Louisville vs SMU Football Odds - SportsBetting3.com

The Cardinals will play the Mustangs on Saturday, November 22nd, 2025. The matchup takes place at Gerald J. Ford Stadium. Watch this exciting Week 13 matchup at 12:00 pm EST. Check local listings for coverage on ESPN2.

Learn more about College Football betting with our handy tutorial and guide. We explain spread, total and money line bets.

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Matchup Stats
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Recent Meetings
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Key Matchup Stats

We're now in the home stretch of the 2025 college football season, with Louisville and SMU meeting at Gerald J. Ford Stadium for a key late-season matchup on Saturday, November 22nd, 2025. The playoffs are fast approaching, along with the annual Bowl games that kick off in December. Here's an overview of some important 2025 performance data for each team.

SportsBetting3.com Power Rankings - As we wrap up the 2025 regular season, Louisville has notched a 96.33 ACC Conference conference power ranking. On the other side of the gridiron, SMU has a 97.67 ACC Conference power ranking.
Away Louisville - Looking at Week 13, Louisville heads into this matchup with a 3-0 record as an away team. This ranks them 2nd in the ACC Conference for away team wins in 2025. Remember that a team's overall record and schedule strength will affect whether or not they make a December bowl game or qualify for the playoffs.
Home SMU - Meanwhile, SMU has a 4-1 record as a home team for 2025. They currently rank 3rd in the ACC Conference for home team wins. Let's see if they can add another win to their record when they battle Louisville on Saturday, November 22nd, 2025.
Points Scored - Now late in the 2025 season, Louisville ranks 8th (315) in the ACC Conference, with SMU currently ranking 7th (322) for points scored in the ACC Conference.
Points Against - Louisville currently stands 12th (215) in the ACC Conference for points scored by opponents in the 2025 college football season. Their opponent, SMU, ranks 13th (204) in the ACC Conference for points against them as the 2025 college football season comes to a close.
Team Records - As we head into Week 13, Louisville has a 7-3 overall record for the 2025 regular season, with SMU possessing a 7-3 standing for the 2025 college football season.

Paddy O'Parlay

The "Sports Network" talking heads have nothing on my Irish arse!

Top o' the mornin' to ya! Louisville faces SMU in a fierce Week 13 matchup!

The game will be held at Gerald J. Ford Stadium, where the stakes are high.

Louisville boasts a Power Ranking of 96.33, while SMU sits at 97.67.

Both teams have a standing of 7-3, making this game a must-watch.

We recommend BetRivers or BetMGM for a bet on this game. Review this game's prop bets. Compare the best point spread, total, and moneylines from our partner sportsbooks below.

Best Cardinals at Mustangs Odds

**Best Point Spread Betting Odds**
Underdog Louisville	Favorite SMU
+4.5 -110 BetMGM Bet	-4.5 -110 BetMGM Bet

SMU has a -4.5 -110 point spread at BetMGM OH. They are the point spread favorite in this matchup. Louisville has a +4.5 -110 point spread at BetMGM OH. Louisville is the point spread underdog. Review how to bet on a point spread with our text and video tutorials.

**Best Total Betting Odds**
Over	Under
49.5 o -110 BetMGM Bet	49.5 u -110 BetMGM Bet

BetMGM has the best over line of 49.5 points. Risk $110 to win $100. BetMGM has the best under line of 49.5 points. Risk $110 to win $100. Our tutorial explains more about total bets.

**Best Moneyline Betting Odds**
Underdog Louisville	Favorite SMU
+155 BetMGM Bet	-190 BetMGM Bet

SMU is the -190 moneyline favorite. Risk $190 to win $100 on SMU at BetMGM. Louisville is the +155 underdog at BetMGM. Risk $100 to win $155 on Louisville. Learn more about how to bet on money lines.

Matchup Odds FAQs

What is the point spread for the Louisville vs SMU College Football game on Saturday, November 22nd, 2025?

SMU is a -4.5 -110 point spread favorite at BetMGM, while Louisville is a +4.5 -110 point spread underdog at BetMGM.

What is the over-under total line for the Louisville vs SMU College Football game on Saturday, November 22nd, 2025?

The best over line is 49.5 -110 points at BetMGM, which means you risk $110 to win $100 betting the over. The best under line is 49.5 -110 points at BetMGM, and that means you risk $110 to win $100 betting the under.

What is the moneyline for the Louisville vs SMU College Football game on Saturday, November 22nd, 2025?

SMU is a -190 moneyline favorite at BetMGM and Louisville is a +155 moneyline underdog at BetMGM.

College Football Odds Example

College Football Odds and Outcomes Explained
Game	BetMGM Bet
Louisville SMU 11/22/25 12:00pm EST	+4.5 -110 -4.5 -110

Bet $100 at BetMGM Ohio
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Underdog Louisville - Louisville bettors risk $100 to win $90.91 at -110 odds.

A +4.5 Louisville underdog bet wins if they lose by 4 or fewer, tie, or win outright. Your bet loses if they lose by 5 or more.

Favorite SMU - SMU bettors risk $100 to win $90.91 at -110 odds.

A -4.5 SMU favorite bet wins if they win by 5 or more. Your bet loses if they win by 4 or fewer, tie, or lose outright.

Louisville at SMU Prop Bets

Important Note: Some states expressly forbid individual college athlete prop bets. The following wagers may not be available depending on your particular state laws.

