The Hilltoppers will play the Tigers on Saturday, November 22nd, 2025. The matchup takes place at Tiger Stadium (LA). Watch this exciting Week 13 matchup at 7:45 pm EST.
Learn more about College Football betting with our handy tutorial and guide. We explain spread, total and money line bets.
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Table of Contents
- Matchup Stats
- Paddy O'Parlay
- Best Odds
- Interactive Odds Example
- Prop Bets
- Recent Meetings
- Team Standings
- Futures Odds
- Team Pages
- Team Schedules & Results
- Other Games Today
Key Matchup Stats
We're now in the home stretch of the 2025 college football season, with Western Kentucky and LSU meeting at Tiger Stadium (LA) for a key late-season matchup on Saturday, November 22nd, 2025. The playoffs are fast approaching, along with the annual Bowl games that kick off in December. Here's an overview of some important 2025 performance data for each team.
- SportsBetting3.com Power Rankings - As we wrap up the 2025 regular season, Western Kentucky has notched a 99.67 C-USA Conference conference power ranking. On the other side of the gridiron, LSU has a 94.00 SEC Conference power ranking.
- Away Western Kentucky - Looking at Week 13, Western Kentucky heads into this matchup with a 3-1 record as an away team. This ranks them 2nd in the C-USA Conference for away team wins in 2025. Remember that a team's overall record and schedule strength will affect whether or not they make a December bowl game or qualify for the playoffs.
- Home LSU - Meanwhile, LSU has a 5-1 record as a home team for 2025. They currently rank 3rd in the SEC Conference for home team wins. Let's see if they can add another win to their record when they battle Western Kentucky on Saturday, November 22nd, 2025.
- Points Scored - Now late in the 2025 season, Western Kentucky ranks 1st (313) in the C-USA Conference, with LSU currently ranking 14th (236) for points scored in the SEC Conference.
- Points Against - Western Kentucky currently stands 10th (231) in the C-USA Conference for points scored by opponents in the 2025 college football season. Their opponent, LSU, ranks 10th (193) in the SEC Conference for points against them as the 2025 college football season comes to a close.
- Team Records - As we head into Week 13, Western Kentucky has a 8-2 overall record for the 2025 regular season, with LSU possessing a 6-4 standing for the 2025 college football season.
Paddy O'Parlay
The "Sports Network" talking heads have nothing on my Irish arse!
Get ready for a wild showdown as Western Kentucky faces off against LSU.
Tiger Stadium in Louisiana will be rockin' for this Week 13 matchup.
Western Kentucky holds a higher Power Ranking than LSU in this matchup.
With a 8-2 record, Western Kentucky is looking to secure a bowl game spot.
LSU, with a 6-4 record, will be fighting hard for a win.
We recommend BetRivers or BetMGM for a bet on this game.
Review this game's prop bets for some extra excitement.
Compare the best point spread, total, and moneylines from our partner sportsbooks below.
Best Hilltoppers at Tigers Odds
| Underdog Western Kentucky | Favorite LSU |
|---|---|
| Over | Under |
|---|---|
| Underdog Western Kentucky | Favorite LSU |
|---|---|
Matchup Odds FAQs
LSU is a -21.5 -110 point spread favorite at BetMGM, while Western Kentucky is a +21.5 -110 point spread underdog at BetMGM.
The best over line is 50.5 -110 points at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 50.5 -110 points at BetMGM, and that means you risk $110 to win $100 betting the under.
LSU is a -1600 moneyline favorite at BetMGM and Western Kentucky is a +900 moneyline underdog at BetMGM.
College Football Odds Example
|
Game |
 BetMGMBet |
|---|---|
Western Kentucky
LSU
11/22/25 7:45pm EST | +21.5 -110-21.5 -110 |
Underdog Western Kentucky - Western Kentucky bettors risk $100 to win $90.91 at -110 odds.
A +21.5 Western Kentucky underdog bet wins if they lose by 21 or fewer, tie, or win outright. Your bet loses if they lose by 22 or more.
Favorite LSU - LSU bettors risk $100 to win $90.91 at -110 odds.
A -21.5 LSU favorite bet wins if they win by 22 or more. Your bet loses if they win by 21 or fewer, tie, or lose outright.
