The Cardinals will play the Mustangs on Saturday, November 22nd, 2025. The matchup takes place at Gerald J. Ford Stadium. Watch this exciting Week 13 matchup at 12:00 pm EST.
Learn more about College Football betting with our handy tutorial and guide. We explain spread, total and money line bets.
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Table of Contents
- Matchup Stats
- Paddy O'Parlay
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Team Schedules & Results
- Other Games Today
Key Matchup Stats
We're now in the home stretch of the 2025 college football season, with Louisville and SMU meeting at Gerald J. Ford Stadium for a key late-season matchup on Saturday, November 22nd, 2025. The playoffs are fast approaching, along with the annual Bowl games that kick off in December. Here's an overview of some important 2025 performance data for each team.
- SportsBetting3.com Power Rankings - As we wrap up the 2025 regular season, Louisville has notched a 96.33 ACC Conference conference power ranking. On the other side of the gridiron, SMU has a 97.67 ACC Conference power ranking.
- Away Louisville - Looking at Week 13, Louisville heads into this matchup with a 3-0 record as an away team. This ranks them 2nd in the ACC Conference for away team wins in 2025. Remember that a team's overall record and schedule strength will affect whether or not they make a December bowl game or qualify for the playoffs.
- Home SMU - Meanwhile, SMU has a 4-1 record as a home team for 2025. They currently rank 3rd in the ACC Conference for home team wins. Let's see if they can add another win to their record when they battle Louisville on Saturday, November 22nd, 2025.
- Points Scored - Now late in the 2025 season, Louisville ranks 8th (315) in the ACC Conference, with SMU currently ranking 7th (322) for points scored in the ACC Conference.
- Points Against - Louisville currently stands 12th (215) in the ACC Conference for points scored by opponents in the 2025 college football season. Their opponent, SMU, ranks 13th (204) in the ACC Conference for points against them as the 2025 college football season comes to a close.
- Team Records - As we head into Week 13, Louisville has a 7-3 overall record for the 2025 regular season, with SMU possessing a 7-3 standing for the 2025 college football season.
Paddy O'Parlay
The "Sports Network" talking heads have nothing on my Irish arse!
Top o' the mornin' to ya! Louisville faces SMU in a fierce Week 13 matchup!
The game will be held at Gerald J. Ford Stadium, where the stakes are high.
Louisville boasts a Power Ranking of 96.33, while SMU sits at 97.67.
Both teams have a standing of 7-3, making this game a must-watch.
We recommend BetRivers or BetMGM for a bet on this game. Review this game's prop bets. Compare the best point spread, total, and moneylines from our partner sportsbooks below.
Best Cardinals at Mustangs Odds
| Underdog Louisville | Favorite SMU |
|---|---|
| Over | Under |
|---|---|
| Underdog Louisville | Favorite SMU |
|---|---|
Matchup Odds FAQs
SMU is a -3.5 -105 point spread favorite at BetMGM, while Louisville is a +3.5 -115 point spread underdog at BetMGM.
The best over line is 52.5 -110 points at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 52.5 -110 points at BetMGM, and that means you risk $110 to win $100 betting the under.
SMU is a -155 moneyline favorite at BetMGM and Louisville is a +130 moneyline underdog at BetMGM.
College Football Odds Example
|
Game |
 BetMGMBet |
|---|---|
Louisville
SMU
11/22/25 12:00pm EST | +3.5 -115-3.5 -105 |
Underdog Louisville - Louisville bettors risk $100 to win $86.96 at -115 odds.
A +3.5 Louisville underdog bet wins if they lose by 3 or fewer, tie, or win outright. Your bet loses if they lose by 4 or more.
Favorite SMU - SMU bettors risk $100 to win $95.24 at -105 odds.
A -3.5 SMU favorite bet wins if they win by 4 or more. Your bet loses if they win by 3 or fewer, tie, or lose outright.