College Football Prop Bets
+ Displays more odds
	BetMGM Bet
Louisville SMU No Touchdown To Score 1st Touchdown 11/22/25 12:00pm EST	+120 -175 +10000 Bet
Louisville SMU Game to Overtime 11/22/25 12:00pm EST	Yes +1050 No -10000 Bet
Louisville SMU Both Teams Score 10+ 11/22/25 12:00pm EST	Yes -900 No +525 Bet
Louisville SMU Both Teams Score 20+ 11/22/25 12:00pm EST	Yes -105 No -120 Bet
	BetMGM
Louisville SMU Both Teams Score 30+ 11/22/25 12:00pm EST	Yes +600 No -1100 Bet

Recent Meetings Since 2021

Recent Meetings Since 2021
Week	Game	Result	Margin
2025 Week 13	Louisville vs SMU Saturday, November 22nd, 2025	SMU 38, LOU 6 Gerald J. Ford Stadium	SMU by 32
2024 Week 6	SMU vs Louisville Saturday, October 5th, 2024	SMU 34, LOU 27 L&N Federal Credit Union Stadium	SMU by 7

Team Standings

2025-2026 College Football Regular Season Standings - Louisville, SMU
Team	Conf	Conf%	W	L	PF	PA	Home	Away	Strk
SMU	6-2	0.750	8	4	395	248	5-1	3-3	L1
Louisville	4-4	0.500	9	4	389	275	5-3	3-1	W2

Louisville & SMU Futures Odds

Latest NCAA Championship odds, if available, for each team. Review odds for other teams and learn the best College Football bets.

Louisville Championship Odds

No NCAA College Football Championship TM Louisville YR: futures available

SMU Championship Odds

No NCAA College Football Championship TM SMU YR: futures available

Louisville & SMU Team Pages

Review each team's season schedule and results, season win total odds, futures odds, betting bonuses and other valuable information on our exclusive team betting odds pages. Team betting odds and stats update throughout the season:

Team Schedules & Results

2025-26 Louisville Games & Results
Week	Matchup	Date & Result
Week 1	Eastern Kentucky vs Louisville	LOU 51, EKU 17 Saturday, August 30th, 2025
Week 2	James Madison vs Louisville	LOU 28, JMU 14 Friday, September 5th, 2025
Week 4	Bowling Green vs Louisville	LOU 40, BGSU 17 Saturday, September 20th, 2025
Week 5	Louisville vs Pittsburgh	LOU 34, PITT 27 Saturday, September 27th, 2025
Week 6	Virginia vs Louisville	UVA 30, LOU 27 (OT) Saturday, October 4th, 2025
Week 8	Louisville vs Miami (FL)	LOU 24, MIA 21 Friday, October 17th, 2025
Week 9	Boston College vs Louisville	LOU 38, BC 24 Saturday, October 25th, 2025
Week 10	Louisville vs Virginia Tech	LOU 28, VT 16 Saturday, November 1st, 2025
Week 11	California vs Louisville	CAL 29, LOU 26 (OT) Saturday, November 8th, 2025
Week 12	Clemson vs Louisville	CLEM 20, LOU 19 Friday, November 14th, 2025
Week 13	Louisville vs SMU	SMU 38, LOU 6 Saturday, November 22nd, 2025
Week 14	Kentucky vs Louisville	LOU 41, UK 0 Saturday, November 29th, 2025
Bowls	Toledo vs Louisville Bush's Boca Raton Bowl	LOU 27, TOL 22 Tuesday, December 23rd, 2025

2025-26 SMU Games & Results
Week	Matchup	Date & Result
Week 1	East Texas A&M vs SMU	SMU 42, ETAM 13 Saturday, August 30th, 2025
Week 2	Baylor vs SMU	BAY 48, SMU 45 (2OT) Saturday, September 6th, 2025
Week 3	SMU vs Missouri State	SMU 28, MOST 10 Saturday, September 13th, 2025
Week 4	SMU vs TCU	TCU 35, SMU 24 Saturday, September 20th, 2025
Week 6	Syracuse vs SMU	SMU 31, SYR 18 Saturday, October 4th, 2025
Week 7	Stanford vs SMU	SMU 34, STAN 10 Saturday, October 11th, 2025
Week 8	SMU vs Clemson	SMU 35, CLEM 24 Saturday, October 18th, 2025
Week 9	SMU vs Wake Forest	WAKE 13, SMU 12 Saturday, October 25th, 2025
Week 10	Miami (FL) vs SMU	SMU 26, MIA 20 (OT) Saturday, November 1st, 2025
Week 11	SMU vs Boston College	SMU 45, BC 13 Saturday, November 8th, 2025
Week 13	Louisville vs SMU	SMU 38, LOU 6 Saturday, November 22nd, 2025
Week 14	SMU vs California	CAL 38, SMU 35 Saturday, November 29th, 2025
Bowls	Arizona vs SMU Trust & Will Holiday Bowl	Friday, January 2nd, 2026 8:00 pm EST

How to Bet on the Game

Time needed: 4 minutes.

How to Bet on the Louisville vs SMU College Football Game

Open a new sports betting account before game time.
Review our list of sports betting sites. Open a new account before the game starts on Saturday, November 22nd, 2025 at 12:00 pm EST, making sure to enter all your personal details correctly. Don't forget to add your bonus code.
Visit the sportsbook’s cashier, banking, or deposit page.
Navigate to the sportsbook's deposit page. Use your Visa card or MasterCard, or deposit with a bank transfer, or other methods like Paypal.
Tap to the sportsbook's College Football page, look for the Louisville vs SMU Game.
Navigate to the sportsbook's College Football page. Next, look for live or upcoming matchups. Select the Louisville vs SMU Game.
Choose your bet and place a wager.
Choose your bet and then use the funds you deposited to place a wager. The sportsbook will pay your winnings or deduct a losing wager from your account balance after the game.

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