Michigan State vs Iowa Football Odds

The Spartans will play the Hawkeyes on Saturday, November 22nd, 2025. The matchup takes place at Kinnick Stadium. Watch this exciting Week 13 matchup at 3:30 pm EST. Check local listings for coverage on FS1.

Learn more about College Football betting with our handy tutorial and guide. We explain spread, total and money line bets.


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Table of Contents

Key Matchup Stats

We're now in the home stretch of the 2025 college football season, with Michigan State and Iowa meeting at Kinnick Stadium for a key late-season matchup on Saturday, November 22nd, 2025. The playoffs are fast approaching, along with the annual Bowl games that kick off in December. Here's an overview of some important 2025 performance data for each team.

  • SportsBetting3.com Power Rankings - As we wrap up the 2025 regular season, Michigan State has notched a 89.67 Big Ten Conference conference power ranking. On the other side of the gridiron, Iowa has a 94.33 Big Ten Conference power ranking.
  • Away Michigan State - Looking at Week 13, Michigan State heads into this matchup with a 0-4 record as an away team. This ranks them 5th in the Big Ten Conference for away team wins in 2025. Remember that a team's overall record and schedule strength will affect whether or not they make a December bowl game or qualify for the playoffs.
  • Home Iowa - Meanwhile, Iowa has a 4-2 record as a home team for 2025. They currently rank 4th in the Big Ten Conference for home team wins. Let's see if they can add another win to their record when they battle Michigan State on Saturday, November 22nd, 2025.
  • Points Scored - Now late in the 2025 season, Michigan State ranks 12th (240) in the Big Ten Conference, with Iowa currently ranking 10th (287) for points scored in the Big Ten Conference.
  • Points Against - Michigan State currently stands 3rd (311) in the Big Ten Conference for points scored by opponents in the 2025 college football season. Their opponent, Iowa, ranks 15th (149) in the Big Ten Conference for points against them as the 2025 college football season comes to a close.
  • Team Records - As we head into Week 13, Michigan State has a 3-7 overall record for the 2025 regular season, with Iowa possessing a 6-4 standing for the 2025 college football season.

Paddy O'Parlay

The "Sports Network" talking heads have nothing on my Irish arse!

Paddy O'Parlay
Paddy O'Parlay

Top o' the morning to ya, lads and lasses! Michigan State faces Iowa in a clash!

This Week 13 showdown takes place at Kinnick Stadium, where the Hawkeyes host the Spartans.

With the regular season winding down, bowl games are on the horizon. Who will prevail?

According to SportsBetting3.com Power Rankings, Iowa holds the edge over Michigan State.

The Spartans have a 3-7 record, while the Hawkeyes boast a 6-4 standing.

We recommend BetRivers or BetMGM for a bet on this game. Review this game's prop bets.

Compare the best point spread, total, and moneylines from our partner sportsbooks below.

Best Spartans at Hawkeyes Odds


Best Point Spread Betting Odds
Underdog

Michigan State
Favorite

Iowa
Iowa has a -17 -110 point spread at BetMGM OH. They are the point spread favorite in this matchup. Michigan State has a +17 -110 point spread at BetMGM OH. Michigan State is the point spread underdog. Review how to bet on a point spread with our text and video tutorials.

Best Total Betting Odds
OverUnder
BetMGM has the best over line of 42.5 points. Risk $110 to win $100. BetMGM has the best under line of 42.5 points. Risk $110 to win $100. Our tutorial explains more about total bets.

Best Moneyline Betting Odds
Underdog

Michigan State
Favorite

Iowa
Iowa is the -900 moneyline favorite. Risk $900 to win $100 on Iowa at BetMGM. Michigan State is the +600 underdog at BetMGM. Risk $100 to win $600 on Michigan State. Learn more about how to bet on money lines.

Matchup Odds FAQs

What is the point spread for the Michigan State vs Iowa College Football game on Saturday, November 22nd, 2025?

Iowa is a -17 -110 point spread favorite at BetMGM, while Michigan State is a +17 -110 point spread underdog at BetMGM.

What is the over-under total line for the Michigan State vs Iowa College Football game on Saturday, November 22nd, 2025?

The best over line is 42.5 -110 points at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 42.5 -110 points at BetMGM, and that means you risk $110 to win $100 betting the under.

What is the moneyline for the Michigan State vs Iowa College Football game on Saturday, November 22nd, 2025?

Iowa is a -900 moneyline favorite at BetMGM and Michigan State is a +600 moneyline underdog at BetMGM.

College Football Odds Example

College Football Odds and Outcomes Explained

Game
BetMGM Sports Betting BetMGM
Bet
Michigan State
Iowa
11/22/25 3:30pm EST
+17 -110-17 -110
Bet $100 at BetMGM Ohio
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Underdog Michigan State - Michigan State bettors risk $100 to win $90.91 at -110 odds.

A +17 Michigan State underdog bet wins if they lose by 16 or fewer, tie, or win outright. The bet pushes if they lose by 17. Your bet loses if they lose by 18 or more.

Favorite Iowa - Iowa bettors risk $100 to win $90.91 at -110 odds.

A -17 Iowa favorite bet wins if they win by 18 or more. The bet pushes if they win by 17. Your bet loses if they win by 16 or fewer, tie, or lose outright.

Michigan State at Iowa Prop Bets

Important Note: Some states expressly forbid individual college athlete prop bets. The following wagers may not be available depending on your particular state laws.

