, November 1st, 2025 12:00 am EDT |
| Week 11 | Colorado vs West Virginia | Saturday, November 8th, 2025 12:00 am EST |
| Week 13 | Arizona State vs Colorado | Saturday, November 22nd, 2025 12:00 am EST |
| Week 14 | Colorado vs Kansas State | Saturday, November 29th, 2025 12:00 am EST |
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Wyoming vs Colorado College Football Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Saturday, September 20th, 2025 at 10:15 pm EDT, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's College Football page, look for the Wyoming vs Colorado Game.
Navigate to the sportsbook's College Football page. Next, look for live or upcoming matchups. Select the Wyoming vs Colorado Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other September 20, 2025 NCAAFB Games
- SMU vs TCU - 9/20/25 3:00pm EDT
- West Virginia vs Kansas - 9/20/25 3:00pm EDT
- South Carolina vs Missouri - 9/20/25 3:00pm EDT
- Florida vs Miami (FL) - 9/20/25 3:00pm EDT
- Oregon State vs Oregon - 9/20/25 3:00pm EDT
- Arizona State vs Baylor - 9/20/25 3:00pm EDT
- Maryland vs Wisconsin - 9/20/25 3:00pm EDT
- UTSA vs Colorado State - 9/20/25 3:00pm EDT
- UNLV vs Miami (OH) - 9/20/25 3:00pm EDT
- Syracuse vs Clemson - 9/20/25 3:00pm EDT
- Texas Tech vs Utah - 9/20/25 3:00pm EDT
- North Texas vs Army - 9/20/25 3:00pm EDT
- Bowling Green vs Louisville - 9/20/25 3:00pm EDT
- Arkansas vs Memphis - 9/20/25 3:00pm EDT
- Illinois vs Indiana - 9/20/25 3:00pm EDT
- Louisiana vs Eastern Michigan - 9/20/25 3:30pm EDT
- James Madison vs Liberty - 9/20/25 3:30pm EDT
- Toledo vs Western Michigan - 9/20/25 3:30pm EDT
- Kent State vs Florida State - 9/20/25 3:30pm EDT
- Ball State vs UConn - 9/20/25 3:30pm EDT
- Michigan vs Nebraska - 9/20/25 3:30pm EDT
- Troy vs Buffalo - 9/20/25 3:30pm EDT
- Purdue vs Notre Dame - 9/20/25 3:30pm EDT
- Tulane vs Ole Miss - 9/20/25 3:30pm EDT
- Auburn vs Oklahoma - 9/20/25 3:30pm EDT
- North Carolina vs UCF - 9/20/25 3:30pm EDT
- UAB vs Tennessee - 9/20/25 3:45pm EDT
- NC State vs Duke - 9/20/25 4:00pm EDT
- Northern Illinois vs Mississippi State - 9/20/25 4:15pm EDT
- Temple vs Georgia Tech - 9/20/25 4:30pm EDT
- Delaware vs FIU - 9/20/25 6:00pm EDT
- Arkansas State vs Kennesaw State - 9/20/25 6:00pm EDT
- Nevada vs Western Kentucky - 9/20/25 7:00pm EDT
- Marshall vs Middle Tennessee - 9/20/25 7:00pm EDT
- Coastal Carolina vs South Alabama - 9/20/25 7:00pm EDT
- Boise State vs Air Force - 9/20/25 7:00pm EDT
- Washington vs Washington State - 9/20/25 7:30pm EDT
- Stanford vs Virginia - 9/20/25 7:30pm EDT
- Southern Miss vs Louisiana Tech - 9/20/25 7:30pm EDT
- Georgia State vs Vanderbilt - 9/20/25 7:30pm EDT
- BYU vs East Carolina - 9/20/25 7:30pm EDT
- Sam Houston State vs Texas - 9/20/25 8:00pm EDT
- Louisiana-Monroe vs UTEP - 9/20/25 9:00pm EDT
- California vs San Diego State - 9/20/25 10:30pm EDT
- Michigan State vs USC - 9/20/25 11:00pm EDT