Syracuse vs Notre Dame Football Odds

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The Orange will play the Fighting Irish on Saturday, November 22nd, 2025. The matchup takes place at Notre Dame Stadium. Watch this exciting Week 13 matchup at 3:30 pm EST. Check local listings for coverage on NBC, Peacock.

Learn more about College Football betting with our handy tutorial and guide. We explain spread, total and money line bets.


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Table of Contents

Key Matchup Stats

We're now in the home stretch of the 2025 college football season, with Syracuse and Notre Dame meeting at Notre Dame Stadium for a key late-season matchup on Saturday, November 22nd, 2025. The playoffs are fast approaching, along with the annual Bowl games that kick off in December. Here's an overview of some important 2025 performance data for each team.

  • SportsBetting3.com Power Rankings - As we wrap up the 2025 regular season, Syracuse has notched a 91.67 ACC Conference conference power ranking. On the other side of the gridiron, Notre Dame has a 100.00 Independent Conference power ranking.
  • Away Syracuse - Looking at Week 13, Syracuse heads into this matchup with a 1-3 record as an away team. This ranks them 4th in the ACC Conference for away team wins in 2025. Remember that a team's overall record and schedule strength will affect whether or not they make a December bowl game or qualify for the playoffs.
  • Home Notre Dame - Meanwhile, Notre Dame has a 5-1 record as a home team for 2025. They currently rank 2nd in the Independent Conference for home team wins. Let's see if they can add another win to their record when they battle Syracuse on Saturday, November 22nd, 2025.
  • Points Scored - Now late in the 2025 season, Syracuse ranks 14th (223) in the ACC Conference, with Notre Dame currently ranking 1st (385) for points scored in the Independent Conference.
  • Points Against - Syracuse currently stands 3rd (315) in the ACC Conference for points scored by opponents in the 2025 college football season. Their opponent, Notre Dame, ranks 3rd (184) in the Independent Conference for points against them as the 2025 college football season comes to a close.
  • Team Records - As we head into Week 13, Syracuse has a 3-7 overall record for the 2025 regular season, with Notre Dame possessing a 8-2 standing for the 2025 college football season.

Paddy O'Parlay

The "Sports Network" talking heads have nothing on my Irish arse!

Paddy O'Parlay
Paddy O'Parlay

Top o' the morning to ya! Syracuse is ready to take on Notre Dame in a wild Week 13 matchup.

The game will be held at the legendary Notre Dame Stadium on Saturday, November 22nd.

The regular season is coming to a close, with bowl games just around the corner.

According to SportsBetting3.com Power Rankings, Notre Dame has the upper hand in this matchup.

Syracuse has a 3-7 record, while Notre Dame boasts an impressive 8-2 standing.

We recommend BetRivers or BetMGM for a bet on this game. Review this game's prop bets. Compare the best point spread, total, and moneylines from our partner sportsbooks below.

Best Orange at Fighting Irish Odds


Best Point Spread Betting Odds
Underdog

Syracuse		Favorite

Notre Dame
+36.5 -105 BetMGM
Bet
-36.5 -115 BetMGM
Bet
Notre Dame has a -36.5 -115 point spread at BetMGM OH. They are the point spread favorite in this matchup. Syracuse has a +36.5 -105 point spread at BetMGM OH. Syracuse is the point spread underdog. Review how to bet on a point spread with our text and video tutorials.

Best Total Betting Odds
OverUnder
50.5 o -110 BetMGM
Bet
50.5 u -110 BetMGM
Bet
BetMGM has the best over line of 50.5 points. Risk $110 to win $100. BetMGM has the best under line of 50.5 points. Risk $110 to win $100. Our tutorial explains more about total bets.

Best Moneyline Betting Odds
TBDTBD
Moneyline odds are updating, please check back soon.

Matchup Odds FAQs

What is the point spread for the Syracuse vs Notre Dame College Football game on Saturday, November 22nd, 2025?

Notre Dame is a -36.5 -115 point spread favorite at BetMGM, while Syracuse is a +36.5 -105 point spread underdog at BetMGM.

What is the over-under total line for the Syracuse vs Notre Dame College Football game on Saturday, November 22nd, 2025?

The best over line is 50.5 -110 points at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 50.5 -110 points at BetMGM, and that means you risk $110 to win $100 betting the under.

College Football Odds Example

College Football Odds and Outcomes Explained

Game		 BetMGM Sports Betting BetMGM
Bet
Syracuse
Notre Dame
11/22/25 3:30pm EST
+36.5 -105-36.5 -115
Bet $100 at BetMGM Ohio
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Gambling Problem? Call 1-800-589-9966

Underdog Syracuse - Syracuse bettors risk $100 to win $95.24 at -105 odds.

A +36.5 Syracuse underdog bet wins if they lose by 36 or fewer, tie, or win outright. Your bet loses if they lose by 37 or more.

Favorite Notre Dame - Notre Dame bettors risk $100 to win $86.96 at -115 odds.