College Football Prop Bets
+ Displays more odds
BetMGM Sports Betting BetMGM
Bet
Michigan State
Iowa
No Touchdown
To Score 1st Touchdown
11/22/25 3:30pm EST
+275-450+10000Bet
Michigan State
Iowa
Game to Overtime
11/22/25 3:30pm EST
Yes +1800No -10000Bet
Michigan State
Iowa
Both Teams Score 10+
11/22/25 3:30pm EST
Yes -200No +154Bet
Michigan State
Iowa
Both Teams Score 20+
11/22/25 3:30pm EST
Yes +340No -500Bet
BetMGM Sports Betting BetMGM
Michigan State
Iowa
Both Teams Score 30+
11/22/25 3:30pm EST
Yes +2200No -10000Bet

Recent Meetings Since 2021

Recent Meetings Since 2021
WeekGameResultMargin
2025
Week 13
Michigan State vs Iowa
Saturday, November 22nd, 2025
IOWA 20, MSU 17
Kinnick Stadium
Iowa by 3
2024
Week 8
Iowa vs Michigan State
Saturday, October 19th, 2024
MSU 32, IOWA 20
Spartan Stadium
Michigan State by 12
2023
Week 5
Michigan State vs Iowa
Saturday, September 30th, 2023
IOWA 26, MSU 16
Kinnick Stadium
Iowa by 10

Team Standings

2025-2026 College Football Regular Season Standings - Michigan State, Iowa
Team Conf Conf% W L PF PA Home Away Strk
#23 Iowa6-30.667843471825-23-2W2
Michigan State1-80.111482953593-30-5W1

Michigan State & Iowa Futures Odds

Latest NCAA Championship odds, if available, for each team. Review odds for other teams and learn the best College Football bets.

Michigan State Championship Odds

No NCAA College Football Championship TM Michigan State YR: futures available

Iowa Championship Odds

No NCAA College Football Championship TM Iowa YR: futures available

Michigan State & Iowa Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Schedules & Results


2025-26 Michigan State Games & Results
WeekMatchupDate & Result
Week 1Western Michigan vs
Michigan State
MSU 23, WMU 6
Friday, August 29th, 2025
Week 2Boston College vs
Michigan State
MSU 42, BC 40 (2OT)
Saturday, September 6th, 2025
Week 3Youngstown State vs
Michigan State
MSU 41, YSU 24
Saturday, September 13th, 2025
Week 4Michigan State vs
USC
USC 45, MSU 31
Saturday, September 20th, 2025
Week 6Michigan State vs
Nebraska
NEB 38, MSU 27
Saturday, October 4th, 2025
Week 7UCLA vs
Michigan State
UCLA 38, MSU 13
Saturday, October 11th, 2025
Week 8Michigan State vs
Indiana
IU 38, MSU 13
Saturday, October 18th, 2025
Week 9Michigan vs
Michigan State
MICH 31, MSU 20
Saturday, October 25th, 2025
Week 10Michigan State vs
Minnesota
MINN 23, MSU 20 (OT)
Saturday, November 1st, 2025
Week 12Penn State vs
Michigan State
PSU 28, MSU 10
Saturday, November 15th, 2025
Week 13Michigan State vs
Iowa
IOWA 20, MSU 17
Saturday, November 22nd, 2025
Week 14Maryland vs
Michigan State
MSU 38, MD 28
Saturday, November 29th, 2025


2025-26 Iowa Games & Results
WeekMatchupDate & Result
Week 1Albany vs
Iowa
IOWA 34, ALB 7
Saturday, August 30th, 2025
Week 2Iowa vs
Iowa State
ISU 16, IOWA 13
Saturday, September 6th, 2025
Week 3UMass vs
Iowa
IOWA 47, MASS 7
Saturday, September 13th, 2025
Week 4Iowa vs
Rutgers
IOWA 38, RUTG 28
Friday, September 19th, 2025
Week 5Indiana vs
Iowa
IU 20, IOWA 15
Saturday, September 27th, 2025
Week 7Iowa vs
Wisconsin
IOWA 37, WIS 0
Saturday, October 11th, 2025
Week 8Penn State vs
Iowa
IOWA 25, PSU 24
Saturday, October 18th, 2025
Week 9Minnesota vs
Iowa
IOWA 41, MINN 3
Saturday, October 25th, 2025
Week 11Oregon vs
Iowa
ORE 18, IOWA 16
Saturday, November 8th, 2025
Week 12Iowa vs
USC
USC 26, IOWA 21
Saturday, November 15th, 2025
Week 13Michigan State vs
Iowa
IOWA 20, MSU 17
Saturday, November 22nd, 2025
Week 14Iowa vs
Nebraska
IOWA 40, NEB 16
Friday, November 28th, 2025
BowlsIowa vs
Vanderbilt
Reliaquest Bowl
Wednesday, December 31st, 2025
12:00 pm EST

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Michigan State vs Iowa College Football Game

  1. Open a new sports betting account before game time.

    Review our list of sports betting sites. Open a new account before the game starts on Saturday, November 22nd, 2025 at 3:30 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.

  2. Visit the sportsbook’s cashier, banking, or deposit page.

    Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.

  3. Tap to the sportsbook's College Football page, look for the Michigan State vs Iowa Game.

    Navigate to the sportsbook's College Football page. Next, look for live or upcoming matchups. Select the Michigan State vs Iowa Game.

  4. Choose your bet and place a wager.

    Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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