Western Kentucky vs LSU Football Odds

The Hilltoppers will play the Tigers on Saturday, November 22nd, 2025. The matchup takes place at Tiger Stadium (LA). Watch this exciting Week 13 matchup at 7:45 pm EST. Check local listings for coverage on SEC Network.

Learn more about College Football betting with our handy tutorial and guide. We explain spread, total and money line bets.

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Matchup Stats
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Best Odds
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Key Matchup Stats

We're now in the home stretch of the 2025 college football season, with Western Kentucky and LSU meeting at Tiger Stadium (LA) for a key late-season matchup on Saturday, November 22nd, 2025. The playoffs are fast approaching, along with the annual Bowl games that kick off in December. Here's an overview of some important 2025 performance data for each team.

SportsBetting3.com Power Rankings - As we wrap up the 2025 regular season, Western Kentucky has notched a 99.67 C-USA Conference conference power ranking. On the other side of the gridiron, LSU has a 94.00 SEC Conference power ranking.
Away Western Kentucky - Looking at Week 13, Western Kentucky heads into this matchup with a 3-1 record as an away team. This ranks them 2nd in the C-USA Conference for away team wins in 2025. Remember that a team's overall record and schedule strength will affect whether or not they make a December bowl game or qualify for the playoffs.
Home LSU - Meanwhile, LSU has a 5-1 record as a home team for 2025. They currently rank 3rd in the SEC Conference for home team wins. Let's see if they can add another win to their record when they battle Western Kentucky on Saturday, November 22nd, 2025.
Points Scored - Now late in the 2025 season, Western Kentucky ranks 1st (313) in the C-USA Conference, with LSU currently ranking 14th (236) for points scored in the SEC Conference.
Points Against - Western Kentucky currently stands 10th (231) in the C-USA Conference for points scored by opponents in the 2025 college football season. Their opponent, LSU, ranks 10th (193) in the SEC Conference for points against them as the 2025 college football season comes to a close.
Team Records - As we head into Week 13, Western Kentucky has a 8-2 overall record for the 2025 regular season, with LSU possessing a 6-4 standing for the 2025 college football season.

Paddy O'Parlay

The "Sports Network" talking heads have nothing on my Irish arse!

Get ready for a wild showdown as Western Kentucky faces off against LSU.

Tiger Stadium in Louisiana will be rockin' for this Week 13 matchup.

Western Kentucky holds a higher Power Ranking than LSU in this matchup.

With a 8-2 record, Western Kentucky is looking to secure a bowl game spot.

LSU, with a 6-4 record, will be fighting hard for a win.

We recommend BetRivers or BetMGM for a bet on this game.

Review this game's prop bets for some extra excitement.

Compare the best point spread, total, and moneylines from our partner sportsbooks below.

Best Hilltoppers at Tigers Odds

**Best Point Spread Betting Odds**
Underdog Western Kentucky	Favorite LSU
+23.5 -110 BetMGM Bet	-23.5 -110 BetMGM Bet

LSU has a -23.5 -110 point spread at BetMGM OH. They are the point spread favorite in this matchup. Western Kentucky has a +23.5 -110 point spread at BetMGM OH. Western Kentucky is the point spread underdog. Review how to bet on a point spread with our text and video tutorials.

**Best Total Betting Odds**
Over	Under
51.5 o -110 BetMGM Bet	51.5 u -110 BetMGM Bet

BetMGM has the best over line of 51.5 points. Risk $110 to win $100. BetMGM has the best under line of 51.5 points. Risk $110 to win $100. Our tutorial explains more about total bets.

**Best Moneyline Betting Odds**
Underdog Western Kentucky	Favorite LSU
+1250 BetMGM Bet	-3000 BetMGM Bet

LSU is the -3000 moneyline favorite. Risk $3,000 to win $100 on LSU at BetMGM. Western Kentucky is the +1250 underdog at BetMGM. Risk $100 to win $1,250 on Western Kentucky. Learn more about how to bet on money lines.

Matchup Odds FAQs

What is the point spread for the Western Kentucky vs LSU College Football game on Saturday, November 22nd, 2025?

LSU is a -23.5 -110 point spread favorite at BetMGM, while Western Kentucky is a +23.5 -110 point spread underdog at BetMGM.

What is the over-under total line for the Western Kentucky vs LSU College Football game on Saturday, November 22nd, 2025?

The best over line is 51.5 -110 points at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 51.5 -110 points at BetMGM, and that means you risk $110 to win $100 betting the under.

What is the moneyline for the Western Kentucky vs LSU College Football game on Saturday, November 22nd, 2025?

LSU is a -3000 moneyline favorite at BetMGM and Western Kentucky is a +1250 moneyline underdog at BetMGM.

College Football Odds Example

College Football Odds and Outcomes Explained
Game	BetMGM Bet
Western Kentucky LSU 11/22/25 7:45pm EST	+23.5 -110 -23.5 -110

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Underdog Western Kentucky - Western Kentucky bettors risk $100 to win $90.91 at -110 odds.

A +23.5 Western Kentucky underdog bet wins if they lose by 23 or fewer, tie, or win outright. Your bet loses if they lose by 24 or more.

Favorite LSU - LSU bettors risk $100 to win $90.91 at -110 odds.

A -23.5 LSU favorite bet wins if they win by 24 or more. Your bet loses if they win by 23 or fewer, tie, or lose outright.