A -36.5 Notre Dame favorite bet wins if they win by 37 or more. Your bet loses if they win by 36 or fewer, tie, or lose outright.

Syracuse at Notre Dame Prop Bets

Important Note: Some states expressly forbid individual college athlete prop bets. The following wagers may not be available depending on your particular state laws.

College Football Prop Bets
+ Displays more odds
BetMGM Sports Betting BetMGM
Bet
Syracuse
Notre Dame
Both Teams Score 10+
11/22/25 3:30pm EST
Yes +180No -235Bet
Syracuse
Notre Dame
Both Teams Score 20+
11/22/25 3:30pm EST
Yes +1050No -3000Bet

Recent Meetings Since 2021

Recent Meetings Since 2021
WeekGameResultMargin
2022
Week 9		Notre Dame vs Syracuse
Saturday, October 29th, 2022		ND 41, SYR 24
JMA Wireless Dome		Notre Dame by 17

Team Standings

2025-2026 College Football Regular Season Standings - Syracuse, Notre Dame
Team Conf Conf% W L PF PA Home Away Strk
Independent
#10 Notre Dame0-00.0001025042116-14-1W10
ACC
Syracuse1-70.125392424192-41-4L8

Syracuse & Notre Dame Futures Odds

Latest NCAA Championship odds, if available, for each team. Review odds for other teams and learn the best College Football bets.

Syracuse Championship Odds

No NCAA College Football Championship TM Syracuse YR: futures available

Notre Dame Championship Odds

No NCAA College Football Championship TM Notre Dame YR: futures available

Syracuse & Notre Dame Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Schedules & Results


2025-26 Syracuse Games & Results
WeekMatchupDate & Result
Week 1Syracuse vs
Tennessee		TENN 45, SYR 26
Saturday, August 30th, 2025
Week 2UConn vs
Syracuse		SYR 27, CONN 20 (OT)
Saturday, September 6th, 2025
Week 3Colgate vs
Syracuse		SYR 66, COLG 24
Friday, September 12th, 2025
Week 4Syracuse vs
Clemson		SYR 34, CLEM 21
Saturday, September 20th, 2025
Week 5Duke vs
Syracuse		DUKE 38, SYR 3
Saturday, September 27th, 2025
Week 6Syracuse vs
SMU		SMU 31, SYR 18
Saturday, October 4th, 2025
Week 8Pittsburgh vs
Syracuse		PITT 30, SYR 13
Saturday, October 18th, 2025
Week 9Syracuse vs
Georgia Tech		Saturday, October 25th, 2025
12:00 pm EDT
Week 10North Carolina vs
Syracuse		Friday, October 31st, 2025
7:30 pm EDT
Week 11Syracuse vs
Miami (FL)		Saturday, November 8th, 2025
12:00 am EST
Week 13Syracuse vs
Notre Dame		Saturday, November 22nd, 2025
3:30 pm EST
Week 14Boston College vs
Syracuse		Saturday, November 29th, 2025
12:00 am EST


2025-26 Notre Dame Games & Results
WeekMatchupDate & Result
Week 1Notre Dame vs
Miami (FL)		MIA 27, ND 24
Sunday, August 31st, 2025
Week 3Texas A&M vs
Notre Dame		TA&M 41, ND 40
Saturday, September 13th, 2025
Week 4Purdue vs
Notre Dame		ND 56, PUR 30
Saturday, September 20th, 2025
Week 5Notre Dame vs
Arkansas		ND 56, ARK 13
Saturday, September 27th, 2025
Week 6Boise State vs
Notre Dame		ND 28, BOIS 7
Saturday, October 4th, 2025
Week 7NC State vs
Notre Dame		ND 36, NCSU 7
Saturday, October 11th, 2025
Week 8USC vs
Notre Dame		ND 34, USC 24
Saturday, October 18th, 2025
Week 10Notre Dame vs
Boston College		Saturday, November 1st, 2025
12:00 am EDT
Week 11Navy vs
Notre Dame		Saturday, November 8th, 2025
7:30 pm EST
Week 12Notre Dame vs
Pittsburgh		Saturday, November 15th, 2025
12:00 am EST
Week 13Syracuse vs
Notre Dame		Saturday, November 22nd, 2025
3:30 pm EST
Week 14Notre Dame vs
Stanford		Saturday, November 29th, 2025
12:00 am EST

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Syracuse vs Notre Dame College Football Game

  1. Open a new sports betting account before game time.

    Review our list of sports betting sites. Open a new account before the game starts on Saturday, November 22nd, 2025 at 3:30 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.

  2. Visit the sportsbook’s cashier, banking, or deposit page.

    Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.

  3. Tap to the sportsbook's College Football page, look for the Syracuse vs Notre Dame Game.

    Navigate to the sportsbook's College Football page. Next, look for live or upcoming matchups. Select the Syracuse vs Notre Dame Game.

  4. Choose your bet and place a wager.

    Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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