Western Kentucky at LSU Prop Bets
Important Note: Some states expressly forbid individual college athlete prop bets. The following wagers may not be available depending on your particular state laws.
| BetMGM Bet |
|
|---|---|
Western Kentucky
LSU
11/22/25 7:45pm EST | Pending BetMGM |
Recent Meetings Since 2021
| Week | Game | Result | Margin |
|---|
Team Standings
| Team | Conf | Conf% | W | L | PF | PA | Home | Away | Strk |
|---|---|---|---|---|---|---|---|---|---|
| C-USA | |||||||||
| Western Kentucky | 6-1 | 0.857 | 8 | 2 | 313 | 231 | 5-1 | 3-1 | W3 |
| SEC | |||||||||
| LSU | 3-4 | 0.429 | 6 | 4 | 236 | 193 | 5-1 | 1-3 | W1 |
Western Kentucky & LSU Futures Odds
Latest NCAA Championship odds, if available, for each team. Review odds for other teams and learn the best College Football bets.
Western Kentucky Championship OddsNo NCAA College Football Championship TM Western Kentucky YR: futures available
LSU Championship OddsNo NCAA College Football Championship TM LSU YR: futures available
Western Kentucky & LSU Team Pages
Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:
Team Schedules & Results
| Week | Matchup | Date & Result |
|---|---|---|
| Week 1 | Sam Houston State vs Western Kentucky | WKU 41, SHSU 24 Saturday, August 23rd, 2025 |
| Week 1 | North Alabama vs Western Kentucky | WKU 55, UNA 6 Saturday, August 30th, 2025 |
| Week 2 | Western Kentucky vs Toledo | TOL 45, WKU 21 Saturday, September 6th, 2025 |
| Week 4 | Nevada vs Western Kentucky | WKU 31, NEV 16 Saturday, September 20th, 2025 |
| Week 5 | Western Kentucky vs Missouri State | WKU 27, MOST 22 Saturday, September 27th, 2025 |
| Week 6 | Western Kentucky vs Delaware | WKU 27, DEL 24 Friday, October 3rd, 2025 |
| Week 8 | FIU vs Western Kentucky | FIU 25, WKU 6 Tuesday, October 14th, 2025 |
| Week 9 | Western Kentucky vs Louisiana Tech | Tuesday, October 21st, 2025 7:30 pm EDT |
| Week 10 | New Mexico State vs Western Kentucky | Saturday, November 1st, 2025 3:30 pm EDT |
| Week 12 | Middle Tennessee vs Western Kentucky | Saturday, November 15th, 2025 3:30 pm EST |
| Week 13 | Western Kentucky vs LSU | Saturday, November 22nd, 2025 12:00 am EST |
| Week 14 | Western Kentucky vs Jacksonville State | Saturday, November 29th, 2025 2:00 pm EST |
| Week | Matchup | Date & Result |
|---|---|---|
| Week 1 | LSU vs Clemson | LSU 17, CLEM 10 Saturday, August 30th, 2025 |
| Week 2 | Louisiana Tech vs LSU | LSU 23, LT 7 Saturday, September 6th, 2025 |
| Week 3 | Florida vs LSU | LSU 20, FLA 10 Saturday, September 13th, 2025 |
| Week 4 | Southeastern Louisiana vs LSU | LSU 56, SELA 10 Saturday, September 20th, 2025 |
| Week 5 | LSU vs Ole Miss | MISS 24, LSU 19 Saturday, September 27th, 2025 |
| Week 7 | South Carolina vs LSU | LSU 20, SC 10 Saturday, October 11th, 2025 |
| Week 8 | LSU vs Vanderbilt | VAN 31, LSU 24 Saturday, October 18th, 2025 |
| Week 9 | Texas A&M vs LSU | Saturday, October 25th, 2025 7:30 pm EDT |
| Week 11 | LSU vs Alabama | Saturday, November 8th, 2025 12:00 am EST |
| Week 12 | Arkansas vs LSU | Saturday, November 15th, 2025 12:00 am EST |
| Week 13 | Western Kentucky vs LSU | Saturday, November 22nd, 2025 12:00 am EST |
| Week 14 | LSU vs Oklahoma | Saturday, November 29th, 2025 12:00 am EST |
How to Bet on the Game
Time needed: 4 minutes.