Western Kentucky at LSU Prop Bets

Important Note: Some states expressly forbid individual college athlete prop bets. The following wagers may not be available depending on your particular state laws.

College Football Prop Bets
+ Displays more odds
	BetMGM Bet
Western Kentucky LSU Game to Overtime 11/22/25 7:45pm EST	Yes +2800 No -10000 Bet
Western Kentucky LSU Both Teams Score 10+ 11/22/25 7:45pm EST	Yes -250 No +190 Bet
Western Kentucky LSU Both Teams Score 20+ 11/22/25 7:45pm EST	Yes +240 No -325 Bet
Western Kentucky LSU Both Teams Score 30+ 11/22/25 7:45pm EST	Yes +1200 No -5000 Bet

Recent Meetings Since 2021

Recent Meetings Since 2021
Week	Game	Result	Margin
2025 Week 13	Western Kentucky vs LSU Saturday, November 22nd, 2025	LSU 13, WKU 10 Tiger Stadium (LA)	LSU by 3

Team Standings

2025-2026 College Football Regular Season Standings - Western Kentucky, LSU
Team	Conf	Conf%	W	L	PF	PA	Home	Away	Strk
C-USA
Western Kentucky	6-2	0.750	9	4	384	297	5-1	3-3	W1
SEC
LSU	3-5	0.375	7	6	297	258	6-1	1-4	L2

Western Kentucky & LSU Futures Odds

Latest NCAA Championship odds, if available, for each team. Review odds for other teams and learn the best College Football bets.

Western Kentucky Championship Odds

No NCAA College Football Championship TM Western Kentucky YR: futures available

LSU Championship Odds

No NCAA College Football Championship TM LSU YR: futures available

Western Kentucky & LSU Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Schedules & Results

2025-26 Western Kentucky Games & Results
Week	Matchup	Date & Result
Week 1	Sam Houston State vs Western Kentucky	WKU 41, SHSU 24 Saturday, August 23rd, 2025
Week 1	North Alabama vs Western Kentucky	WKU 55, UNA 6 Saturday, August 30th, 2025
Week 2	Western Kentucky vs Toledo	TOL 45, WKU 21 Saturday, September 6th, 2025
Week 4	Nevada vs Western Kentucky	WKU 31, NEV 16 Saturday, September 20th, 2025
Week 5	Western Kentucky vs Missouri State	WKU 27, MOST 22 Saturday, September 27th, 2025
Week 6	Western Kentucky vs Delaware	WKU 27, DEL 24 Friday, October 3rd, 2025
Week 8	FIU vs Western Kentucky	FIU 25, WKU 6 Tuesday, October 14th, 2025
Week 9	Western Kentucky vs Louisiana Tech	WKU 28, LT 27 (OT) Tuesday, October 21st, 2025
Week 10	New Mexico State vs Western Kentucky	WKU 35, NMSU 16 Saturday, November 1st, 2025
Week 12	Middle Tennessee vs Western Kentucky	WKU 42, MTSU 26 Saturday, November 15th, 2025
Week 13	Western Kentucky vs LSU	LSU 13, WKU 10 Saturday, November 22nd, 2025
Week 14	Western Kentucky vs Jacksonville State	JVST 37, WKU 34 Saturday, November 29th, 2025
Bowls	Western Kentucky vs Southern Miss New Orleans Bowl	WKU 27, USM 16 Tuesday, December 23rd, 2025

2025-26 LSU Games & Results
Week	Matchup	Date & Result
Week 1	LSU vs Clemson	LSU 17, CLEM 10 Saturday, August 30th, 2025
Week 2	Louisiana Tech vs LSU	LSU 23, LT 7 Saturday, September 6th, 2025
Week 3	Florida vs LSU	LSU 20, FLA 10 Saturday, September 13th, 2025
Week 4	Southeastern Louisiana vs LSU	LSU 56, SELA 10 Saturday, September 20th, 2025
Week 5	LSU vs Ole Miss	MISS 24, LSU 19 Saturday, September 27th, 2025
Week 7	South Carolina vs LSU	LSU 20, SC 10 Saturday, October 11th, 2025
Week 8	LSU vs Vanderbilt	VAN 31, LSU 24 Saturday, October 18th, 2025
Week 9	Texas A&M vs LSU	TA&M 49, LSU 25 Saturday, October 25th, 2025
Week 11	LSU vs Alabama	ALA 20, LSU 9 Saturday, November 8th, 2025
Week 12	Arkansas vs LSU	LSU 23, ARK 22 Saturday, November 15th, 2025
Week 13	Western Kentucky vs LSU	LSU 13, WKU 10 Saturday, November 22nd, 2025
Week 14	LSU vs Oklahoma	OU 17, LSU 13 Saturday, November 29th, 2025
Bowls	LSU vs Houston Kinder's Texas Bowl	HOU 38, LSU 35 Saturday, December 27th, 2025

How to Bet on the Game

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How to Bet on the Western Kentucky vs LSU College Football Game

Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Saturday, November 22nd, 2025 at 7:45 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
Tap to the sportsbook's College Football page, look for the Western Kentucky vs LSU Game.
Navigate to the sportsbook's College Football page. Next, look for live or upcoming matchups. Select the Western Kentucky vs LSU Game.
Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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