Louisville at SMU Prop Bets
Important Note: Some states expressly forbid individual college athlete prop bets. The following wagers may not be available depending on your particular state laws.
| BetMGM Bet |
|
|---|---|
Louisville
SMU
11/22/25 12:00pm EST | Pending BetMGM |
Recent Meetings Since 2021
| Week | Game | Result | Margin |
|---|---|---|---|
| 2024 Week 6 | SMU vs Louisville Saturday, October 5th, 2024 | SMU 34, LOU 27 L&N Federal Credit Union Stadium | SMU by 7 |
Team Standings
| Team | Conf | Conf% | W | L | PF | PA | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|---|
| SMU | 5-1 | 0.833 | 7 | 3 | 322 | 204 | 4-1 | 3-2 | W2 |
| #20 Louisville | 4-3 | 0.571 | 7 | 3 | 315 | 215 | 4-3 | 3-0 | L2 |
Louisville & SMU Futures Odds
Latest NCAA Championship odds, if available, for each team. Review odds for other teams and learn the best College Football bets.
Louisville Championship Odds|
Team | BetMGM |
|---|---|
| Louisville | +50000 Bet |
|
Team | BetMGM |
|---|---|
| SMU | +50000 Bet |
Louisville & SMU Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
Team Schedules & Results
| Week | Matchup | Date & Result |
|---|---|---|
| Week 1 | Eastern Kentucky vs Louisville | LOU 51, EKU 17 Saturday, August 30th, 2025 |
| Week 2 | James Madison vs Louisville | LOU 28, JMU 14 Friday, September 5th, 2025 |
| Week 4 | Bowling Green vs Louisville | LOU 40, BGSU 17 Saturday, September 20th, 2025 |
| Week 5 | Louisville vs Pittsburgh | LOU 34, PITT 27 Saturday, September 27th, 2025 |
| Week 6 | Virginia vs Louisville | UVA 30, LOU 27 (OT) Saturday, October 4th, 2025 |
| Week 8 | Louisville vs Miami (FL) | LOU 24, MIA 21 Friday, October 17th, 2025 |
| Week 9 | Boston College vs Louisville | Saturday, October 25th, 2025 7:30 pm EDT |
| Week 10 | Louisville vs Virginia Tech | Saturday, November 1st, 2025 3:00 pm EDT |
| Week 11 | California vs Louisville | Saturday, November 8th, 2025 12:00 am EST |
| Week 12 | Clemson vs Louisville | Friday, November 14th, 2025 7:30 pm EST |
| Week 13 | Louisville vs SMU | Saturday, November 22nd, 2025 12:00 am EST |
| Week 14 | Kentucky vs Louisville | Saturday, November 29th, 2025 12:00 am EST |
| Week | Matchup | Date & Result |
|---|---|---|
| Week 1 | East Texas A&M vs SMU | SMU 42, ETAM 13 Saturday, August 30th, 2025 |
| Week 2 | Baylor vs SMU | BAY 48, SMU 45 (2OT) Saturday, September 6th, 2025 |
| Week 3 | SMU vs Missouri State | SMU 28, MOST 10 Saturday, September 13th, 2025 |
| Week 4 | SMU vs TCU | TCU 35, SMU 24 Saturday, September 20th, 2025 |
| Week 6 | Syracuse vs SMU | SMU 31, SYR 18 Saturday, October 4th, 2025 |
| Week 7 | Stanford vs SMU | SMU 34, STAN 10 Saturday, October 11th, 2025 |
| Week 8 | SMU vs Clemson | SMU 35, CLEM 24 Saturday, October 18th, 2025 |
| Week 9 | SMU vs Wake Forest | Saturday, October 25th, 2025 12:00 pm EDT |
| Week 10 | Miami (FL) vs SMU | Saturday, November 1st, 2025 12:00 am EDT |
| Week 11 | SMU vs Boston College | Saturday, November 8th, 2025 12:00 am EST |
| Week 13 | Louisville vs SMU | Saturday, November 22nd, 2025 12:00 am EST |
| Week 14 | SMU vs California | Saturday, November 29th, 2025 12:00 am EST |
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Louisville vs SMU College Football Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Saturday, November 22nd, 2025 at 12:00 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's College Football page, look for the Louisville vs SMU Game.