How to Bet on the Western Kentucky vs LSU College Football Game
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Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Saturday, November 22nd, 2025 at 7:45 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
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Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
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Tap to the sportsbook's College Football page, look for the Western Kentucky vs LSU Game.
Navigate to the sportsbook's College Football page. Next, look for live or upcoming matchups. Select the Western Kentucky vs LSU Game.
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Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.
Other November 22, 2025 NCAAFB Games
- Arkansas vs Texas - 11/22/25 12:00pm EST
- Illinois vs Wisconsin - 11/22/25 12:00pm EST
- TCU vs Houston - 11/22/25 12:00pm EST
- Michigan State vs Iowa - 11/22/25 12:00pm EST
- Kansas vs Iowa State - 11/22/25 12:00pm EST
- Delaware vs Wake Forest - 11/22/25 12:00pm EST
- Michigan vs Maryland - 11/22/25 12:00pm EST
- Miami (FL) vs Virginia Tech - 11/22/25 12:00pm EST
- Minnesota vs Northwestern - 11/22/25 12:00pm EST
- Washington vs UCLA - 11/22/25 12:00pm EST
- North Texas vs Rice - 11/22/25 12:00pm EST
- Louisville vs SMU - 11/22/25 12:00pm EST
- San Jose State vs San Diego State - 11/22/25 12:00pm EST
- South Florida vs UAB - 11/22/25 12:00pm EST
- Tulane vs Temple - 11/22/25 12:00pm EST
- Arizona State vs Colorado - 11/22/25 12:00pm EST
- Colorado State vs Boise State - 11/22/25 12:00pm EST
- Nebraska vs Penn State - 11/22/25 12:00pm EST
- Missouri vs Oklahoma - 11/22/25 12:00pm EST
- Pittsburgh vs Georgia Tech - 11/22/25 12:00pm EST
- Kansas State vs Utah - 11/22/25 12:00pm EST
- BYU vs Cincinnati - 11/22/25 12:00pm EST
- Washington State vs James Madison - 11/22/25 12:00pm EST
- East Carolina vs UTSA - 11/22/25 12:00pm EST
- Baylor vs Arizona - 11/22/25 12:00pm EST
- Tulsa vs Army - 11/22/25 12:00pm EST
- Charlotte vs Georgia - 11/22/25 12:45pm EST
- Old Dominion vs Georgia Southern - 11/22/25 1:00pm EST
- Rutgers vs Ohio State - 11/22/25 1:00pm EST
- Missouri State vs Kennesaw State - 11/22/25 2:00pm EST
- Ball State vs Toledo - 11/22/25 2:00pm EST
- Nevada vs Wyoming - 11/22/25 2:00pm EST
- Marshall vs Appalachian State - 11/22/25 2:30pm EST
- New Mexico State vs UTEP - 11/22/25 3:00pm EST
- Liberty vs Louisiana Tech - 11/22/25 3:00pm EST
- Sam Houston State vs Middle Tennessee - 11/22/25 3:00pm EST
- UConn vs Florida Atlantic - 11/22/25 3:00pm EST
- Jacksonville State vs FIU - 11/22/25 3:30pm EST
- Duke vs North Carolina - 11/22/25 3:30pm EST
- Tennessee vs Florida - 11/22/25 3:30pm EST
- Kentucky vs Vanderbilt - 11/22/25 3:30pm EST
- Southern Miss vs South Alabama - 11/22/25 3:30pm EST
- Syracuse vs Notre Dame - 11/22/25 3:30pm EST
- Oklahoma State vs UCF - 11/22/25 4:00pm EST
- Georgia State vs Troy - 11/22/25 4:00pm EST
- Coastal Carolina vs South Carolina - 11/22/25 4:15pm EST
- Louisiana-Monroe vs Texas State - 11/22/25 5:00pm EST
- New Mexico vs Air Force - 11/22/25 7:00pm EST
- California vs Stanford - 11/22/25 7:30pm EST
- USC vs Oregon - 11/22/25 7:30pm EST
- Utah State vs Fresno State - 11/22/25 10:30pm EST