Navigate to the sportsbook's College Football page. Next, look for live or upcoming matchups. Select the Louisville vs SMU Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other November 22, 2025 NCAAFB Games
- Arkansas vs Texas - 11/22/25 12:00pm EST
- Illinois vs Wisconsin - 11/22/25 12:00pm EST
- TCU vs Houston - 11/22/25 12:00pm EST
- Michigan State vs Iowa - 11/22/25 12:00pm EST
- Kansas vs Iowa State - 11/22/25 12:00pm EST
- Delaware vs Wake Forest - 11/22/25 12:00pm EST
- Michigan vs Maryland - 11/22/25 12:00pm EST
- Miami (FL) vs Virginia Tech - 11/22/25 12:00pm EST
- Minnesota vs Northwestern - 11/22/25 12:00pm EST
- Washington vs UCLA - 11/22/25 12:00pm EST
- North Texas vs Rice - 11/22/25 12:00pm EST
- San Jose State vs San Diego State - 11/22/25 12:00pm EST
- South Florida vs UAB - 11/22/25 12:00pm EST
- Tulane vs Temple - 11/22/25 12:00pm EST
- Arizona State vs Colorado - 11/22/25 12:00pm EST
- Colorado State vs Boise State - 11/22/25 12:00pm EST
- Nebraska vs Penn State - 11/22/25 12:00pm EST
- Missouri vs Oklahoma - 11/22/25 12:00pm EST
- Pittsburgh vs Georgia Tech - 11/22/25 12:00pm EST
- Kansas State vs Utah - 11/22/25 12:00pm EST
- BYU vs Cincinnati - 11/22/25 12:00pm EST
- Washington State vs James Madison - 11/22/25 12:00pm EST
- East Carolina vs UTSA - 11/22/25 12:00pm EST
- Baylor vs Arizona - 11/22/25 12:00pm EST
- Tulsa vs Army - 11/22/25 12:00pm EST
- Charlotte vs Georgia - 11/22/25 12:45pm EST
- Old Dominion vs Georgia Southern - 11/22/25 1:00pm EST
- Rutgers vs Ohio State - 11/22/25 1:00pm EST
- Missouri State vs Kennesaw State - 11/22/25 2:00pm EST
- Ball State vs Toledo - 11/22/25 2:00pm EST
- Nevada vs Wyoming - 11/22/25 2:00pm EST
- Marshall vs Appalachian State - 11/22/25 2:30pm EST
- New Mexico State vs UTEP - 11/22/25 3:00pm EST
- Liberty vs Louisiana Tech - 11/22/25 3:00pm EST
- Sam Houston State vs Middle Tennessee - 11/22/25 3:00pm EST
- UConn vs Florida Atlantic - 11/22/25 3:00pm EST
- Jacksonville State vs FIU - 11/22/25 3:30pm EST
- Duke vs North Carolina - 11/22/25 3:30pm EST
- Tennessee vs Florida - 11/22/25 3:30pm EST
- Kentucky vs Vanderbilt - 11/22/25 3:30pm EST
- Southern Miss vs South Alabama - 11/22/25 3:30pm EST
- Syracuse vs Notre Dame - 11/22/25 3:30pm EST
- Oklahoma State vs UCF - 11/22/25 4:00pm EST
- Georgia State vs Troy - 11/22/25 4:00pm EST
- Coastal Carolina vs South Carolina - 11/22/25 4:15pm EST
- Louisiana-Monroe vs Texas State - 11/22/25 5:00pm EST
- New Mexico vs Air Force - 11/22/25 7:00pm EST
- California vs Stanford - 11/22/25 7:30pm EST
- USC vs Oregon - 11/22/25 7:30pm EST
- Western Kentucky vs LSU - 11/22/25 7:45pm EST
- Utah State vs Fresno State - 11/22/25 10:30pm EST